Atypical Brain Responses to Reward Cues in Autism as Revealed by Event-Related Potentials / Gregor KOHLS in Journal of Autism and Developmental Disorders, 41-11 (November 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-11 (November 2011) . - p.1523-1533 Titre : Atypical Brain Responses to Reward Cues in Autism as Revealed by Event-Related Potentials Type de document : texte imprimé Auteurs : Gregor KOHLS, Auteur ; Judith PELTZER, Auteur ; Martin SCHULTE-RUTHER, Auteur ; Inge KAMP-BECKER, Auteur ; Helmut REMSCHMIDT, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Kerstin KONRAD, Auteur Année de publication : 2011 Article en page(s) : p.1523-1533 Langues : Anglais (eng) Mots-clés : Social reward  Monetary reward  Motivation  Autism spectrum disorders  Event-related brain potentials  P3  Go/no-go task Index. décimale : PER Périodiques Résumé : Social motivation deficit theories suggest that children with autism do not properly anticipate and appreciate the pleasure of social stimuli. In this study, we investigated event-related brain potentials evoked by cues that triggered social versus monetary reward anticipation in children with autism. Children with autism showed attenuated P3 activity in response to cues associated with a timely reaction to obtain a reward, irrespective of reward type. We attribute this atypical P3 activity in response to reward cues as reflective of diminished motivated attention to reward signals, a possible contributor to reduced social motivation in autism. Thus, our findings suggest a general reward processing deficit rather than a specific social reward dysfunction in autism. En ligne : http://dx.doi.org/10.1007/s10803-011-1177-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=147 [article] Atypical Brain Responses to Reward Cues in Autism as Revealed by Event-Related Potentials [texte imprimé] / Gregor KOHLS, Auteur ; Judith PELTZER, Auteur ; Martin SCHULTE-RUTHER, Auteur ; Inge KAMP-BECKER, Auteur ; Helmut REMSCHMIDT, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Kerstin KONRAD, Auteur . - 2011 . - p.1523-1533. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-11 (November 2011) . - p.1523-1533 Mots-clés : Social reward  Monetary reward  Motivation  Autism spectrum disorders  Event-related brain potentials  P3  Go/no-go task Index. décimale : PER Périodiques Résumé : Social motivation deficit theories suggest that children with autism do not properly anticipate and appreciate the pleasure of social stimuli. In this study, we investigated event-related brain potentials evoked by cues that triggered social versus monetary reward anticipation in children with autism. Children with autism showed attenuated P3 activity in response to cues associated with a timely reaction to obtain a reward, irrespective of reward type. We attribute this atypical P3 activity in response to reward cues as reflective of diminished motivated attention to reward signals, a possible contributor to reduced social motivation in autism. Thus, our findings suggest a general reward processing deficit rather than a specific social reward dysfunction in autism. En ligne : http://dx.doi.org/10.1007/s10803-011-1177-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=147

Group-based cognitive behavioural psychotherapy for children and adolescents with ASD: the randomized, multicentre, controlled SOSTA – net trial / Christine M. FREITAG in Journal of Child Psychology and Psychiatry, 57-5 (May 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-5 (May 2016) . - p.596-605 Titre : Group-based cognitive behavioural psychotherapy for children and adolescents with ASD: the randomized, multicentre, controlled SOSTA – net trial Type de document : texte imprimé Auteurs : Christine M. FREITAG, Auteur ; Katrin JENSEN, Auteur ; Leyla ELSUNI, Auteur ; Michael SACHSE, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Martin SCHULTE-RUTHER, Auteur ; Susann HÄNIG, Auteur ; Alexander VON GONTARD, Auteur ; Luise POUSTKA, Auteur ; Tanja SCHAD-HANSJOSTEN, Auteur ; Christina WENZL, Auteur ; Judith SINZIG, Auteur ; Regina TAURINES, Auteur ; Julia GEIßLER, Auteur ; Meinhard KIESER, Auteur ; Hannah CHOLEMKERY, Auteur Article en page(s) : p.596-605 Langues : Anglais (eng) Mots-clés : Group therapy  social skills  autism spectrum disorders  randomized-controlled trial Index. décimale : PER Périodiques Résumé : Background Group-based psychotherapy in Autism Spectrum Disorder (ASD) has predominantly been studied in the United States by small studies in school-aged children without long-term follow-up. We report results of a large, confirmatory, multicentre randomized-controlled phase-III trial in children and adolescents studying the ASD specific, manualized group-based cognitive behavioural SOSTA-FRA approach. Methods High-functioning ASD individuals aged 8–19 years old were randomized to 12 sessions SOSTA-FRA or treatment as usual. Primary outcomes were change in total raw score of the parent-rated Social Responsiveness Scale (pSRS) between baseline (T2) and end of intervention (T4), and between T2 and 3 months after end of intervention (T5). Trial registration: ISRCTN94863788. Results Between 20/5/2010 and 14/2/2013, n = 320 ASD patients were screened, n = 228 patients were randomized, and N = 209 analysed. Mean pSRS difference between groups at T4 was −6.5 (95% CI −11.6 to – 1.4; p = .013), and at T5 −6.4 (−11.5 to −1.3, p = .015). Pre-treatment SRS and IQ were positively associated with stronger improvement at T4 and T5. Conclusions Short-term ASD-specific add-on group-based psychotherapy has shown postintervention efficacy with regard to parent-rated social responsiveness predominantly in male high-functioning children and adolescents with ASD. Future studies should implement blinded standardized observational measures of peer-related social interaction. En ligne : http://dx.doi.org/10.1111/jcpp.12509 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288 [article] Group-based cognitive behavioural psychotherapy for children and adolescents with ASD: the randomized, multicentre, controlled SOSTA – net trial [texte imprimé] / Christine M. FREITAG, Auteur ; Katrin JENSEN, Auteur ; Leyla ELSUNI, Auteur ; Michael SACHSE, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Martin SCHULTE-RUTHER, Auteur ; Susann HÄNIG, Auteur ; Alexander VON GONTARD, Auteur ; Luise POUSTKA, Auteur ; Tanja SCHAD-HANSJOSTEN, Auteur ; Christina WENZL, Auteur ; Judith SINZIG, Auteur ; Regina TAURINES, Auteur ; Julia GEIßLER, Auteur ; Meinhard KIESER, Auteur ; Hannah CHOLEMKERY, Auteur . - p.596-605. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-5 (May 2016) . - p.596-605 Mots-clés : Group therapy  social skills  autism spectrum disorders  randomized-controlled trial Index. décimale : PER Périodiques Résumé : Background Group-based psychotherapy in Autism Spectrum Disorder (ASD) has predominantly been studied in the United States by small studies in school-aged children without long-term follow-up. We report results of a large, confirmatory, multicentre randomized-controlled phase-III trial in children and adolescents studying the ASD specific, manualized group-based cognitive behavioural SOSTA-FRA approach. Methods High-functioning ASD individuals aged 8–19 years old were randomized to 12 sessions SOSTA-FRA or treatment as usual. Primary outcomes were change in total raw score of the parent-rated Social Responsiveness Scale (pSRS) between baseline (T2) and end of intervention (T4), and between T2 and 3 months after end of intervention (T5). Trial registration: ISRCTN94863788. Results Between 20/5/2010 and 14/2/2013, n = 320 ASD patients were screened, n = 228 patients were randomized, and N = 209 analysed. Mean pSRS difference between groups at T4 was −6.5 (95% CI −11.6 to – 1.4; p = .013), and at T5 −6.4 (−11.5 to −1.3, p = .015). Pre-treatment SRS and IQ were positively associated with stronger improvement at T4 and T5. Conclusions Short-term ASD-specific add-on group-based psychotherapy has shown postintervention efficacy with regard to parent-rated social responsiveness predominantly in male high-functioning children and adolescents with ASD. Future studies should implement blinded standardized observational measures of peer-related social interaction. En ligne : http://dx.doi.org/10.1111/jcpp.12509 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288

Implicit sequence learning in juvenile anorexia nervosa: neural mechanisms and the impact of starvation / Christine FIRK in Journal of Child Psychology and Psychiatry, 56-11 (November 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-11 (November 2015) . - p.1168-1176 Titre : Implicit sequence learning in juvenile anorexia nervosa: neural mechanisms and the impact of starvation Type de document : texte imprimé Auteurs : Christine FIRK, Auteur ; Verena MAINZ, Auteur ; Martin SCHULTE-RUETHER, Auteur ; Gereon R. FINK, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Kerstin KONRAD, Auteur Article en page(s) : p.1168-1176 Langues : Anglais (eng) Mots-clés : Anorexia nervosa  implicit sequence learning  serial reaction time task  functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : Background Previous studies have reported that cognitive deficits occur in patients with anorexia nervosa (AN) and that these deficits may represent a predisposition towards developing AN or perpetuate the disorder. Specifically, dysfunctional implicit learning may contribute to the development of highly resistant dieting behaviours that are fundamental to the persistence of the disorder. Thus, the aims of this study were (a) to investigate implicit sequence learning in adolescent patients with AN before and after weight recovery and (b) to elucidate the associated neural mechanisms in acute AN relative to healthy controls. Methods In a behavioural study, implicit sequence learning was assessed using a serial reaction time task in 27 adolescents with AN before (T1) and after weight recovery (T2) compared with age-matched healthy controls (HC) who were assessed at similar time intervals. The neural correlates of implicit sequence learning were subsequently investigated in 19 AN patients shortly after they were admitted to the hospital and 20 HC using functional magnetic resonance imaging (fMRI). Results At T1, AN patients showed reduced sequence learning compared with HC. However, no behavioural differences between HC and AN patients were found at T2. At the neural level, acute AN patients showed reduced thalamic activation during sequence learning compared with HC subjects. Conclusions Our data suggest that the impaired implicit learning observed in adolescent AN patients before weight gain is a state-related dysfunction that normalises with weight gain. Thus, implicit learning deficits do not appear to represent a predisposition towards developing AN; rather, these deficits should be considered when planning psychotherapeutic interventions for acute AN. Reduced thalamic activation during the acute stage of AN may indicate a starvation-induced dysfunction of the neural circuitry that is involved in behavioural flexibility. En ligne : http://dx.doi.org/10.1111/jcpp.12384 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Implicit sequence learning in juvenile anorexia nervosa: neural mechanisms and the impact of starvation [texte imprimé] / Christine FIRK, Auteur ; Verena MAINZ, Auteur ; Martin SCHULTE-RUETHER, Auteur ; Gereon R. FINK, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Kerstin KONRAD, Auteur . - p.1168-1176. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-11 (November 2015) . - p.1168-1176 Mots-clés : Anorexia nervosa  implicit sequence learning  serial reaction time task  functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : Background Previous studies have reported that cognitive deficits occur in patients with anorexia nervosa (AN) and that these deficits may represent a predisposition towards developing AN or perpetuate the disorder. Specifically, dysfunctional implicit learning may contribute to the development of highly resistant dieting behaviours that are fundamental to the persistence of the disorder. Thus, the aims of this study were (a) to investigate implicit sequence learning in adolescent patients with AN before and after weight recovery and (b) to elucidate the associated neural mechanisms in acute AN relative to healthy controls. Methods In a behavioural study, implicit sequence learning was assessed using a serial reaction time task in 27 adolescents with AN before (T1) and after weight recovery (T2) compared with age-matched healthy controls (HC) who were assessed at similar time intervals. The neural correlates of implicit sequence learning were subsequently investigated in 19 AN patients shortly after they were admitted to the hospital and 20 HC using functional magnetic resonance imaging (fMRI). Results At T1, AN patients showed reduced sequence learning compared with HC. However, no behavioural differences between HC and AN patients were found at T2. At the neural level, acute AN patients showed reduced thalamic activation during sequence learning compared with HC subjects. Conclusions Our data suggest that the impaired implicit learning observed in adolescent AN patients before weight gain is a state-related dysfunction that normalises with weight gain. Thus, implicit learning deficits do not appear to represent a predisposition towards developing AN; rather, these deficits should be considered when planning psychotherapeutic interventions for acute AN. Reduced thalamic activation during the acute stage of AN may indicate a starvation-induced dysfunction of the neural circuitry that is involved in behavioural flexibility. En ligne : http://dx.doi.org/10.1111/jcpp.12384 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

Intact mirror mechanisms for automatic facial emotions in children and adolescents with autism spectrum disorder / Martin SCHULTE-RUTHER in Autism Research, 10-2 (February 2017)  

Public ISBD [article]  inAutism Research > 10-2 (February 2017) . - p.298-310 Titre : Intact mirror mechanisms for automatic facial emotions in children and adolescents with autism spectrum disorder Type de document : texte imprimé Auteurs : Martin SCHULTE-RUTHER, Auteur ; Ellen OTTE, Auteur ; Kübra ADIGÃœZEL, Auteur ; Christine FIRK, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Iring KOCH, Auteur ; Kerstin KONRAD, Auteur Article en page(s) : p.298-310 Langues : Anglais (eng) Mots-clés : mirror neuron system  electromyography  imitation  autism  perception action compatibility  facial emotions Index. décimale : PER Périodiques Résumé : It has been suggested that an early deficit in the human mirror neuron system (MNS) is an important feature of autism. Recent findings related to simple hand and finger movements do not support a general dysfunction of the MNS in autism. Studies investigating facial actions (e.g., emotional expressions) have been more consistent, however, mostly relied on passive observation tasks. We used a new variant of a compatibility task for the assessment of automatic facial mimicry responses that allowed for simultaneous control of attention to facial stimuli. We used facial electromyography in 18 children and adolescents with Autism spectrum disorder (ASD) and 18 typically developing controls (TDCs). We observed a robust compatibility effect in ASD, that is, the execution of a facial expression was facilitated if a congruent facial expression was observed. Time course analysis of RT distributions and comparison to a classic compatibility task (symbolic Simon task) revealed that the facial compatibility effect appeared early and increased with time, suggesting fast and sustained activation of motor codes during observation of facial expressions. We observed a negative correlation of the compatibility effect with age across participants and in ASD, and a positive correlation between self-rated empathy and congruency for smiling faces in TDC but not in ASD. This pattern of results suggests that basic motor mimicry is intact in ASD, but is not associated with complex social cognitive abilities such as emotion understanding and empathy. En ligne : http://dx.doi.org/10.1002/aur.1654 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Intact mirror mechanisms for automatic facial emotions in children and adolescents with autism spectrum disorder [texte imprimé] / Martin SCHULTE-RUTHER, Auteur ; Ellen OTTE, Auteur ; Kübra ADIGÃœZEL, Auteur ; Christine FIRK, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Iring KOCH, Auteur ; Kerstin KONRAD, Auteur . - p.298-310. Langues : Anglais (eng) in Autism Research > 10-2 (February 2017) . - p.298-310 Mots-clés : mirror neuron system  electromyography  imitation  autism  perception action compatibility  facial emotions Index. décimale : PER Périodiques Résumé : It has been suggested that an early deficit in the human mirror neuron system (MNS) is an important feature of autism. Recent findings related to simple hand and finger movements do not support a general dysfunction of the MNS in autism. Studies investigating facial actions (e.g., emotional expressions) have been more consistent, however, mostly relied on passive observation tasks. We used a new variant of a compatibility task for the assessment of automatic facial mimicry responses that allowed for simultaneous control of attention to facial stimuli. We used facial electromyography in 18 children and adolescents with Autism spectrum disorder (ASD) and 18 typically developing controls (TDCs). We observed a robust compatibility effect in ASD, that is, the execution of a facial expression was facilitated if a congruent facial expression was observed. Time course analysis of RT distributions and comparison to a classic compatibility task (symbolic Simon task) revealed that the facial compatibility effect appeared early and increased with time, suggesting fast and sustained activation of motor codes during observation of facial expressions. We observed a negative correlation of the compatibility effect with age across participants and in ASD, and a positive correlation between self-rated empathy and congruency for smiling faces in TDC but not in ASD. This pattern of results suggests that basic motor mimicry is intact in ASD, but is not associated with complex social cognitive abilities such as emotion understanding and empathy. En ligne : http://dx.doi.org/10.1002/aur.1654 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

Using machine learning to improve diagnostic assessment of ASD in the light of specific differential and co-occurring diagnoses / Martin SCHULTE-RUTHER in Journal of Child Psychology and Psychiatry, 64-1 (January 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-1 (January 2023) . - p.16-26 Titre : Using machine learning to improve diagnostic assessment of ASD in the light of specific differential and co-occurring diagnoses Type de document : texte imprimé Auteurs : Martin SCHULTE-RUTHER, Auteur ; Tomas KULVICIUS, Auteur ; Sanna STROTH, Auteur ; Nicole WOLFF, Auteur ; Veit ROESSNER, Auteur ; Peter B. MARSCHIK, Auteur ; Inge KAMP-BECKER, Auteur ; Luise POUSTKA, Auteur Article en page(s) : p.16-26 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Diagnostic assessment of ASD requires substantial clinical experience and is particularly difficult in the context of other disorders with behavioral symptoms in the domain of social interaction and communication. Observation measures such as the Autism Diagnostic Observation Schedule (ADOS) do not take into account such co-occurring disorders. Method We used a well-characterized clinical sample of individuals (n=1,251) that had received detailed outpatient evaluation for the presence of an ASD diagnosis (n=481) and covered a range of additional overlapping diagnoses, including anxiety-related disorders (ANX, n=122), ADHD (n=439), and conduct disorder (CD, n=194). We focused on ADOS module 3, covering the age range with particular high prevalence of such differential diagnoses. We used machine learning (ML) and trained random forest models on ADOS single item scores to predict a clinical best-estimate diagnosis of ASD in the context of these differential diagnoses (ASD vs. ANX, ASD vs. ADHD, ASD vs. CD), in the context of co-occurring ADHD, and an unspecific model using all available data. We employed nested cross-validation for an unbiased estimate of classification performance and made available a Webapp to showcase the results and feasibility for translation into clinical practice. Results We obtained very good overall sensitivity (0.89-0.94) and specificity (0.87-0.89). In particular for individuals with less severe symptoms, our models showed increases of up to 35% in sensitivity or specificity. Furthermore, we analyzed item importance profiles of the ANX, ADHD, and CD models in comparison with the unspecific model revealing distinct patterns of importance for specific ADOS items with respect to differential diagnoses. Conclusions ML-based diagnostic classification may improve clinical decisions by utilizing the full range of information from detailed diagnostic observation instruments such as the ADOS. Importantly, this strategy might be of particular relevance for older children with less severe symptoms for whom the diagnostic decision is often particularly difficult. En ligne : https://doi.org/10.1111/jcpp.13650 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Using machine learning to improve diagnostic assessment of ASD in the light of specific differential and co-occurring diagnoses [texte imprimé] / Martin SCHULTE-RUTHER, Auteur ; Tomas KULVICIUS, Auteur ; Sanna STROTH, Auteur ; Nicole WOLFF, Auteur ; Veit ROESSNER, Auteur ; Peter B. MARSCHIK, Auteur ; Inge KAMP-BECKER, Auteur ; Luise POUSTKA, Auteur . - p.16-26. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-1 (January 2023) . - p.16-26 Index. décimale : PER Périodiques Résumé : Background Diagnostic assessment of ASD requires substantial clinical experience and is particularly difficult in the context of other disorders with behavioral symptoms in the domain of social interaction and communication. Observation measures such as the Autism Diagnostic Observation Schedule (ADOS) do not take into account such co-occurring disorders. Method We used a well-characterized clinical sample of individuals (n=1,251) that had received detailed outpatient evaluation for the presence of an ASD diagnosis (n=481) and covered a range of additional overlapping diagnoses, including anxiety-related disorders (ANX, n=122), ADHD (n=439), and conduct disorder (CD, n=194). We focused on ADOS module 3, covering the age range with particular high prevalence of such differential diagnoses. We used machine learning (ML) and trained random forest models on ADOS single item scores to predict a clinical best-estimate diagnosis of ASD in the context of these differential diagnoses (ASD vs. ANX, ASD vs. ADHD, ASD vs. CD), in the context of co-occurring ADHD, and an unspecific model using all available data. We employed nested cross-validation for an unbiased estimate of classification performance and made available a Webapp to showcase the results and feasibility for translation into clinical practice. Results We obtained very good overall sensitivity (0.89-0.94) and specificity (0.87-0.89). In particular for individuals with less severe symptoms, our models showed increases of up to 35% in sensitivity or specificity. Furthermore, we analyzed item importance profiles of the ANX, ADHD, and CD models in comparison with the unspecific model revealing distinct patterns of importance for specific ADOS items with respect to differential diagnoses. Conclusions ML-based diagnostic classification may improve clinical decisions by utilizing the full range of information from detailed diagnostic observation instruments such as the ADOS. Importantly, this strategy might be of particular relevance for older children with less severe symptoms for whom the diagnostic decision is often particularly difficult. En ligne : https://doi.org/10.1111/jcpp.13650 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

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