Annotation: The Development of Antisocial Behavior: An Integrative Causal Model / Benjamin B. LAHEY in Journal of Child Psychology and Psychiatry, 40-5 (July 1999)

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 40-5 (July 1999) . - p.669-682 Titre : Annotation: The Development of Antisocial Behavior: An Integrative Causal Model Type de document : Texte imprimé et/ou numérique Auteurs : Benjamin B. LAHEY, Auteur ; Irwin D. WALDMAN, Auteur ; Keith MCBURNETT, Auteur Année de publication : 1999 Article en page(s) : p.669-682 Langues : Anglais (eng) Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=124 [article] Annotation: The Development of Antisocial Behavior: An Integrative Causal Model [Texte imprimé et/ou numérique] / Benjamin B. LAHEY, Auteur ; Irwin D. WALDMAN, Auteur ; Keith MCBURNETT, Auteur . - 1999 . - p.669-682. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 40-5 (July 1999) . - p.669-682 Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=124

Annual Research Review: Phenotypic and causal structure of conduct disorder in the broader context of prevalent forms of psychopathology / Benjamin B. LAHEY in Journal of Child Psychology and Psychiatry, 53-5 (May 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-5 (May 2012) . - p.536-557 Titre : Annual Research Review: Phenotypic and causal structure of conduct disorder in the broader context of prevalent forms of psychopathology Type de document : Texte imprimé et/ou numérique Auteurs : Benjamin B. LAHEY, Auteur ; Irwin D. WALDMAN, Auteur Année de publication : 2012 Article en page(s) : p.536-557 Langues : Anglais (eng) Mots-clés : Conduct disorder  oppositional defiant disorder  taxonomy  etiology  homotypic and heterotypic continuity Index. décimale : PER Périodiques Résumé : Background:  A better understanding of the nature and etiology of conduct disorder (CD) can inform nosology and vice versa. We posit that any prevalent form of psychopathology, including CD, can be best understood if it is studied in the context of other correlated forms of child and adolescent psychopathology using formal models to guide inquiry. Methods:  Review of both cross-sectional and longitudinal studies of the place of CD in the phenotypic and causal structure of prevalent psychopathology, with an emphasis on similarities and differences between CD and oppositional defiant disorder (ODD). Papers were located using Web of Science by topic searches with no restriction on year of publication. Results:  Although some important nosologic questions remain unanswered, the dimensional phenotype of CD is well defined. CD differs from other disorders in its correlates, associated impairment, and course. Nonetheless, it is robustly correlated with many other prevalent dimensions of psychopathology both concurrently and predictively, including both other ‘externalizing’ disorders and some ‘internalizing’ disorders. Based on emerging evidence, we hypothesize that these concurrent and predictive correlations result primarily from widespread genetic pleiotropy, with some genetic factors nonspecifically influencing risk for multiple correlated dimensions of psychopathology. In contrast, environmental influences mostly act to differentiate dimensions of psychopathology from one another both concurrently and over time. CD and ODD share half of their genetic influences, but their genetic etiologies are distinct in other ways. Unlike most other dimensions of psychopathology, half of the genetic influences on CD appear to be unique to CD. In contrast, ODD broadly shares nearly all of its genetic influences with other disorders and has little unique genetic variance. Conclusions:  Conduct disorder is a relatively distinct syndrome at both phenotypic and etiologic levels, but much is revealed by studying CD in the context of its causal and phenotypic associations with other disorders over time. Advancing and refining formal causal models that specify the common and unique causes and biological mechanisms underlying each correlated dimension of psychopathology should facilitate research on the fundamental nature and nosology of CD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02509.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=154 [article] Annual Research Review: Phenotypic and causal structure of conduct disorder in the broader context of prevalent forms of psychopathology [Texte imprimé et/ou numérique] / Benjamin B. LAHEY, Auteur ; Irwin D. WALDMAN, Auteur . - 2012 . - p.536-557. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-5 (May 2012) . - p.536-557 Mots-clés : Conduct disorder  oppositional defiant disorder  taxonomy  etiology  homotypic and heterotypic continuity Index. décimale : PER Périodiques Résumé : Background:  A better understanding of the nature and etiology of conduct disorder (CD) can inform nosology and vice versa. We posit that any prevalent form of psychopathology, including CD, can be best understood if it is studied in the context of other correlated forms of child and adolescent psychopathology using formal models to guide inquiry. Methods:  Review of both cross-sectional and longitudinal studies of the place of CD in the phenotypic and causal structure of prevalent psychopathology, with an emphasis on similarities and differences between CD and oppositional defiant disorder (ODD). Papers were located using Web of Science by topic searches with no restriction on year of publication. Results:  Although some important nosologic questions remain unanswered, the dimensional phenotype of CD is well defined. CD differs from other disorders in its correlates, associated impairment, and course. Nonetheless, it is robustly correlated with many other prevalent dimensions of psychopathology both concurrently and predictively, including both other ‘externalizing’ disorders and some ‘internalizing’ disorders. Based on emerging evidence, we hypothesize that these concurrent and predictive correlations result primarily from widespread genetic pleiotropy, with some genetic factors nonspecifically influencing risk for multiple correlated dimensions of psychopathology. In contrast, environmental influences mostly act to differentiate dimensions of psychopathology from one another both concurrently and over time. CD and ODD share half of their genetic influences, but their genetic etiologies are distinct in other ways. Unlike most other dimensions of psychopathology, half of the genetic influences on CD appear to be unique to CD. In contrast, ODD broadly shares nearly all of its genetic influences with other disorders and has little unique genetic variance. Conclusions:  Conduct disorder is a relatively distinct syndrome at both phenotypic and etiologic levels, but much is revealed by studying CD in the context of its causal and phenotypic associations with other disorders over time. Advancing and refining formal causal models that specify the common and unique causes and biological mechanisms underlying each correlated dimension of psychopathology should facilitate research on the fundamental nature and nosology of CD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02509.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=154

Choline transporter gene variation is associated with attention-deficit hyperactivity disorder / B. A. ENGLISH in Journal of Neurodevelopmental Disorders, 1-4 (December 2009)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 1-4 (December 2009) . - p.252-63 Titre : Choline transporter gene variation is associated with attention-deficit hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : B. A. ENGLISH, Auteur ; M. K. HAHN, Auteur ; I. R. GIZER, Auteur ; M. MAZEI-ROBISON, Auteur ; A. STEELE, Auteur ; D. M. KURNIK, Auteur ; M. A. STEIN, Auteur ; Irwin D. WALDMAN, Auteur ; R. D. BLAKELY, Auteur Article en page(s) : p.252-63 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The neurotransmitter acetylcholine (ACh) plays a critical role in brain circuits mediating motor control, attention, learning and memory. Cholinergic dysfunction is associated with multiple brain disorders including Alzheimer's Disease, addiction, schizophrenia and Attention-Deficit Hyperactivity Disorder (ADHD). The presynaptic choline transporter (CHT, SLC5A7) is the major, rate-limiting determinant of ACh production in the brain and periphery and is consequently upregulated during tasks that require sustained attention. Given the contribution of central cholinergic circuits to the control of movement and attention, we hypothesized that functional CHT gene variants might impact risk for ADHD. We performed a case-control study, followed by family-based association tests on a separate cohort, of two purportedly functional CHT polymorphisms (coding variant Ile89Val (rs1013940) and a genomic SNP 3' of the CHT gene (rs333229), affording both a replication sample and opportunities to reduce potential population stratification biases. Initial genotyping of pediatric ADHD subjects for two purportedly functional CHT alleles revealed a 2-3 fold elevation of the Val89 allele (n = 100; P = 0.02) relative to healthy controls, as well as a significant decrease of the 3'SNP minor allele in Caucasian male subjects (n = 60; P = 0.004). In family based association tests, we found significant overtransmission of the Val89 variant to children with a Combined subtype diagnosis (OR = 3.16; P = 0.01), with an increased Odds Ratio for a haplotype comprising both minor alleles. These studies show evidence of cholinergic deficits in ADHD, particularly for subjects with the Combined subtype, and, if replicated, may encourage further consideration of cholinergic agonist therapy in the disorder. En ligne : http://dx.doi.org/10.1007/s11689-009-9033-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=341 [article] Choline transporter gene variation is associated with attention-deficit hyperactivity disorder [Texte imprimé et/ou numérique] / B. A. ENGLISH, Auteur ; M. K. HAHN, Auteur ; I. R. GIZER, Auteur ; M. MAZEI-ROBISON, Auteur ; A. STEELE, Auteur ; D. M. KURNIK, Auteur ; M. A. STEIN, Auteur ; Irwin D. WALDMAN, Auteur ; R. D. BLAKELY, Auteur . - p.252-63. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 1-4 (December 2009) . - p.252-63 Index. décimale : PER Périodiques Résumé : The neurotransmitter acetylcholine (ACh) plays a critical role in brain circuits mediating motor control, attention, learning and memory. Cholinergic dysfunction is associated with multiple brain disorders including Alzheimer's Disease, addiction, schizophrenia and Attention-Deficit Hyperactivity Disorder (ADHD). The presynaptic choline transporter (CHT, SLC5A7) is the major, rate-limiting determinant of ACh production in the brain and periphery and is consequently upregulated during tasks that require sustained attention. Given the contribution of central cholinergic circuits to the control of movement and attention, we hypothesized that functional CHT gene variants might impact risk for ADHD. We performed a case-control study, followed by family-based association tests on a separate cohort, of two purportedly functional CHT polymorphisms (coding variant Ile89Val (rs1013940) and a genomic SNP 3' of the CHT gene (rs333229), affording both a replication sample and opportunities to reduce potential population stratification biases. Initial genotyping of pediatric ADHD subjects for two purportedly functional CHT alleles revealed a 2-3 fold elevation of the Val89 allele (n = 100; P = 0.02) relative to healthy controls, as well as a significant decrease of the 3'SNP minor allele in Caucasian male subjects (n = 60; P = 0.004). In family based association tests, we found significant overtransmission of the Val89 variant to children with a Combined subtype diagnosis (OR = 3.16; P = 0.01), with an increased Odds Ratio for a haplotype comprising both minor alleles. These studies show evidence of cholinergic deficits in ADHD, particularly for subjects with the Combined subtype, and, if replicated, may encourage further consideration of cholinergic agonist therapy in the disorder. En ligne : http://dx.doi.org/10.1007/s11689-009-9033-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=341

Early concern and disregard for others as predictors of antisocial behavior / Soo Hyun RHEE in Journal of Child Psychology and Psychiatry, 54-2 (February 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-2 (February 2013) . - p.157-166 Titre : Early concern and disregard for others as predictors of antisocial behavior Type de document : Texte imprimé et/ou numérique Auteurs : Soo Hyun RHEE, Auteur ; Naomi P. FRIEDMAN, Auteur ; Debra L. BOELDT, Auteur ; Robin P. CORLEY, Auteur ; John K. HEWITT, Auteur ; Ariel KNAFO, Auteur ; Benjamin B. LAHEY, Auteur ; JoAnn ROBINSON, Auteur ; Carol A. VAN HULLE, Auteur ; Irwin D. WALDMAN, Auteur ; Susan E. YOUNG, Auteur ; Carolyn ZAHN-WAXLER, Auteur Année de publication : 2013 Article en page(s) : p.157-166 Langues : Anglais (eng) Mots-clés : Antisocial behavior  empathy  concern for others  disregard for others Index. décimale : PER Périodiques Résumé : Background: Prediction of antisocial behavior is important, given its adverse impact on both the individuals engaging in antisocial behavior and society. Additional research identifying early predictors of future antisocial behavior, or antisocial propensity, is needed. The present study tested the hypothesis that both concern for others and active disregard for others in distress in toddlers and young children predict antisocial behavior during middle childhood and adolescence. Methods: A representative sample of same-sex twins (N = 956) recruited in Colorado was examined. Mother-rated and researcher-observed concern and disregard for others assessed at age 14–36 months were examined as predictors of parent- (age 4–12), teacher- (age 7–12), and self-reported (age 17) antisocial behavior. Results: Observed disregard for others predicted antisocial behavior assessed by three different informants (parents, teachers, and self), including antisocial behavior assessed 14 years later. It also predicted a higher order antisocial behavior factor (? = .58, p .01) after controlling for observed concern for others. Mother-rated disregard for others predicted parent-reported antisocial behavior. Contrary to predictions, neither mother-rated nor observed concern for others inversely predicted antisocial behavior. Results of twin analyses suggested that the covariation between observed disregard for others and antisocial behavior was due to shared environmental influences. Conclusions: Disregard for others in toddlerhood/early childhood is a strong predictor of antisocial behavior in middle childhood and adolescence. The results suggest the potential need for early assessment of disregard for others and the development of potential interventions. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02574.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=188 [article] Early concern and disregard for others as predictors of antisocial behavior [Texte imprimé et/ou numérique] / Soo Hyun RHEE, Auteur ; Naomi P. FRIEDMAN, Auteur ; Debra L. BOELDT, Auteur ; Robin P. CORLEY, Auteur ; John K. HEWITT, Auteur ; Ariel KNAFO, Auteur ; Benjamin B. LAHEY, Auteur ; JoAnn ROBINSON, Auteur ; Carol A. VAN HULLE, Auteur ; Irwin D. WALDMAN, Auteur ; Susan E. YOUNG, Auteur ; Carolyn ZAHN-WAXLER, Auteur . - 2013 . - p.157-166. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-2 (February 2013) . - p.157-166 Mots-clés : Antisocial behavior  empathy  concern for others  disregard for others Index. décimale : PER Périodiques Résumé : Background: Prediction of antisocial behavior is important, given its adverse impact on both the individuals engaging in antisocial behavior and society. Additional research identifying early predictors of future antisocial behavior, or antisocial propensity, is needed. The present study tested the hypothesis that both concern for others and active disregard for others in distress in toddlers and young children predict antisocial behavior during middle childhood and adolescence. Methods: A representative sample of same-sex twins (N = 956) recruited in Colorado was examined. Mother-rated and researcher-observed concern and disregard for others assessed at age 14–36 months were examined as predictors of parent- (age 4–12), teacher- (age 7–12), and self-reported (age 17) antisocial behavior. Results: Observed disregard for others predicted antisocial behavior assessed by three different informants (parents, teachers, and self), including antisocial behavior assessed 14 years later. It also predicted a higher order antisocial behavior factor (? = .58, p .01) after controlling for observed concern for others. Mother-rated disregard for others predicted parent-reported antisocial behavior. Contrary to predictions, neither mother-rated nor observed concern for others inversely predicted antisocial behavior. Results of twin analyses suggested that the covariation between observed disregard for others and antisocial behavior was due to shared environmental influences. Conclusions: Disregard for others in toddlerhood/early childhood is a strong predictor of antisocial behavior in middle childhood and adolescence. The results suggest the potential need for early assessment of disregard for others and the development of potential interventions. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02574.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=188

Extending the ‘cross-disorder’ relevance of executive functions to dimensional neuropsychiatric traits in youth / Lauren M. MCGRATH in Journal of Child Psychology and Psychiatry, 57-4 (April 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-4 (April 2016) . - p.462-471 Titre : Extending the ‘cross-disorder’ relevance of executive functions to dimensional neuropsychiatric traits in youth Type de document : Texte imprimé et/ou numérique Auteurs : Lauren M. MCGRATH, Auteur ; Ellen B. BRAATEN, Auteur ; Nathan D. DOTY, Auteur ; Brian L. WILLOUGHBY, Auteur ; H. Kent WILSON, Auteur ; Ellen H. O'DONNELL, Auteur ; Mary K. COLVIN, Auteur ; Hillary L. DITMARS, Auteur ; Jessica E. BLAIS, Auteur ; Erin N. HILL, Auteur ; Aaron METZGER, Auteur ; Roy H. PERLIS, Auteur ; Erik G. WILLCUTT, Auteur ; Jordan W. SMOLLER, Auteur ; Irwin D. WALDMAN, Auteur ; Stephen V. FARAONE, Auteur ; Larry J. SEIDMAN, Auteur ; Alysa E. DOYLE, Auteur Article en page(s) : p.462-471 Langues : Anglais (eng) Mots-clés : Executive functions  mania  psychosis  social responsiveness  cross-disorder  dimensional traits Index. décimale : PER Périodiques Résumé : Background Evidence that different neuropsychiatric conditions share genetic liability has increased interest in phenotypes with ‘cross-disorder’ relevance, as they may contribute to revised models of psychopathology. Cognition is a promising construct for study; yet, evidence that the same cognitive functions are impaired across different forms of psychopathology comes primarily from separate studies of individual categorical diagnoses versus controls. Given growing support for dimensional models that cut across traditional diagnostic boundaries, we aimed to determine, within a single cohort, whether performance on measures of executive functions (EFs) predicted dimensions of different psychopathological conditions known to share genetic liability. Methods Data are from 393 participants, ages 8–17, consecutively enrolled in the Longitudinal Study of Genetic Influences on Cognition (LOGIC). This project is conducting deep phenotyping and genomic analyses in youth referred for neuropsychiatric evaluation. Using structural equation modeling, we examined whether EFs predicted variation in core dimensions of the autism spectrum disorder, bipolar illness, and schizophrenia (including social responsiveness, mania/emotion regulation, and positive symptoms of psychosis, respectively). Results We modeled three cognitive factors (working memory, shifting, and executive processing speed) that loaded on a second-order EF factor. The EF factor predicted variation in our three target traits, but not in a negative control (somatization). Moreover, this EF factor was primarily associated with the overlapping (rather than unique) variance across the three outcome measures, suggesting that it related to a general increase in psychopathology symptoms across those dimensions. Conclusions Findings extend support for the relevance of cognition to neuropsychiatric conditions that share underlying genetic risk. They suggest that higher-order cognition, including EFs, relates to the dimensional spectrum of each of these disorders and not just the clinical diagnoses. Moreover, results have implications for bottom-up models linking genes, cognition, and a general psychopathology liability. En ligne : http://dx.doi.org/10.1111/jcpp.12463 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285 [article] Extending the ‘cross-disorder’ relevance of executive functions to dimensional neuropsychiatric traits in youth [Texte imprimé et/ou numérique] / Lauren M. MCGRATH, Auteur ; Ellen B. BRAATEN, Auteur ; Nathan D. DOTY, Auteur ; Brian L. WILLOUGHBY, Auteur ; H. Kent WILSON, Auteur ; Ellen H. O'DONNELL, Auteur ; Mary K. COLVIN, Auteur ; Hillary L. DITMARS, Auteur ; Jessica E. BLAIS, Auteur ; Erin N. HILL, Auteur ; Aaron METZGER, Auteur ; Roy H. PERLIS, Auteur ; Erik G. WILLCUTT, Auteur ; Jordan W. SMOLLER, Auteur ; Irwin D. WALDMAN, Auteur ; Stephen V. FARAONE, Auteur ; Larry J. SEIDMAN, Auteur ; Alysa E. DOYLE, Auteur . - p.462-471. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-4 (April 2016) . - p.462-471 Mots-clés : Executive functions  mania  psychosis  social responsiveness  cross-disorder  dimensional traits Index. décimale : PER Périodiques Résumé : Background Evidence that different neuropsychiatric conditions share genetic liability has increased interest in phenotypes with ‘cross-disorder’ relevance, as they may contribute to revised models of psychopathology. Cognition is a promising construct for study; yet, evidence that the same cognitive functions are impaired across different forms of psychopathology comes primarily from separate studies of individual categorical diagnoses versus controls. Given growing support for dimensional models that cut across traditional diagnostic boundaries, we aimed to determine, within a single cohort, whether performance on measures of executive functions (EFs) predicted dimensions of different psychopathological conditions known to share genetic liability. Methods Data are from 393 participants, ages 8–17, consecutively enrolled in the Longitudinal Study of Genetic Influences on Cognition (LOGIC). This project is conducting deep phenotyping and genomic analyses in youth referred for neuropsychiatric evaluation. Using structural equation modeling, we examined whether EFs predicted variation in core dimensions of the autism spectrum disorder, bipolar illness, and schizophrenia (including social responsiveness, mania/emotion regulation, and positive symptoms of psychosis, respectively). Results We modeled three cognitive factors (working memory, shifting, and executive processing speed) that loaded on a second-order EF factor. The EF factor predicted variation in our three target traits, but not in a negative control (somatization). Moreover, this EF factor was primarily associated with the overlapping (rather than unique) variance across the three outcome measures, suggesting that it related to a general increase in psychopathology symptoms across those dimensions. Conclusions Findings extend support for the relevance of cognition to neuropsychiatric conditions that share underlying genetic risk. They suggest that higher-order cognition, including EFs, relates to the dimensional spectrum of each of these disorders and not just the clinical diagnoses. Moreover, results have implications for bottom-up models linking genes, cognition, and a general psychopathology liability. En ligne : http://dx.doi.org/10.1111/jcpp.12463 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285

Gene–environment interactions reexamined: Does mother's marital stability interact with the dopamine receptor D2 gene in the etiology of childhood attention-deficit/hyperactivity disorder? / Irwin D. WALDMAN in Development and Psychopathology, 19-4 (Fall 2007)  

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Maternal age at childbirth and offspring disruptive behaviors: testing the causal hypothesis / Brian M. D'ONOFRIO in Journal of Child Psychology and Psychiatry, 50-8 (August 2009)  

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Population density and youth antisocial behavior / K. Paige HARDEN in Journal of Child Psychology and Psychiatry, 50-8 (August 2009)  

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Prospective test of the developmental propensity model of antisocial behavior: from childhood and adolescence into early adulthood / B. B. LAHEY in Journal of Child Psychology and Psychiatry, 59-6 (June 2018)  

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Psychometric Characteristics of a Measure of Emotional Dispositions Developed to Test a Developmental Propensity Model of Conduct Disorder / Benjamin B. LAHEY in Journal of Clinical Child & Adolescent Psychology, 37-4 (October-December 2008)  

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Psychometrics of a Self-Report Version of the Child and Adolescent Dispositions Scale / Benjamin B. LAHEY in Journal of Clinical Child & Adolescent Psychology, 39-3 (May-June 2010)  

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Smoking during pregnancy and offspring externalizing problems: An exploration of genetic and environmental confounds / Brian M. D'ONOFRIO in Development and Psychopathology, 20-1 (Winter 2008)  

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Using epidemiologic methods to test hypotheses regarding causal influences on child and adolescent mental disorders / Benjamin B. LAHEY in Journal of Child Psychology and Psychiatry, 50-1-2 (January/February 2009)  

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