Attunement in Music Therapy for Young Children with Autism: Revisiting Qualities of Relationship as Mechanisms of Change / Karin MÖSSLER in Journal of Autism and Developmental Disorders, 50-11 (November 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-11 (November 2020) . - p.3921-3934 Titre : Attunement in Music Therapy for Young Children with Autism: Revisiting Qualities of Relationship as Mechanisms of Change Type de document : Texte imprimé et/ou numérique Auteurs : Karin MÖSSLER, Auteur ; Wolfgang SCHMID, Auteur ; Jörg AßMUS, Auteur ; Laura FUSAR-POLI, Auteur ; Christian GOLD, Auteur Article en page(s) : p.3921-3934 Langues : Anglais (eng) Mots-clés : Affect  Attunement  Body  Child and parent perspectives  Restricted and repetitive behavior  Sensory processing  trained music therapists. Index. décimale : PER Périodiques Résumé : This study examined whether musical and emotional attunement predicts changes in improvisational music therapy with children with autism (4-7 years, N?=?101, majority: no/limited speech, low IQ), assessed over 12 months. Attunement, as observed from session videos, and changes in generalized social skills, judged by blinded assessors and parents, were evaluated using standardized tools (Assessment of the Quality of Relationship, Improvisational Music Therapy Principles, ADOS, SRS). In contrast to the smaller pilot, we did not find significant effects between attunement and changes in outcomes, only tendencies in the same direction are observed. Findings suggest that symptom severity is associated with the therapist's ability to attune to the child. They further raise questions concerning outcome selection and user involvement. En ligne : http://dx.doi.org/10.1007/s10803-020-04448-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432 [article] Attunement in Music Therapy for Young Children with Autism: Revisiting Qualities of Relationship as Mechanisms of Change [Texte imprimé et/ou numérique] / Karin MÖSSLER, Auteur ; Wolfgang SCHMID, Auteur ; Jörg AßMUS, Auteur ; Laura FUSAR-POLI, Auteur ; Christian GOLD, Auteur . - p.3921-3934. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-11 (November 2020) . - p.3921-3934 Mots-clés : Affect  Attunement  Body  Child and parent perspectives  Restricted and repetitive behavior  Sensory processing  trained music therapists. Index. décimale : PER Périodiques Résumé : This study examined whether musical and emotional attunement predicts changes in improvisational music therapy with children with autism (4-7 years, N?=?101, majority: no/limited speech, low IQ), assessed over 12 months. Attunement, as observed from session videos, and changes in generalized social skills, judged by blinded assessors and parents, were evaluated using standardized tools (Assessment of the Quality of Relationship, Improvisational Music Therapy Principles, ADOS, SRS). In contrast to the smaller pilot, we did not find significant effects between attunement and changes in outcomes, only tendencies in the same direction are observed. Findings suggest that symptom severity is associated with the therapist's ability to attune to the child. They further raise questions concerning outcome selection and user involvement. En ligne : http://dx.doi.org/10.1007/s10803-020-04448-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432

Pharmacological Modulation of GABA Function in Autism Spectrum Disorders: A Systematic Review of Human Studies / Natascia BRONDINO in Journal of Autism and Developmental Disorders, 46-3 (March 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.825-839 Titre : Pharmacological Modulation of GABA Function in Autism Spectrum Disorders: A Systematic Review of Human Studies Type de document : Texte imprimé et/ou numérique Auteurs : Natascia BRONDINO, Auteur ; Laura FUSAR-POLI, Auteur ; Cristina PANISI, Auteur ; Stefano DAMIANI, Auteur ; Francesco BARALE, Auteur ; Pierluigi POLITI, Auteur Article en page(s) : p.825-839 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  GABA  Clinical trials  Systematic review Index. décimale : PER Périodiques Résumé : Autism spectrum disorders are an emerging health problem worldwide, but little is known about their pathogenesis. It has been hypothesized that autism may result from an imbalance between excitatory glutamatergic and inhibitory GABAergic pathways. Commonly used medications such as valproate, acamprosate, and arbaclofen may act on the GABAergic system and be a potential treatment for people with ASD. The present systematic review aimed at evaluating the state-of-the-art of clinical trials of GABA modulators in autism. To date there is insufficient evidence to suggest the use of these drugs in autistic subjects, even if data are promising. Of note, short-term use of all the reviewed medications appears to be safe. Future well designed trials are needed to elucidate these preliminary findings. En ligne : http://dx.doi.org/10.1007/s10803-015-2619-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=281 [article] Pharmacological Modulation of GABA Function in Autism Spectrum Disorders: A Systematic Review of Human Studies [Texte imprimé et/ou numérique] / Natascia BRONDINO, Auteur ; Laura FUSAR-POLI, Auteur ; Cristina PANISI, Auteur ; Stefano DAMIANI, Auteur ; Francesco BARALE, Auteur ; Pierluigi POLITI, Auteur . - p.825-839. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.825-839 Mots-clés : Autism spectrum disorder  GABA  Clinical trials  Systematic review Index. décimale : PER Périodiques Résumé : Autism spectrum disorders are an emerging health problem worldwide, but little is known about their pathogenesis. It has been hypothesized that autism may result from an imbalance between excitatory glutamatergic and inhibitory GABAergic pathways. Commonly used medications such as valproate, acamprosate, and arbaclofen may act on the GABAergic system and be a potential treatment for people with ASD. The present systematic review aimed at evaluating the state-of-the-art of clinical trials of GABA modulators in autism. To date there is insufficient evidence to suggest the use of these drugs in autistic subjects, even if data are promising. Of note, short-term use of all the reviewed medications appears to be safe. Future well designed trials are needed to elucidate these preliminary findings. En ligne : http://dx.doi.org/10.1007/s10803-015-2619-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=281

Psychometric properties of the Autism Spectrum Disorder in Adults Screening Questionnaire (ASDASQ) in a sample of Italian psychiatric outpatients / Laura FUSAR-POLI in Research in Autism Spectrum Disorders, 78 (October 2020)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 78 (October 2020) . - 101668 Titre : Psychometric properties of the Autism Spectrum Disorder in Adults Screening Questionnaire (ASDASQ) in a sample of Italian psychiatric outpatients Type de document : Texte imprimé et/ou numérique Auteurs : Laura FUSAR-POLI, Auteur ; Emanuele BISSO, Auteur ; Ilaria CONCAS, Auteur ; Teresa SURACE, Auteur ; Silvia TINACCI, Auteur ; Antonio VANELLA, Auteur ; Rosaria FURNARI, Auteur ; Maria Salvina SIGNORELLI, Auteur ; Lena NYLANDER, Auteur ; Eugenio AGUGLIA, Auteur Article en page(s) : 101668 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Psychiatry  Adult  Screening  Differential diagnosis  Misdiagnosis  Clinician-rated tool Index. décimale : PER Périodiques Résumé : Background The present study aimed to examine the reliability and validity of the Italian version of the Autism Spectrum Disorder in Adults Screening Questionnaire (ASDASQ), a screening tool for autism spectrum disorder (ASD) among psychiatric outpatients. Methods We recruited 340 subjects via an outpatient psychiatric service in Italy. Forty-eight had a diagnosis of ASD, confirmed after a comprehensive clinical assessment and the administration of the Autism Diagnostic Observation Schedule-2 (ADOS-2). The remaining 292 participants had other diagnoses, confirmed after a careful psychiatric evaluation and the administration of the Structured Clinical Interview for DSM-5 (SCID-5). The ASDASQ was administered to contact clinicians of each subject. Results The ASDASQ showed outstanding accuracy (AUC = 0.96) in discriminating between ASD and non-ASD patients, with good sensitivity (0.85) and specificity (0.92). Agreement with clinical diagnosis was substantial (k = 0.68). Internal consistency of the tool was good (Cronbach’s alpha = 0.82), while intra- (ICC = 0.97) and inter-rater reliability (ICC = 0.92) were excellent. We found also a moderate correlation between ASDASQ and ADOS-2 scores in the ASD sample (r = 0.56). Conclusion Our findings suggest that the ASDASQ, in the Italian adaptation, may be considered a quick, simple, and effective tool to screen for ASD among psychiatric outpatients. Further studies are needed to evaluate its utility in other clinical settings. En ligne : https://doi.org/10.1016/j.rasd.2020.101668 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433 [article] Psychometric properties of the Autism Spectrum Disorder in Adults Screening Questionnaire (ASDASQ) in a sample of Italian psychiatric outpatients [Texte imprimé et/ou numérique] / Laura FUSAR-POLI, Auteur ; Emanuele BISSO, Auteur ; Ilaria CONCAS, Auteur ; Teresa SURACE, Auteur ; Silvia TINACCI, Auteur ; Antonio VANELLA, Auteur ; Rosaria FURNARI, Auteur ; Maria Salvina SIGNORELLI, Auteur ; Lena NYLANDER, Auteur ; Eugenio AGUGLIA, Auteur . - 101668. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 78 (October 2020) . - 101668 Mots-clés : Autism spectrum disorder  Psychiatry  Adult  Screening  Differential diagnosis  Misdiagnosis  Clinician-rated tool Index. décimale : PER Périodiques Résumé : Background The present study aimed to examine the reliability and validity of the Italian version of the Autism Spectrum Disorder in Adults Screening Questionnaire (ASDASQ), a screening tool for autism spectrum disorder (ASD) among psychiatric outpatients. Methods We recruited 340 subjects via an outpatient psychiatric service in Italy. Forty-eight had a diagnosis of ASD, confirmed after a comprehensive clinical assessment and the administration of the Autism Diagnostic Observation Schedule-2 (ADOS-2). The remaining 292 participants had other diagnoses, confirmed after a careful psychiatric evaluation and the administration of the Structured Clinical Interview for DSM-5 (SCID-5). The ASDASQ was administered to contact clinicians of each subject. Results The ASDASQ showed outstanding accuracy (AUC = 0.96) in discriminating between ASD and non-ASD patients, with good sensitivity (0.85) and specificity (0.92). Agreement with clinical diagnosis was substantial (k = 0.68). Internal consistency of the tool was good (Cronbach’s alpha = 0.82), while intra- (ICC = 0.97) and inter-rater reliability (ICC = 0.92) were excellent. We found also a moderate correlation between ASDASQ and ADOS-2 scores in the ASD sample (r = 0.56). Conclusion Our findings suggest that the ASDASQ, in the Italian adaptation, may be considered a quick, simple, and effective tool to screen for ASD among psychiatric outpatients. Further studies are needed to evaluate its utility in other clinical settings. En ligne : https://doi.org/10.1016/j.rasd.2020.101668 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433

What are we targeting when we treat autism spectrum disorder? A systematic review of 406 clinical trials / Umberto PROVENZANI in Autism, 24-2 (February 2020)  

Public ISBD [article]  inAutism > 24-2 (February 2020) . - p.274-284 Titre : What are we targeting when we treat autism spectrum disorder? A systematic review of 406 clinical trials Type de document : Texte imprimé et/ou numérique Auteurs : Umberto PROVENZANI, Auteur ; Laura FUSAR-POLI, Auteur ; Natascia BRONDINO, Auteur ; Stefano DAMIANI, Auteur ; Marco VERCESI, Auteur ; Nicholas MEYER, Auteur ; Matteo ROCCHETTI, Auteur ; Pierluigi POLITI, Auteur Article en page(s) : p.274-284 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  core symptoms  outcome measures  systematic review  trials Index. décimale : PER Périodiques Résumé : The number of trials aimed at evaluating treatments for autism spectrum disorder has been increasing progressively. However, it is not clear which outcome measures should be used to assess their efficacy, especially for treatments which target core symptoms. The present review aimed to provide a comprehensive overview regarding the outcome measures used in clinical trials for people with autism spectrum disorder. We systematically searched the Web of Knowledge(SM) database between 1980 and 2016 to identify published controlled trials investigating the efficacy of interventions in autism spectrum disorder. We included 406 trials in the final database, from which a total of 327 outcome measures were identified. Only seven scales were used in more than 5% of the studies, among which only three measured core symptoms (Autism Diagnostic Observation Schedule, Childhood Autism Rating Scale, and Social Responsiveness Scale). Of note, 69% of the tools were used in the literature only once. Our systematic review has shown that the evaluation of efficacy in intervention trials for autism spectrum disorder relies on heterogeneous and often non-specific tools for this condition. The fragmentation of tools may significantly hamper the comparisons between studies and thus the discovery of effective treatments for autism spectrum disorder. Greater consensus regarding the choice of these measures should be reached. En ligne : http://dx.doi.org/10.1177/1362361319854641 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415 [article] What are we targeting when we treat autism spectrum disorder? A systematic review of 406 clinical trials [Texte imprimé et/ou numérique] / Umberto PROVENZANI, Auteur ; Laura FUSAR-POLI, Auteur ; Natascia BRONDINO, Auteur ; Stefano DAMIANI, Auteur ; Marco VERCESI, Auteur ; Nicholas MEYER, Auteur ; Matteo ROCCHETTI, Auteur ; Pierluigi POLITI, Auteur . - p.274-284. Langues : Anglais (eng) in Autism > 24-2 (February 2020) . - p.274-284 Mots-clés : autism spectrum disorder  core symptoms  outcome measures  systematic review  trials Index. décimale : PER Périodiques Résumé : The number of trials aimed at evaluating treatments for autism spectrum disorder has been increasing progressively. However, it is not clear which outcome measures should be used to assess their efficacy, especially for treatments which target core symptoms. The present review aimed to provide a comprehensive overview regarding the outcome measures used in clinical trials for people with autism spectrum disorder. We systematically searched the Web of Knowledge(SM) database between 1980 and 2016 to identify published controlled trials investigating the efficacy of interventions in autism spectrum disorder. We included 406 trials in the final database, from which a total of 327 outcome measures were identified. Only seven scales were used in more than 5% of the studies, among which only three measured core symptoms (Autism Diagnostic Observation Schedule, Childhood Autism Rating Scale, and Social Responsiveness Scale). Of note, 69% of the tools were used in the literature only once. Our systematic review has shown that the evaluation of efficacy in intervention trials for autism spectrum disorder relies on heterogeneous and often non-specific tools for this condition. The fragmentation of tools may significantly hamper the comparisons between studies and thus the discovery of effective treatments for autism spectrum disorder. Greater consensus regarding the choice of these measures should be reached. En ligne : http://dx.doi.org/10.1177/1362361319854641 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415

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