Altered Medial Frontal and Superior Temporal Response to Implicit Processing of Emotions in Autism / Rajesh K. KANA in Autism Research, 9-1 (January 2016)  

Public ISBD [article]  inAutism Research > 9-1 (January 2016) . - p.55-66 Titre : Altered Medial Frontal and Superior Temporal Response to Implicit Processing of Emotions in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Rajesh K. KANA, Auteur ; Michelle A. PATRIQUIN, Auteur ; Briley S. BLACK, Auteur ; Marie M. CHANNELL, Auteur ; Bruno WICKER, Auteur Article en page(s) : p.55-66 Langues : Anglais (eng) Mots-clés : implicit emotion  explicit emotion  fMRI  functional connectivity  autism Index. décimale : PER Périodiques Résumé : Interpreting emotional expressions appropriately poses a challenge for individuals with autism spectrum disorder (ASD). In particular, difficulties with emotional processing in ASD are more pronounced in contexts where emotional expressions are subtle, automatic, and reflexive—that is, implicit. In contrast, explicit emotional processing, which requires the cognitive evaluation of an emotional experience, appears to be relatively intact in individuals with ASD. In the present study, we examined the brain activation and functional connectivity differences underlying explicit and implicit emotional processing in age- and IQ-matched adults with (n?=?17) and without (n?=?15) ASD. Results indicated: (1) significantly reduced levels of brain activation in participants with ASD in medial prefrontal cortex (MPFC) and superior temporal gyrus (STG) during implicit emotion processing; (2) significantly weaker functional connectivity in the ASD group in connections of the MPFC with the amygdala, temporal lobe, parietal lobe, and fusiform gyrus; (3) No group difference in performance accuracy or reaction time; and (4) Significant positive relationship between empathizing ability and STG activity in ASD but not in typically developing participants. These findings suggest that the neural mechanisms underlying implicit, but not explicit, emotion processing may be altered at multiple levels in individuals with ASD. En ligne : http://dx.doi.org/10.1002/aur.1496 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 [article] Altered Medial Frontal and Superior Temporal Response to Implicit Processing of Emotions in Autism [Texte imprimé et/ou numérique] / Rajesh K. KANA, Auteur ; Michelle A. PATRIQUIN, Auteur ; Briley S. BLACK, Auteur ; Marie M. CHANNELL, Auteur ; Bruno WICKER, Auteur . - p.55-66. Langues : Anglais (eng) in Autism Research > 9-1 (January 2016) . - p.55-66 Mots-clés : implicit emotion  explicit emotion  fMRI  functional connectivity  autism Index. décimale : PER Périodiques Résumé : Interpreting emotional expressions appropriately poses a challenge for individuals with autism spectrum disorder (ASD). In particular, difficulties with emotional processing in ASD are more pronounced in contexts where emotional expressions are subtle, automatic, and reflexive—that is, implicit. In contrast, explicit emotional processing, which requires the cognitive evaluation of an emotional experience, appears to be relatively intact in individuals with ASD. In the present study, we examined the brain activation and functional connectivity differences underlying explicit and implicit emotional processing in age- and IQ-matched adults with (n?=?17) and without (n?=?15) ASD. Results indicated: (1) significantly reduced levels of brain activation in participants with ASD in medial prefrontal cortex (MPFC) and superior temporal gyrus (STG) during implicit emotion processing; (2) significantly weaker functional connectivity in the ASD group in connections of the MPFC with the amygdala, temporal lobe, parietal lobe, and fusiform gyrus; (3) No group difference in performance accuracy or reaction time; and (4) Significant positive relationship between empathizing ability and STG activity in ASD but not in typically developing participants. These findings suggest that the neural mechanisms underlying implicit, but not explicit, emotion processing may be altered at multiple levels in individuals with ASD. En ligne : http://dx.doi.org/10.1002/aur.1496 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282

Characteristics Associated with Autism Spectrum Disorder Risk in Individuals with Down Syndrome / Marie M. CHANNELL in Journal of Autism and Developmental Disorders, 49-9 (September 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-9 (September 2019) . - p.3543-3556 Titre : Characteristics Associated with Autism Spectrum Disorder Risk in Individuals with Down Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Marie M. CHANNELL, Auteur ; Laura J. HAHN, Auteur ; T. C. ROSSER, Auteur ; D. HAMILTON, Auteur ; Michelle A. FRANK-CRAWFORD, Auteur ; George T. CAPONE, Auteur ; S. L. SHERMAN, Auteur Article en page(s) : p.3543-3556 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Down syndrome  Intellectual disability  Maladaptive behavior  Psychiatric comorbidities Index. décimale : PER Périodiques Résumé : We examined autism spectrum disorder (ASD) risk in a large national sample of 203 individuals with Down syndrome, 6-25 years old, to determine the association of ASD risk with age, sex, IQ, adaptive behaviors, and maladaptive behaviors. We used a two-pronged approach by (1) considering ASD symptomatology continuously across the sample of individuals with DS and examining associations with each characteristic, and (2) dichotomizing our sample into high and low ASD risk groups and comparing groups on each characteristic. The pattern of results was largely similar across both types of analyses. ASD symptomatology/risk was negatively associated with IQ and adaptive behaviors and positively associated with certain types of maladaptive behaviors. Clinical implications for screening and therapeutic purposes are discussed. En ligne : http://dx.doi.org/10.1007/s10803-019-04074-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405 [article] Characteristics Associated with Autism Spectrum Disorder Risk in Individuals with Down Syndrome [Texte imprimé et/ou numérique] / Marie M. CHANNELL, Auteur ; Laura J. HAHN, Auteur ; T. C. ROSSER, Auteur ; D. HAMILTON, Auteur ; Michelle A. FRANK-CRAWFORD, Auteur ; George T. CAPONE, Auteur ; S. L. SHERMAN, Auteur . - p.3543-3556. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-9 (September 2019) . - p.3543-3556 Mots-clés : Autism spectrum disorder  Down syndrome  Intellectual disability  Maladaptive behavior  Psychiatric comorbidities Index. décimale : PER Périodiques Résumé : We examined autism spectrum disorder (ASD) risk in a large national sample of 203 individuals with Down syndrome, 6-25 years old, to determine the association of ASD risk with age, sex, IQ, adaptive behaviors, and maladaptive behaviors. We used a two-pronged approach by (1) considering ASD symptomatology continuously across the sample of individuals with DS and examining associations with each characteristic, and (2) dichotomizing our sample into high and low ASD risk groups and comparing groups on each characteristic. The pattern of results was largely similar across both types of analyses. ASD symptomatology/risk was negatively associated with IQ and adaptive behaviors and positively associated with certain types of maladaptive behaviors. Clinical implications for screening and therapeutic purposes are discussed. En ligne : http://dx.doi.org/10.1007/s10803-019-04074-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405

Learning Words in a Social World: Impairments Associated With ASD and Fragile X Syndrome / Andrea MCDUFFIE  

Public ISBD in Innovative Investigations of Language in Autism Spectrum Disorder / Letitia NAIGLES Titre : Learning Words in a Social World: Impairments Associated With ASD and Fragile X Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Andrea MCDUFFIE, Auteur ; John THURMAN ANGELA, Auteur ; Marie M. CHANNELL, Auteur ; Leonard ABBEDUTO, Auteur Année de publication : 2016 Importance : p.71-88 Langues : Anglais (eng) Index. décimale : COM-A COM-A - Communication - Langage - Orthophonie En ligne : http://dx.doi.org/10.1515/9783110409871-005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=300 in Innovative Investigations of Language in Autism Spectrum Disorder / Letitia NAIGLES Learning Words in a Social World: Impairments Associated With ASD and Fragile X Syndrome [Texte imprimé et/ou numérique] / Andrea MCDUFFIE, Auteur ; John THURMAN ANGELA, Auteur ; Marie M. CHANNELL, Auteur ; Leonard ABBEDUTO, Auteur . - 2016 . - p.71-88. Langues : Anglais (eng) Index. décimale : COM-A COM-A - Communication - Langage - Orthophonie En ligne : http://dx.doi.org/10.1515/9783110409871-005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=300

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Patterns of autism spectrum symptomatology in individuals with Down syndrome without comorbid autism spectrum disorder / Marie M. CHANNELL in Journal of Neurodevelopmental Disorders, 7-1 (December 2015)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.5 Titre : Patterns of autism spectrum symptomatology in individuals with Down syndrome without comorbid autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Marie M. CHANNELL, Auteur ; B. A. PHILLIPS, Auteur ; S. J. LOVEALL, Auteur ; F. A. CONNERS, Auteur ; P. M. BUSSANICH, Auteur ; L. G. KLINGER, Auteur Article en page(s) : p.5 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Comorbidity  Down syndrome  Intellectual disability  Social communication Index. décimale : PER Périodiques Résumé : BACKGROUND: Prevalence estimates of autism spectrum disorder (ASD) in Down syndrome (DS) are highly varied. This variation is partly due to the difficulty of screening for and diagnosing comorbid ASD in individuals with a syndrome that carries its own set of social communicative and behavioral difficulties that are not well documented. The aim of this study was to identify the typical range of social communicative impairments observed in children, adolescents, and young adults with DS who do not have comorbid ASD. METHODS: We examined patterns of scores from the five subscales of the Social Responsiveness Scale (SRS) in 46 individuals with DS (ages 10-21 years) without comorbid ASD relative to the published normative sample. We also explored the correlations between SRS symptomatology and age, nonverbal cognition, and receptive language. RESULTS: SRS scores were elevated (i.e., more ASD symptoms endorsed), with mean scores falling into the clinically significant range. Analysis by subscale revealed a specific pattern, with Autistic Mannerisms and Social Cognition scores significantly more elevated than Social Communication scores, which were significantly more elevated than Social Awareness and Social Motivation scores. Correlations between SRS scores and the other measures varied by subscale. CONCLUSIONS: General elevated ASD symptomatology on the SRS indicates the need for developing population-based norms specific to DS. The pattern of scores across subscales should inform clinicians of the typical range of behaviors observed in DS so that individuals with atypical patterns of behavior can be more easily identified and considered for a full ASD evaluation. En ligne : http://dx.doi.org/10.1186/1866-1955-7-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347 [article] Patterns of autism spectrum symptomatology in individuals with Down syndrome without comorbid autism spectrum disorder [Texte imprimé et/ou numérique] / Marie M. CHANNELL, Auteur ; B. A. PHILLIPS, Auteur ; S. J. LOVEALL, Auteur ; F. A. CONNERS, Auteur ; P. M. BUSSANICH, Auteur ; L. G. KLINGER, Auteur . - p.5. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.5 Mots-clés : Autism spectrum disorder  Comorbidity  Down syndrome  Intellectual disability  Social communication Index. décimale : PER Périodiques Résumé : BACKGROUND: Prevalence estimates of autism spectrum disorder (ASD) in Down syndrome (DS) are highly varied. This variation is partly due to the difficulty of screening for and diagnosing comorbid ASD in individuals with a syndrome that carries its own set of social communicative and behavioral difficulties that are not well documented. The aim of this study was to identify the typical range of social communicative impairments observed in children, adolescents, and young adults with DS who do not have comorbid ASD. METHODS: We examined patterns of scores from the five subscales of the Social Responsiveness Scale (SRS) in 46 individuals with DS (ages 10-21 years) without comorbid ASD relative to the published normative sample. We also explored the correlations between SRS symptomatology and age, nonverbal cognition, and receptive language. RESULTS: SRS scores were elevated (i.e., more ASD symptoms endorsed), with mean scores falling into the clinically significant range. Analysis by subscale revealed a specific pattern, with Autistic Mannerisms and Social Cognition scores significantly more elevated than Social Communication scores, which were significantly more elevated than Social Awareness and Social Motivation scores. Correlations between SRS scores and the other measures varied by subscale. CONCLUSIONS: General elevated ASD symptomatology on the SRS indicates the need for developing population-based norms specific to DS. The pattern of scores across subscales should inform clinicians of the typical range of behaviors observed in DS so that individuals with atypical patterns of behavior can be more easily identified and considered for a full ASD evaluation. En ligne : http://dx.doi.org/10.1186/1866-1955-7-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347

The Social Responsiveness Scale (SRS-2) in school-age children with Down syndrome at low risk for autism spectrum disorder / Marie M. CHANNELL in Autism & Developmental Language Impairments, 5 (January-December 2020)  

Public ISBD [article]  inAutism & Developmental Language Impairments > 5 (January-December 2020) Titre : The Social Responsiveness Scale (SRS-2) in school-age children with Down syndrome at low risk for autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Marie M. CHANNELL, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background and aimsLittle is known about how autism spectrum disorder (ASD) symptoms present in individuals with Down syndrome (DS). Some behaviors may be symptomatic of comorbid ASD or more broadly representative of the DS phenotype. A prior research study documented elevated ASD-like symptoms in adolescents and young adults with DS without comorbid ASD, using a common ASD risk screening tool?the Social Responsiveness Scale (SRS). The current study applied a similar approach to younger children with DS using the SRS-2. The primary aim was to document patterns of ASD-like symptoms in children with DS at low risk of comorbid ASD to distinguish the symptoms that may be present across DS in general.MethodsSRS-2 standard scores were analyzed in a sample of 40 children with DS, 6?11?years old, who were considered to be at low risk for ASD based on the Social Communication Questionnaire (SCQ) screener. Other developmental characteristics (i.e., age, nonverbal IQ, expressive language), social skills, and problem behaviors were also examined across the sample.ResultsSRS-2 scores were significantly elevated in this sample compared to the normative population sample. A pattern of ASD-like symptomatology was observed across SRS-2 subdomains. These findings were similar to the findings of the prior study. However, nuanced differences were observed across the two samples that may represent developmental differences across different ages in this population.ConclusionsReplicating and extending a prior study's findings, certain ASD-like behaviors may occur in individuals with DS who are at low risk for comorbid ASD.Implications: Understanding the pattern of ASD-like behaviors that occur in children with DS who are at low risk for comorbid ASD will help clinicians in screening and identification efforts. In particular, it will lead to better specification of the behaviors or symptoms that are not characteristic of the DS phenotype and thus are red flags for comorbid ASD in this population. En ligne : http://dx.doi.org/10.1177/2396941520962406 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438 [article] The Social Responsiveness Scale (SRS-2) in school-age children with Down syndrome at low risk for autism spectrum disorder [Texte imprimé et/ou numérique] / Marie M. CHANNELL, Auteur. Langues : Anglais (eng) in Autism & Developmental Language Impairments > 5 (January-December 2020) Index. décimale : PER Périodiques Résumé : Background and aimsLittle is known about how autism spectrum disorder (ASD) symptoms present in individuals with Down syndrome (DS). Some behaviors may be symptomatic of comorbid ASD or more broadly representative of the DS phenotype. A prior research study documented elevated ASD-like symptoms in adolescents and young adults with DS without comorbid ASD, using a common ASD risk screening tool?the Social Responsiveness Scale (SRS). The current study applied a similar approach to younger children with DS using the SRS-2. The primary aim was to document patterns of ASD-like symptoms in children with DS at low risk of comorbid ASD to distinguish the symptoms that may be present across DS in general.MethodsSRS-2 standard scores were analyzed in a sample of 40 children with DS, 6?11?years old, who were considered to be at low risk for ASD based on the Social Communication Questionnaire (SCQ) screener. Other developmental characteristics (i.e., age, nonverbal IQ, expressive language), social skills, and problem behaviors were also examined across the sample.ResultsSRS-2 scores were significantly elevated in this sample compared to the normative population sample. A pattern of ASD-like symptomatology was observed across SRS-2 subdomains. These findings were similar to the findings of the prior study. However, nuanced differences were observed across the two samples that may represent developmental differences across different ages in this population.ConclusionsReplicating and extending a prior study's findings, certain ASD-like behaviors may occur in individuals with DS who are at low risk for comorbid ASD.Implications: Understanding the pattern of ASD-like behaviors that occur in children with DS who are at low risk for comorbid ASD will help clinicians in screening and identification efforts. In particular, it will lead to better specification of the behaviors or symptoms that are not characteristic of the DS phenotype and thus are red flags for comorbid ASD in this population. En ligne : http://dx.doi.org/10.1177/2396941520962406 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438

Use of Emotional Cues for Lexical Learning: A Comparison of Autism Spectrum Disorder and Fragile X Syndrome / Angela John THURMAN in Journal of Autism and Developmental Disorders, 45-4 (April 2015)  

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