Disconnection from others in autism is more than just a feeling: whole-brain neural synchrony in adults during implicit processing of emotional faces / R. MENNELLA in Molecular Autism, 8 (2017)  

Public ISBD [article]  inMolecular Autism > 8 (2017) . - 7p. Titre : Disconnection from others in autism is more than just a feeling: whole-brain neural synchrony in adults during implicit processing of emotional faces Type de document : Texte imprimé et/ou numérique Auteurs : R. MENNELLA, Auteur ; R. C. LEUNG, Auteur ; M. J. TAYLOR, Auteur ; B. T. DUNKLEY, Auteur Article en page(s) : 7p. Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder/*psychology  Brain/*physiology  Brain Mapping/*methods  Facial Expression  Female  Humans  Image Processing, Computer-Assisted  Magnetoencephalography/*methods  Male  Social Perception  Young Adult  *Autism  *Emotional faces  *Functional connectivity  *Magnetoencephalography  *Social brain  *Young adults Index. décimale : PER Périodiques Résumé : BACKGROUND: Socio-emotional difficulties in autism spectrum disorder (ASD) are thought to reflect impaired functional connectivity within the "social brain". Nonetheless, a whole-brain characterization of the fast responses in functional connectivity during implicit processing of emotional faces in adults with ASD is lacking. METHODS: The present study used magnetoencephalography to investigate early responses in functional connectivity, as measured by interregional phase synchronization, during implicit processing of angry, neutral and happy faces. The sample (n = 44) consisted of 22 young adults with ASD and 22 age- and sex-matched typically developed (TD) controls. RESULTS: Reduced phase-synchrony in the beta band around 300 ms emerged during processing of angry faces in the ASD compared to TD group, involving key areas of the social brain. In the same time window, de-synchronization in the beta band in the amygdala was reduced in the ASD group across conditions. CONCLUSIONS: This is the first demonstration of atypical global and local synchrony patterns in the social brain in adults with ASD during implicit processing of emotional faces. The present results replicate and substantially extend previous findings on adolescents, highlighting that atypical brain synchrony during processing of socio-emotional stimuli is a hallmark of clinical sequelae in autism. En ligne : http://dx.doi.org/10.1186/s13229-017-0123-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330 [article] Disconnection from others in autism is more than just a feeling: whole-brain neural synchrony in adults during implicit processing of emotional faces [Texte imprimé et/ou numérique] / R. MENNELLA, Auteur ; R. C. LEUNG, Auteur ; M. J. TAYLOR, Auteur ; B. T. DUNKLEY, Auteur . - 7p. Langues : Anglais (eng) in Molecular Autism > 8 (2017) . - 7p. Mots-clés : Adult  Autism Spectrum Disorder/*psychology  Brain/*physiology  Brain Mapping/*methods  Facial Expression  Female  Humans  Image Processing, Computer-Assisted  Magnetoencephalography/*methods  Male  Social Perception  Young Adult  *Autism  *Emotional faces  *Functional connectivity  *Magnetoencephalography  *Social brain  *Young adults Index. décimale : PER Périodiques Résumé : BACKGROUND: Socio-emotional difficulties in autism spectrum disorder (ASD) are thought to reflect impaired functional connectivity within the "social brain". Nonetheless, a whole-brain characterization of the fast responses in functional connectivity during implicit processing of emotional faces in adults with ASD is lacking. METHODS: The present study used magnetoencephalography to investigate early responses in functional connectivity, as measured by interregional phase synchronization, during implicit processing of angry, neutral and happy faces. The sample (n = 44) consisted of 22 young adults with ASD and 22 age- and sex-matched typically developed (TD) controls. RESULTS: Reduced phase-synchrony in the beta band around 300 ms emerged during processing of angry faces in the ASD compared to TD group, involving key areas of the social brain. In the same time window, de-synchronization in the beta band in the amygdala was reduced in the ASD group across conditions. CONCLUSIONS: This is the first demonstration of atypical global and local synchrony patterns in the social brain in adults with ASD during implicit processing of emotional faces. The present results replicate and substantially extend previous findings on adolescents, highlighting that atypical brain synchrony during processing of socio-emotional stimuli is a hallmark of clinical sequelae in autism. En ligne : http://dx.doi.org/10.1186/s13229-017-0123-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330

Widespread White Matter Differences in Children and Adolescents with Autism Spectrum Disorder / V. M. VOGAN in Journal of Autism and Developmental Disorders, 46-6 (June 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-6 (June 2016) . - p.2138-2147 Titre : Widespread White Matter Differences in Children and Adolescents with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : V. M. VOGAN, Auteur ; B. R. MORGAN, Auteur ; R. C. LEUNG, Auteur ; Evdokia ANAGNOSTOU, Auteur ; K. DOYLE-THOMAS, Auteur ; M. J. TAYLOR, Auteur Article en page(s) : p.2138-2147 Langues : Anglais (eng) Mots-clés : White matter  Diffusion tensor imaging  Autism Development Index. décimale : PER Périodiques Résumé : Diffusion tensor imaging studies show white matter (WM) abnormalities in children with autism spectrum disorder (ASD). However, investigations are often limited by small samples, particularly problematic given the heterogeneity of ASD. We explored WM using DTI in a large sample of 130 children and adolescents (7–15 years) with and without ASD, whether age-related changes differed between ASD and control groups, and the relation between DTI measures and ASD symptomatology. Reduced fractional anisotropy and axial diffusivity were observed in ASD in numerous WM tracts, including the corpus callosum and thalamocortical fibres—tracts crucial for interhemispheric connectivity and higher order information processing. Widespread WM compromise in ASD is consistent with the view that ASD is a disorder of generalized complex information processing. En ligne : http://dx.doi.org/10.1007/s10803-016-2744-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288 [article] Widespread White Matter Differences in Children and Adolescents with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / V. M. VOGAN, Auteur ; B. R. MORGAN, Auteur ; R. C. LEUNG, Auteur ; Evdokia ANAGNOSTOU, Auteur ; K. DOYLE-THOMAS, Auteur ; M. J. TAYLOR, Auteur . - p.2138-2147. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-6 (June 2016) . - p.2138-2147 Mots-clés : White matter  Diffusion tensor imaging  Autism Development Index. décimale : PER Périodiques Résumé : Diffusion tensor imaging studies show white matter (WM) abnormalities in children with autism spectrum disorder (ASD). However, investigations are often limited by small samples, particularly problematic given the heterogeneity of ASD. We explored WM using DTI in a large sample of 130 children and adolescents (7–15 years) with and without ASD, whether age-related changes differed between ASD and control groups, and the relation between DTI measures and ASD symptomatology. Reduced fractional anisotropy and axial diffusivity were observed in ASD in numerous WM tracts, including the corpus callosum and thalamocortical fibres—tracts crucial for interhemispheric connectivity and higher order information processing. Widespread WM compromise in ASD is consistent with the view that ASD is a disorder of generalized complex information processing. En ligne : http://dx.doi.org/10.1007/s10803-016-2744-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288

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