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Disconnection from others in autism is more than just a feeling: whole-brain neural synchrony in adults during implicit processing of emotional faces / R. MENNELLA in Molecular Autism, 8 (2017)
[article]
Titre : Disconnection from others in autism is more than just a feeling: whole-brain neural synchrony in adults during implicit processing of emotional faces Type de document : Texte imprimé et/ou numérique Auteurs : R. MENNELLA, Auteur ; R. C. LEUNG, Auteur ; M. J. TAYLOR, Auteur ; B. T. DUNKLEY, Auteur Article en page(s) : 7p. Langues : Anglais (eng) Mots-clés : Adult Autism Spectrum Disorder/*psychology Brain/*physiology Brain Mapping/*methods Facial Expression Female Humans Image Processing, Computer-Assisted Magnetoencephalography/*methods Male Social Perception Young Adult *Autism *Emotional faces *Functional connectivity *Magnetoencephalography *Social brain *Young adults Index. décimale : PER Périodiques Résumé : BACKGROUND: Socio-emotional difficulties in autism spectrum disorder (ASD) are thought to reflect impaired functional connectivity within the "social brain". Nonetheless, a whole-brain characterization of the fast responses in functional connectivity during implicit processing of emotional faces in adults with ASD is lacking. METHODS: The present study used magnetoencephalography to investigate early responses in functional connectivity, as measured by interregional phase synchronization, during implicit processing of angry, neutral and happy faces. The sample (n = 44) consisted of 22 young adults with ASD and 22 age- and sex-matched typically developed (TD) controls. RESULTS: Reduced phase-synchrony in the beta band around 300 ms emerged during processing of angry faces in the ASD compared to TD group, involving key areas of the social brain. In the same time window, de-synchronization in the beta band in the amygdala was reduced in the ASD group across conditions. CONCLUSIONS: This is the first demonstration of atypical global and local synchrony patterns in the social brain in adults with ASD during implicit processing of emotional faces. The present results replicate and substantially extend previous findings on adolescents, highlighting that atypical brain synchrony during processing of socio-emotional stimuli is a hallmark of clinical sequelae in autism. En ligne : http://dx.doi.org/10.1186/s13229-017-0123-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330
in Molecular Autism > 8 (2017) . - 7p.[article] Disconnection from others in autism is more than just a feeling: whole-brain neural synchrony in adults during implicit processing of emotional faces [Texte imprimé et/ou numérique] / R. MENNELLA, Auteur ; R. C. LEUNG, Auteur ; M. J. TAYLOR, Auteur ; B. T. DUNKLEY, Auteur . - 7p.
Langues : Anglais (eng)
in Molecular Autism > 8 (2017) . - 7p.
Mots-clés : Adult Autism Spectrum Disorder/*psychology Brain/*physiology Brain Mapping/*methods Facial Expression Female Humans Image Processing, Computer-Assisted Magnetoencephalography/*methods Male Social Perception Young Adult *Autism *Emotional faces *Functional connectivity *Magnetoencephalography *Social brain *Young adults Index. décimale : PER Périodiques Résumé : BACKGROUND: Socio-emotional difficulties in autism spectrum disorder (ASD) are thought to reflect impaired functional connectivity within the "social brain". Nonetheless, a whole-brain characterization of the fast responses in functional connectivity during implicit processing of emotional faces in adults with ASD is lacking. METHODS: The present study used magnetoencephalography to investigate early responses in functional connectivity, as measured by interregional phase synchronization, during implicit processing of angry, neutral and happy faces. The sample (n = 44) consisted of 22 young adults with ASD and 22 age- and sex-matched typically developed (TD) controls. RESULTS: Reduced phase-synchrony in the beta band around 300 ms emerged during processing of angry faces in the ASD compared to TD group, involving key areas of the social brain. In the same time window, de-synchronization in the beta band in the amygdala was reduced in the ASD group across conditions. CONCLUSIONS: This is the first demonstration of atypical global and local synchrony patterns in the social brain in adults with ASD during implicit processing of emotional faces. The present results replicate and substantially extend previous findings on adolescents, highlighting that atypical brain synchrony during processing of socio-emotional stimuli is a hallmark of clinical sequelae in autism. En ligne : http://dx.doi.org/10.1186/s13229-017-0123-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330 Neural circuitry at age 6 months associated with later repetitive behavior and sensory responsiveness in autism / J. J. WOLFF in Molecular Autism, 8 (2017)
[article]
Titre : Neural circuitry at age 6 months associated with later repetitive behavior and sensory responsiveness in autism Type de document : Texte imprimé et/ou numérique Auteurs : J. J. WOLFF, Auteur ; M. R. SWANSON, Auteur ; J. T. ELISON, Auteur ; G. GERIG, Auteur ; J. R. PRUETT, Auteur ; M. A. STYNER, Auteur ; C. VACHET, Auteur ; Kelly N. BOTTERON, Auteur ; Stephen R. DAGER, Auteur ; A. M. ESTES, Auteur ; Heather C. HAZLETT, Auteur ; Robert T. SCHULTZ, Auteur ; M. D. SHEN, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; J. PIVEN, Auteur Article en page(s) : 8p. Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnostic imaging/*psychology Brain/diagnostic imaging/*physiology Brain Mapping/*methods Child, Preschool Diffusion Tensor Imaging/*methods Female Humans Infant Longitudinal Studies Male Stereotyped Behavior/*physiology *Autism *Diffusion tensor imaging *Infant *Longitudinal *Repetitive behavior *White matter Index. décimale : PER Périodiques Résumé : BACKGROUND: Restricted and repetitive behaviors are defining features of autism spectrum disorder (ASD). Under revised diagnostic criteria for ASD, this behavioral domain now includes atypical responses to sensory stimuli. To date, little is known about the neural circuitry underlying these features of ASD early in life. METHODS: Longitudinal diffusion tensor imaging data were collected from 217 infants at high familial risk for ASD. Forty-four of these infants were diagnosed with ASD at age 2. Targeted cortical, cerebellar, and striatal white matter pathways were defined and measured at ages 6, 12, and 24 months. Dependent variables included the Repetitive Behavior Scale-Revised and the Sensory Experiences Questionnaire. RESULTS: Among children diagnosed with ASD, repetitive behaviors and sensory response patterns were strongly correlated, even when accounting for developmental level or social impairment. Longitudinal analyses indicated that the genu and cerebellar pathways were significantly associated with both repetitive behaviors and sensory responsiveness but not social deficits. At age 6 months, fractional anisotropy in the genu significantly predicted repetitive behaviors and sensory responsiveness at age 2. Cerebellar pathways significantly predicted later sensory responsiveness. Exploratory analyses suggested a possible disordinal interaction based on diagnostic status for the association between fractional anisotropy and repetitive behavior. CONCLUSIONS: Our findings suggest that restricted and repetitive behaviors contributing to a diagnosis of ASD at age 2 years are associated with structural properties of callosal and cerebellar white matter pathways measured during infancy and toddlerhood. We further identified that repetitive behaviors and unusual sensory response patterns co-occur and share common brain-behavior relationships. These results were strikingly specific given the absence of association between targeted pathways and social deficits. En ligne : http://dx.doi.org/10.1186/s13229-017-0126-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331
in Molecular Autism > 8 (2017) . - 8p.[article] Neural circuitry at age 6 months associated with later repetitive behavior and sensory responsiveness in autism [Texte imprimé et/ou numérique] / J. J. WOLFF, Auteur ; M. R. SWANSON, Auteur ; J. T. ELISON, Auteur ; G. GERIG, Auteur ; J. R. PRUETT, Auteur ; M. A. STYNER, Auteur ; C. VACHET, Auteur ; Kelly N. BOTTERON, Auteur ; Stephen R. DAGER, Auteur ; A. M. ESTES, Auteur ; Heather C. HAZLETT, Auteur ; Robert T. SCHULTZ, Auteur ; M. D. SHEN, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; J. PIVEN, Auteur . - 8p.
Langues : Anglais (eng)
in Molecular Autism > 8 (2017) . - 8p.
Mots-clés : Autism Spectrum Disorder/diagnostic imaging/*psychology Brain/diagnostic imaging/*physiology Brain Mapping/*methods Child, Preschool Diffusion Tensor Imaging/*methods Female Humans Infant Longitudinal Studies Male Stereotyped Behavior/*physiology *Autism *Diffusion tensor imaging *Infant *Longitudinal *Repetitive behavior *White matter Index. décimale : PER Périodiques Résumé : BACKGROUND: Restricted and repetitive behaviors are defining features of autism spectrum disorder (ASD). Under revised diagnostic criteria for ASD, this behavioral domain now includes atypical responses to sensory stimuli. To date, little is known about the neural circuitry underlying these features of ASD early in life. METHODS: Longitudinal diffusion tensor imaging data were collected from 217 infants at high familial risk for ASD. Forty-four of these infants were diagnosed with ASD at age 2. Targeted cortical, cerebellar, and striatal white matter pathways were defined and measured at ages 6, 12, and 24 months. Dependent variables included the Repetitive Behavior Scale-Revised and the Sensory Experiences Questionnaire. RESULTS: Among children diagnosed with ASD, repetitive behaviors and sensory response patterns were strongly correlated, even when accounting for developmental level or social impairment. Longitudinal analyses indicated that the genu and cerebellar pathways were significantly associated with both repetitive behaviors and sensory responsiveness but not social deficits. At age 6 months, fractional anisotropy in the genu significantly predicted repetitive behaviors and sensory responsiveness at age 2. Cerebellar pathways significantly predicted later sensory responsiveness. Exploratory analyses suggested a possible disordinal interaction based on diagnostic status for the association between fractional anisotropy and repetitive behavior. CONCLUSIONS: Our findings suggest that restricted and repetitive behaviors contributing to a diagnosis of ASD at age 2 years are associated with structural properties of callosal and cerebellar white matter pathways measured during infancy and toddlerhood. We further identified that repetitive behaviors and unusual sensory response patterns co-occur and share common brain-behavior relationships. These results were strikingly specific given the absence of association between targeted pathways and social deficits. En ligne : http://dx.doi.org/10.1186/s13229-017-0126-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331