Auditory brainstem response in infants and children with autism spectrum disorder: A meta?analysis of wave V / Oren MIRON in Autism Research, 11-2 (February 2018)  

Public ISBD [article]  inAutism Research > 11-2 (February 2018) . - p.355-363 Titre : Auditory brainstem response in infants and children with autism spectrum disorder: A meta?analysis of wave V Type de document : Texte imprimé et/ou numérique Auteurs : Oren MIRON, Auteur ; Andrew L. BEAM, Auteur ; Isaac S. KOHANE, Auteur Année de publication : 2018 Article en page(s) : p.355-363 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Infants with autism spectrum disorder (ASD) were recently found to have prolonged auditory brainstem response (ABR); however, at older ages, findings are contradictory. We compared ABR differences between participants with ASD and controls with respect to age using a meta?analysis. Data sources included MEDLINE, EMBASE, Web of Science, Google Scholar, HOLLIS, and ScienceDirect from their inception to June 2016. The 25 studies that were included had a total of 1349 participants (727 participants with ASD and 622 controls) and an age range of 0–40 years. Prolongation of the absolute latency of wave V in ASD had a significant negative correlation with age (R2?=?0.23; P?=?0.01). The 22 studies below age 18 years showed a significantly prolonged wave V in ASD (Standard Mean Difference?=?0.6 [95% CI, 0.5–0.8]; P? En ligne : https://doi.org/10.1002/aur.1886 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=334 [article] Auditory brainstem response in infants and children with autism spectrum disorder: A meta?analysis of wave V [Texte imprimé et/ou numérique] / Oren MIRON, Auteur ; Andrew L. BEAM, Auteur ; Isaac S. KOHANE, Auteur . - 2018 . - p.355-363. Langues : Anglais (eng) in Autism Research > 11-2 (February 2018) . - p.355-363 Index. décimale : PER Périodiques Résumé : Infants with autism spectrum disorder (ASD) were recently found to have prolonged auditory brainstem response (ABR); however, at older ages, findings are contradictory. We compared ABR differences between participants with ASD and controls with respect to age using a meta?analysis. Data sources included MEDLINE, EMBASE, Web of Science, Google Scholar, HOLLIS, and ScienceDirect from their inception to June 2016. The 25 studies that were included had a total of 1349 participants (727 participants with ASD and 622 controls) and an age range of 0–40 years. Prolongation of the absolute latency of wave V in ASD had a significant negative correlation with age (R2?=?0.23; P?=?0.01). The 22 studies below age 18 years showed a significantly prolonged wave V in ASD (Standard Mean Difference?=?0.6 [95% CI, 0.5–0.8]; P? En ligne : https://doi.org/10.1002/aur.1886 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=334

Newborn Auditory Brainstem Responses in Children with Developmental Disabilities / Elizabeth A. SIMPSON ; Guangyu ZENG ; Rafael E. DELGADO ; Oren MIRON in Journal of Autism and Developmental Disorders, 53-2 (February 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-2 (February 2023) . - p.776-788 Titre : Newborn Auditory Brainstem Responses in Children with Developmental Disabilities Type de document : Texte imprimé et/ou numérique Auteurs : Elizabeth A. SIMPSON, Auteur ; Guangyu ZENG, Auteur ; Rafael E. DELGADO, Auteur ; Oren MIRON, Auteur Article en page(s) : p.776-788 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We integrated data from a newborn hearing screening database and a preschool disability database to examine the relationship between newborn click evoked auditory brainstem responses (ABRs) and developmental disabilities. This sample included children with developmental delay (n = 2992), speech impairment (SI, n = 905), language impairment (n = 566), autism spectrum disorder (ASD, n = 370), and comparison children (n = 128,181). We compared the phase of the ABR waveform, a measure of sound processing latency, across groups. Children with SI and children with ASD had greater newborn ABR phase values than both the comparison group and the developmental delay group. Newborns later diagnosed with SI or ASD have slower neurological responses to auditory stimuli, suggesting sensory differences at birth. En ligne : https://doi.org/10.1007/s10803-021-05126-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=495 [article] Newborn Auditory Brainstem Responses in Children with Developmental Disabilities [Texte imprimé et/ou numérique] / Elizabeth A. SIMPSON, Auteur ; Guangyu ZENG, Auteur ; Rafael E. DELGADO, Auteur ; Oren MIRON, Auteur . - p.776-788. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-2 (February 2023) . - p.776-788 Index. décimale : PER Périodiques Résumé : We integrated data from a newborn hearing screening database and a preschool disability database to examine the relationship between newborn click evoked auditory brainstem responses (ABRs) and developmental disabilities. This sample included children with developmental delay (n = 2992), speech impairment (SI, n = 905), language impairment (n = 566), autism spectrum disorder (ASD, n = 370), and comparison children (n = 128,181). We compared the phase of the ABR waveform, a measure of sound processing latency, across groups. Children with SI and children with ASD had greater newborn ABR phase values than both the comparison group and the developmental delay group. Newborns later diagnosed with SI or ASD have slower neurological responses to auditory stimuli, suggesting sensory differences at birth. En ligne : https://doi.org/10.1007/s10803-021-05126-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=495

Prolonged Auditory Brainstem Response in Universal Hearing Screening of Newborns with Autism Spectrum Disorder / Oren MIRON in Autism Research, 14-1 (January 2021)  

Public ISBD [article]  inAutism Research > 14-1 (January 2021) . - p.46-52 Titre : Prolonged Auditory Brainstem Response in Universal Hearing Screening of Newborns with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Oren MIRON, Auteur ; Rafael E. DELGADO, Auteur ; Christine F. DELGADO, Auteur ; Elizabeth A. SIMPSON, Auteur ; Kun-Hsing YU, Auteur ; Anibal GUTIERREZ, Auteur ; Guangyu ZENG, Auteur ; Jillian N. GERSTENBERGER, Auteur ; Isaac S. KOHANE, Auteur Article en page(s) : p.46-52 Langues : Anglais (eng) Mots-clés : auditory  biomarker  children  event-related potential  infants Index. décimale : PER Périodiques Résumé : Previous studies report prolonged auditory brainstem response (ABR) in children and adults with autism spectrum disorder (ASD). Despite its promise as a biomarker, it is unclear whether healthy newborns who later develop ASD also show ABR abnormalities. In the current study, we extracted ABR data on 139,154 newborns from their Universal Newborn Hearing Screening, including 321 newborns who were later diagnosed with ASD. We found that the ASD newborns had significant prolongations of their ABR phase and V-negative latency compared with the non-ASD newborns. Newborns in the ASD group also exhibited greater variance in their latencies compared to previous studies in older ASD samples, likely due in part to the low intensity of the ABR stimulus. These findings suggest that newborns display neurophysiological variation associated with ASD at birth. Future studies with higher-intensity stimulus ABRs may allow more accurate predictions of ASD risk, which could augment the universal ABR test that currently screens millions of newborns worldwide. LAY SUMMARY: Children with autism spectrum disorder (ASD) have slow brain responses to sounds. We examined these brain responses from newborns' hearing tests and found that newborns who were later diagnosed with autism also had slower brain responses to sounds. Future studies might use these findings to better predict autism risk, with a hearing test that is already used on millions of newborns worldwide. En ligne : http://dx.doi.org/10.1002/aur.2422 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=441 [article] Prolonged Auditory Brainstem Response in Universal Hearing Screening of Newborns with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Oren MIRON, Auteur ; Rafael E. DELGADO, Auteur ; Christine F. DELGADO, Auteur ; Elizabeth A. SIMPSON, Auteur ; Kun-Hsing YU, Auteur ; Anibal GUTIERREZ, Auteur ; Guangyu ZENG, Auteur ; Jillian N. GERSTENBERGER, Auteur ; Isaac S. KOHANE, Auteur . - p.46-52. Langues : Anglais (eng) in Autism Research > 14-1 (January 2021) . - p.46-52 Mots-clés : auditory  biomarker  children  event-related potential  infants Index. décimale : PER Périodiques Résumé : Previous studies report prolonged auditory brainstem response (ABR) in children and adults with autism spectrum disorder (ASD). Despite its promise as a biomarker, it is unclear whether healthy newborns who later develop ASD also show ABR abnormalities. In the current study, we extracted ABR data on 139,154 newborns from their Universal Newborn Hearing Screening, including 321 newborns who were later diagnosed with ASD. We found that the ASD newborns had significant prolongations of their ABR phase and V-negative latency compared with the non-ASD newborns. Newborns in the ASD group also exhibited greater variance in their latencies compared to previous studies in older ASD samples, likely due in part to the low intensity of the ABR stimulus. These findings suggest that newborns display neurophysiological variation associated with ASD at birth. Future studies with higher-intensity stimulus ABRs may allow more accurate predictions of ASD risk, which could augment the universal ABR test that currently screens millions of newborns worldwide. LAY SUMMARY: Children with autism spectrum disorder (ASD) have slow brain responses to sounds. We examined these brain responses from newborns' hearing tests and found that newborns who were later diagnosed with autism also had slower brain responses to sounds. Future studies might use these findings to better predict autism risk, with a hearing test that is already used on millions of newborns worldwide. En ligne : http://dx.doi.org/10.1002/aur.2422 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=441

Prolonged auditory brainstem responses in infants with autism / Oren MIRON in Autism Research, 9-6 (June 2016)  

Public ISBD [article]  inAutism Research > 9-6 (June 2016) . - p.689-695 Titre : Prolonged auditory brainstem responses in infants with autism Type de document : Texte imprimé et/ou numérique Auteurs : Oren MIRON, Auteur ; Daphne ARI-EVEN ROTH, Auteur ; Lidia V. GABIS, Auteur ; Yael HENKIN, Auteur ; Shahar SHEFER, Auteur ; Ilan DINSTEIN, Auteur ; Ronny GEVA, Auteur Article en page(s) : p.689-695 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  auditory brainstem response  hearing Index. décimale : PER Périodiques Résumé : Numerous studies have attempted to identify early physiological abnormalities in infants and toddlers who later develop autism spectrum disorder (ASD). One potential measure of early neurophysiology is the auditory brainstem response (ABR), which has been reported to exhibit prolonged latencies in children with ASD. We examined whether prolonged ABR latencies appear in infancy, before the onset of ASD symptoms, and irrespective of hearing thresholds. To determine how early in development these differences appear, we retrospectively examined clinical ABR recordings of infants who were later diagnosed with ASD. Of the 118 children in the participant pool, 48 were excluded due to elevated ABR thresholds, genetic aberrations, or old testing age, leaving a sample of 70 children: 30 of which were tested at 0–3 months, and 40 were tested at toddlerhood (1.5–3.5 years). In the infant group, the ABR wave-V was significantly prolonged in those who later developed ASD as compared with case-matched controls (n?=?30). Classification of infants who later developed ASD and case-matched controls using this measure enabled accurate identification of ASD infants with 80% specificity and 70% sensitivity. In the group of toddlers with ASD, absolute and interpeak latencies were prolonged compared to clinical norms. Findings indicate that ABR latencies are significantly prolonged in infants who are later diagnosed with ASD irrespective of their hearing thresholds; suggesting that abnormal responses might be detected soon after birth. Further research is needed to determine if ABR might be a valid marker for ASD risk. Autism Res 2016, 9: 689–695. © 2015 The Authors Autism Research published by Wiley Periodicals, Inc. on behalf of International Society for Autism Research En ligne : http://dx.doi.org/10.1002/aur.1561 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290 [article] Prolonged auditory brainstem responses in infants with autism [Texte imprimé et/ou numérique] / Oren MIRON, Auteur ; Daphne ARI-EVEN ROTH, Auteur ; Lidia V. GABIS, Auteur ; Yael HENKIN, Auteur ; Shahar SHEFER, Auteur ; Ilan DINSTEIN, Auteur ; Ronny GEVA, Auteur . - p.689-695. Langues : Anglais (eng) in Autism Research > 9-6 (June 2016) . - p.689-695 Mots-clés : autism spectrum disorder  auditory brainstem response  hearing Index. décimale : PER Périodiques Résumé : Numerous studies have attempted to identify early physiological abnormalities in infants and toddlers who later develop autism spectrum disorder (ASD). One potential measure of early neurophysiology is the auditory brainstem response (ABR), which has been reported to exhibit prolonged latencies in children with ASD. We examined whether prolonged ABR latencies appear in infancy, before the onset of ASD symptoms, and irrespective of hearing thresholds. To determine how early in development these differences appear, we retrospectively examined clinical ABR recordings of infants who were later diagnosed with ASD. Of the 118 children in the participant pool, 48 were excluded due to elevated ABR thresholds, genetic aberrations, or old testing age, leaving a sample of 70 children: 30 of which were tested at 0–3 months, and 40 were tested at toddlerhood (1.5–3.5 years). In the infant group, the ABR wave-V was significantly prolonged in those who later developed ASD as compared with case-matched controls (n?=?30). Classification of infants who later developed ASD and case-matched controls using this measure enabled accurate identification of ASD infants with 80% specificity and 70% sensitivity. In the group of toddlers with ASD, absolute and interpeak latencies were prolonged compared to clinical norms. Findings indicate that ABR latencies are significantly prolonged in infants who are later diagnosed with ASD irrespective of their hearing thresholds; suggesting that abnormal responses might be detected soon after birth. Further research is needed to determine if ABR might be a valid marker for ASD risk. Autism Res 2016, 9: 689–695. © 2015 The Authors Autism Research published by Wiley Periodicals, Inc. on behalf of International Society for Autism Research En ligne : http://dx.doi.org/10.1002/aur.1561 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290

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