Contribution of childhood lead exposure to psychopathology in the US population over the past 75?years / Aaron REUBEN ; Matt HAUER in Journal of Child Psychology and Psychiatry, 66-5 (May 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-5 (May 2025) . - p.659-666 Titre : Contribution of childhood lead exposure to psychopathology in the US population over the past 75?years Type de document : Texte imprimé et/ou numérique Auteurs : Aaron REUBEN, Auteur ; Matt HAUER, Auteur Article en page(s) : p.659-666 Langues : Anglais (eng) Mots-clés : Lead  psychopathology  personality  cohort  population burden Index. décimale : PER Périodiques Résumé : Background More than half of the current US population was exposed to adverse lead levels in childhood as a result of lead's past use in gasoline. The total contribution of childhood lead exposures to US-population mental health and personality has yet to be evaluated. Methods We combined serial, cross-sectional blood?lead level (BLL) data from National Health and Nutrition Examination Surveys (NHANES) with historic leaded-gasoline data to estimate US childhood BLLs from 1940 to 2015 and calculate population mental-health symptom elevations from known lead-psychopathology associations. We utilized five outcomes: (1) General Psychopathology ?points?, reflecting an individual's liability to overall mental disorder, scaled to match IQ scores (M?=?100, SD?=?15); (2) Symptoms of Internalizing disorders (anxiety and depression) and Attention-deficit/Hyperactivity Disorder (AD/HD), both z-scored (M?=?0, SD?=?1); and (3) Differences in the personality traits of Neuroticism and Conscientiousness (M?=?0, SD?=?1). Results Assuming that published lead-psychopathology associations are causal and not purely correlational: We estimate that by 2015, the US population had gained 602-million General Psychopathology factor points because of exposure arising from leaded gasoline, reflecting a 0.13-standard-deviation increase in overall liability to mental illness in the population and an estimated 151 million excess mental disorders attributable to lead exposure. Investigation of specific disorder-domain symptoms identified a 0.64-standard-deviation increase in population-level Internalizing symptoms and a 0.42-standard-deviation increase in AD/HD symptoms. Population-level Neuroticism increased by 0.14 standard deviations and Conscientiousness decreased by 0.20 standard deviations. Lead-associated mental health and personality differences were most pronounced for cohorts born from 1966 through 1986 (Generation X). Conclusions A significant burden of mental illness symptomatology and disadvantageous personality differences can be attributed to US children's exposure to lead over the past 75?years. Lead's potential contribution to psychiatry, medicine, and children's health may be larger than previously assumed. En ligne : https://doi.org/10.1111/jcpp.14072 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554 [article] Contribution of childhood lead exposure to psychopathology in the US population over the past 75?years [Texte imprimé et/ou numérique] / Aaron REUBEN, Auteur ; Matt HAUER, Auteur . - p.659-666. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-5 (May 2025) . - p.659-666 Mots-clés : Lead  psychopathology  personality  cohort  population burden Index. décimale : PER Périodiques Résumé : Background More than half of the current US population was exposed to adverse lead levels in childhood as a result of lead's past use in gasoline. The total contribution of childhood lead exposures to US-population mental health and personality has yet to be evaluated. Methods We combined serial, cross-sectional blood?lead level (BLL) data from National Health and Nutrition Examination Surveys (NHANES) with historic leaded-gasoline data to estimate US childhood BLLs from 1940 to 2015 and calculate population mental-health symptom elevations from known lead-psychopathology associations. We utilized five outcomes: (1) General Psychopathology ?points?, reflecting an individual's liability to overall mental disorder, scaled to match IQ scores (M?=?100, SD?=?15); (2) Symptoms of Internalizing disorders (anxiety and depression) and Attention-deficit/Hyperactivity Disorder (AD/HD), both z-scored (M?=?0, SD?=?1); and (3) Differences in the personality traits of Neuroticism and Conscientiousness (M?=?0, SD?=?1). Results Assuming that published lead-psychopathology associations are causal and not purely correlational: We estimate that by 2015, the US population had gained 602-million General Psychopathology factor points because of exposure arising from leaded gasoline, reflecting a 0.13-standard-deviation increase in overall liability to mental illness in the population and an estimated 151 million excess mental disorders attributable to lead exposure. Investigation of specific disorder-domain symptoms identified a 0.64-standard-deviation increase in population-level Internalizing symptoms and a 0.42-standard-deviation increase in AD/HD symptoms. Population-level Neuroticism increased by 0.14 standard deviations and Conscientiousness decreased by 0.20 standard deviations. Lead-associated mental health and personality differences were most pronounced for cohorts born from 1966 through 1986 (Generation X). Conclusions A significant burden of mental illness symptomatology and disadvantageous personality differences can be attributed to US children's exposure to lead over the past 75?years. Lead's potential contribution to psychiatry, medicine, and children's health may be larger than previously assumed. En ligne : https://doi.org/10.1111/jcpp.14072 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554

Lest we forget: comparing retrospective and prospective assessments of adverse childhood experiences in the prediction of adult health / Aaron REUBEN in Journal of Child Psychology and Psychiatry, 57-10 (October 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-10 (October 2016) . - p.1103-1112 Titre : Lest we forget: comparing retrospective and prospective assessments of adverse childhood experiences in the prediction of adult health Type de document : Texte imprimé et/ou numérique Auteurs : Aaron REUBEN, Auteur ; Terrie E. MOFFITT, Auteur ; Avshalom CASPI, Auteur ; Daniel W. BELSKY, Auteur ; Honalee HARRINGTON, Auteur ; Felix SCHROEDER, Auteur ; Sean HOGAN, Auteur ; Sandhya RAMRAKHA, Auteur ; Richie POULTON, Auteur ; Andrea DANESE, Auteur Article en page(s) : p.1103-1112 Langues : Anglais (eng) Mots-clés : Adverse childhood experiences  physical health  mental health  cognitive health  epidemiology Index. décimale : PER Périodiques Résumé : Background Adverse childhood experiences (ACEs; e.g. abuse, neglect, and parental loss) have been associated with increased risk for later-life disease and dysfunction using adults’ retrospective self-reports of ACEs. Research should test whether associations between ACEs and health outcomes are the same for prospective and retrospective ACE measures. Methods We estimated agreement between ACEs prospectively recorded throughout childhood (by Study staff at Study member ages 3, 5, 7, 9, 11, 13, and 15) and retrospectively recalled in adulthood (by Study members when they reached age 38), in the population-representative Dunedin cohort (N = 1,037). We related both retrospective and prospective ACE measures to physical, mental, cognitive, and social health at midlife measured through both objective (e.g. biomarkers and neuropsychological tests) and subjective (e.g. self-reported) means. Results Dunedin and U.S. Centers for Disease Control ACE distributions were similar. Retrospective and prospective measures of adversity showed moderate agreement (r = .47, p < .001; weighted Kappa = .31, 95% CI: .27–.35). Both associated with all midlife outcomes. As compared to prospective ACEs, retrospective ACEs showed stronger associations with life outcomes that were subjectively assessed, and weaker associations with life outcomes that were objectively assessed. Recalled ACEs and poor subjective outcomes were correlated regardless of whether prospectively recorded ACEs were evident. Individuals who recalled more ACEs than had been prospectively recorded were more neurotic than average, and individuals who recalled fewer ACEs than recorded were more agreeable. Conclusions Prospective ACE records confirm associations between childhood adversity and negative life outcomes found previously using retrospective ACE reports. However, more agreeable and neurotic dispositions may, respectively, bias retrospective ACE measures toward underestimating the impact of adversity on objectively measured life outcomes and overestimating the impact of adversity on self-reported outcomes. Associations between personality factors and the propensity to recall adversity were extremely modest and warrant further investigation. Risk predictions based on retrospective ACE reports should utilize objective outcome measures. Where objective outcome measurements are difficult to obtain, correction factors may be warranted. En ligne : http://dx.doi.org/10.1111/jcpp.12621 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295 [article] Lest we forget: comparing retrospective and prospective assessments of adverse childhood experiences in the prediction of adult health [Texte imprimé et/ou numérique] / Aaron REUBEN, Auteur ; Terrie E. MOFFITT, Auteur ; Avshalom CASPI, Auteur ; Daniel W. BELSKY, Auteur ; Honalee HARRINGTON, Auteur ; Felix SCHROEDER, Auteur ; Sean HOGAN, Auteur ; Sandhya RAMRAKHA, Auteur ; Richie POULTON, Auteur ; Andrea DANESE, Auteur . - p.1103-1112. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-10 (October 2016) . - p.1103-1112 Mots-clés : Adverse childhood experiences  physical health  mental health  cognitive health  epidemiology Index. décimale : PER Périodiques Résumé : Background Adverse childhood experiences (ACEs; e.g. abuse, neglect, and parental loss) have been associated with increased risk for later-life disease and dysfunction using adults’ retrospective self-reports of ACEs. Research should test whether associations between ACEs and health outcomes are the same for prospective and retrospective ACE measures. Methods We estimated agreement between ACEs prospectively recorded throughout childhood (by Study staff at Study member ages 3, 5, 7, 9, 11, 13, and 15) and retrospectively recalled in adulthood (by Study members when they reached age 38), in the population-representative Dunedin cohort (N = 1,037). We related both retrospective and prospective ACE measures to physical, mental, cognitive, and social health at midlife measured through both objective (e.g. biomarkers and neuropsychological tests) and subjective (e.g. self-reported) means. Results Dunedin and U.S. Centers for Disease Control ACE distributions were similar. Retrospective and prospective measures of adversity showed moderate agreement (r = .47, p < .001; weighted Kappa = .31, 95% CI: .27–.35). Both associated with all midlife outcomes. As compared to prospective ACEs, retrospective ACEs showed stronger associations with life outcomes that were subjectively assessed, and weaker associations with life outcomes that were objectively assessed. Recalled ACEs and poor subjective outcomes were correlated regardless of whether prospectively recorded ACEs were evident. Individuals who recalled more ACEs than had been prospectively recorded were more neurotic than average, and individuals who recalled fewer ACEs than recorded were more agreeable. Conclusions Prospective ACE records confirm associations between childhood adversity and negative life outcomes found previously using retrospective ACE reports. However, more agreeable and neurotic dispositions may, respectively, bias retrospective ACE measures toward underestimating the impact of adversity on objectively measured life outcomes and overestimating the impact of adversity on self-reported outcomes. Associations between personality factors and the propensity to recall adversity were extremely modest and warrant further investigation. Risk predictions based on retrospective ACE reports should utilize objective outcome measures. Where objective outcome measurements are difficult to obtain, correction factors may be warranted. En ligne : http://dx.doi.org/10.1111/jcpp.12621 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295

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