Auditory processing in noise is associated with complex patterns of disrupted functional connectivity in autism spectrum disorder / Fahimeh MAMASHLI in Autism Research, 10-4 (April 2017)  

Public ISBD [article]  inAutism Research > 10-4 (April 2017) . - p.631-647 Titre : Auditory processing in noise is associated with complex patterns of disrupted functional connectivity in autism spectrum disorder Type de document : texte imprimé Auteurs : Fahimeh MAMASHLI, Auteur ; Sheraz KHAN, Auteur ; Hari BHARADWAJ, Auteur ; Konstantinos MICHMIZOS, Auteur ; Santosh GANESAN, Auteur ; Keri-Lee A. GAREL, Auteur ; Javeria ALI HASHMI, Auteur ; Martha R. HERBERT, Auteur ; Matti S. HÄMÄLÄINEN, Auteur ; Tal KENET, Auteur Article en page(s) : p.631-647 Langues : Anglais (eng) Mots-clés : autism  MEG  auditory  noise  connectivity  feedback  top-down Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is associated with difficulty in processing speech in a noisy background, but the neural mechanisms that underlie this deficit have not been mapped. To address this question, we used magnetoencephalography to compare the cortical responses between ASD and typically developing (TD) individuals to a passive mismatch paradigm. We repeated the paradigm twice, once in a quiet background, and once in the presence of background noise. We focused on both the evoked mismatch field (MMF) response in temporal and frontal cortical locations, and functional connectivity with spectral specificity between those locations. In the quiet condition, we found common neural sources of the MMF response in both groups, in the right temporal gyrus and inferior frontal gyrus (IFG). In the noise condition, the MMF response in the right IFG was preserved in the TD group, but reduced relative to the quiet condition in ASD group. The MMF response in the right IFG also correlated with severity of ASD. Moreover, in noise, we found significantly reduced normalized coherence (deviant normalized by standard) in ASD relative to TD, in the beta band (14–25 Hz), between left temporal and left inferior frontal sub-regions. However, unnormalized coherence (coherence during deviant or standard) was significantly increased in ASD relative to TD, in multiple frequency bands. Our findings suggest increased recruitment of neural resources in ASD irrespective of the task difficulty, alongside a reduction in top-down modulations, usually mediated by the beta band, needed to mitigate the impact of noise on auditory processing. En ligne : http://dx.doi.org/10.1002/aur.1714 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Auditory processing in noise is associated with complex patterns of disrupted functional connectivity in autism spectrum disorder [texte imprimé] / Fahimeh MAMASHLI, Auteur ; Sheraz KHAN, Auteur ; Hari BHARADWAJ, Auteur ; Konstantinos MICHMIZOS, Auteur ; Santosh GANESAN, Auteur ; Keri-Lee A. GAREL, Auteur ; Javeria ALI HASHMI, Auteur ; Martha R. HERBERT, Auteur ; Matti S. HÄMÄLÄINEN, Auteur ; Tal KENET, Auteur . - p.631-647. Langues : Anglais (eng) in Autism Research > 10-4 (April 2017) . - p.631-647 Mots-clés : autism  MEG  auditory  noise  connectivity  feedback  top-down Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is associated with difficulty in processing speech in a noisy background, but the neural mechanisms that underlie this deficit have not been mapped. To address this question, we used magnetoencephalography to compare the cortical responses between ASD and typically developing (TD) individuals to a passive mismatch paradigm. We repeated the paradigm twice, once in a quiet background, and once in the presence of background noise. We focused on both the evoked mismatch field (MMF) response in temporal and frontal cortical locations, and functional connectivity with spectral specificity between those locations. In the quiet condition, we found common neural sources of the MMF response in both groups, in the right temporal gyrus and inferior frontal gyrus (IFG). In the noise condition, the MMF response in the right IFG was preserved in the TD group, but reduced relative to the quiet condition in ASD group. The MMF response in the right IFG also correlated with severity of ASD. Moreover, in noise, we found significantly reduced normalized coherence (deviant normalized by standard) in ASD relative to TD, in the beta band (14–25 Hz), between left temporal and left inferior frontal sub-regions. However, unnormalized coherence (coherence during deviant or standard) was significantly increased in ASD relative to TD, in multiple frequency bands. Our findings suggest increased recruitment of neural resources in ASD irrespective of the task difficulty, alongside a reduction in top-down modulations, usually mediated by the beta band, needed to mitigate the impact of noise on auditory processing. En ligne : http://dx.doi.org/10.1002/aur.1714 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Children with autism spectrum disorder show altered functional connectivity and abnormal maturation trajectories in response to inverted faces / Fahimeh MAMASHLI in Autism Research, 14-6 (June 2021)  

Public ISBD [article]  inAutism Research > 14-6 (June 2021) . - p.1101-1114 Titre : Children with autism spectrum disorder show altered functional connectivity and abnormal maturation trajectories in response to inverted faces Type de document : texte imprimé Auteurs : Fahimeh MAMASHLI, Auteur ; Nataliia KOZHEMIAKO, Auteur ; Sheraz KHAN, Auteur ; Adonay NUNES, Auteur ; Nicole M. MCGUIGGAN, Auteur ; Ainsley LOSH, Auteur ; Robert M. JOSEPH, Auteur ; Jyrki AHVENINEN, Auteur ; Sam M. DOESBURG, Auteur ; Matti S. HÄMÄLÄINEN, Auteur ; Tal KENET, Auteur Article en page(s) : p.1101-1114 Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder/diagnostic imaging  Child  Gamma Rhythm  Humans  Magnetic Resonance Imaging  Magnetoencephalography  Prefrontal Cortex  autism spectrum disorder  functional connectivity  inverted faces  phase-amplitude coupling Index. décimale : PER Périodiques Résumé : The processing of information conveyed by faces is a critical component of social communication. While the neurophysiology of processing upright faces has been studied extensively in autism spectrum disorder (ASD), less is known about the neurophysiological abnormalities associated with processing inverted faces in ASD. We used magnetoencephalography (MEG) to study both long-range and local functional connectivity, with the latter assessed using local cross-frequency coupling, in response to inverted faces stimuli, in 7-18 years old individuals with ASD and age and IQ matched typically developing (TD) individuals. We found abnormally reduced coupling between the phase of the alpha rhythm and the amplitude of the gamma rhythm in the fusiform face area (FFA) in response to inverted faces, as well as reduced long-range functional connectivity between the FFA and the inferior frontal gyrus (IFG) in response to inverted faces in the ASD group. These group differences were absent in response to upright faces. The magnitude of functional connectivity between the FFA and the IFG was significantly correlated with the severity of ASD, and FFA-IFG long-range functional connectivity increased with age in TD group, but not in the ASD group. Our findings suggest that both local and long-range functional connectivity are abnormally reduced in children with ASD when processing inverted faces, and that the pattern of abnormalities associated with the processing of inverted faces differs from the pattern of upright faces in ASD, likely due to the presumed greater reliance on top-down regulations necessary for efficient processing of inverted faces. LAY SUMMARY: We found alterations in the neurophysiological responses to inverted faces in children with ASD, that were not reflected in the evoked responses, and were not observed in the responses to upright faces. These alterations included reduced local functional connectivity in the fusiform face area (FFA), and decreased long-range alpha-band modulated functional connectivity between the FFA and the left IFG. The magnitude of long-range functional connectivity between the FFA and the inferior frontal gyrus was correlated with the severity of ASD. En ligne : http://dx.doi.org/10.1002/aur.2497 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Children with autism spectrum disorder show altered functional connectivity and abnormal maturation trajectories in response to inverted faces [texte imprimé] / Fahimeh MAMASHLI, Auteur ; Nataliia KOZHEMIAKO, Auteur ; Sheraz KHAN, Auteur ; Adonay NUNES, Auteur ; Nicole M. MCGUIGGAN, Auteur ; Ainsley LOSH, Auteur ; Robert M. JOSEPH, Auteur ; Jyrki AHVENINEN, Auteur ; Sam M. DOESBURG, Auteur ; Matti S. HÄMÄLÄINEN, Auteur ; Tal KENET, Auteur . - p.1101-1114. Langues : Anglais (eng) in Autism Research > 14-6 (June 2021) . - p.1101-1114 Mots-clés : Adolescent  Autism Spectrum Disorder/diagnostic imaging  Child  Gamma Rhythm  Humans  Magnetic Resonance Imaging  Magnetoencephalography  Prefrontal Cortex  autism spectrum disorder  functional connectivity  inverted faces  phase-amplitude coupling Index. décimale : PER Périodiques Résumé : The processing of information conveyed by faces is a critical component of social communication. While the neurophysiology of processing upright faces has been studied extensively in autism spectrum disorder (ASD), less is known about the neurophysiological abnormalities associated with processing inverted faces in ASD. We used magnetoencephalography (MEG) to study both long-range and local functional connectivity, with the latter assessed using local cross-frequency coupling, in response to inverted faces stimuli, in 7-18 years old individuals with ASD and age and IQ matched typically developing (TD) individuals. We found abnormally reduced coupling between the phase of the alpha rhythm and the amplitude of the gamma rhythm in the fusiform face area (FFA) in response to inverted faces, as well as reduced long-range functional connectivity between the FFA and the inferior frontal gyrus (IFG) in response to inverted faces in the ASD group. These group differences were absent in response to upright faces. The magnitude of functional connectivity between the FFA and the IFG was significantly correlated with the severity of ASD, and FFA-IFG long-range functional connectivity increased with age in TD group, but not in the ASD group. Our findings suggest that both local and long-range functional connectivity are abnormally reduced in children with ASD when processing inverted faces, and that the pattern of abnormalities associated with the processing of inverted faces differs from the pattern of upright faces in ASD, likely due to the presumed greater reliance on top-down regulations necessary for efficient processing of inverted faces. LAY SUMMARY: We found alterations in the neurophysiological responses to inverted faces in children with ASD, that were not reflected in the evoked responses, and were not observed in the responses to upright faces. These alterations included reduced local functional connectivity in the fusiform face area (FFA), and decreased long-range alpha-band modulated functional connectivity between the FFA and the left IFG. The magnitude of long-range functional connectivity between the FFA and the inferior frontal gyrus was correlated with the severity of ASD. En ligne : http://dx.doi.org/10.1002/aur.2497 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

Lower Cortical Activation and Altered Functional Connectivity Characterize Passive Auditory Spatial Attention in ASD / Sergio OSORIO in Autism Research, 18-11 (November 2025)  

Public ISBD [article]  inAutism Research > 18-11 (November 2025) . - p.2240-2253 Titre : Lower Cortical Activation and Altered Functional Connectivity Characterize Passive Auditory Spatial Attention in ASD Type de document : texte imprimé Auteurs : Sergio OSORIO, Auteur ; Jasmine TAN, Auteur ; Grace LEVINE, Auteur ; Seppo P. AHLFORS, Auteur ; Steven GRAHAM, Auteur ; Fahimeh MAMASHLI, Auteur ; Sheraz KHAN, Auteur ; Robert M. JOSEPH, Auteur ; Zein NAYAL, Auteur ; Ainsley LOSH, Auteur ; Stephanie PAWLYSZYN, Auteur ; Nicole M. MCGUIGGAN, Auteur ; Matti S. HÄMÄLÄINEN, Auteur ; Hari BHARADWAJ, Auteur ; Tal KENET, Auteur Article en page(s) : p.2240-2253 Langues : Anglais (eng) Mots-clés : autism  functional connectivity  magnetoencephalography  sensory processing  sound localization Index. décimale : PER Périodiques Résumé : ABSTRACT Autism Spectrum Disorder (ASD) is a developmental condition characterized by difficulties in social interaction, communication, and sensory processing. The ability to orient towards sounds is a key component of social interactions, yet auditory spatial attention remains relatively understudied in ASD, despite prior research indicating differences in this domain. Here, we investigate the neural signatures associated with passive auditory spatial attention in children with ASD (n?=?21, ages 6?17) relative to age- and IQ-matched Typically Developing (TD) children (n?=?31), using source-localized magnetoencephalography (MEG). Participants listened passively, while watching a silenced movie, to non-social auditory stimuli designed to either remain lateralized to one hemifield (stay trials) or to change in location from one side to the contralateral hemifield (jump trials). Linear mixed effects modeling showed lower cortical activation in the auditory cortex in the ASD group in response to jump trials, relative to the TD group. Additionally, functional connectivity analyses showed higher alpha-band functional connectivity in the ASD group between left auditory cortex seeds and right prefrontal and left parietal regions known to be recruited during auditory spatial attention. Right prefrontal alpha-band connectivity estimates were associated with behaviorally assessed auditory processing scores, whereas left parietal connectivity estimates were associated with ASD symptomatology. Our results align with the hypothesis that auditory spatial attention generally, and specifically orientation to sounds even when experienced passively, differs in ASD versus TD children. En ligne : https://doi.org/10.1002/aur.70120 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571 [article] Lower Cortical Activation and Altered Functional Connectivity Characterize Passive Auditory Spatial Attention in ASD [texte imprimé] / Sergio OSORIO, Auteur ; Jasmine TAN, Auteur ; Grace LEVINE, Auteur ; Seppo P. AHLFORS, Auteur ; Steven GRAHAM, Auteur ; Fahimeh MAMASHLI, Auteur ; Sheraz KHAN, Auteur ; Robert M. JOSEPH, Auteur ; Zein NAYAL, Auteur ; Ainsley LOSH, Auteur ; Stephanie PAWLYSZYN, Auteur ; Nicole M. MCGUIGGAN, Auteur ; Matti S. HÄMÄLÄINEN, Auteur ; Hari BHARADWAJ, Auteur ; Tal KENET, Auteur . - p.2240-2253. Langues : Anglais (eng) in Autism Research > 18-11 (November 2025) . - p.2240-2253 Mots-clés : autism  functional connectivity  magnetoencephalography  sensory processing  sound localization Index. décimale : PER Périodiques Résumé : ABSTRACT Autism Spectrum Disorder (ASD) is a developmental condition characterized by difficulties in social interaction, communication, and sensory processing. The ability to orient towards sounds is a key component of social interactions, yet auditory spatial attention remains relatively understudied in ASD, despite prior research indicating differences in this domain. Here, we investigate the neural signatures associated with passive auditory spatial attention in children with ASD (n?=?21, ages 6?17) relative to age- and IQ-matched Typically Developing (TD) children (n?=?31), using source-localized magnetoencephalography (MEG). Participants listened passively, while watching a silenced movie, to non-social auditory stimuli designed to either remain lateralized to one hemifield (stay trials) or to change in location from one side to the contralateral hemifield (jump trials). Linear mixed effects modeling showed lower cortical activation in the auditory cortex in the ASD group in response to jump trials, relative to the TD group. Additionally, functional connectivity analyses showed higher alpha-band functional connectivity in the ASD group between left auditory cortex seeds and right prefrontal and left parietal regions known to be recruited during auditory spatial attention. Right prefrontal alpha-band connectivity estimates were associated with behaviorally assessed auditory processing scores, whereas left parietal connectivity estimates were associated with ASD symptomatology. Our results align with the hypothesis that auditory spatial attention generally, and specifically orientation to sounds even when experienced passively, differs in ASD versus TD children. En ligne : https://doi.org/10.1002/aur.70120 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571

No Differences in Auditory Steady-State Responses in Children with Autism Spectrum Disorder and Typically Developing Children / Seppo P. AHLFORS in Journal of Autism and Developmental Disorders, 54-5 (May 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-5 (May 2024) . - p.1947-1960 Titre : No Differences in Auditory Steady-State Responses in Children with Autism Spectrum Disorder and Typically Developing Children Type de document : texte imprimé Auteurs : Seppo P. AHLFORS, Auteur ; Steven GRAHAM, Auteur ; Hari BHARADWAJ, Auteur ; Fahimeh MAMASHLI, Auteur ; Sheraz KHAN, Auteur ; Robert M. JOSEPH, Auteur ; Ainsley LOSH, Auteur ; Stephanie PAWLYSZYN, Auteur ; Nicole M. MCGUIGGAN, Auteur ; Mark VANGEL, Auteur ; Matti S. HÄMÄLÄINEN, Auteur ; Tal KENET, Auteur Article en page(s) : p.1947-1960 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Auditory steady-state response (ASSR) has been studied as a potential biomarker for abnormal auditory sensory processing in autism spectrum disorder (ASD), with mixed results. Motivated by prior somatosensory findings of group differences in inter-trial coherence (ITC) between ASD and typically developing (TD) individuals at twice the steady-state stimulation frequency, we examined ASSR at 25 and 50 as well as 43 and 86 Hz in response to 25-Hz and 43-Hz auditory stimuli, respectively, using magnetoencephalography. Data were recorded from 22 ASD and 31 TD children, ages 6-17 years. ITC measures showed prominent ASSRs at the stimulation and double frequencies, without significant group differences. These results do not support ASSR as a robust ASD biomarker of abnormal auditory processing in ASD. Furthermore, the previously observed atypical double-frequency somatosensory response in ASD did not generalize to the auditory modality. Thus, the hypothesis about modality-independent abnormal local connectivity in ASD was not supported. En ligne : https://doi.org/10.1007/s10803-023-05907-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=530 [article] No Differences in Auditory Steady-State Responses in Children with Autism Spectrum Disorder and Typically Developing Children [texte imprimé] / Seppo P. AHLFORS, Auteur ; Steven GRAHAM, Auteur ; Hari BHARADWAJ, Auteur ; Fahimeh MAMASHLI, Auteur ; Sheraz KHAN, Auteur ; Robert M. JOSEPH, Auteur ; Ainsley LOSH, Auteur ; Stephanie PAWLYSZYN, Auteur ; Nicole M. MCGUIGGAN, Auteur ; Mark VANGEL, Auteur ; Matti S. HÄMÄLÄINEN, Auteur ; Tal KENET, Auteur . - p.1947-1960. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-5 (May 2024) . - p.1947-1960 Index. décimale : PER Périodiques Résumé : Auditory steady-state response (ASSR) has been studied as a potential biomarker for abnormal auditory sensory processing in autism spectrum disorder (ASD), with mixed results. Motivated by prior somatosensory findings of group differences in inter-trial coherence (ITC) between ASD and typically developing (TD) individuals at twice the steady-state stimulation frequency, we examined ASSR at 25 and 50 as well as 43 and 86 Hz in response to 25-Hz and 43-Hz auditory stimuli, respectively, using magnetoencephalography. Data were recorded from 22 ASD and 31 TD children, ages 6-17 years. ITC measures showed prominent ASSRs at the stimulation and double frequencies, without significant group differences. These results do not support ASSR as a robust ASD biomarker of abnormal auditory processing in ASD. Furthermore, the previously observed atypical double-frequency somatosensory response in ASD did not generalize to the auditory modality. Thus, the hypothesis about modality-independent abnormal local connectivity in ASD was not supported. En ligne : https://doi.org/10.1007/s10803-023-05907-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=530

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