Altered task?related modulation of long?range connectivity in children with autism / Ajay S. PILLAI in Autism Research, 11-2 (February 2018)  

Public ISBD [article]  inAutism Research > 11-2 (February 2018) . - p.245-257 Titre : Altered task?related modulation of long?range connectivity in children with autism Type de document : Texte imprimé et/ou numérique Auteurs : Ajay S. PILLAI, Auteur ; Danielle MCAULIFFE, Auteur ; Balaji M. LAKSHMANAN, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Nathan E. CRONE, Auteur ; Joshua B. EWEN, Auteur Année de publication : 2018 Article en page(s) : p.245-257 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Functional connectivity differences between children with autism spectrum disorder (ASD) and typically developing children have been described in multiple datasets. However, few studies examine the task?related changes in connectivity in disorder?relevant behavioral paradigms. In this paper, we examined the task?related changes in functional connectivity using EEG and a movement?based paradigm that has behavioral relevance to ASD. Resting?state studies motivated our hypothesis that children with ASD would show a decreased magnitude of functional connectivity during the performance of a motor?control task. Contrary to our initial hypothesis, however, we observed that task?related modulation of functional connectivity in children with ASD was in the direction opposite to that of TDs. The task?related connectivity changes were correlated with clinical symptom scores. Our results suggest that children with ASD may have differences in cortical segregation/integration during the performance of a task, and that part of the differences in connectivity modulation may serve as a compensatory mechanism. Autism Res 2018, 11: 245–257. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Decreased connectivity between brain regions is thought to cause the symptoms of autism. Because most of our knowledge comes from data in which children are at rest, we do not know how connectivity changes directly lead to autistic behaviors, such as impaired gestures. When typically developing children produced complex movements, connectivity decreased between brain regions. In children with autism, connectivity increased. It may be that behavior?related changes in brain connectivity are more important than absolute differences in connectivity in autism. En ligne : https://doi.org/10.1002/aur.1858 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=334 [article] Altered task?related modulation of long?range connectivity in children with autism [Texte imprimé et/ou numérique] / Ajay S. PILLAI, Auteur ; Danielle MCAULIFFE, Auteur ; Balaji M. LAKSHMANAN, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Nathan E. CRONE, Auteur ; Joshua B. EWEN, Auteur . - 2018 . - p.245-257. Langues : Anglais (eng) in Autism Research > 11-2 (February 2018) . - p.245-257 Index. décimale : PER Périodiques Résumé : Functional connectivity differences between children with autism spectrum disorder (ASD) and typically developing children have been described in multiple datasets. However, few studies examine the task?related changes in connectivity in disorder?relevant behavioral paradigms. In this paper, we examined the task?related changes in functional connectivity using EEG and a movement?based paradigm that has behavioral relevance to ASD. Resting?state studies motivated our hypothesis that children with ASD would show a decreased magnitude of functional connectivity during the performance of a motor?control task. Contrary to our initial hypothesis, however, we observed that task?related modulation of functional connectivity in children with ASD was in the direction opposite to that of TDs. The task?related connectivity changes were correlated with clinical symptom scores. Our results suggest that children with ASD may have differences in cortical segregation/integration during the performance of a task, and that part of the differences in connectivity modulation may serve as a compensatory mechanism. Autism Res 2018, 11: 245–257. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Decreased connectivity between brain regions is thought to cause the symptoms of autism. Because most of our knowledge comes from data in which children are at rest, we do not know how connectivity changes directly lead to autistic behaviors, such as impaired gestures. When typically developing children produced complex movements, connectivity decreased between brain regions. In children with autism, connectivity increased. It may be that behavior?related changes in brain connectivity are more important than absolute differences in connectivity in autism. En ligne : https://doi.org/10.1002/aur.1858 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=334

Autism and Hierarchical Models of Intelligence / Huan CHEN ; Ericka L. WODKA ; Brian S. CAFFO ; Joshua B. EWEN in Journal of Autism and Developmental Disorders, 55-6 (June 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-6 (June 2025) . - p.2034-2042 Titre : Autism and Hierarchical Models of Intelligence Type de document : Texte imprimé et/ou numérique Auteurs : Huan CHEN, Auteur ; Ericka L. WODKA, Auteur ; Brian S. CAFFO, Auteur ; Joshua B. EWEN, Auteur Article en page(s) : p.2034-2042 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The Wechsler Intelligence Scale for Children (WISC) employs a hierarchical model of general intelligence in which index scores separate out different clinically-relevant aspects of intelligence; the test is designed such that index scores are statistically independent from one another within the normative sample. Whether or not the existing index scores meet the desired psychometric property of being statistically independent within autistic samples is unknown. En ligne : https://doi.org/10.1007/s10803-023-05984-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=556 [article] Autism and Hierarchical Models of Intelligence [Texte imprimé et/ou numérique] / Huan CHEN, Auteur ; Ericka L. WODKA, Auteur ; Brian S. CAFFO, Auteur ; Joshua B. EWEN, Auteur . - p.2034-2042. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-6 (June 2025) . - p.2034-2042 Index. décimale : PER Périodiques Résumé : The Wechsler Intelligence Scale for Children (WISC) employs a hierarchical model of general intelligence in which index scores separate out different clinically-relevant aspects of intelligence; the test is designed such that index scores are statistically independent from one another within the normative sample. Whether or not the existing index scores meet the desired psychometric property of being statistically independent within autistic samples is unknown. En ligne : https://doi.org/10.1007/s10803-023-05984-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=556

Dyspraxia in ASD: Impaired coordination of movement elements / Danielle MCAULIFFE in Autism Research, 10-4 (April 2017)  

Public ISBD [article]  inAutism Research > 10-4 (April 2017) . - p.648-652 Titre : Dyspraxia in ASD: Impaired coordination of movement elements Type de document : Texte imprimé et/ou numérique Auteurs : Danielle MCAULIFFE, Auteur ; Ajay S. PILLAI, Auteur ; Alyssa TIEDEMANN, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Joshua B. EWEN, Auteur Article en page(s) : p.648-652 Langues : Anglais (eng) Mots-clés : dyspraxia  autism  motor planning  divided attention  multiple task interference Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorders (ASD) have long been known to have deficits in the performance of praxis gestures; these motor deficits also correlate with social and communicative deficits. To date, the precise nature of the errors involved in praxis has not been clearly mapped out. Based on observations of individuals with ASD performing gestures, we hypothesized that the simultaneous execution of multiple movement elements is especially impaired in affected children. We examined 25 school-aged participants with ASD and 25 age-matched controls performing seven simultaneous gestures that required the concurrent performance of movement elements and nine serial gestures, in which all elements were performed serially. There was indeed a group × gesture-type interaction (P? En ligne : http://dx.doi.org/10.1002/aur.1693 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Dyspraxia in ASD: Impaired coordination of movement elements [Texte imprimé et/ou numérique] / Danielle MCAULIFFE, Auteur ; Ajay S. PILLAI, Auteur ; Alyssa TIEDEMANN, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Joshua B. EWEN, Auteur . - p.648-652. Langues : Anglais (eng) in Autism Research > 10-4 (April 2017) . - p.648-652 Mots-clés : dyspraxia  autism  motor planning  divided attention  multiple task interference Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorders (ASD) have long been known to have deficits in the performance of praxis gestures; these motor deficits also correlate with social and communicative deficits. To date, the precise nature of the errors involved in praxis has not been clearly mapped out. Based on observations of individuals with ASD performing gestures, we hypothesized that the simultaneous execution of multiple movement elements is especially impaired in affected children. We examined 25 school-aged participants with ASD and 25 age-matched controls performing seven simultaneous gestures that required the concurrent performance of movement elements and nine serial gestures, in which all elements were performed serially. There was indeed a group × gesture-type interaction (P? En ligne : http://dx.doi.org/10.1002/aur.1693 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Mechanisms of Altered Imitation in Autism Spectrum Disorders / Ata KOLDAY ; Ericka L. WODKA ; Stewart H. MOSTOFSKY ; Brian S. CAFFO ; Joshua B. EWEN in Autism Research, 18-7 (July 2025)  

Public ISBD [article]  inAutism Research > 18-7 (July 2025) . - p.1397-1411 Titre : Mechanisms of Altered Imitation in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Ata KOLDAY, Auteur ; Ericka L. WODKA, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Brian S. CAFFO, Auteur ; Joshua B. EWEN, Auteur Article en page(s) : p.1397-1411 Langues : Anglais (eng) Mots-clés : autism  autism spectrum disorder  cognition  executive function  mediation analysis  movement Index. décimale : PER Périodiques Résumé : ABSTRACT Imitation plays a critical role in enhancing social reciprocity and social/non-social skill learning. Accordingly, impaired imitation may have downstream implications on skill acquisition in autism. Social, motor, representational, and executive processes contribute to imitation performance, but it is unknown the degree to which differences in these domains contribute to imitation differences in autism. In the present study, we evaluated the role of various psychological mechanisms of autism-related imitation differences using mediation models. We assessed autistic and non-autistic 7?12-year-old children (n?=?708) with FSIQ ??80, using a wide battery of performance-based and parent-report tests that measured meaningful and non-meaningful gesture imitation performance, motor execution, action representation, social motivation, and executive function processes. Multiple marginal mediation analyses revealed that motor execution tests most strongly mediated imitation deficits in autism, though effects from social motivation, action representation, and executive function also partially mediated the relationship between autism diagnosis and imitation performance. Using cross-validated regression models, the domains tested here accounted for 39% of the variation in imitation performance. Results are contextualized across a broad range of experimental and observational studies with respect to the prompted imitation task utilized here. Future research will require longitudinal data, particularly from earlier stages of development. En ligne : https://doi.org/10.1002/aur.70046 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] Mechanisms of Altered Imitation in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Ata KOLDAY, Auteur ; Ericka L. WODKA, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Brian S. CAFFO, Auteur ; Joshua B. EWEN, Auteur . - p.1397-1411. Langues : Anglais (eng) in Autism Research > 18-7 (July 2025) . - p.1397-1411 Mots-clés : autism  autism spectrum disorder  cognition  executive function  mediation analysis  movement Index. décimale : PER Périodiques Résumé : ABSTRACT Imitation plays a critical role in enhancing social reciprocity and social/non-social skill learning. Accordingly, impaired imitation may have downstream implications on skill acquisition in autism. Social, motor, representational, and executive processes contribute to imitation performance, but it is unknown the degree to which differences in these domains contribute to imitation differences in autism. In the present study, we evaluated the role of various psychological mechanisms of autism-related imitation differences using mediation models. We assessed autistic and non-autistic 7?12-year-old children (n?=?708) with FSIQ ??80, using a wide battery of performance-based and parent-report tests that measured meaningful and non-meaningful gesture imitation performance, motor execution, action representation, social motivation, and executive function processes. Multiple marginal mediation analyses revealed that motor execution tests most strongly mediated imitation deficits in autism, though effects from social motivation, action representation, and executive function also partially mediated the relationship between autism diagnosis and imitation performance. Using cross-validated regression models, the domains tested here accounted for 39% of the variation in imitation performance. Results are contextualized across a broad range of experimental and observational studies with respect to the prompted imitation task utilized here. Future research will require longitudinal data, particularly from earlier stages of development. En ligne : https://doi.org/10.1002/aur.70046 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565

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