Early life stress, cortisol, frontolimbic connectivity, and depressive symptoms during puberty / Katharina KIRCANSKI in Development and Psychopathology, 31-3 (August 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-3 (August 2019) . - p.1011-1022 Titre : Early life stress, cortisol, frontolimbic connectivity, and depressive symptoms during puberty Type de document : texte imprimé Auteurs : Katharina KIRCANSKI, Auteur ; Lucinda M. SISK, Auteur ; Tiffany C. HO, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Lucy S. KING, Auteur ; Natalie L. COLICH, Auteur ; Sarah J. ORDAZ, Auteur ; Ian H. GOTLIB, Auteur Article en page(s) : p.1011-1022 Langues : Anglais (eng) Mots-clés : cortisol  depression  diffusion tensor imaging  emotion dysregulation  early life stress  puberty Index. décimale : PER Périodiques Résumé : Early life stress (ELS) is a risk factor for the development of depression in adolescence; the mediating neurobiological mechanisms, however, are unknown. In this study, we examined in early pubertal youth the associations among ELS, cortisol stress responsivity, and white matter microstructure of the uncinate fasciculus and the fornix, two key frontolimbic tracts; we also tested whether and how these variables predicted depressive symptoms in later puberty. A total of 208 participants (117 females; M age = 11.37 years; M Tanner stage = 2.03) provided data across two or more assessment modalities: ELS; salivary cortisol levels during a psychosocial stress task; diffusion magnetic resonance imaging; and depressive symptoms. In early puberty there were significant associations between higher ELS and decreased cortisol production, and between decreased cortisol production and increased fractional anisotropy in the uncinate fasciculus. Further, increased fractional anisotropy in the uncinate fasciculus predicted higher depressive symptoms in later puberty, above and beyond earlier symptoms. In post hoc analyses, we found that sex moderated several additional associations. We discuss these findings within a broader conceptual model linking ELS, emotion dysregulation, and depression across the transition through puberty, and contend that brain circuits implicated in the control of hypothalamic–pituitary–adrenal axis function should be a focus of continued research. En ligne : http://dx.doi.org/10.1017/S0954579419000555 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403 [article] Early life stress, cortisol, frontolimbic connectivity, and depressive symptoms during puberty [texte imprimé] / Katharina KIRCANSKI, Auteur ; Lucinda M. SISK, Auteur ; Tiffany C. HO, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Lucy S. KING, Auteur ; Natalie L. COLICH, Auteur ; Sarah J. ORDAZ, Auteur ; Ian H. GOTLIB, Auteur . - p.1011-1022. Langues : Anglais (eng) in Development and Psychopathology > 31-3 (August 2019) . - p.1011-1022 Mots-clés : cortisol  depression  diffusion tensor imaging  emotion dysregulation  early life stress  puberty Index. décimale : PER Périodiques Résumé : Early life stress (ELS) is a risk factor for the development of depression in adolescence; the mediating neurobiological mechanisms, however, are unknown. In this study, we examined in early pubertal youth the associations among ELS, cortisol stress responsivity, and white matter microstructure of the uncinate fasciculus and the fornix, two key frontolimbic tracts; we also tested whether and how these variables predicted depressive symptoms in later puberty. A total of 208 participants (117 females; M age = 11.37 years; M Tanner stage = 2.03) provided data across two or more assessment modalities: ELS; salivary cortisol levels during a psychosocial stress task; diffusion magnetic resonance imaging; and depressive symptoms. In early puberty there were significant associations between higher ELS and decreased cortisol production, and between decreased cortisol production and increased fractional anisotropy in the uncinate fasciculus. Further, increased fractional anisotropy in the uncinate fasciculus predicted higher depressive symptoms in later puberty, above and beyond earlier symptoms. In post hoc analyses, we found that sex moderated several additional associations. We discuss these findings within a broader conceptual model linking ELS, emotion dysregulation, and depression across the transition through puberty, and contend that brain circuits implicated in the control of hypothalamic–pituitary–adrenal axis function should be a focus of continued research. En ligne : http://dx.doi.org/10.1017/S0954579419000555 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403

Neurodevelopment and executive function in autism / Kirsten O'HEARN in Development and Psychopathology, 20-4 (Fall 2008)  

Public ISBD [article]  inDevelopment and Psychopathology > 20-4 (Fall 2008) . - p.1103-1132 Titre : Neurodevelopment and executive function in autism Type de document : texte imprimé Auteurs : Kirsten O'HEARN, Auteur ; Sarah J. ORDAZ, Auteur ; Beatriz LUNA, Auteur ; Miya R. ASATO, Auteur Année de publication : 2008 Article en page(s) : p.1103-1132 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism is a neurodevelopmental disorder characterized by social and communication deficits, and repetitive behavior. Studies investigating the integrity of brain systems in autism suggest a wide range of gray and white matter abnormalities that are present early in life and change with development. These abnormalities predominantly affect association areas and undermine functional integration. Executive function, which has a protracted development into adolescence and reflects the integration of complex widely distributed brain function, is also affected in autism. Evidence from studies probing response inhibition and working memory indicate impairments in these core components of executive function, as well as compensatory mechanisms that permit normative function in autism. Studies also demonstrate age-related improvements in executive function from childhood to adolescence in autism, indicating the presence of plasticity and suggesting a prolonged window for effective treatment. Despite developmental gains, mature executive functioning is limited in autism, reflecting abnormalities in wide-spread brain networks that may lead to impaired processing of complex information across all domains. En ligne : http://dx.doi.org/10.1017/s0954579408000527 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=602 [article] Neurodevelopment and executive function in autism [texte imprimé] / Kirsten O'HEARN, Auteur ; Sarah J. ORDAZ, Auteur ; Beatriz LUNA, Auteur ; Miya R. ASATO, Auteur . - 2008 . - p.1103-1132. Langues : Anglais (eng) in Development and Psychopathology > 20-4 (Fall 2008) . - p.1103-1132 Index. décimale : PER Périodiques Résumé : Autism is a neurodevelopmental disorder characterized by social and communication deficits, and repetitive behavior. Studies investigating the integrity of brain systems in autism suggest a wide range of gray and white matter abnormalities that are present early in life and change with development. These abnormalities predominantly affect association areas and undermine functional integration. Executive function, which has a protracted development into adolescence and reflects the integration of complex widely distributed brain function, is also affected in autism. Evidence from studies probing response inhibition and working memory indicate impairments in these core components of executive function, as well as compensatory mechanisms that permit normative function in autism. Studies also demonstrate age-related improvements in executive function from childhood to adolescence in autism, indicating the presence of plasticity and suggesting a prolonged window for effective treatment. Despite developmental gains, mature executive functioning is limited in autism, reflecting abnormalities in wide-spread brain networks that may lead to impaired processing of complex information across all domains. En ligne : http://dx.doi.org/10.1017/s0954579408000527 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=602

A pediatric twin study of brain morphometry / Gregory L. WALLACE in Journal of Child Psychology and Psychiatry, 47-10 (October 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-10 (October 2006) . - p.987–993 Titre : A pediatric twin study of brain morphometry Type de document : texte imprimé Auteurs : Gregory L. WALLACE, Auteur ; Michael A. ROSENTHAL, Auteur ; Michael C. NEALE, Auteur ; Kenneth S. KENDLER, Auteur ; Liv S. CLASEN, Auteur ; Elizabeth A. MOLLOY, Auteur ; Sarah J. ORDAZ, Auteur ; Essi VIDING, Auteur ; Rhoshel LENROOT, Auteur ; J. Eric SCHMITT, Auteur ; Jay N. GIEDD, Auteur Année de publication : 2007 Article en page(s) : p.987–993 Langues : Anglais (eng) Mots-clés : Brain-development brain-imaging pediatric twin behavioral-genetics Index. décimale : PER Périodiques Résumé : Background: Longitudinal pediatric neuroimaging studies have demonstrated increasing volumes of white matter and regionally-specific inverted U shaped developmental trajectories of gray matter volumes during childhood and adolescence. Studies of monozygotic and dyzygotic twins during this developmental period allow exploration of genetic and non-genetic influences on these developmental trajectories. Method: Magnetic resonance imaging brain scans were acquired on a pediatric sample of 90 monozygotic twin pairs, 38 same-sex dyzygotic twin pairs, and 158 unrelated typically developing singletons. Structural equation modeling was used to estimate the additive genetic, common environment, and unique environment effects, as well as age by heritability interactions, on measures of brain volumes from these images. Results: Consistent with previous adult studies, additive genetic effects accounted for a substantial portion of variability in nearly all brain regions with the notable exception of the cerebellum. Significant age by heritability interactions were observed with gray matter volumes showing a reduction in heritability with increasing age, while white matter volume heritability increased with greater age. Conclusion: Understanding the relative contributions of genetic and nongenetic factors on developmental brain trajectories may have implications for better understanding brain-based disorders and typical cognitive development. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01676.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=788 [article] A pediatric twin study of brain morphometry [texte imprimé] / Gregory L. WALLACE, Auteur ; Michael A. ROSENTHAL, Auteur ; Michael C. NEALE, Auteur ; Kenneth S. KENDLER, Auteur ; Liv S. CLASEN, Auteur ; Elizabeth A. MOLLOY, Auteur ; Sarah J. ORDAZ, Auteur ; Essi VIDING, Auteur ; Rhoshel LENROOT, Auteur ; J. Eric SCHMITT, Auteur ; Jay N. GIEDD, Auteur . - 2007 . - p.987–993. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-10 (October 2006) . - p.987–993 Mots-clés : Brain-development brain-imaging pediatric twin behavioral-genetics Index. décimale : PER Périodiques Résumé : Background: Longitudinal pediatric neuroimaging studies have demonstrated increasing volumes of white matter and regionally-specific inverted U shaped developmental trajectories of gray matter volumes during childhood and adolescence. Studies of monozygotic and dyzygotic twins during this developmental period allow exploration of genetic and non-genetic influences on these developmental trajectories. Method: Magnetic resonance imaging brain scans were acquired on a pediatric sample of 90 monozygotic twin pairs, 38 same-sex dyzygotic twin pairs, and 158 unrelated typically developing singletons. Structural equation modeling was used to estimate the additive genetic, common environment, and unique environment effects, as well as age by heritability interactions, on measures of brain volumes from these images. Results: Consistent with previous adult studies, additive genetic effects accounted for a substantial portion of variability in nearly all brain regions with the notable exception of the cerebellum. Significant age by heritability interactions were observed with gray matter volumes showing a reduction in heritability with increasing age, while white matter volume heritability increased with greater age. Conclusion: Understanding the relative contributions of genetic and nongenetic factors on developmental brain trajectories may have implications for better understanding brain-based disorders and typical cognitive development. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01676.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=788

The association between early life stress and prefrontal cortex activation during implicit emotion regulation is moderated by sex in early adolescence / Natalie L. COLICH in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1851-1864 Titre : The association between early life stress and prefrontal cortex activation during implicit emotion regulation is moderated by sex in early adolescence Type de document : texte imprimé Auteurs : Natalie L. COLICH, Auteur ; Eileen S. WILLIAMS, Auteur ; Tiffany C. HO, Auteur ; Lucy S. KING, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Alexandria N. PRICE, Auteur ; Sarah J. ORDAZ, Auteur ; Ian H. GOTLIB, Auteur Article en page(s) : p.1851-1864 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Early life stress (ELS) is a significant risk factor for the emergence of internalizing problems in adolescence. Beginning in adolescence, females are twice as likely as males to experience internalizing disorders. The present study was designed to examine sex differences in the association between ELS and internalizing problems in early pubertal adolescents, and whether and how corticolimbic function and connectivity may underlie these associations. Fifty-nine early pubertal males and 78 early pubertal females, ages 9–13 years (all Tanner Stage 3 or below) underwent functional magnetic resonance imaging as they performed an emotion label task that robustly interrogates corticolimbic function. Participants were also interviewed about their experience of ELS. Females exhibited a positive association between ELS and internalizing problems, whereas males exhibited no such association. Whole-brain and amygdala region of interest analyses indicated that whereas females exhibited a positive association between ELS and the ventrolateral prefrontal cortex during implicit emotion regulation, males showed no such association. Activation in these regions was positively associated with internalizing problems in females but not males; however, activation in these regions did not mediate the association between ELS and internalizing problems. Finally, both boys and girls exhibited an association between ELS and increased negative connectivity between the right ventrolateral prefrontal cortex and bilateral amygdala. Using a carefully characterized sample of early pubertal adolescents, the current study highlights important sex differences in the development of corticolimbic circuitry during a critical period of brain development. These sex differences may play a significant role in subsequent risk for internalizing problems. En ligne : http://dx.doi.org/10.1017/S0954579417001444 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324 [article] The association between early life stress and prefrontal cortex activation during implicit emotion regulation is moderated by sex in early adolescence [texte imprimé] / Natalie L. COLICH, Auteur ; Eileen S. WILLIAMS, Auteur ; Tiffany C. HO, Auteur ; Lucy S. KING, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Alexandria N. PRICE, Auteur ; Sarah J. ORDAZ, Auteur ; Ian H. GOTLIB, Auteur . - p.1851-1864. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1851-1864 Index. décimale : PER Périodiques Résumé : Early life stress (ELS) is a significant risk factor for the emergence of internalizing problems in adolescence. Beginning in adolescence, females are twice as likely as males to experience internalizing disorders. The present study was designed to examine sex differences in the association between ELS and internalizing problems in early pubertal adolescents, and whether and how corticolimbic function and connectivity may underlie these associations. Fifty-nine early pubertal males and 78 early pubertal females, ages 9–13 years (all Tanner Stage 3 or below) underwent functional magnetic resonance imaging as they performed an emotion label task that robustly interrogates corticolimbic function. Participants were also interviewed about their experience of ELS. Females exhibited a positive association between ELS and internalizing problems, whereas males exhibited no such association. Whole-brain and amygdala region of interest analyses indicated that whereas females exhibited a positive association between ELS and the ventrolateral prefrontal cortex during implicit emotion regulation, males showed no such association. Activation in these regions was positively associated with internalizing problems in females but not males; however, activation in these regions did not mediate the association between ELS and internalizing problems. Finally, both boys and girls exhibited an association between ELS and increased negative connectivity between the right ventrolateral prefrontal cortex and bilateral amygdala. Using a carefully characterized sample of early pubertal adolescents, the current study highlights important sex differences in the development of corticolimbic circuitry during a critical period of brain development. These sex differences may play a significant role in subsequent risk for internalizing problems. En ligne : http://dx.doi.org/10.1017/S0954579417001444 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324

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