Correlates and predictors of the severity of suicidal ideation in adolescence: an examination of brain connectomics and psychosocial characteristics / Jaclyn S. KIRSHENBAUM in Journal of Child Psychology and Psychiatry, 63-6 (June 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-6 (June 2022) . - p.701-714 Titre : Correlates and predictors of the severity of suicidal ideation in adolescence: an examination of brain connectomics and psychosocial characteristics Type de document : Texte imprimé et/ou numérique Auteurs : Jaclyn S. KIRSHENBAUM, Auteur ; Rajpreet CHAHAL, Auteur ; Tiffany C. HO, Auteur ; Lucy S. KING, Auteur ; Anthony J. GIFUNI, Auteur ; Dana MASTROVITO, Auteur ; Saché M. COURY, Auteur ; Rachel L. WEISENBURGER, Auteur ; Ian H. GOTLIB, Auteur Article en page(s) : p.701-714 Langues : Anglais (eng) Mots-clés : Suicidal ideation  adolescence  graph theory  internalizing and externalizing symptoms  resting-state fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Suicidal ideation (SI) typically emerges during adolescence but is challenging to predict. Given the potentially lethal consequences of SI, it is important to identify neurobiological and psychosocial variables explaining the severity of SI in adolescents. METHODS: In 106 participants (59 female) recruited from the community, we assessed psychosocial characteristics and obtained resting-state fMRI data in early adolescence (baseline: aged 9-13?years). Across 250 brain regions, we assessed local graph theory-based properties of interconnectedness: local efficiency, eigenvector centrality, nodal degree, within-module z-score, and participation coefficient. Four years later (follow-up: ages 13-19?years), participants self-reported their SI severity. We used least absolute shrinkage and selection operator (LASSO) regressions to identify a linear combination of psychosocial and brain-based variables that best explain the severity of SI symptoms at follow-up. Nested-cross-validation yielded model performance statistics for all LASSO models. RESULTS: A combination of psychosocial and brain-based variables explained subsequent severity of SI (R(2?) =?.55); the strongest was internalizing and externalizing symptom severity at follow-up. Follow-up LASSO regressions of psychosocial-only and brain-based-only variables indicated that psychosocial-only variables explained 55% of the variance in SI severity; in contrast, brain-based-only variables performed worse than the null model. CONCLUSIONS: A linear combination of baseline and follow-up psychosocial variables best explained the severity of SI. Follow-up analyses indicated that graph theory resting-state metrics did not increase the prediction of the severity of SI in adolescents. Attending to internalizing and externalizing symptoms is important in early adolescence; resting-state connectivity properties other than local graph theory metrics might yield a stronger prediction of the severity of SI. En ligne : http://dx.doi.org/10.1111/jcpp.13512 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475 [article] Correlates and predictors of the severity of suicidal ideation in adolescence: an examination of brain connectomics and psychosocial characteristics [Texte imprimé et/ou numérique] / Jaclyn S. KIRSHENBAUM, Auteur ; Rajpreet CHAHAL, Auteur ; Tiffany C. HO, Auteur ; Lucy S. KING, Auteur ; Anthony J. GIFUNI, Auteur ; Dana MASTROVITO, Auteur ; Saché M. COURY, Auteur ; Rachel L. WEISENBURGER, Auteur ; Ian H. GOTLIB, Auteur . - p.701-714. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-6 (June 2022) . - p.701-714 Mots-clés : Suicidal ideation  adolescence  graph theory  internalizing and externalizing symptoms  resting-state fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Suicidal ideation (SI) typically emerges during adolescence but is challenging to predict. Given the potentially lethal consequences of SI, it is important to identify neurobiological and psychosocial variables explaining the severity of SI in adolescents. METHODS: In 106 participants (59 female) recruited from the community, we assessed psychosocial characteristics and obtained resting-state fMRI data in early adolescence (baseline: aged 9-13?years). Across 250 brain regions, we assessed local graph theory-based properties of interconnectedness: local efficiency, eigenvector centrality, nodal degree, within-module z-score, and participation coefficient. Four years later (follow-up: ages 13-19?years), participants self-reported their SI severity. We used least absolute shrinkage and selection operator (LASSO) regressions to identify a linear combination of psychosocial and brain-based variables that best explain the severity of SI symptoms at follow-up. Nested-cross-validation yielded model performance statistics for all LASSO models. RESULTS: A combination of psychosocial and brain-based variables explained subsequent severity of SI (R(2?) =?.55); the strongest was internalizing and externalizing symptom severity at follow-up. Follow-up LASSO regressions of psychosocial-only and brain-based-only variables indicated that psychosocial-only variables explained 55% of the variance in SI severity; in contrast, brain-based-only variables performed worse than the null model. CONCLUSIONS: A linear combination of baseline and follow-up psychosocial variables best explained the severity of SI. Follow-up analyses indicated that graph theory resting-state metrics did not increase the prediction of the severity of SI in adolescents. Attending to internalizing and externalizing symptoms is important in early adolescence; resting-state connectivity properties other than local graph theory metrics might yield a stronger prediction of the severity of SI. En ligne : http://dx.doi.org/10.1111/jcpp.13512 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475

Early life stress, cortisol, frontolimbic connectivity, and depressive symptoms during puberty / Katharina KIRCANSKI in Development and Psychopathology, 31-3 (August 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-3 (August 2019) . - p.1011-1022 Titre : Early life stress, cortisol, frontolimbic connectivity, and depressive symptoms during puberty Type de document : Texte imprimé et/ou numérique Auteurs : Katharina KIRCANSKI, Auteur ; Lucinda M. SISK, Auteur ; Tiffany C. HO, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Lucy S. KING, Auteur ; Natalie L. COLICH, Auteur ; Sarah J. ORDAZ, Auteur ; Ian H. GOTLIB, Auteur Article en page(s) : p.1011-1022 Langues : Anglais (eng) Mots-clés : cortisol  depression  diffusion tensor imaging  emotion dysregulation  early life stress  puberty Index. décimale : PER Périodiques Résumé : Early life stress (ELS) is a risk factor for the development of depression in adolescence; the mediating neurobiological mechanisms, however, are unknown. In this study, we examined in early pubertal youth the associations among ELS, cortisol stress responsivity, and white matter microstructure of the uncinate fasciculus and the fornix, two key frontolimbic tracts; we also tested whether and how these variables predicted depressive symptoms in later puberty. A total of 208 participants (117 females; M age = 11.37 years; M Tanner stage = 2.03) provided data across two or more assessment modalities: ELS; salivary cortisol levels during a psychosocial stress task; diffusion magnetic resonance imaging; and depressive symptoms. In early puberty there were significant associations between higher ELS and decreased cortisol production, and between decreased cortisol production and increased fractional anisotropy in the uncinate fasciculus. Further, increased fractional anisotropy in the uncinate fasciculus predicted higher depressive symptoms in later puberty, above and beyond earlier symptoms. In post hoc analyses, we found that sex moderated several additional associations. We discuss these findings within a broader conceptual model linking ELS, emotion dysregulation, and depression across the transition through puberty, and contend that brain circuits implicated in the control of hypothalamic–pituitary–adrenal axis function should be a focus of continued research. En ligne : http://dx.doi.org/10.1017/S0954579419000555 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403 [article] Early life stress, cortisol, frontolimbic connectivity, and depressive symptoms during puberty [Texte imprimé et/ou numérique] / Katharina KIRCANSKI, Auteur ; Lucinda M. SISK, Auteur ; Tiffany C. HO, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Lucy S. KING, Auteur ; Natalie L. COLICH, Auteur ; Sarah J. ORDAZ, Auteur ; Ian H. GOTLIB, Auteur . - p.1011-1022. Langues : Anglais (eng) in Development and Psychopathology > 31-3 (August 2019) . - p.1011-1022 Mots-clés : cortisol  depression  diffusion tensor imaging  emotion dysregulation  early life stress  puberty Index. décimale : PER Périodiques Résumé : Early life stress (ELS) is a risk factor for the development of depression in adolescence; the mediating neurobiological mechanisms, however, are unknown. In this study, we examined in early pubertal youth the associations among ELS, cortisol stress responsivity, and white matter microstructure of the uncinate fasciculus and the fornix, two key frontolimbic tracts; we also tested whether and how these variables predicted depressive symptoms in later puberty. A total of 208 participants (117 females; M age = 11.37 years; M Tanner stage = 2.03) provided data across two or more assessment modalities: ELS; salivary cortisol levels during a psychosocial stress task; diffusion magnetic resonance imaging; and depressive symptoms. In early puberty there were significant associations between higher ELS and decreased cortisol production, and between decreased cortisol production and increased fractional anisotropy in the uncinate fasciculus. Further, increased fractional anisotropy in the uncinate fasciculus predicted higher depressive symptoms in later puberty, above and beyond earlier symptoms. In post hoc analyses, we found that sex moderated several additional associations. We discuss these findings within a broader conceptual model linking ELS, emotion dysregulation, and depression across the transition through puberty, and contend that brain circuits implicated in the control of hypothalamic–pituitary–adrenal axis function should be a focus of continued research. En ligne : http://dx.doi.org/10.1017/S0954579419000555 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403

Heart rate variability moderates the effects of COVID-19-related stress and family adversity on emotional problems in adolescents: Testing models of differential susceptibility and diathesis stress / Jonas G. MILLER in Development and Psychopathology, 34-5 (December 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-5 (December 2022) . - p.1974-1985 Titre : Heart rate variability moderates the effects of COVID-19-related stress and family adversity on emotional problems in adolescents: Testing models of differential susceptibility and diathesis stress Type de document : Texte imprimé et/ou numérique Auteurs : Jonas G. MILLER, Auteur ; Rajpreet CHAHAL, Auteur ; Jaclyn S. KIRSHENBAUM, Auteur ; Tiffany C. HO, Auteur ; Anthony J. GIFUNI, Auteur ; Ian H. GOTLIB, Auteur Article en page(s) : p.1974-1985 Langues : Anglais (eng) Mots-clés : adolescence  biological sensitivity to context  COVID-19  diathesis stress  differential susceptibility  heart rate variability Index. décimale : PER Périodiques Résumé : The COVID-19 pandemic is a unique period of stress, uncertainty, and adversity that will have significant implications for adolescent mental health. Nevertheless, stress and adversity related to COVID-19 may be more consequential for some adolescents’ mental health than for others. We examined whether heart rate variability (HRV) indicated differential susceptibility to mental health difficulties associated with COVID-19 stress and COVID-19 family adversity. Approximately 4 years prior to the pandemic, we assessed resting HRV and HRV reactivity to a well-validated stress paradigm in 87 adolescents. During the pandemic, these adolescents (ages 13 “19) reported on their health-related stress and concerns about COVID-19, family adversity related to COVID-19, and their recent emotional problems. The association between COVID-19 stress and emotional problems was significantly stronger for adolescents who previously exhibited higher resting HRV or higher HRV reactivity. For adolescents who exhibited lower resting HRV or HRV augmentation, COVID-19 stress was not associated with emotional problems. Conversely, lower resting HRV indicated vulnerability to the effect of COVID-19 family adversity on emotional problems. Different patterns of parasympathetic functioning may reflect differential susceptibility to the effects of COVID-19 stress versus vulnerability to the effects of COVID-19 family adversity on mental health during the pandemic. En ligne : http://dx.doi.org/10.1017/S095457942100033X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 [article] Heart rate variability moderates the effects of COVID-19-related stress and family adversity on emotional problems in adolescents: Testing models of differential susceptibility and diathesis stress [Texte imprimé et/ou numérique] / Jonas G. MILLER, Auteur ; Rajpreet CHAHAL, Auteur ; Jaclyn S. KIRSHENBAUM, Auteur ; Tiffany C. HO, Auteur ; Anthony J. GIFUNI, Auteur ; Ian H. GOTLIB, Auteur . - p.1974-1985. Langues : Anglais (eng) in Development and Psychopathology > 34-5 (December 2022) . - p.1974-1985 Mots-clés : adolescence  biological sensitivity to context  COVID-19  diathesis stress  differential susceptibility  heart rate variability Index. décimale : PER Périodiques Résumé : The COVID-19 pandemic is a unique period of stress, uncertainty, and adversity that will have significant implications for adolescent mental health. Nevertheless, stress and adversity related to COVID-19 may be more consequential for some adolescents’ mental health than for others. We examined whether heart rate variability (HRV) indicated differential susceptibility to mental health difficulties associated with COVID-19 stress and COVID-19 family adversity. Approximately 4 years prior to the pandemic, we assessed resting HRV and HRV reactivity to a well-validated stress paradigm in 87 adolescents. During the pandemic, these adolescents (ages 13 “19) reported on their health-related stress and concerns about COVID-19, family adversity related to COVID-19, and their recent emotional problems. The association between COVID-19 stress and emotional problems was significantly stronger for adolescents who previously exhibited higher resting HRV or higher HRV reactivity. For adolescents who exhibited lower resting HRV or HRV augmentation, COVID-19 stress was not associated with emotional problems. Conversely, lower resting HRV indicated vulnerability to the effect of COVID-19 family adversity on emotional problems. Different patterns of parasympathetic functioning may reflect differential susceptibility to the effects of COVID-19 stress versus vulnerability to the effects of COVID-19 family adversity on mental health during the pandemic. En ligne : http://dx.doi.org/10.1017/S095457942100033X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492

Multi-level predictors of depression symptoms in the Adolescent Brain Cognitive Development (ABCD) study / Tiffany C. HO in Journal of Child Psychology and Psychiatry, 63-12 (December 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1523-1533 Titre : Multi-level predictors of depression symptoms in the Adolescent Brain Cognitive Development (ABCD) study Type de document : Texte imprimé et/ou numérique Auteurs : Tiffany C. HO, Auteur ; Rutvik SHAH, Auteur ; Jyoti MISHRA, Auteur ; April C. MAY, Auteur ; Susan F. TAPERT, Auteur Article en page(s) : p.1523-1533 Langues : Anglais (eng) Mots-clés : Child  Adolescent  Humans  Depression/psychology  Magnetic Resonance Imaging/methods  Family Conflict  Brain/diagnostic imaging  Cognition  ABCD Study  Adolescence  depression  functional MRI (fMRI)  sleep Index. décimale : PER Périodiques Résumé : BACKGROUND: While identifying risk factors for adolescent depression is critical for early prevention and intervention, most studies have sought to understand the role of isolated factors rather than across a broad set of factors. Here, we sought to examine multi-level factors that maximize the prediction of depression symptoms in US children participating in the Adolescent Brain and Cognitive Development (ABCD) study. METHODS: A total of 7,995 participants from ABCD (version 3.0 release) provided complete data at baseline and 1-year follow-up data. Depression symptoms were measured with the Child Behavior Checklist. Predictive features included child demographic, environmental, and structural and resting-state fMRI variables, parental depression history and demographic characteristics. We used linear (elastic net regression, EN) and non-linear (gradient-boosted trees, GBT) predictive models to identify which set of features maximized prediction of depression symptoms at baseline and, separately, at 1-year follow-up. RESULTS: Both linear and non-linear models achieved comparable results for predicting baseline (EN: MAE=3.757; R(2) =0.156; GBT: MAE=3.761; R(2) =0.147) and 1-year follow-up (EN: MAE=4.255; R(2) =0.103; GBT: MAE=4.262; R(2) =0.089) depression. Parental history of depression, greater family conflict, and shorter child sleep duration were among the top predictors of concurrent and future child depression symptoms across both models. Although resting-state fMRI features were relatively weaker predictors, functional connectivity of the caudate was consistently the strongest neural feature associated with depression symptoms at both timepoints. CONCLUSIONS: Consistent with prior research, parental mental health, family environment, and child sleep quality are important risk factors for youth depression. Functional connectivity of the caudate is a relatively weaker predictor of depression symptoms but may represent a biomarker for depression risk. En ligne : http://dx.doi.org/10.1111/jcpp.13608 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Multi-level predictors of depression symptoms in the Adolescent Brain Cognitive Development (ABCD) study [Texte imprimé et/ou numérique] / Tiffany C. HO, Auteur ; Rutvik SHAH, Auteur ; Jyoti MISHRA, Auteur ; April C. MAY, Auteur ; Susan F. TAPERT, Auteur . - p.1523-1533. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1523-1533 Mots-clés : Child  Adolescent  Humans  Depression/psychology  Magnetic Resonance Imaging/methods  Family Conflict  Brain/diagnostic imaging  Cognition  ABCD Study  Adolescence  depression  functional MRI (fMRI)  sleep Index. décimale : PER Périodiques Résumé : BACKGROUND: While identifying risk factors for adolescent depression is critical for early prevention and intervention, most studies have sought to understand the role of isolated factors rather than across a broad set of factors. Here, we sought to examine multi-level factors that maximize the prediction of depression symptoms in US children participating in the Adolescent Brain and Cognitive Development (ABCD) study. METHODS: A total of 7,995 participants from ABCD (version 3.0 release) provided complete data at baseline and 1-year follow-up data. Depression symptoms were measured with the Child Behavior Checklist. Predictive features included child demographic, environmental, and structural and resting-state fMRI variables, parental depression history and demographic characteristics. We used linear (elastic net regression, EN) and non-linear (gradient-boosted trees, GBT) predictive models to identify which set of features maximized prediction of depression symptoms at baseline and, separately, at 1-year follow-up. RESULTS: Both linear and non-linear models achieved comparable results for predicting baseline (EN: MAE=3.757; R(2) =0.156; GBT: MAE=3.761; R(2) =0.147) and 1-year follow-up (EN: MAE=4.255; R(2) =0.103; GBT: MAE=4.262; R(2) =0.089) depression. Parental history of depression, greater family conflict, and shorter child sleep duration were among the top predictors of concurrent and future child depression symptoms across both models. Although resting-state fMRI features were relatively weaker predictors, functional connectivity of the caudate was consistently the strongest neural feature associated with depression symptoms at both timepoints. CONCLUSIONS: Consistent with prior research, parental mental health, family environment, and child sleep quality are important risk factors for youth depression. Functional connectivity of the caudate is a relatively weaker predictor of depression symptoms but may represent a biomarker for depression risk. En ligne : http://dx.doi.org/10.1111/jcpp.13608 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

The association between early life stress and prefrontal cortex activation during implicit emotion regulation is moderated by sex in early adolescence / Natalie L. COLICH in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1851-1864 Titre : The association between early life stress and prefrontal cortex activation during implicit emotion regulation is moderated by sex in early adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Natalie L. COLICH, Auteur ; Eileen S. WILLIAMS, Auteur ; Tiffany C. HO, Auteur ; Lucy S. KING, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Alexandria N. PRICE, Auteur ; Sarah J. ORDAZ, Auteur ; Ian H. GOTLIB, Auteur Article en page(s) : p.1851-1864 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Early life stress (ELS) is a significant risk factor for the emergence of internalizing problems in adolescence. Beginning in adolescence, females are twice as likely as males to experience internalizing disorders. The present study was designed to examine sex differences in the association between ELS and internalizing problems in early pubertal adolescents, and whether and how corticolimbic function and connectivity may underlie these associations. Fifty-nine early pubertal males and 78 early pubertal females, ages 9–13 years (all Tanner Stage 3 or below) underwent functional magnetic resonance imaging as they performed an emotion label task that robustly interrogates corticolimbic function. Participants were also interviewed about their experience of ELS. Females exhibited a positive association between ELS and internalizing problems, whereas males exhibited no such association. Whole-brain and amygdala region of interest analyses indicated that whereas females exhibited a positive association between ELS and the ventrolateral prefrontal cortex during implicit emotion regulation, males showed no such association. Activation in these regions was positively associated with internalizing problems in females but not males; however, activation in these regions did not mediate the association between ELS and internalizing problems. Finally, both boys and girls exhibited an association between ELS and increased negative connectivity between the right ventrolateral prefrontal cortex and bilateral amygdala. Using a carefully characterized sample of early pubertal adolescents, the current study highlights important sex differences in the development of corticolimbic circuitry during a critical period of brain development. These sex differences may play a significant role in subsequent risk for internalizing problems. En ligne : http://dx.doi.org/10.1017/S0954579417001444 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324 [article] The association between early life stress and prefrontal cortex activation during implicit emotion regulation is moderated by sex in early adolescence [Texte imprimé et/ou numérique] / Natalie L. COLICH, Auteur ; Eileen S. WILLIAMS, Auteur ; Tiffany C. HO, Auteur ; Lucy S. KING, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Alexandria N. PRICE, Auteur ; Sarah J. ORDAZ, Auteur ; Ian H. GOTLIB, Auteur . - p.1851-1864. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1851-1864 Index. décimale : PER Périodiques Résumé : Early life stress (ELS) is a significant risk factor for the emergence of internalizing problems in adolescence. Beginning in adolescence, females are twice as likely as males to experience internalizing disorders. The present study was designed to examine sex differences in the association between ELS and internalizing problems in early pubertal adolescents, and whether and how corticolimbic function and connectivity may underlie these associations. Fifty-nine early pubertal males and 78 early pubertal females, ages 9–13 years (all Tanner Stage 3 or below) underwent functional magnetic resonance imaging as they performed an emotion label task that robustly interrogates corticolimbic function. Participants were also interviewed about their experience of ELS. Females exhibited a positive association between ELS and internalizing problems, whereas males exhibited no such association. Whole-brain and amygdala region of interest analyses indicated that whereas females exhibited a positive association between ELS and the ventrolateral prefrontal cortex during implicit emotion regulation, males showed no such association. Activation in these regions was positively associated with internalizing problems in females but not males; however, activation in these regions did not mediate the association between ELS and internalizing problems. Finally, both boys and girls exhibited an association between ELS and increased negative connectivity between the right ventrolateral prefrontal cortex and bilateral amygdala. Using a carefully characterized sample of early pubertal adolescents, the current study highlights important sex differences in the development of corticolimbic circuitry during a critical period of brain development. These sex differences may play a significant role in subsequent risk for internalizing problems. En ligne : http://dx.doi.org/10.1017/S0954579417001444 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324

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