Altered functional connectivity of the amygdaloid input nuclei in adolescents and young adults with autism spectrum disorder: a resting state fMRI study / A. RAUSCH in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 13p. Titre : Altered functional connectivity of the amygdaloid input nuclei in adolescents and young adults with autism spectrum disorder: a resting state fMRI study Type de document : Texte imprimé et/ou numérique Auteurs : A. RAUSCH, Auteur ; W. ZHANG, Auteur ; K. V. HAAK, Auteur ; M. MENNES, Auteur ; E. J. HERMANS, Auteur ; E. VAN OORT, Auteur ; G. VAN WINGEN, Auteur ; Christian F. BECKMANN, Auteur ; Jan K. BUITELAAR, Auteur ; W. B. GROEN, Auteur Article en page(s) : 13p. Langues : Anglais (eng) Mots-clés : Adolescent  Afferent Pathways/pathology/physiopathology  Amygdala/pathology/physiopathology  Autism Spectrum Disorder/pathology/physiopathology  Basolateral Nuclear Complex/pathology/physiopathology  Central Amygdaloid Nucleus/pathology/physiopathology  Connectome  Efferent Pathways/pathology/physiopathology  Emotions  Female  Humans  Image Processing, Computer-Assisted  Magnetic Resonance Imaging  Male  Models, Neurological  Models, Psychological  Neocortex/pathology/physiopathology  Nerve Net/pathology/physiopathology  Signal-To-Noise Ratio  Social Perception  Surveys and Questionnaires  Temporal Lobe/pathology/physiopathology  Young Adult  Amygdala  Autism spectrum disorder  Centromedial  Connectivity  Input-output  Laterobasal  Nuclei  Superficial Index. décimale : PER Périodiques Résumé : BACKGROUND: Amygdala dysfunction is hypothesized to underlie the social deficits observed in autism spectrum disorders (ASD). However, the neurobiological basis of this hypothesis is underspecified because it is unknown whether ASD relates to abnormalities of the amygdaloid input or output nuclei. Here, we investigated the functional connectivity of the amygdaloid social-perceptual input nuclei and emotion-regulation output nuclei in ASD versus controls. METHODS: We collected resting state functional magnetic resonance imaging (fMRI) data, tailored to provide optimal sensitivity in the amygdala as well as the neocortex, in 20 adolescents and young adults with ASD and 25 matched controls. We performed a regular correlation analysis between the entire amygdala (EA) and the whole brain and used a partial correlation analysis to investigate whole-brain functional connectivity uniquely related to each of the amygdaloid subregions. RESULTS: Between-group comparison of regular EA correlations showed significantly reduced connectivity in visuospatial and superior parietal areas in ASD compared to controls. Partial correlation analysis revealed that this effect was driven by the left superficial and right laterobasal input subregions, but not the centromedial output nuclei. CONCLUSIONS: These results indicate reduced connectivity of specifically the amygdaloid sensory input channels in ASD, suggesting that abnormal amygdalo-cortical connectivity can be traced down to the socio-perceptual pathways. En ligne : http://dx.doi.org/10.1186/s13229-015-0060-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329 [article] Altered functional connectivity of the amygdaloid input nuclei in adolescents and young adults with autism spectrum disorder: a resting state fMRI study [Texte imprimé et/ou numérique] / A. RAUSCH, Auteur ; W. ZHANG, Auteur ; K. V. HAAK, Auteur ; M. MENNES, Auteur ; E. J. HERMANS, Auteur ; E. VAN OORT, Auteur ; G. VAN WINGEN, Auteur ; Christian F. BECKMANN, Auteur ; Jan K. BUITELAAR, Auteur ; W. B. GROEN, Auteur . - 13p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 13p. Mots-clés : Adolescent  Afferent Pathways/pathology/physiopathology  Amygdala/pathology/physiopathology  Autism Spectrum Disorder/pathology/physiopathology  Basolateral Nuclear Complex/pathology/physiopathology  Central Amygdaloid Nucleus/pathology/physiopathology  Connectome  Efferent Pathways/pathology/physiopathology  Emotions  Female  Humans  Image Processing, Computer-Assisted  Magnetic Resonance Imaging  Male  Models, Neurological  Models, Psychological  Neocortex/pathology/physiopathology  Nerve Net/pathology/physiopathology  Signal-To-Noise Ratio  Social Perception  Surveys and Questionnaires  Temporal Lobe/pathology/physiopathology  Young Adult  Amygdala  Autism spectrum disorder  Centromedial  Connectivity  Input-output  Laterobasal  Nuclei  Superficial Index. décimale : PER Périodiques Résumé : BACKGROUND: Amygdala dysfunction is hypothesized to underlie the social deficits observed in autism spectrum disorders (ASD). However, the neurobiological basis of this hypothesis is underspecified because it is unknown whether ASD relates to abnormalities of the amygdaloid input or output nuclei. Here, we investigated the functional connectivity of the amygdaloid social-perceptual input nuclei and emotion-regulation output nuclei in ASD versus controls. METHODS: We collected resting state functional magnetic resonance imaging (fMRI) data, tailored to provide optimal sensitivity in the amygdala as well as the neocortex, in 20 adolescents and young adults with ASD and 25 matched controls. We performed a regular correlation analysis between the entire amygdala (EA) and the whole brain and used a partial correlation analysis to investigate whole-brain functional connectivity uniquely related to each of the amygdaloid subregions. RESULTS: Between-group comparison of regular EA correlations showed significantly reduced connectivity in visuospatial and superior parietal areas in ASD compared to controls. Partial correlation analysis revealed that this effect was driven by the left superficial and right laterobasal input subregions, but not the centromedial output nuclei. CONCLUSIONS: These results indicate reduced connectivity of specifically the amygdaloid sensory input channels in ASD, suggesting that abnormal amygdalo-cortical connectivity can be traced down to the socio-perceptual pathways. En ligne : http://dx.doi.org/10.1186/s13229-015-0060-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329

Connectivity-Based Parcellation of the Amygdala Predicts Social Skills in Adolescents with Autism Spectrum Disorder / A. RAUSCH in Journal of Autism and Developmental Disorders, 48-2 (February 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-2 (February 2018) . - p.572-582 Titre : Connectivity-Based Parcellation of the Amygdala Predicts Social Skills in Adolescents with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : A. RAUSCH, Auteur ; W. ZHANG, Auteur ; Christian F. BECKMANN, Auteur ; Jan K. BUITELAAR, Auteur ; W. B. GROEN, Auteur ; K. V. HAAK, Auteur Article en page(s) : p.572-582 Langues : Anglais (eng) Mots-clés : Amygdala  Autism spectrum disorder  Functional connectivity  Parcellation  Prefrontal Index. décimale : PER Périodiques Résumé : Amygdala dysfunction plays a role in the social impairments in autism spectrum disorders (ASD), but it is unclear which of its subregions are abnormal in ASD. This study compared the volume and functional connectivity (FC) strength of three FC-defined amygdala subregions between ASD and controls, and assessed their relation to social skills in ASD. A subregion associated with the social perception network was enlarged in ASD (F1 = 7.842, p = .008) and its volume correlated significantly with symptom severity (social skills: r = .548, p = .009). Posthoc analysis revealed that the enlargement was driven by the vmPFC amygdala network. These findings refine our understanding of abnormal amygdala connectivity in ASD and may inform future strategies for therapeutic interventions targeting the amygdalofrontal pathway. En ligne : https://doi.org/10.1007/s10803-017-3370-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=338 [article] Connectivity-Based Parcellation of the Amygdala Predicts Social Skills in Adolescents with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / A. RAUSCH, Auteur ; W. ZHANG, Auteur ; Christian F. BECKMANN, Auteur ; Jan K. BUITELAAR, Auteur ; W. B. GROEN, Auteur ; K. V. HAAK, Auteur . - p.572-582. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-2 (February 2018) . - p.572-582 Mots-clés : Amygdala  Autism spectrum disorder  Functional connectivity  Parcellation  Prefrontal Index. décimale : PER Périodiques Résumé : Amygdala dysfunction plays a role in the social impairments in autism spectrum disorders (ASD), but it is unclear which of its subregions are abnormal in ASD. This study compared the volume and functional connectivity (FC) strength of three FC-defined amygdala subregions between ASD and controls, and assessed their relation to social skills in ASD. A subregion associated with the social perception network was enlarged in ASD (F1 = 7.842, p = .008) and its volume correlated significantly with symptom severity (social skills: r = .548, p = .009). Posthoc analysis revealed that the enlargement was driven by the vmPFC amygdala network. These findings refine our understanding of abnormal amygdala connectivity in ASD and may inform future strategies for therapeutic interventions targeting the amygdalofrontal pathway. En ligne : https://doi.org/10.1007/s10803-017-3370-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=338

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