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Altered functional connectivity of the amygdaloid input nuclei in adolescents and young adults with autism spectrum disorder: a resting state fMRI study / A. RAUSCH in Molecular Autism, 7 (2016)
[article]
Titre : Altered functional connectivity of the amygdaloid input nuclei in adolescents and young adults with autism spectrum disorder: a resting state fMRI study Type de document : Texte imprimé et/ou numérique Auteurs : A. RAUSCH, Auteur ; W. ZHANG, Auteur ; K. V. HAAK, Auteur ; M. MENNES, Auteur ; E. J. HERMANS, Auteur ; E. VAN OORT, Auteur ; G. VAN WINGEN, Auteur ; Christian F. BECKMANN, Auteur ; Jan K. BUITELAAR, Auteur ; W. B. GROEN, Auteur Article en page(s) : 13p. Langues : Anglais (eng) Mots-clés : Adolescent Afferent Pathways/pathology/physiopathology Amygdala/pathology/physiopathology Autism Spectrum Disorder/pathology/physiopathology Basolateral Nuclear Complex/pathology/physiopathology Central Amygdaloid Nucleus/pathology/physiopathology Connectome Efferent Pathways/pathology/physiopathology Emotions Female Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Models, Neurological Models, Psychological Neocortex/pathology/physiopathology Nerve Net/pathology/physiopathology Signal-To-Noise Ratio Social Perception Surveys and Questionnaires Temporal Lobe/pathology/physiopathology Young Adult Amygdala Autism spectrum disorder Centromedial Connectivity Input-output Laterobasal Nuclei Superficial Index. décimale : PER Périodiques Résumé : BACKGROUND: Amygdala dysfunction is hypothesized to underlie the social deficits observed in autism spectrum disorders (ASD). However, the neurobiological basis of this hypothesis is underspecified because it is unknown whether ASD relates to abnormalities of the amygdaloid input or output nuclei. Here, we investigated the functional connectivity of the amygdaloid social-perceptual input nuclei and emotion-regulation output nuclei in ASD versus controls. METHODS: We collected resting state functional magnetic resonance imaging (fMRI) data, tailored to provide optimal sensitivity in the amygdala as well as the neocortex, in 20 adolescents and young adults with ASD and 25 matched controls. We performed a regular correlation analysis between the entire amygdala (EA) and the whole brain and used a partial correlation analysis to investigate whole-brain functional connectivity uniquely related to each of the amygdaloid subregions. RESULTS: Between-group comparison of regular EA correlations showed significantly reduced connectivity in visuospatial and superior parietal areas in ASD compared to controls. Partial correlation analysis revealed that this effect was driven by the left superficial and right laterobasal input subregions, but not the centromedial output nuclei. CONCLUSIONS: These results indicate reduced connectivity of specifically the amygdaloid sensory input channels in ASD, suggesting that abnormal amygdalo-cortical connectivity can be traced down to the socio-perceptual pathways. En ligne : http://dx.doi.org/10.1186/s13229-015-0060-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329
in Molecular Autism > 7 (2016) . - 13p.[article] Altered functional connectivity of the amygdaloid input nuclei in adolescents and young adults with autism spectrum disorder: a resting state fMRI study [Texte imprimé et/ou numérique] / A. RAUSCH, Auteur ; W. ZHANG, Auteur ; K. V. HAAK, Auteur ; M. MENNES, Auteur ; E. J. HERMANS, Auteur ; E. VAN OORT, Auteur ; G. VAN WINGEN, Auteur ; Christian F. BECKMANN, Auteur ; Jan K. BUITELAAR, Auteur ; W. B. GROEN, Auteur . - 13p.
Langues : Anglais (eng)
in Molecular Autism > 7 (2016) . - 13p.
Mots-clés : Adolescent Afferent Pathways/pathology/physiopathology Amygdala/pathology/physiopathology Autism Spectrum Disorder/pathology/physiopathology Basolateral Nuclear Complex/pathology/physiopathology Central Amygdaloid Nucleus/pathology/physiopathology Connectome Efferent Pathways/pathology/physiopathology Emotions Female Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Models, Neurological Models, Psychological Neocortex/pathology/physiopathology Nerve Net/pathology/physiopathology Signal-To-Noise Ratio Social Perception Surveys and Questionnaires Temporal Lobe/pathology/physiopathology Young Adult Amygdala Autism spectrum disorder Centromedial Connectivity Input-output Laterobasal Nuclei Superficial Index. décimale : PER Périodiques Résumé : BACKGROUND: Amygdala dysfunction is hypothesized to underlie the social deficits observed in autism spectrum disorders (ASD). However, the neurobiological basis of this hypothesis is underspecified because it is unknown whether ASD relates to abnormalities of the amygdaloid input or output nuclei. Here, we investigated the functional connectivity of the amygdaloid social-perceptual input nuclei and emotion-regulation output nuclei in ASD versus controls. METHODS: We collected resting state functional magnetic resonance imaging (fMRI) data, tailored to provide optimal sensitivity in the amygdala as well as the neocortex, in 20 adolescents and young adults with ASD and 25 matched controls. We performed a regular correlation analysis between the entire amygdala (EA) and the whole brain and used a partial correlation analysis to investigate whole-brain functional connectivity uniquely related to each of the amygdaloid subregions. RESULTS: Between-group comparison of regular EA correlations showed significantly reduced connectivity in visuospatial and superior parietal areas in ASD compared to controls. Partial correlation analysis revealed that this effect was driven by the left superficial and right laterobasal input subregions, but not the centromedial output nuclei. CONCLUSIONS: These results indicate reduced connectivity of specifically the amygdaloid sensory input channels in ASD, suggesting that abnormal amygdalo-cortical connectivity can be traced down to the socio-perceptual pathways. En ligne : http://dx.doi.org/10.1186/s13229-015-0060-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329 Subregional differences in intrinsic amygdala hyperconnectivity and hypoconnectivity in autism spectrum disorder / Natalia M. KLEINHANS in Autism Research, 9-7 (July 2016)
[article]
Titre : Subregional differences in intrinsic amygdala hyperconnectivity and hypoconnectivity in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Natalia M. KLEINHANS, Auteur ; Maya A. REITER, Auteur ; Emily NEUHAUS, Auteur ; Greg PAULEY, Auteur ; Nathalie MARTIN, Auteur ; Stephen R. DAGER, Auteur ; Annette ESTES, Auteur Article en page(s) : p.760-772 Langues : Anglais (eng) Mots-clés : autism amygdala resting state fMRI laterobasal superficial centromedial depression anxiety Index. décimale : PER Périodiques Résumé : The amygdala is a complex structure with distinct subregions and dissociable functional networks. The laterobasal subregion of the amygdala is hypothesized to mediate the presentation and severity of autism symptoms, although very little data are available regarding amygdala dysfunction at the subregional level. In this study, we investigated the relationship between abnormal amygdalar intrinsic connectivity, autism symptom severity, and anxiety and depressive symptoms. We collected resting state fMRI data on 31 high functioning adolescents and adults with autism spectrum disorder and 38 typically developing (TD) controls aged 14–45. Twenty-five participants with ASD and 28 TD participants were included in the final analyses. ASD participants were administered the Autism Diagnostic Interview–Revised and the Autism Diagnostic Observation Schedule. Adult participants were administered the Beck Depression Inventory II and the Beck Anxiety Inventory. Functional connectivity analyses were conducted from three amygdalar subregions: centromedial (CM), laterobasal (LB) and superficial (SF). In addition, correlations with the behavioral measures were tested in the adult participants. In general, the ASD group showed significantly decreased connectivity from the LB subregion and increased connectivity from the CM and SF subregions compared to the TD group. We found evidence that social symptoms are primarily associated with under-connectivity from the LB subregion whereas over-connectivity and under-connectivity from the CM, SF and LB subregions are related to co-morbid depression and anxiety in ASD, in brain regions that were distinct from those associated with social dysfunction, and in different patterns than were observed in mildly symptomatic TD participants. Our findings provide new evidence for functional subregional differences in amygdala pathophysiology in ASD. Autism Res 2016, 9: 760–772. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1589 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292
in Autism Research > 9-7 (July 2016) . - p.760-772[article] Subregional differences in intrinsic amygdala hyperconnectivity and hypoconnectivity in autism spectrum disorder [Texte imprimé et/ou numérique] / Natalia M. KLEINHANS, Auteur ; Maya A. REITER, Auteur ; Emily NEUHAUS, Auteur ; Greg PAULEY, Auteur ; Nathalie MARTIN, Auteur ; Stephen R. DAGER, Auteur ; Annette ESTES, Auteur . - p.760-772.
Langues : Anglais (eng)
in Autism Research > 9-7 (July 2016) . - p.760-772
Mots-clés : autism amygdala resting state fMRI laterobasal superficial centromedial depression anxiety Index. décimale : PER Périodiques Résumé : The amygdala is a complex structure with distinct subregions and dissociable functional networks. The laterobasal subregion of the amygdala is hypothesized to mediate the presentation and severity of autism symptoms, although very little data are available regarding amygdala dysfunction at the subregional level. In this study, we investigated the relationship between abnormal amygdalar intrinsic connectivity, autism symptom severity, and anxiety and depressive symptoms. We collected resting state fMRI data on 31 high functioning adolescents and adults with autism spectrum disorder and 38 typically developing (TD) controls aged 14–45. Twenty-five participants with ASD and 28 TD participants were included in the final analyses. ASD participants were administered the Autism Diagnostic Interview–Revised and the Autism Diagnostic Observation Schedule. Adult participants were administered the Beck Depression Inventory II and the Beck Anxiety Inventory. Functional connectivity analyses were conducted from three amygdalar subregions: centromedial (CM), laterobasal (LB) and superficial (SF). In addition, correlations with the behavioral measures were tested in the adult participants. In general, the ASD group showed significantly decreased connectivity from the LB subregion and increased connectivity from the CM and SF subregions compared to the TD group. We found evidence that social symptoms are primarily associated with under-connectivity from the LB subregion whereas over-connectivity and under-connectivity from the CM, SF and LB subregions are related to co-morbid depression and anxiety in ASD, in brain regions that were distinct from those associated with social dysfunction, and in different patterns than were observed in mildly symptomatic TD participants. Our findings provide new evidence for functional subregional differences in amygdala pathophysiology in ASD. Autism Res 2016, 9: 760–772. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1589 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292