Age as a Moderator of Social Skills Intervention Response Among Korean Adolescents with Autism Spectrum Disorder / J. K. HONG in Journal of Autism and Developmental Disorders, 49-4 (April 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-4 (April 2019) . - p.1626-1637 Titre : Age as a Moderator of Social Skills Intervention Response Among Korean Adolescents with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : J. K. HONG, Auteur ; M. OH, Auteur ; Guiyoung BONG, Auteur ; J. H. KIM, Auteur ; Geonho BAHN, Auteur ; In Hee CHO, Auteur ; H. J. YOO, Auteur Article en page(s) : p.1626-1637 Langues : Anglais (eng) Mots-clés : Adolescent  Age difference  Autism spectrum disorder  Peers  Social skills training Index. décimale : PER Périodiques Résumé : Few studies have investigated the effect of age on treatment effectiveness of evidence-based social skills training in autism spectrum disorder (ASD) adolescents. This study evaluated the effectiveness of Program for the Education and Enrichment of Relational Skills (PEERS((R))) in different ages of ASD adolescents. A total of 110 ASD adolescents aged 11-19 years were divided into early, middle, and late adolescence groups, and the changes in outcome measures following intervention were compared among the three groups. We found that the improvements in social competence after PEERS((R)) were significant, but the treatment effects were not significantly different among the three age groups. The findings suggest that PEERS((R)) is beneficial for ASD adolescents regardless of patient age and adolescence stage. En ligne : https://dx.doi.org/10.1007/s10803-018-3859-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388 [article] Age as a Moderator of Social Skills Intervention Response Among Korean Adolescents with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / J. K. HONG, Auteur ; M. OH, Auteur ; Guiyoung BONG, Auteur ; J. H. KIM, Auteur ; Geonho BAHN, Auteur ; In Hee CHO, Auteur ; H. J. YOO, Auteur . - p.1626-1637. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-4 (April 2019) . - p.1626-1637 Mots-clés : Adolescent  Age difference  Autism spectrum disorder  Peers  Social skills training Index. décimale : PER Périodiques Résumé : Few studies have investigated the effect of age on treatment effectiveness of evidence-based social skills training in autism spectrum disorder (ASD) adolescents. This study evaluated the effectiveness of Program for the Education and Enrichment of Relational Skills (PEERS((R))) in different ages of ASD adolescents. A total of 110 ASD adolescents aged 11-19 years were divided into early, middle, and late adolescence groups, and the changes in outcome measures following intervention were compared among the three groups. We found that the improvements in social competence after PEERS((R)) were significant, but the treatment effects were not significantly different among the three age groups. The findings suggest that PEERS((R)) is beneficial for ASD adolescents regardless of patient age and adolescence stage. En ligne : https://dx.doi.org/10.1007/s10803-018-3859-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388

Replicative genetic association study between functional polymorphisms in AVPR1A and social behavior scales of autism spectrum disorder in the Korean population / S. Y. YANG in Molecular Autism, 8 (2017)  

Public ISBD [article]  inMolecular Autism > 8 (2017) . - 44p. Titre : Replicative genetic association study between functional polymorphisms in AVPR1A and social behavior scales of autism spectrum disorder in the Korean population Type de document : Texte imprimé et/ou numérique Auteurs : S. Y. YANG, Auteur ; S. A. KIM, Auteur ; G. M. HUR, Auteur ; M. PARK, Auteur ; J. E. PARK, Auteur ; H. J. YOO, Auteur Article en page(s) : 44p. Langues : Anglais (eng) Mots-clés : Arginine vasopressin receptor 1A (AVPR1A)  Association  Autism spectrum disorder  Microsatellite  Promoter  Single nucleotide polymorphism Index. décimale : PER Périodiques Résumé : BACKGROUND: Arginine vasopressin has been shown to affect social and emotional behaviors, which is mediated by the arginine vasopressin receptor (AVPR1A). Genetic polymorphisms in the AVPR1A promoter region have been identified to be associated with susceptibility to social deficits in autism spectrum disorder (ASD). We hypothesize that alleles of polymorphisms in the promoter region of AVPR1A may differentially interact with certain transcriptional factors, which in turn affect quantitative traits, such as sociality, in children with autism. METHODS: We performed an association study between ASD and polymorphisms in the AVPR1A promoter region in the Korean population using a family-based association test (FBAT). We evaluated the correlation between genotypes and the quantitative traits that are related to sociality in children with autism. We also performed a promoter assay in T98G cells and evaluated the binding affinities of transcription factors to alleles of rs7294536. RESULTS: The polymorphisms-RS1, RS3, rs7294536, and rs10877969-were analyzed. Under the dominant model, RS1-310, the shorter allele, was preferentially transmitted. The FBAT showed that the rs7294536 A allele was also preferentially transmitted in an additive and dominant model under the bi-allelic mode. When quantitative traits were used in the FBAT, rs7294536 and rs10877969 were statistically significant in all genotype models and modes. Luciferase and electrophoretic mobility-shift assays suggest that the rs7294536 A/G allele results in a Nf-kappaB binding site that exhibits differential binding affinities depending on the allele. CONCLUSION: These results demonstrate that polymorphisms in the AVPR1A promoter region might be involved in pathophysiology of ASD and in functional regulation of the expression of AVPR1A. En ligne : http://dx.doi.org/10.1186/s13229-017-0161-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331 [article] Replicative genetic association study between functional polymorphisms in AVPR1A and social behavior scales of autism spectrum disorder in the Korean population [Texte imprimé et/ou numérique] / S. Y. YANG, Auteur ; S. A. KIM, Auteur ; G. M. HUR, Auteur ; M. PARK, Auteur ; J. E. PARK, Auteur ; H. J. YOO, Auteur . - 44p. Langues : Anglais (eng) in Molecular Autism > 8 (2017) . - 44p. Mots-clés : Arginine vasopressin receptor 1A (AVPR1A)  Association  Autism spectrum disorder  Microsatellite  Promoter  Single nucleotide polymorphism Index. décimale : PER Périodiques Résumé : BACKGROUND: Arginine vasopressin has been shown to affect social and emotional behaviors, which is mediated by the arginine vasopressin receptor (AVPR1A). Genetic polymorphisms in the AVPR1A promoter region have been identified to be associated with susceptibility to social deficits in autism spectrum disorder (ASD). We hypothesize that alleles of polymorphisms in the promoter region of AVPR1A may differentially interact with certain transcriptional factors, which in turn affect quantitative traits, such as sociality, in children with autism. METHODS: We performed an association study between ASD and polymorphisms in the AVPR1A promoter region in the Korean population using a family-based association test (FBAT). We evaluated the correlation between genotypes and the quantitative traits that are related to sociality in children with autism. We also performed a promoter assay in T98G cells and evaluated the binding affinities of transcription factors to alleles of rs7294536. RESULTS: The polymorphisms-RS1, RS3, rs7294536, and rs10877969-were analyzed. Under the dominant model, RS1-310, the shorter allele, was preferentially transmitted. The FBAT showed that the rs7294536 A allele was also preferentially transmitted in an additive and dominant model under the bi-allelic mode. When quantitative traits were used in the FBAT, rs7294536 and rs10877969 were statistically significant in all genotype models and modes. Luciferase and electrophoretic mobility-shift assays suggest that the rs7294536 A/G allele results in a Nf-kappaB binding site that exhibits differential binding affinities depending on the allele. CONCLUSION: These results demonstrate that polymorphisms in the AVPR1A promoter region might be involved in pathophysiology of ASD and in functional regulation of the expression of AVPR1A. En ligne : http://dx.doi.org/10.1186/s13229-017-0161-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331

Short caregiver interview and play observation for early screening of autism spectrum disorder: Behavior development screening for toddlers (BeDevel) / Guiyoung BONG in Autism Research, 14-7 (July 2021)  

Public ISBD [article]  inAutism Research > 14-7 (July 2021) . - p.1472-1483 Titre : Short caregiver interview and play observation for early screening of autism spectrum disorder: Behavior development screening for toddlers (BeDevel) Type de document : Texte imprimé et/ou numérique Auteurs : Guiyoung BONG, Auteur ; S. Y. KIM, Auteur ; D. Y. SONG, Auteur ; J. H. KIM, Auteur ; Y. HONG, Auteur ; N. H. YOON, Auteur ; H. SUNWOO, Auteur ; J. Y. JANG, Auteur ; M. OH, Auteur ; J. M. KIM, Auteur ; K. S. LEE, Auteur ; S. JUNG, Auteur ; C. W. CHOI, Auteur ; J. S. RYU, Auteur ; H. J. YOO, Auteur Article en page(s) : p.1472-1483 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder  Caregivers  Child  Child, Preschool  Humans  Infant  Male  Mass Screening  Reproducibility of Results  autism spectrum disorder  early detection  screening  social referencing Index. décimale : PER Périodiques Résumé : This study validates behavior development screening for toddlers (BeDevel), which utilizes a combination of short caregiver interviews (BeDevel-I) and semistructured play observations (BeDevel-P). The data of 431 toddlers (male 66.2%; mean age (SD) = 29.11 (8.59) months; ASD, n = 201; developmental delay, n = 46; typically developing, n = 184), aged 18?~?42?months, were included in the validation of BeDevel. The best clinical estimate diagnosis, screening rate, validity, sensitivity, and reliability of BeDevel were determined based on data cross-sectionally collected using BeDevel and existing diagnostic/screening instruments: autism diagnostic observation schedule (ADOS), autism diagnostic interview (ADI-R), Vineland adaptive behavior scales-II (VABS-II), social response scales (SRS), sequenced language scale for infants (SELSI), Korean childhood autism rating scale (K-CARS), and Korean social communication questionnaire (K-SCQ). The k values of BeDevel-I and BeDevel-P were 0.055?~?0.732 and 0.291?~?0.752, respectively. Items related to social referencing in BeDevel-P had a particularly high diagnostic validity (k = 0.483?~?0.684). Reliabilities of BeDevel-I and BeDevel-P were sufficient (Cronbach's alpha = 0.86?~?0.88 and 0.92?~?0.95, respectively). BeDevel-I and BeDevel-P showed high sensitivity (BeDevel-I: 85.00?~?89.29%; BeDevel-P: 85.00?~?91.75%), specificity (BeDevel-I: 77.55?~?89.55%; BeDevel-P: 85.09?~?97.01%), PPV (BeDevel-I: 70.83?~?88.54%; BeDevel-P: 81.52?~?94.68%), and NPV (BeDevel-I: 76.00?~?95.24%; BeDevel-P: 84.62?~?95.45%). The agreement between the composite BeDevel score and ADOS, ADI-R, K-CARS, and K-SCQ was >67.6% (range = 67.6?~?90.8%). Combining a short caregiver interview and direct play observation is a valid and reliable screening process. More studies on social referencing as an important early marker are needed. BeDevel can be utilized as a secondary screening instrument before diagnostic confirmation in clinical and community settings. LAY SUMMARY: BeDevel, which consists of a short caregiver interview and direct play observation, is a valid and reliable screening instrument for autism spectrum disorder (ASD). We suggest that BeDevel can be utilized as a secondary instrument before administering diagnostic assessments in clinical and community settings. More studies examining social referencing as a potential behavioral marker of ASD are needed. En ligne : http://dx.doi.org/10.1002/aur.2510 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Short caregiver interview and play observation for early screening of autism spectrum disorder: Behavior development screening for toddlers (BeDevel) [Texte imprimé et/ou numérique] / Guiyoung BONG, Auteur ; S. Y. KIM, Auteur ; D. Y. SONG, Auteur ; J. H. KIM, Auteur ; Y. HONG, Auteur ; N. H. YOON, Auteur ; H. SUNWOO, Auteur ; J. Y. JANG, Auteur ; M. OH, Auteur ; J. M. KIM, Auteur ; K. S. LEE, Auteur ; S. JUNG, Auteur ; C. W. CHOI, Auteur ; J. S. RYU, Auteur ; H. J. YOO, Auteur . - p.1472-1483. Langues : Anglais (eng) in Autism Research > 14-7 (July 2021) . - p.1472-1483 Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder  Caregivers  Child  Child, Preschool  Humans  Infant  Male  Mass Screening  Reproducibility of Results  autism spectrum disorder  early detection  screening  social referencing Index. décimale : PER Périodiques Résumé : This study validates behavior development screening for toddlers (BeDevel), which utilizes a combination of short caregiver interviews (BeDevel-I) and semistructured play observations (BeDevel-P). The data of 431 toddlers (male 66.2%; mean age (SD) = 29.11 (8.59) months; ASD, n = 201; developmental delay, n = 46; typically developing, n = 184), aged 18?~?42?months, were included in the validation of BeDevel. The best clinical estimate diagnosis, screening rate, validity, sensitivity, and reliability of BeDevel were determined based on data cross-sectionally collected using BeDevel and existing diagnostic/screening instruments: autism diagnostic observation schedule (ADOS), autism diagnostic interview (ADI-R), Vineland adaptive behavior scales-II (VABS-II), social response scales (SRS), sequenced language scale for infants (SELSI), Korean childhood autism rating scale (K-CARS), and Korean social communication questionnaire (K-SCQ). The k values of BeDevel-I and BeDevel-P were 0.055?~?0.732 and 0.291?~?0.752, respectively. Items related to social referencing in BeDevel-P had a particularly high diagnostic validity (k = 0.483?~?0.684). Reliabilities of BeDevel-I and BeDevel-P were sufficient (Cronbach's alpha = 0.86?~?0.88 and 0.92?~?0.95, respectively). BeDevel-I and BeDevel-P showed high sensitivity (BeDevel-I: 85.00?~?89.29%; BeDevel-P: 85.00?~?91.75%), specificity (BeDevel-I: 77.55?~?89.55%; BeDevel-P: 85.09?~?97.01%), PPV (BeDevel-I: 70.83?~?88.54%; BeDevel-P: 81.52?~?94.68%), and NPV (BeDevel-I: 76.00?~?95.24%; BeDevel-P: 84.62?~?95.45%). The agreement between the composite BeDevel score and ADOS, ADI-R, K-CARS, and K-SCQ was >67.6% (range = 67.6?~?90.8%). Combining a short caregiver interview and direct play observation is a valid and reliable screening process. More studies on social referencing as an important early marker are needed. BeDevel can be utilized as a secondary screening instrument before diagnostic confirmation in clinical and community settings. LAY SUMMARY: BeDevel, which consists of a short caregiver interview and direct play observation, is a valid and reliable screening instrument for autism spectrum disorder (ASD). We suggest that BeDevel can be utilized as a secondary instrument before administering diagnostic assessments in clinical and community settings. More studies examining social referencing as a potential behavioral marker of ASD are needed. En ligne : http://dx.doi.org/10.1002/aur.2510 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

The Feasibility and Validity of Autism Spectrum Disorder Screening Instrument: Behavior Development Screening for Toddlers (BeDevel)-A Pilot Study / Guiyoung BONG in Autism Research, 12-7 (July 2019)  

Public ISBD [article]  inAutism Research > 12-7 (July 2019) . - p.1112-1128 Titre : The Feasibility and Validity of Autism Spectrum Disorder Screening Instrument: Behavior Development Screening for Toddlers (BeDevel)-A Pilot Study Type de document : Texte imprimé et/ou numérique Auteurs : Guiyoung BONG, Auteur ; J. H. KIM, Auteur ; Y. HONG, Auteur ; N. H. YOON, Auteur ; H. SUNWOO, Auteur ; J. Y. JANG, Auteur ; M. OH, Auteur ; K. S. LEE, Auteur ; S. JUNG, Auteur ; H. J. YOO, Auteur Année de publication : 2019 Article en page(s) : p.1112-1128 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  early detection  early screening  early sign  toddler Index. décimale : PER Périodiques Résumé : Although early screening is critical for individuals with autism spectrum disorder (ASD) in order to receive early intervention and improve function later in life, screening is often delayed. Limitations of existing screening instruments, and the need for a culturally appropriate early screening tool in Korean children, led us to develop Behavior Development Screening for Toddlers (BeDevel). The BeDevel assessment consists of two parts: BeDevel-Interview, a structured interview measure for parents/primary caregivers; and BeDevel-Play, a play-based semi-structured observational measure in children. To examine the feasibility and validity of BeDevel, 155 children (N = 75 ASD, N = 55 typical development, N = 25 developmentally delayed) aged 18-42 months (M = 31.54 months, SD = 7.60) were examined through parent-reported screening questionnaires, BeDevel, and standard diagnostic assessments. When BeDevel items were analyzed using Cohen's kappa statistics, most items in BeDevel-Interview and all items in BeDevel-Play were reasonably consistent with diagnoses. We identified primary items, which were significantly interacted with actual diagnosis in the chi-squared test (P < 0.05, range = 0.000-0.032). Using cutoff numbers of items determined using the receiver operating characteristics curve, BeDevel showed satisfactory levels of sensitivity (83.33%-100%), specificity (81.25%-100%), positive predictive values (80.65%-100%), and negative predictive values (83.87%-100%), as well as high internal consistency (Cronbach's alpha = 0.866-959). The agreement between BeDevel and most other screening/diagnostic instruments was moderate (k = 0.419-1.000). These results suggest that BeDevel can be a useful instrument for early screening of ASD. Autism Res 2019, 12: 1112-1128. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Although early screening is critical for individuals with autism spectrum disorder (ASD) in order to receive early intervention and improve function later in life, screening is often delayed. Limitations of existing screening instruments and the need for a culturally appropriate early screening tool in Korean children led us to develop Behavior Development Screening for Toddlers (BeDevel). The BeDevel assessment consists of two parts: BeDevel-Interview, a structured interview measure for parents/primary caregivers; and BeDevel-Play, a play-based, semi-structured observational measure in children. In order to test the feasibility and validity of BeDevel, we analyzed preliminary data of total 155 children aged 18-42 months, examined through parent-reported screening questionnaires, BeDevel, and standard diagnostic assessments. When individual items were analyzed, responses of all BeDevel-Interview items and of most BeDevel-Play items well matched actual diagnoses, and we identified primary items, which were particularly useful in differentiating between the ASD group and the non-ASD group. With the optimal screening criteria determined, the BeDevel was able to identify individuals with a diagnosis of ASD and those without it, all at satisfactory levels. Lastly, BeDevel items were closely related as a set, and the BeDevel screening results were reasonably consistent with the results of most other screening/diagnostic instruments. These results suggest that BeDevel can be a useful instrument for early screening of ASD. En ligne : http://dx.doi.org/10.1002/aur.2117 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402 [article] The Feasibility and Validity of Autism Spectrum Disorder Screening Instrument: Behavior Development Screening for Toddlers (BeDevel)-A Pilot Study [Texte imprimé et/ou numérique] / Guiyoung BONG, Auteur ; J. H. KIM, Auteur ; Y. HONG, Auteur ; N. H. YOON, Auteur ; H. SUNWOO, Auteur ; J. Y. JANG, Auteur ; M. OH, Auteur ; K. S. LEE, Auteur ; S. JUNG, Auteur ; H. J. YOO, Auteur . - 2019 . - p.1112-1128. Langues : Anglais (eng) in Autism Research > 12-7 (July 2019) . - p.1112-1128 Mots-clés : autism spectrum disorder  early detection  early screening  early sign  toddler Index. décimale : PER Périodiques Résumé : Although early screening is critical for individuals with autism spectrum disorder (ASD) in order to receive early intervention and improve function later in life, screening is often delayed. Limitations of existing screening instruments, and the need for a culturally appropriate early screening tool in Korean children, led us to develop Behavior Development Screening for Toddlers (BeDevel). The BeDevel assessment consists of two parts: BeDevel-Interview, a structured interview measure for parents/primary caregivers; and BeDevel-Play, a play-based semi-structured observational measure in children. To examine the feasibility and validity of BeDevel, 155 children (N = 75 ASD, N = 55 typical development, N = 25 developmentally delayed) aged 18-42 months (M = 31.54 months, SD = 7.60) were examined through parent-reported screening questionnaires, BeDevel, and standard diagnostic assessments. When BeDevel items were analyzed using Cohen's kappa statistics, most items in BeDevel-Interview and all items in BeDevel-Play were reasonably consistent with diagnoses. We identified primary items, which were significantly interacted with actual diagnosis in the chi-squared test (P < 0.05, range = 0.000-0.032). Using cutoff numbers of items determined using the receiver operating characteristics curve, BeDevel showed satisfactory levels of sensitivity (83.33%-100%), specificity (81.25%-100%), positive predictive values (80.65%-100%), and negative predictive values (83.87%-100%), as well as high internal consistency (Cronbach's alpha = 0.866-959). The agreement between BeDevel and most other screening/diagnostic instruments was moderate (k = 0.419-1.000). These results suggest that BeDevel can be a useful instrument for early screening of ASD. Autism Res 2019, 12: 1112-1128. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Although early screening is critical for individuals with autism spectrum disorder (ASD) in order to receive early intervention and improve function later in life, screening is often delayed. Limitations of existing screening instruments and the need for a culturally appropriate early screening tool in Korean children led us to develop Behavior Development Screening for Toddlers (BeDevel). The BeDevel assessment consists of two parts: BeDevel-Interview, a structured interview measure for parents/primary caregivers; and BeDevel-Play, a play-based, semi-structured observational measure in children. In order to test the feasibility and validity of BeDevel, we analyzed preliminary data of total 155 children aged 18-42 months, examined through parent-reported screening questionnaires, BeDevel, and standard diagnostic assessments. When individual items were analyzed, responses of all BeDevel-Interview items and of most BeDevel-Play items well matched actual diagnoses, and we identified primary items, which were particularly useful in differentiating between the ASD group and the non-ASD group. With the optimal screening criteria determined, the BeDevel was able to identify individuals with a diagnosis of ASD and those without it, all at satisfactory levels. Lastly, BeDevel items were closely related as a set, and the BeDevel screening results were reasonably consistent with the results of most other screening/diagnostic instruments. These results suggest that BeDevel can be a useful instrument for early screening of ASD. En ligne : http://dx.doi.org/10.1002/aur.2117 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402

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