Autism-specific maternal anti-fetal brain autoantibodies are associated with metabolic conditions / Paula KRAKOWIAK in Autism Research, 10-1 (January 2017)  

Public ISBD [article]  inAutism Research > 10-1 (January 2017) . - p.89-98 Titre : Autism-specific maternal anti-fetal brain autoantibodies are associated with metabolic conditions Type de document : Texte imprimé et/ou numérique Auteurs : Paula KRAKOWIAK, Auteur ; Cheryl K. WALKER, Auteur ; Daniel J. TANCREDI, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Judy VAN DE WATER, Auteur Article en page(s) : p.89-98 Langues : Anglais (eng) Mots-clés : autism  pregnancy  maternal autoantibodies  anti-fetal brain autoantibodies  metabolic conditions  diabetes Index. décimale : PER Périodiques Résumé : Approximately 23% of mothers of children with autism spectrum disorder (ASD) produce specific patterns of autoantibodies to fetal brain proteins that have been detected in only 1% of mothers of typically developing children. The biological mechanisms underlying the development of ASD-specific maternal autoantibodies are poorly understood. We sought to determine whether ASD-specific maternal autoantibodies identified postnatally were associated with metabolic conditions (MCs) during gestation. Participants were 227 mothers of 2–5 year old children with confirmed ASD, enrolled in CHARGE (Childhood Autism Risk from Genetics and the Environment) between January 2003 and April 2008, and from whom blood samples were collected and analyzed for anti-fetal brain autoantibodies (Ab+). MCs included diabetes, hypertensive disorders, and prepregnancy obesity or overweight, ascertained from medical records or structured telephone interviews. Log-linear regression models were performed to estimate prevalence ratios and 95% confidence intervals (CI) based on robust standard errors. Fifty-six (25%) mothers were Ab+. Ab+ prevalence was higher among mothers with diabetes, hypertensive disorders, or overweight compared to healthy mothers, but differences were not statistically significant. In a subset of 145 mothers whose children exhibited severe ASD (31 Ab+), those diagnosed with type 2 or gestational diabetes were 2.7-fold more likely to be Ab+ (95% CI 1.1, 6.6), controlling for delivery payer and smoking. Gestational diabetes specifically was associated with a 3.2-fold increased Ab+ prevalence (95% CI 1.2, 8.6). In this exploratory study, mothers whose children had severe ASD and who experienced diabetes were more likely to have anti-fetal brain autoantibodies 2–5 years later. En ligne : http://dx.doi.org/10.1002/aur.1657 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Autism-specific maternal anti-fetal brain autoantibodies are associated with metabolic conditions [Texte imprimé et/ou numérique] / Paula KRAKOWIAK, Auteur ; Cheryl K. WALKER, Auteur ; Daniel J. TANCREDI, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Judy VAN DE WATER, Auteur . - p.89-98. Langues : Anglais (eng) in Autism Research > 10-1 (January 2017) . - p.89-98 Mots-clés : autism  pregnancy  maternal autoantibodies  anti-fetal brain autoantibodies  metabolic conditions  diabetes Index. décimale : PER Périodiques Résumé : Approximately 23% of mothers of children with autism spectrum disorder (ASD) produce specific patterns of autoantibodies to fetal brain proteins that have been detected in only 1% of mothers of typically developing children. The biological mechanisms underlying the development of ASD-specific maternal autoantibodies are poorly understood. We sought to determine whether ASD-specific maternal autoantibodies identified postnatally were associated with metabolic conditions (MCs) during gestation. Participants were 227 mothers of 2–5 year old children with confirmed ASD, enrolled in CHARGE (Childhood Autism Risk from Genetics and the Environment) between January 2003 and April 2008, and from whom blood samples were collected and analyzed for anti-fetal brain autoantibodies (Ab+). MCs included diabetes, hypertensive disorders, and prepregnancy obesity or overweight, ascertained from medical records or structured telephone interviews. Log-linear regression models were performed to estimate prevalence ratios and 95% confidence intervals (CI) based on robust standard errors. Fifty-six (25%) mothers were Ab+. Ab+ prevalence was higher among mothers with diabetes, hypertensive disorders, or overweight compared to healthy mothers, but differences were not statistically significant. In a subset of 145 mothers whose children exhibited severe ASD (31 Ab+), those diagnosed with type 2 or gestational diabetes were 2.7-fold more likely to be Ab+ (95% CI 1.1, 6.6), controlling for delivery payer and smoking. Gestational diabetes specifically was associated with a 3.2-fold increased Ab+ prevalence (95% CI 1.2, 8.6). In this exploratory study, mothers whose children had severe ASD and who experienced diabetes were more likely to have anti-fetal brain autoantibodies 2–5 years later. En ligne : http://dx.doi.org/10.1002/aur.1657 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

Brief Report: Plasma Leptin Levels are Elevated in Autism: Association with Early Onset Phenotype? / Paul ASHWOOD in Journal of Autism and Developmental Disorders, 38-1 (January 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-1 (January 2008) . - p.169-175 Titre : Brief Report: Plasma Leptin Levels are Elevated in Autism: Association with Early Onset Phenotype? Type de document : Texte imprimé et/ou numérique Auteurs : Paul ASHWOOD, Auteur ; Christina KWONG, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Paula KRAKOWIAK, Auteur ; Wynn WALKER, Auteur ; Isaac N. PESSAH, Auteur ; Judy VAN DE WATER, Auteur ; David J. HANSEN, Auteur ; Lisa A. CROEN, Auteur Année de publication : 2008 Article en page(s) : p.169-175 Langues : Anglais (eng) Mots-clés : Inflammation Leptin Autism Regression Index. décimale : PER Périodiques Résumé : There is evidence of both immune dysregulation and autoimmune phenomena in children with autism spectrum disorders (ASD). We examined the hormone/cytokine leptin in 70 children diagnosed with autism (including 37 with regression) compared with 99 age-matched controls including 50 typically developing (TD) controls, 26 siblings without autism, and 23 children with developmental disabilities (DD). Children with autism had significantly higher plasma leptin levels compared with TD controls (p < .006). When further sub-classified into regression or early onset autism, children with early onset autism had significantly higher plasma leptin levels compared with children with regressive autism (p < .042), TD controls (p < .0015), and DD controls (p < .004). We demonstrated an increase in leptin levels in autism, a finding driven by the early onset group. En ligne : http://dx.doi.org/10.1007/s10803-006-0353-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316 [article] Brief Report: Plasma Leptin Levels are Elevated in Autism: Association with Early Onset Phenotype? [Texte imprimé et/ou numérique] / Paul ASHWOOD, Auteur ; Christina KWONG, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Paula KRAKOWIAK, Auteur ; Wynn WALKER, Auteur ; Isaac N. PESSAH, Auteur ; Judy VAN DE WATER, Auteur ; David J. HANSEN, Auteur ; Lisa A. CROEN, Auteur . - 2008 . - p.169-175. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-1 (January 2008) . - p.169-175 Mots-clés : Inflammation Leptin Autism Regression Index. décimale : PER Périodiques Résumé : There is evidence of both immune dysregulation and autoimmune phenomena in children with autism spectrum disorders (ASD). We examined the hormone/cytokine leptin in 70 children diagnosed with autism (including 37 with regression) compared with 99 age-matched controls including 50 typically developing (TD) controls, 26 siblings without autism, and 23 children with developmental disabilities (DD). Children with autism had significantly higher plasma leptin levels compared with TD controls (p < .006). When further sub-classified into regression or early onset autism, children with early onset autism had significantly higher plasma leptin levels compared with children with regressive autism (p < .042), TD controls (p < .0015), and DD controls (p < .004). We demonstrated an increase in leptin levels in autism, a finding driven by the early onset group. En ligne : http://dx.doi.org/10.1007/s10803-006-0353-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316

Minor physical anomalies in children with autism spectrum disorders / Kathleen ANGKUSTSIRI in Autism, 15-6 (November 2011)  

Public ISBD [article]  inAutism > 15-6 (November 2011) . - p.746-760 Titre : Minor physical anomalies in children with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Kathleen ANGKUSTSIRI, Auteur ; Paula KRAKOWIAK, Auteur ; Billur MOGHADDAM, Auteur ; Terrance WARDINSKY, Auteur ; Jerald GARDNER, Auteur ; Nareg KALAMKARIAN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; David J. HANSEN, Auteur Année de publication : 2011 Article en page(s) : p.746-760 Langues : Anglais (eng) Mots-clés : autism  dysmorphology  minor physical anomalies Index. décimale : PER Périodiques Résumé : Objective: There is clinical heterogeneity among the autism spectrum disorders (ASD). The presence of dysmorphology (minor physical anomalies; MPAs) is one possible tool for defining a clinically relevant subset in ASD. This study employs an adaptation of Miles and Hillman’s (2000) classifications by using photographs to identify a subgroup with significant dysmorphology among children with ASD, typical development (TYP), and developmental delay (DD). Method: Children with ASD, DD, and TYP between 2 and 5 years old were part of the CHARGE Study. Pediatric specialists blinded to diagnostic group classified photographs based on the number of MPAs present: ‘dysmorphic’ if >3 and ‘nondysmorphic’ if <3 MPAs. Results: Photographs for 324 children were included. Significantly more children with ASD were classified as dysmorphic compared to TYP children (p = .007). In children with ASD, seizures were more prevalent in those rated dysmorphic (p = .005). Frequencies were similar between ASD versus DD (p = .19) after removing those with known syndromes. Conclusion: Photographic assessment can be used to detect generalized dysmorphology in children who are often difficult to examine. This has clinical relevance, as children with multiple MPAs can be identified through the use of photographs and prioritized for investigation of brain abnormalities and underlying genetic disorders. En ligne : http://dx.doi.org/10.1177/1362361310397620 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=149 [article] Minor physical anomalies in children with autism spectrum disorders [Texte imprimé et/ou numérique] / Kathleen ANGKUSTSIRI, Auteur ; Paula KRAKOWIAK, Auteur ; Billur MOGHADDAM, Auteur ; Terrance WARDINSKY, Auteur ; Jerald GARDNER, Auteur ; Nareg KALAMKARIAN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; David J. HANSEN, Auteur . - 2011 . - p.746-760. Langues : Anglais (eng) in Autism > 15-6 (November 2011) . - p.746-760 Mots-clés : autism  dysmorphology  minor physical anomalies Index. décimale : PER Périodiques Résumé : Objective: There is clinical heterogeneity among the autism spectrum disorders (ASD). The presence of dysmorphology (minor physical anomalies; MPAs) is one possible tool for defining a clinically relevant subset in ASD. This study employs an adaptation of Miles and Hillman’s (2000) classifications by using photographs to identify a subgroup with significant dysmorphology among children with ASD, typical development (TYP), and developmental delay (DD). Method: Children with ASD, DD, and TYP between 2 and 5 years old were part of the CHARGE Study. Pediatric specialists blinded to diagnostic group classified photographs based on the number of MPAs present: ‘dysmorphic’ if >3 and ‘nondysmorphic’ if <3 MPAs. Results: Photographs for 324 children were included. Significantly more children with ASD were classified as dysmorphic compared to TYP children (p = .007). In children with ASD, seizures were more prevalent in those rated dysmorphic (p = .005). Frequencies were similar between ASD versus DD (p = .19) after removing those with known syndromes. Conclusion: Photographic assessment can be used to detect generalized dysmorphology in children who are often difficult to examine. This has clinical relevance, as children with multiple MPAs can be identified through the use of photographs and prioritized for investigation of brain abnormalities and underlying genetic disorders. En ligne : http://dx.doi.org/10.1177/1362361310397620 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=149

Reduced levels of immunoglobulin in children with autism correlates with behavioral symptoms / Luke HEUER in Autism Research, 1-5 (October 2008)  

Public ISBD [article]  inAutism Research > 1-5 (October 2008) . - p.275-283 Titre : Reduced levels of immunoglobulin in children with autism correlates with behavioral symptoms Type de document : Texte imprimé et/ou numérique Auteurs : Luke HEUER, Auteur ; David J. HANSEN, Auteur ; Joseph SCHAUER, Auteur ; Paula GOINES, Auteur ; Paul ASHWOOD, Auteur ; Judy VAN DE WATER, Auteur ; Isaac N. PESSAH, Auteur ; Paula KRAKOWIAK, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Lisa A. CROEN, Auteur Année de publication : 2008 Article en page(s) : p.275-283 Langues : Anglais (eng) Mots-clés : Autism immunoglobulin behavior IgG Index. décimale : PER Périodiques Résumé : Objectives: To assay if plasma antibody levels in children with autism or developmental delays (DD) differ from those with typical development as an indicator of immune function and to correlate antibody levels with severity of behavioral symptoms. Methods: Plasma was collected from children with autistic disorder (AU; n=116), DD but not autism (n=32), autism spectrum disorder but not full autism (n=27), and age-matched typically developing (TD) controls (n=96). Samples were assayed for systemic levels of immunoglobulin (IgG, IgM, IgA, and IgE) by enzyme-linked immunosorbent assay. Subjects with autism were evaluated using the Autism Diagnostic Observation Schedule and the Autism Diagnostic Interview - Revised, and all subjects were scored on the Aberrant Behavior Checklist (ABC) by the parents. Numerical scores for each of the ABC subscales as well as the total scores were then correlated with Ig levels. Results: Children with AU have a significantly reduced level of plasma IgG (5.39±0.29 mg/mL) compared to the TD (7.72±0.28 mg/mL; P<0.001) and DD children (8.23±0.49 mg/mL; P<0.001). Children with autism also had a reduced level of plasma IgM (0.670.06mg/mL) compared to TD (0.79±0.05 mg/mL; P<0.05). Ig levels were negatively correlated with ABC scores for all children (IgG: r=-0.334, P<0.0001; IgM: r=-0.167, P=0.0285). Conclusion: Children with AU have significantly reduced levels of plasma IgG and IgM compared to both DD and TD controls, suggesting an underlying defect in immune function. This reduction in specific Ig levels correlates with behavioral severity, where those patients with the highest scores in the behavioral battery have the most reduced levels of IgG and IgM. En ligne : http://dx.doi.org/10.1002/aur.42 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=933 [article] Reduced levels of immunoglobulin in children with autism correlates with behavioral symptoms [Texte imprimé et/ou numérique] / Luke HEUER, Auteur ; David J. HANSEN, Auteur ; Joseph SCHAUER, Auteur ; Paula GOINES, Auteur ; Paul ASHWOOD, Auteur ; Judy VAN DE WATER, Auteur ; Isaac N. PESSAH, Auteur ; Paula KRAKOWIAK, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Lisa A. CROEN, Auteur . - 2008 . - p.275-283. Langues : Anglais (eng) in Autism Research > 1-5 (October 2008) . - p.275-283 Mots-clés : Autism immunoglobulin behavior IgG Index. décimale : PER Périodiques Résumé : Objectives: To assay if plasma antibody levels in children with autism or developmental delays (DD) differ from those with typical development as an indicator of immune function and to correlate antibody levels with severity of behavioral symptoms. Methods: Plasma was collected from children with autistic disorder (AU; n=116), DD but not autism (n=32), autism spectrum disorder but not full autism (n=27), and age-matched typically developing (TD) controls (n=96). Samples were assayed for systemic levels of immunoglobulin (IgG, IgM, IgA, and IgE) by enzyme-linked immunosorbent assay. Subjects with autism were evaluated using the Autism Diagnostic Observation Schedule and the Autism Diagnostic Interview - Revised, and all subjects were scored on the Aberrant Behavior Checklist (ABC) by the parents. Numerical scores for each of the ABC subscales as well as the total scores were then correlated with Ig levels. Results: Children with AU have a significantly reduced level of plasma IgG (5.39±0.29 mg/mL) compared to the TD (7.72±0.28 mg/mL; P<0.001) and DD children (8.23±0.49 mg/mL; P<0.001). Children with autism also had a reduced level of plasma IgM (0.670.06mg/mL) compared to TD (0.79±0.05 mg/mL; P<0.05). Ig levels were negatively correlated with ABC scores for all children (IgG: r=-0.334, P<0.0001; IgM: r=-0.167, P=0.0285). Conclusion: Children with AU have significantly reduced levels of plasma IgG and IgM compared to both DD and TD controls, suggesting an underlying defect in immune function. This reduction in specific Ig levels correlates with behavioral severity, where those patients with the highest scores in the behavioral battery have the most reduced levels of IgG and IgM. En ligne : http://dx.doi.org/10.1002/aur.42 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=933

Sociodemographic Disparities in Intervention Service Utilization in Families of Children with Autism Spectrum Disorder / Cathina T. NGUYEN in Journal of Autism and Developmental Disorders, 46-12 (December 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-12 (December 2016) . - p.3729-3738 Titre : Sociodemographic Disparities in Intervention Service Utilization in Families of Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Cathina T. NGUYEN, Auteur ; Paula KRAKOWIAK, Auteur ; Robin HANSEN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Kathleen ANGKUSTSIRI, Auteur Article en page(s) : p.3729-3738 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Intervention services  Utilization  Family characteristics Index. décimale : PER Périodiques Résumé : This study investigates whether sociodemographic factors are associated with utilization of intervention services for children with autism spectrum disorder (ASD) enrolled in the Childhood Autism Risks from Genetics and the Environment Study. Maternal ethnicity, insurance status, and education for 696 families of children with ASD were available. Children of Black mothers entered intervention earlier compared to White mothers (2 vs. 2.6 years; p?=?0.001). Having public insurance was associated with receiving <15 h/week of individual services, while having a Bachelor degree was associated with receiving <15 h/week of classroom-based services. These differences suggest that SES may be a factor in utilization of services. Efforts should be made to ensure that interventions offered are culturally and linguistically accessible. En ligne : http://dx.doi.org/10.1007/s10803-016-2913-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 [article] Sociodemographic Disparities in Intervention Service Utilization in Families of Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Cathina T. NGUYEN, Auteur ; Paula KRAKOWIAK, Auteur ; Robin HANSEN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Kathleen ANGKUSTSIRI, Auteur . - p.3729-3738. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-12 (December 2016) . - p.3729-3738 Mots-clés : Autism spectrum disorder  Intervention services  Utilization  Family characteristics Index. décimale : PER Périodiques Résumé : This study investigates whether sociodemographic factors are associated with utilization of intervention services for children with autism spectrum disorder (ASD) enrolled in the Childhood Autism Risks from Genetics and the Environment Study. Maternal ethnicity, insurance status, and education for 696 families of children with ASD were available. Children of Black mothers entered intervention earlier compared to White mothers (2 vs. 2.6 years; p?=?0.001). Having public insurance was associated with receiving <15 h/week of individual services, while having a Bachelor degree was associated with receiving <15 h/week of classroom-based services. These differences suggest that SES may be a factor in utilization of services. Efforts should be made to ensure that interventions offered are culturally and linguistically accessible. En ligne : http://dx.doi.org/10.1007/s10803-016-2913-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297

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