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Fish Oil Supplementation Ameliorated Brain Lesions Induced by Diabetes and Hypercholesterolemia in Male Wistar Albino Rats / Hassan I.H. EL SAYYAD in Autism - Open Access, 5-3 ([01/06/2015])
[article]
Titre : Fish Oil Supplementation Ameliorated Brain Lesions Induced by Diabetes and Hypercholesterolemia in Male Wistar Albino Rats Type de document : Texte imprimé et/ou numérique Auteurs : Hassan I.H. EL SAYYAD, Auteur ; Iman H.M. BAKR, Auteur ; Ahmed A. EL MANSI, Auteur ; Ali H. AMIN, Auteur ; Mohamed E. EL BEEH, Auteur ; Adel M.A. ASIRI, Auteur Article en page(s) : 6 p. Langues : Anglais (eng) Mots-clés : Cerebral Hemisphere Cerebellum Brain Function Diabetes Hypercholesterolemia Fish Oil Index. décimale : PER Périodiques Résumé : Diabetes and hypercholesterolemia are dyslipidemic diseases and have certain role in brain dysfunction, but little of works are concerning with it. In the present study we used eighty male Wistar rats weighing approximately 100 ±15 gram. The animals were arranged into 8 groups; Control (C), fish oil-treatment, hypercholesterolemic group (H), hypercholesterolemic & fish oil-treatment (HF), diabetic- group (D), diabetic and fish oil-treatment (DF), combined hypercholesterolemic and diabetic group (HD) and combined hypercholesterolemic and diabetic group and fish-oil-treatment (HDF). Diabetes was induced by streptozotocin (40mg/kg single dose in citrate buffer pH4.6). Hypercholesterolemia was carried out by feeding rats on diet containin3% cholesterol. Fish oil (Menhaden, Sigma-aldrich, highest purity) was supplemented orally every other day at 100mg/kg body weight. Treatment was carried out for 16 weeks. At the end of treatment, brain tissues were subjected for histological investigation and biochemical assessments of dopamine, serotonin, vascular endothelial growth factor, 8-deoxyhydroxy-guanosine, adhesion molecules and phospholipids beside histological investigation of cerebral hemisphere and cerebellum. The present finding revealed marked depletion of the assayed neurotransmitters and phospholipids and increased of vascular endothelial growth factor, adhesion molecules and 8-deoxy hydroxy-guanosine. Histological observations of cerebral hemisphere revealed widespread of hemorrhagic spots in hypercholesterolemia, neovascualarization in combined diabetes and hypercholesterolemia and dense lymphocytic infiltration in diabetic group. All the experimental groups possessed edematous lesions in the inner plexiform layer. Cerebellar cortex exhibited massive degeneration of Purkinje cells and granular cell layer in diabetic and or hypercholesterolemia. Fish oil supplementation improved the brain function and histological picture. The authors concluded that fish oil contain short and long chain omega-3 fatty acids fatty acid which support the brain function and scavenge the free radicals damaging brain cells. En ligne : https://dx.doi.org/10.4172/2165-7890.1000148 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409
in Autism - Open Access > 5-3 [01/06/2015] . - 6 p.[article] Fish Oil Supplementation Ameliorated Brain Lesions Induced by Diabetes and Hypercholesterolemia in Male Wistar Albino Rats [Texte imprimé et/ou numérique] / Hassan I.H. EL SAYYAD, Auteur ; Iman H.M. BAKR, Auteur ; Ahmed A. EL MANSI, Auteur ; Ali H. AMIN, Auteur ; Mohamed E. EL BEEH, Auteur ; Adel M.A. ASIRI, Auteur . - 6 p.
Langues : Anglais (eng)
in Autism - Open Access > 5-3 [01/06/2015] . - 6 p.
Mots-clés : Cerebral Hemisphere Cerebellum Brain Function Diabetes Hypercholesterolemia Fish Oil Index. décimale : PER Périodiques Résumé : Diabetes and hypercholesterolemia are dyslipidemic diseases and have certain role in brain dysfunction, but little of works are concerning with it. In the present study we used eighty male Wistar rats weighing approximately 100 ±15 gram. The animals were arranged into 8 groups; Control (C), fish oil-treatment, hypercholesterolemic group (H), hypercholesterolemic & fish oil-treatment (HF), diabetic- group (D), diabetic and fish oil-treatment (DF), combined hypercholesterolemic and diabetic group (HD) and combined hypercholesterolemic and diabetic group and fish-oil-treatment (HDF). Diabetes was induced by streptozotocin (40mg/kg single dose in citrate buffer pH4.6). Hypercholesterolemia was carried out by feeding rats on diet containin3% cholesterol. Fish oil (Menhaden, Sigma-aldrich, highest purity) was supplemented orally every other day at 100mg/kg body weight. Treatment was carried out for 16 weeks. At the end of treatment, brain tissues were subjected for histological investigation and biochemical assessments of dopamine, serotonin, vascular endothelial growth factor, 8-deoxyhydroxy-guanosine, adhesion molecules and phospholipids beside histological investigation of cerebral hemisphere and cerebellum. The present finding revealed marked depletion of the assayed neurotransmitters and phospholipids and increased of vascular endothelial growth factor, adhesion molecules and 8-deoxy hydroxy-guanosine. Histological observations of cerebral hemisphere revealed widespread of hemorrhagic spots in hypercholesterolemia, neovascualarization in combined diabetes and hypercholesterolemia and dense lymphocytic infiltration in diabetic group. All the experimental groups possessed edematous lesions in the inner plexiform layer. Cerebellar cortex exhibited massive degeneration of Purkinje cells and granular cell layer in diabetic and or hypercholesterolemia. Fish oil supplementation improved the brain function and histological picture. The authors concluded that fish oil contain short and long chain omega-3 fatty acids fatty acid which support the brain function and scavenge the free radicals damaging brain cells. En ligne : https://dx.doi.org/10.4172/2165-7890.1000148 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 Maternal Diabetes and the Risk of Autism Spectrum Disorders in the Offspring: A Systematic Review and Meta-Analysis / Guifeng XU in Journal of Autism and Developmental Disorders, 44-4 (April 2014)
[article]
Titre : Maternal Diabetes and the Risk of Autism Spectrum Disorders in the Offspring: A Systematic Review and Meta-Analysis Type de document : Texte imprimé et/ou numérique Auteurs : Guifeng XU, Auteur ; Jin JING, Auteur ; Katherine BOWERS, Auteur ; Buyun LIU, Auteur ; Wei BAO, Auteur Année de publication : 2014 Article en page(s) : p.766-775 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Diabetes Pregnancy Index. décimale : PER Périodiques Résumé : We performed a systematic literature search regarding maternal diabetes before and during pregnancy and the risk of autism spectrum disorders (ASD) in the offspring. Of the 178 potentially relevant articles, 12 articles including three cohort studies and nine case–control studies were included in the meta-analysis. Both the meta-analyses of cohort studies and case–control studies showed significant associations. The pooled relative risk and 95 % confidence interval (CI) among cohort studies was 1.48 (1.25–1.75, p 0.001). For case–control studies, the pooled odds ratio and 95 % CI was 1.72 (1.24–2.41, p = 0.001). No indication of significant heterogeneity across studies or publication bias was observed. In conclusion, maternal diabetes was significantly associated with a greater risk of ASD in the offspring. En ligne : http://dx.doi.org/10.1007/s10803-013-1928-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228
in Journal of Autism and Developmental Disorders > 44-4 (April 2014) . - p.766-775[article] Maternal Diabetes and the Risk of Autism Spectrum Disorders in the Offspring: A Systematic Review and Meta-Analysis [Texte imprimé et/ou numérique] / Guifeng XU, Auteur ; Jin JING, Auteur ; Katherine BOWERS, Auteur ; Buyun LIU, Auteur ; Wei BAO, Auteur . - 2014 . - p.766-775.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 44-4 (April 2014) . - p.766-775
Mots-clés : Autism spectrum disorders Diabetes Pregnancy Index. décimale : PER Périodiques Résumé : We performed a systematic literature search regarding maternal diabetes before and during pregnancy and the risk of autism spectrum disorders (ASD) in the offspring. Of the 178 potentially relevant articles, 12 articles including three cohort studies and nine case–control studies were included in the meta-analysis. Both the meta-analyses of cohort studies and case–control studies showed significant associations. The pooled relative risk and 95 % confidence interval (CI) among cohort studies was 1.48 (1.25–1.75, p 0.001). For case–control studies, the pooled odds ratio and 95 % CI was 1.72 (1.24–2.41, p = 0.001). No indication of significant heterogeneity across studies or publication bias was observed. In conclusion, maternal diabetes was significantly associated with a greater risk of ASD in the offspring. En ligne : http://dx.doi.org/10.1007/s10803-013-1928-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228 Peer Relationship Problems in Children with Tourette's Disorder or Diabetes Mellitus / Harry N. BAWDEN in Journal of Child Psychology and Psychiatry, 39-5 (July 1998)
[article]
Titre : Peer Relationship Problems in Children with Tourette's Disorder or Diabetes Mellitus Type de document : Texte imprimé et/ou numérique Auteurs : Harry N. BAWDEN, Auteur ; Aidan STOKES, Auteur ; Carol S. CAMFIELD, Auteur ; Peter R. CAMFIELD, Auteur ; Sonia SALISBURY, Auteur Année de publication : 1998 Article en page(s) : p.663-668 Langues : Anglais (eng) Mots-clés : Diabetes Tourette's disorder intelligence peer relationships Index. décimale : PER Périodiques Résumé : Peer relationships, social skills, self-esteem, parental psychopathology, and family functioning of children with Tourette's disorder and a chronic disease control group of children with diabetes mellitus were compared. Children with Tourette's disorder had poorer peer relationships than their classmates and were more likely to have extreme scores reflecting increased risk for peer relationship problems than children with diabetes mellitus, but did not report self-esteem problems or social skills deficits. Measures of peer relationships were not related to severity or duration of tics. Children with Tourette's disorder and Attention Deficit Hyperactivity Disorder were at increased risk for poor peer relationships. The psychosocial problems of children with Tourette's disorder do not appear to be the generic result of having a chronic disease. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=123
in Journal of Child Psychology and Psychiatry > 39-5 (July 1998) . - p.663-668[article] Peer Relationship Problems in Children with Tourette's Disorder or Diabetes Mellitus [Texte imprimé et/ou numérique] / Harry N. BAWDEN, Auteur ; Aidan STOKES, Auteur ; Carol S. CAMFIELD, Auteur ; Peter R. CAMFIELD, Auteur ; Sonia SALISBURY, Auteur . - 1998 . - p.663-668.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 39-5 (July 1998) . - p.663-668
Mots-clés : Diabetes Tourette's disorder intelligence peer relationships Index. décimale : PER Périodiques Résumé : Peer relationships, social skills, self-esteem, parental psychopathology, and family functioning of children with Tourette's disorder and a chronic disease control group of children with diabetes mellitus were compared. Children with Tourette's disorder had poorer peer relationships than their classmates and were more likely to have extreme scores reflecting increased risk for peer relationship problems than children with diabetes mellitus, but did not report self-esteem problems or social skills deficits. Measures of peer relationships were not related to severity or duration of tics. Children with Tourette's disorder and Attention Deficit Hyperactivity Disorder were at increased risk for poor peer relationships. The psychosocial problems of children with Tourette's disorder do not appear to be the generic result of having a chronic disease. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=123 Autism-specific maternal anti-fetal brain autoantibodies are associated with metabolic conditions / Paula KRAKOWIAK in Autism Research, 10-1 (January 2017)
[article]
Titre : Autism-specific maternal anti-fetal brain autoantibodies are associated with metabolic conditions Type de document : Texte imprimé et/ou numérique Auteurs : Paula KRAKOWIAK, Auteur ; Cheryl K. WALKER, Auteur ; Daniel J. TANCREDI, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Judy VAN DE WATER, Auteur Article en page(s) : p.89-98 Langues : Anglais (eng) Mots-clés : autism pregnancy maternal autoantibodies anti-fetal brain autoantibodies metabolic conditions diabetes Index. décimale : PER Périodiques Résumé : Approximately 23% of mothers of children with autism spectrum disorder (ASD) produce specific patterns of autoantibodies to fetal brain proteins that have been detected in only 1% of mothers of typically developing children. The biological mechanisms underlying the development of ASD-specific maternal autoantibodies are poorly understood. We sought to determine whether ASD-specific maternal autoantibodies identified postnatally were associated with metabolic conditions (MCs) during gestation. Participants were 227 mothers of 2–5 year old children with confirmed ASD, enrolled in CHARGE (Childhood Autism Risk from Genetics and the Environment) between January 2003 and April 2008, and from whom blood samples were collected and analyzed for anti-fetal brain autoantibodies (Ab+). MCs included diabetes, hypertensive disorders, and prepregnancy obesity or overweight, ascertained from medical records or structured telephone interviews. Log-linear regression models were performed to estimate prevalence ratios and 95% confidence intervals (CI) based on robust standard errors. Fifty-six (25%) mothers were Ab+. Ab+ prevalence was higher among mothers with diabetes, hypertensive disorders, or overweight compared to healthy mothers, but differences were not statistically significant. In a subset of 145 mothers whose children exhibited severe ASD (31 Ab+), those diagnosed with type 2 or gestational diabetes were 2.7-fold more likely to be Ab+ (95% CI 1.1, 6.6), controlling for delivery payer and smoking. Gestational diabetes specifically was associated with a 3.2-fold increased Ab+ prevalence (95% CI 1.2, 8.6). In this exploratory study, mothers whose children had severe ASD and who experienced diabetes were more likely to have anti-fetal brain autoantibodies 2–5 years later. En ligne : http://dx.doi.org/10.1002/aur.1657 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303
in Autism Research > 10-1 (January 2017) . - p.89-98[article] Autism-specific maternal anti-fetal brain autoantibodies are associated with metabolic conditions [Texte imprimé et/ou numérique] / Paula KRAKOWIAK, Auteur ; Cheryl K. WALKER, Auteur ; Daniel J. TANCREDI, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Judy VAN DE WATER, Auteur . - p.89-98.
Langues : Anglais (eng)
in Autism Research > 10-1 (January 2017) . - p.89-98
Mots-clés : autism pregnancy maternal autoantibodies anti-fetal brain autoantibodies metabolic conditions diabetes Index. décimale : PER Périodiques Résumé : Approximately 23% of mothers of children with autism spectrum disorder (ASD) produce specific patterns of autoantibodies to fetal brain proteins that have been detected in only 1% of mothers of typically developing children. The biological mechanisms underlying the development of ASD-specific maternal autoantibodies are poorly understood. We sought to determine whether ASD-specific maternal autoantibodies identified postnatally were associated with metabolic conditions (MCs) during gestation. Participants were 227 mothers of 2–5 year old children with confirmed ASD, enrolled in CHARGE (Childhood Autism Risk from Genetics and the Environment) between January 2003 and April 2008, and from whom blood samples were collected and analyzed for anti-fetal brain autoantibodies (Ab+). MCs included diabetes, hypertensive disorders, and prepregnancy obesity or overweight, ascertained from medical records or structured telephone interviews. Log-linear regression models were performed to estimate prevalence ratios and 95% confidence intervals (CI) based on robust standard errors. Fifty-six (25%) mothers were Ab+. Ab+ prevalence was higher among mothers with diabetes, hypertensive disorders, or overweight compared to healthy mothers, but differences were not statistically significant. In a subset of 145 mothers whose children exhibited severe ASD (31 Ab+), those diagnosed with type 2 or gestational diabetes were 2.7-fold more likely to be Ab+ (95% CI 1.1, 6.6), controlling for delivery payer and smoking. Gestational diabetes specifically was associated with a 3.2-fold increased Ab+ prevalence (95% CI 1.2, 8.6). In this exploratory study, mothers whose children had severe ASD and who experienced diabetes were more likely to have anti-fetal brain autoantibodies 2–5 years later. En ligne : http://dx.doi.org/10.1002/aur.1657 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 Health-Related Quality of Life in Pediatric Patients with Syndromic Autism and their Caregivers / C. BOLBOCEAN in Journal of Autism and Developmental Disorders, 52-3 (March 2022)
[article]
Titre : Health-Related Quality of Life in Pediatric Patients with Syndromic Autism and their Caregivers Type de document : Texte imprimé et/ou numérique Auteurs : C. BOLBOCEAN, Auteur ; F. N. ANDÚJAR, Auteur ; M. MCCORMACK, Auteur ; B. SUTER, Auteur ; J. L. HOLDER, Auteur Article en page(s) : p.1334-1345 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/genetics Autistic Disorder Caregivers Child Chromosome Disorders/genetics Humans Intellectual Disability/diagnosis Quality of Life Autism spectrum disorder Beach center family quality of life Clinical research Diabetes Health related quality of life Idiopathic autism Intellectual disability Pediatric quality of life inventory Phelan-McDermid syndrome Rett syndrome SYNGAP1 related intellectual disability Index. décimale : PER Périodiques Résumé : Children with autism have a significantly lower quality of life compared with their neurotypical peers. While multiple studies have quantified the impact of autism on health-related quality of life (HRQoL) through standardized surveys such as the PedsQL, none have specifically investigated the impact of syndromic autism. Here we evaluate HRQoL in children diagnosed with three genetic disorders that strongly predispose to syndromic autism: Phelan-McDermid syndrome (PMD), Rett syndrome (RTT), and SYNGAP1-related intellectual disability (SYNGAP1-ID). We find the most severely impacted dimension is physical functioning. Strikingly, syndromic autism results in worse quality of life than other chronic disorders including idiopathic autism. This study demonstrates the utility of caregiver surveys in prioritizing phenotypes, which may be targeted as clinical endpoints for genetically defined ASDs. En ligne : http://dx.doi.org/10.1007/s10803-021-05030-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455
in Journal of Autism and Developmental Disorders > 52-3 (March 2022) . - p.1334-1345[article] Health-Related Quality of Life in Pediatric Patients with Syndromic Autism and their Caregivers [Texte imprimé et/ou numérique] / C. BOLBOCEAN, Auteur ; F. N. ANDÚJAR, Auteur ; M. MCCORMACK, Auteur ; B. SUTER, Auteur ; J. L. HOLDER, Auteur . - p.1334-1345.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-3 (March 2022) . - p.1334-1345
Mots-clés : Autism Spectrum Disorder/genetics Autistic Disorder Caregivers Child Chromosome Disorders/genetics Humans Intellectual Disability/diagnosis Quality of Life Autism spectrum disorder Beach center family quality of life Clinical research Diabetes Health related quality of life Idiopathic autism Intellectual disability Pediatric quality of life inventory Phelan-McDermid syndrome Rett syndrome SYNGAP1 related intellectual disability Index. décimale : PER Périodiques Résumé : Children with autism have a significantly lower quality of life compared with their neurotypical peers. While multiple studies have quantified the impact of autism on health-related quality of life (HRQoL) through standardized surveys such as the PedsQL, none have specifically investigated the impact of syndromic autism. Here we evaluate HRQoL in children diagnosed with three genetic disorders that strongly predispose to syndromic autism: Phelan-McDermid syndrome (PMD), Rett syndrome (RTT), and SYNGAP1-related intellectual disability (SYNGAP1-ID). We find the most severely impacted dimension is physical functioning. Strikingly, syndromic autism results in worse quality of life than other chronic disorders including idiopathic autism. This study demonstrates the utility of caregiver surveys in prioritizing phenotypes, which may be targeted as clinical endpoints for genetically defined ASDs. En ligne : http://dx.doi.org/10.1007/s10803-021-05030-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 Understanding environmental contributions to autism: Causal concepts and the state of science / I. HERTZ-PICCIOTTO in Autism Research, 11-4 (April 2018)
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