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Auteur Hilary H. COON
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Documents disponibles écrits par cet auteur (16)
 
                
             
            
                
                     
                
             
						
					
						
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					   Faire une suggestion  Affiner la rechercheAre There Enhanced MBP Autoantibodies in Autism? / Jane E. LIBBEY in Journal of Autism and Developmental Disorders, 38-2 (February 2008)

Titre : Are There Enhanced MBP Autoantibodies in Autism? Type de document : texte imprimé Auteurs : Jane E. LIBBEY, Auteur ; William M. MCMAHON, Auteur ; Janet E. LAINHART, Auteur ; Hilary H. COON, Auteur ; Nikki J. KIRKMAN, Auteur ; Thayne L. SWEETEN, Auteur ; Judith N. MILLER, Auteur ; Edward K. STEVENSON, Auteur ; Robert S. FUJINAMI, Auteur Année de publication : 2008 Article en page(s) : p.324-332 Langues : Anglais (eng) Mots-clés : Autism Tourette-syndrome Autoantibody Myelin-basic-protein Immunoglobulin Index. décimale : PER Périodiques Résumé : Autoantibodies to central nervous system antigens, such as myelin basic protein (MBP), may play a role in autism. We measured autoantibody titers to MBP in children with autism, both classic onset and regressive onset forms, controls (healthy age- and gender-matched) and individuals with Tourette syndrome via enzyme-linked immunosorbent assays. We found a significant difference in autoantibody titers to MBP, not accounted for by age or medication, between Tourette and classic autism (both significantly lower) when compared to regressive autism, but not when compared to controls. Autoantibody responses against MBP are unlikely to play a pathogenic role in autism. En ligne : http://dx.doi.org/10.1007/s10803-007-0400-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=318 
in Journal of Autism and Developmental Disorders > 38-2 (February 2008) . - p.324-332[article] Are There Enhanced MBP Autoantibodies in Autism? [texte imprimé] / Jane E. LIBBEY, Auteur ; William M. MCMAHON, Auteur ; Janet E. LAINHART, Auteur ; Hilary H. COON, Auteur ; Nikki J. KIRKMAN, Auteur ; Thayne L. SWEETEN, Auteur ; Judith N. MILLER, Auteur ; Edward K. STEVENSON, Auteur ; Robert S. FUJINAMI, Auteur . - 2008 . - p.324-332.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 38-2 (February 2008) . - p.324-332
Mots-clés : Autism Tourette-syndrome Autoantibody Myelin-basic-protein Immunoglobulin Index. décimale : PER Périodiques Résumé : Autoantibodies to central nervous system antigens, such as myelin basic protein (MBP), may play a role in autism. We measured autoantibody titers to MBP in children with autism, both classic onset and regressive onset forms, controls (healthy age- and gender-matched) and individuals with Tourette syndrome via enzyme-linked immunosorbent assays. We found a significant difference in autoantibody titers to MBP, not accounted for by age or medication, between Tourette and classic autism (both significantly lower) when compared to regressive autism, but not when compared to controls. Autoantibody responses against MBP are unlikely to play a pathogenic role in autism. En ligne : http://dx.doi.org/10.1007/s10803-007-0400-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=318 Autism Spectrum Disorder Reclassified: A Second Look at the 1980s Utah/UCLA Autism Epidemiologic Study / Judith S. MILLER in Journal of Autism and Developmental Disorders, 43-1 (January 2013)

Titre : Autism Spectrum Disorder Reclassified: A Second Look at the 1980s Utah/UCLA Autism Epidemiologic Study Type de document : texte imprimé Auteurs : Judith S. MILLER, Auteur ; Deborah A. BILDER, Auteur ; Megan A. FARLEY, Auteur ; Hilary H. COON, Auteur ; Judith PINBOROUGH-ZIMMERMAN, Auteur ; William R. JENSON, Auteur ; Catherine E. RICE, Auteur ; Eric FOMBONNE, Auteur ; Carmen B. PINGREE, Auteur ; Edward R. RITVO, Auteur ; Riva-Ariella RITVO, Auteur ; William M. MCMAHON, Auteur Année de publication : 2013 Article en page(s) : p.200-210 Langues : Anglais (eng) Mots-clés : Autism Epidemiology Prevalence Diagnostic criteria Intellectual disability Index. décimale : PER Périodiques Résumé : The purpose of the present study was to re-examine diagnostic data from a state-wide autism prevalence study (n = 489) conducted in the 1980s to investigate the impact of broader diagnostic criteria on autism spectrum disorder (ASD) case status. Sixty-four (59 %) of the 108 originally 'Diagnosed Not Autistic' met the current ASD case definition. The average IQ estimate in the newly identified group (IQ = 35.58; SD = 23.01) was significantly lower than in the original group (IQ = 56.19 SD = 21.21; t = 5.75; p .0001). Today's diagnostic criteria applied to participants ascertained in the 1980s identified more cases of autism with intellectual disability. The current analysis puts this historic work into context and highlights differences in ascertainment between epidemiological studies performed decades ago and those of today. En ligne : http://dx.doi.org/10.1007/s10803-012-1566-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187 
in Journal of Autism and Developmental Disorders > 43-1 (January 2013) . - p.200-210[article] Autism Spectrum Disorder Reclassified: A Second Look at the 1980s Utah/UCLA Autism Epidemiologic Study [texte imprimé] / Judith S. MILLER, Auteur ; Deborah A. BILDER, Auteur ; Megan A. FARLEY, Auteur ; Hilary H. COON, Auteur ; Judith PINBOROUGH-ZIMMERMAN, Auteur ; William R. JENSON, Auteur ; Catherine E. RICE, Auteur ; Eric FOMBONNE, Auteur ; Carmen B. PINGREE, Auteur ; Edward R. RITVO, Auteur ; Riva-Ariella RITVO, Auteur ; William M. MCMAHON, Auteur . - 2013 . - p.200-210.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 43-1 (January 2013) . - p.200-210
Mots-clés : Autism Epidemiology Prevalence Diagnostic criteria Intellectual disability Index. décimale : PER Périodiques Résumé : The purpose of the present study was to re-examine diagnostic data from a state-wide autism prevalence study (n = 489) conducted in the 1980s to investigate the impact of broader diagnostic criteria on autism spectrum disorder (ASD) case status. Sixty-four (59 %) of the 108 originally 'Diagnosed Not Autistic' met the current ASD case definition. The average IQ estimate in the newly identified group (IQ = 35.58; SD = 23.01) was significantly lower than in the original group (IQ = 56.19 SD = 21.21; t = 5.75; p .0001). Today's diagnostic criteria applied to participants ascertained in the 1980s identified more cases of autism with intellectual disability. The current analysis puts this historic work into context and highlights differences in ascertainment between epidemiological studies performed decades ago and those of today. En ligne : http://dx.doi.org/10.1007/s10803-012-1566-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187 Brief Report: Genetic Links Between Autism and Suicidal Behavior-A Preliminary Investigation / Emily DIBLASI in Journal of Autism and Developmental Disorders, 50-10 (October 2020)

Titre : Brief Report: Genetic Links Between Autism and Suicidal Behavior-A Preliminary Investigation Type de document : texte imprimé Auteurs : Emily DIBLASI, Auteur ; Anne V. KIRBY, Auteur ; Eoin GAJ, Auteur ; Anna R. DOCHERTY, Auteur ; Brooks R. KEESHIN, Auteur ; Amanda V. BAKIAN, Auteur ; Hilary H. COON, Auteur Article en page(s) : p.3525-3530 Langues : Anglais (eng) Mots-clés : Autism Gene set enrichment Genetic Suicide publicly-available databases and existing published literature no direct research was conducted with human participants nor animals. No informed consent procedures were used. Index. décimale : PER Périodiques Résumé : Evidence suggests there may be increased risk for suicidal behavior among individuals with autism spectrum disorder (ASD). An emerging body of research explores social factors that may contribute to increased risk, however little is known about the potential role of biological factors. The current project addresses this knowledge gap through a preliminary study of genes associated with both ASD and suicidal behavior. Gene set enrichment tests of eight genes strongly associated with both ASD and suicidal behavior revealed overrepresentation of nine biological processes, including cognition and synapse function, and 14 cellular components, including the neuron, the synapse, and the synaptic and postsynaptic membrane. These results can be used to inform future investigations of the biological underpinnings of suicidal behavior and ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04419-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432 
in Journal of Autism and Developmental Disorders > 50-10 (October 2020) . - p.3525-3530[article] Brief Report: Genetic Links Between Autism and Suicidal Behavior-A Preliminary Investigation [texte imprimé] / Emily DIBLASI, Auteur ; Anne V. KIRBY, Auteur ; Eoin GAJ, Auteur ; Anna R. DOCHERTY, Auteur ; Brooks R. KEESHIN, Auteur ; Amanda V. BAKIAN, Auteur ; Hilary H. COON, Auteur . - p.3525-3530.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 50-10 (October 2020) . - p.3525-3530
Mots-clés : Autism Gene set enrichment Genetic Suicide publicly-available databases and existing published literature no direct research was conducted with human participants nor animals. No informed consent procedures were used. Index. décimale : PER Périodiques Résumé : Evidence suggests there may be increased risk for suicidal behavior among individuals with autism spectrum disorder (ASD). An emerging body of research explores social factors that may contribute to increased risk, however little is known about the potential role of biological factors. The current project addresses this knowledge gap through a preliminary study of genes associated with both ASD and suicidal behavior. Gene set enrichment tests of eight genes strongly associated with both ASD and suicidal behavior revealed overrepresentation of nine biological processes, including cognition and synapse function, and 14 cellular components, including the neuron, the synapse, and the synaptic and postsynaptic membrane. These results can be used to inform future investigations of the biological underpinnings of suicidal behavior and ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04419-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432 A description of medical conditions in adults with autism spectrum disorder: A follow-up of the 1980s Utah/UCLA Autism Epidemiologic Study / Kyle B. JONES in Autism, 20-5 (July 2016)

Titre : A description of medical conditions in adults with autism spectrum disorder: A follow-up of the 1980s Utah/UCLA Autism Epidemiologic Study Type de document : texte imprimé Auteurs : Kyle B. JONES, Auteur ; Kristina J. COTTLE, Auteur ; Amanda V. BAKIAN, Auteur ; Megan FARLEY, Auteur ; Deborah A. BILDER, Auteur ; Hilary H. COON, Auteur ; William M MCMAHON, Auteur Article en page(s) : p.551-561 Langues : Anglais (eng) Mots-clés : autism spectrum disorder medical comorbidity Index. décimale : PER Périodiques Résumé : This study describes medical conditions experienced by a population-based cohort of adults with autism spectrum disorder whose significant developmental concerns were apparent during childhood. As part of a 25-year outcome study of autism spectrum disorder in adulthood, medical histories were collected on 92 participants (N = 69 males) who were first ascertained as children in the mid-1980s, 11 of whom were deceased at the time of follow-up. Questionnaires queried medical symptoms, disorders, hospitalizations, surgeries, and medication use. Median age at follow-up was 36 years (range: 23.5–50.5 years), and intellectual disability co-occurred in 62%. The most common medical conditions were seizures, obesity, insomnia, and constipation. The median number of medical conditions per person was 11. Increased medical comorbidity was associated with female gender (p = 0.01) and obesity (p = 0.03), but not intellectual disability (p = 0.79). Adults in this cohort of autism spectrum disorder first ascertained in the 1980s experience a high number of chronic medical conditions, regardless of intellectual ability. Understanding of these conditions commonly experienced should direct community-based and medical primary care for this population. En ligne : http://dx.doi.org/10.1177/1362361315594798 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290 
in Autism > 20-5 (July 2016) . - p.551-561[article] A description of medical conditions in adults with autism spectrum disorder: A follow-up of the 1980s Utah/UCLA Autism Epidemiologic Study [texte imprimé] / Kyle B. JONES, Auteur ; Kristina J. COTTLE, Auteur ; Amanda V. BAKIAN, Auteur ; Megan FARLEY, Auteur ; Deborah A. BILDER, Auteur ; Hilary H. COON, Auteur ; William M MCMAHON, Auteur . - p.551-561.
Langues : Anglais (eng)
in Autism > 20-5 (July 2016) . - p.551-561
Mots-clés : autism spectrum disorder medical comorbidity Index. décimale : PER Périodiques Résumé : This study describes medical conditions experienced by a population-based cohort of adults with autism spectrum disorder whose significant developmental concerns were apparent during childhood. As part of a 25-year outcome study of autism spectrum disorder in adulthood, medical histories were collected on 92 participants (N = 69 males) who were first ascertained as children in the mid-1980s, 11 of whom were deceased at the time of follow-up. Questionnaires queried medical symptoms, disorders, hospitalizations, surgeries, and medication use. Median age at follow-up was 36 years (range: 23.5–50.5 years), and intellectual disability co-occurred in 62%. The most common medical conditions were seizures, obesity, insomnia, and constipation. The median number of medical conditions per person was 11. Increased medical comorbidity was associated with female gender (p = 0.01) and obesity (p = 0.03), but not intellectual disability (p = 0.79). Adults in this cohort of autism spectrum disorder first ascertained in the 1980s experience a high number of chronic medical conditions, regardless of intellectual ability. Understanding of these conditions commonly experienced should direct community-based and medical primary care for this population. En ligne : http://dx.doi.org/10.1177/1362361315594798 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290 Excess Mortality and Causes of Death in Autism Spectrum Disorders: A Follow up of the 1980s Utah/UCLA Autism Epidemiologic Study / Deborah A. BILDER in Journal of Autism and Developmental Disorders, 43-5 (May 2013)

Titre : Excess Mortality and Causes of Death in Autism Spectrum Disorders: A Follow up of the 1980s Utah/UCLA Autism Epidemiologic Study Type de document : texte imprimé Auteurs : Deborah A. BILDER, Auteur ; Elizabeth L. BOTTS, Auteur ; Ken R. SMITH, Auteur ; Richard PIMENTEL, Auteur ; Megan A. FARLEY, Auteur ; Joseph VISKOCHIL, Auteur ; William M. MCMAHON, Auteur ; Heidi BLOCK, Auteur ; Edward R. RITVO, Auteur ; Riva-Ariella RITVO, Auteur ; Hilary H. COON, Auteur Article en page(s) : p.1196-1204 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Mortality Causes of death Epilepsy Intellectual disability Index. décimale : PER Périodiques Résumé : This study’s purpose was to investigate mortality among individuals with autism spectrum disorders (ASD) ascertained during a 1980s statewide autism prevalence study (n = 305) in relation to controls. Twenty-nine of these individuals (9.5 %) died by the time of follow up, representing a hazard rate ratio of 9.9 (95 % CI 5.7–17.2) in relation to population controls. Death certificates identified respiratory, cardiac, and epileptic events as the most common causes of death. The elevated mortality risk associated with ASD in the study cohort appeared related to the presence of comorbid medical conditions and intellectual disability rather than ASD itself suggesting the importance of coordinated medical care for this high risk sub-population of individuals with ASD. En ligne : http://dx.doi.org/10.1007/s10803-012-1664-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=195 
in Journal of Autism and Developmental Disorders > 43-5 (May 2013) . - p.1196-1204[article] Excess Mortality and Causes of Death in Autism Spectrum Disorders: A Follow up of the 1980s Utah/UCLA Autism Epidemiologic Study [texte imprimé] / Deborah A. BILDER, Auteur ; Elizabeth L. BOTTS, Auteur ; Ken R. SMITH, Auteur ; Richard PIMENTEL, Auteur ; Megan A. FARLEY, Auteur ; Joseph VISKOCHIL, Auteur ; William M. MCMAHON, Auteur ; Heidi BLOCK, Auteur ; Edward R. RITVO, Auteur ; Riva-Ariella RITVO, Auteur ; Hilary H. COON, Auteur . - p.1196-1204.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 43-5 (May 2013) . - p.1196-1204
Mots-clés : Autism spectrum disorders Mortality Causes of death Epilepsy Intellectual disability Index. décimale : PER Périodiques Résumé : This study’s purpose was to investigate mortality among individuals with autism spectrum disorders (ASD) ascertained during a 1980s statewide autism prevalence study (n = 305) in relation to controls. Twenty-nine of these individuals (9.5 %) died by the time of follow up, representing a hazard rate ratio of 9.9 (95 % CI 5.7–17.2) in relation to population controls. Death certificates identified respiratory, cardiac, and epileptic events as the most common causes of death. The elevated mortality risk associated with ASD in the study cohort appeared related to the presence of comorbid medical conditions and intellectual disability rather than ASD itself suggesting the importance of coordinated medical care for this high risk sub-population of individuals with ASD. En ligne : http://dx.doi.org/10.1007/s10803-012-1664-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=195 Genome-wide linkage analyses of two repetitive behavior phenotypes in Utah pedigrees with autism spectrum disorders / Dale CANNON in Molecular Autism, (February 2010)

PermalinkGenome-wide linkage using the Social Responsiveness Scale in Utah autism pedigrees / Hilary H. COON in Molecular Autism, (April 2010)

PermalinkHow Relevant are GFAP Autoantibodies in Autism and Tourette Syndrome? / Nikki J. KIRKMAN in Journal of Autism and Developmental Disorders, 38-2 (February 2008)

PermalinkMid‐life social outcomes for a population‐based sample of adults with ASD / Megan FARLEY in Autism Research, 11-1 (January 2018)

PermalinkNarrowing the broader autism phenotype: A study using the Communication Checklist - Adult Version (CC-A) / Andrew J. O. WHITEHOUSE in Autism, 14-6 (November 2010)

PermalinkNo evidence for IL1RAPL1 involvement in selected high-risk autism pedigrees from the AGRE data set / Kristina ALLEN-BRADY in Autism Research, 4-4 (August 2011)

PermalinkPsychiatric Comorbidity and Medication Use in Adults with Autism Spectrum Disorder / Tara R. BUCK in Journal of Autism and Developmental Disorders, 44-12 (December 2014)

PermalinkSpatial Relative Risk Patterns of Autism Spectrum Disorders in Utah / Amanda V. BAKIAN in Journal of Autism and Developmental Disorders, 45-4 (April 2015)

PermalinkThe Autism Simplex Collection: an international, expertly phenotyped autism sample for genetic and phenotypic analyses / Joseph D. BUXBAUM in Molecular Autism, (May 2014)

PermalinkUnderstanding heterogeneity in suicidal thoughts and behaviours and the implications for genetic studies - a commentary on Lannoy et al. (2022) / Salahudeen MIRZA in Journal of Child Psychology and Psychiatry, 64-6 (June 2023)

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