[article] 
inJournal of Child Psychology and Psychiatry > 62-8 (August 2021) . - p.961-970

Titre :	Investigating associations between birth order and autism diagnostic phenotypes
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Gail A. ALVARES, Auteur ; M. K. LICARI, Auteur ; P. G. STEVENSON, Auteur ; Keely BEBBINGTON, Auteur ; Matthew N. COOPER, Auteur ; E. J. GLASSON, Auteur ; D. W. TAN, Auteur ; M. ULJAREVIC, Auteur ; Kandice J. VARCIN, Auteur ; J. WRAY, Auteur ; Andrew J. O. WHITEHOUSE, Auteur
Article en page(s) :	p.961-970
Langues :	Anglais (eng)
Mots-clés :	Autism Spectrum Disorder/diagnosis/epidemiology  Autistic Disorder  Birth Order  Child, Preschool  Female  Humans  Male  Phenotype  Prospective Studies  Autism spectrum disorder  diagnosis  first birth  intellectual disability
Index. décimale :	PER Périodiques
Résumé :	BACKGROUND: Birth order effects have been linked to variability in intelligence, educational attainment and sexual orientation. First- and later-born children have been linked to an increased likelihood of an Autism Spectrum Disorder (ASD) diagnosis, with a smaller body of evidence implicating decreases in cognitive functioning with increased birth order. The present study investigated the potential association between birth order and ASD diagnostic phenotypes in a large and representative population sample. METHODS: Data were obtained from an ongoing prospective diagnostic registry, collected between 1999 and 2017, including children (1-18 years of age, n = 5,404) diagnosed with ASD in the state of Western Australia. Children with ASD were ranked relative to sibling's birth to establish birth order within families at time of ASD diagnosis. Information reported to the registry by health professionals at the time of diagnostic evaluation included demographic and family characteristics, functional abilities and intellectual capacity. RESULTS: Adaptive functioning and intelligence scores decreased with increasing birth order, with later-born children more likely to have an intellectual disability. Compared to first-born children with siblings, first-born children without siblings at the time of diagnosis also exhibited decreased cognitive functioning. CONCLUSIONS: These findings demonstrate for the first time an association between increasing birth order and variability in ASD clinical phenotypes at diagnosis, with potential evidence of reproductive curtailment in children without siblings. Taken together, these findings have significant implications for advancing understanding about the potential mechanisms that contribute to heterogeneity in ASD clinical presentations as a function of birth order and family size.
En ligne :	http://dx.doi.org/10.1111/jcpp.13349
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

[article] Investigating associations between birth order and autism diagnostic phenotypes [Texte imprimé et/ou numérique] / Gail A. ALVARES, Auteur ; M. K. LICARI, Auteur ; P. G. STEVENSON, Auteur ; Keely BEBBINGTON, Auteur ; Matthew N. COOPER, Auteur ; E. J. GLASSON, Auteur ; D. W. TAN, Auteur ; M. ULJAREVIC, Auteur ; Kandice J. VARCIN, Auteur ; J. WRAY, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - p.961-970.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 62-8 (August 2021) . - p.961-970

Mots-clés :	Autism Spectrum Disorder/diagnosis/epidemiology  Autistic Disorder  Birth Order  Child, Preschool  Female  Humans  Male  Phenotype  Prospective Studies  Autism spectrum disorder  diagnosis  first birth  intellectual disability
Index. décimale :	PER Périodiques
Résumé :	BACKGROUND: Birth order effects have been linked to variability in intelligence, educational attainment and sexual orientation. First- and later-born children have been linked to an increased likelihood of an Autism Spectrum Disorder (ASD) diagnosis, with a smaller body of evidence implicating decreases in cognitive functioning with increased birth order. The present study investigated the potential association between birth order and ASD diagnostic phenotypes in a large and representative population sample. METHODS: Data were obtained from an ongoing prospective diagnostic registry, collected between 1999 and 2017, including children (1-18 years of age, n = 5,404) diagnosed with ASD in the state of Western Australia. Children with ASD were ranked relative to sibling's birth to establish birth order within families at time of ASD diagnosis. Information reported to the registry by health professionals at the time of diagnostic evaluation included demographic and family characteristics, functional abilities and intellectual capacity. RESULTS: Adaptive functioning and intelligence scores decreased with increasing birth order, with later-born children more likely to have an intellectual disability. Compared to first-born children with siblings, first-born children without siblings at the time of diagnosis also exhibited decreased cognitive functioning. CONCLUSIONS: These findings demonstrate for the first time an association between increasing birth order and variability in ASD clinical phenotypes at diagnosis, with potential evidence of reproductive curtailment in children without siblings. Taken together, these findings have significant implications for advancing understanding about the potential mechanisms that contribute to heterogeneity in ASD clinical presentations as a function of birth order and family size.
En ligne :	http://dx.doi.org/10.1111/jcpp.13349
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456