[article] 
inJournal of Child Psychology and Psychiatry > 62-11 (November 2021) . - p.1363-1373

Titre :	Ethical dimensions of translational developmental neuroscience research in autism
Type de document :	Texte imprimé et/ou numérique
Auteurs :	A. MANZINI, Auteur ; E. J. H. JONES, Auteur ; Tony CHARMAN, Auteur ; M. ELSABBAGH, Auteur ; M. H. JOHNSON, Auteur ; I. SINGH, Auteur
Article en page(s) :	p.1363-1373
Langues :	Anglais (eng)
Mots-clés :	Autism Spectrum Disorder/diagnosis/genetics  Autistic Disorder  Brain  Child  Early Intervention, Educational  Humans  Neurosciences  Parents  Autism  biomarkers  ethics  genetics  infant siblings  neurodevelopment  Ltd. and Servier  and has received royalties from Sage Publications and Guilford  Publications.
Index. décimale :	PER Périodiques
Résumé :	BACKGROUND: Since the 1990s, increasing research has been devoted to the identification of biomarkers for autism to help attain more objective diagnosis; enable early prediction of prognosis; and guide individualized intervention options. Early studies focused on the identification of genetic variants associated with autism, but more recently, research has expanded to investigate neurodevelopmental markers. While ethicists have extensively discussed issues around advances in autism genomics, much less ethical scrutiny has focused on research on early neurodevelopment and on the interventions being developed as a result. OBJECTIVES: We summarize the current state of the science on the identification of early markers for autism and its potential clinical applications, before providing an overview of the ethical issues arising from increasing understanding of children's neurodevelopment in very early life. RESULTS: Advances in the understanding of brain and behavioral trajectories preceding later autism diagnosis raise ethical concerns around three themes: (a) New models for understanding autism; (b) Risks and benefits of early identification and intervention; and (c) Communication of early concerns to families. These ethical issues should be further investigated in research conducted in partnership with autistic people and their families. CONCLUSIONS: This paper highlights the need for ethical scrutiny of early neurodevelopmental research in autism. Scrutiny requires expertise and methods from the basic sciences and bioethics, as well as constructive collaborations among autistic people, their parents, and autism researchers to anticipate early interventions that serve the community's interests and accommodate the varied experiences and preferences of people on the spectrum and their families.
En ligne :	http://dx.doi.org/10.1111/jcpp.13494
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

[article] Ethical dimensions of translational developmental neuroscience research in autism [Texte imprimé et/ou numérique] / A. MANZINI, Auteur ; E. J. H. JONES, Auteur ; Tony CHARMAN, Auteur ; M. ELSABBAGH, Auteur ; M. H. JOHNSON, Auteur ; I. SINGH, Auteur . - p.1363-1373.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 62-11 (November 2021) . - p.1363-1373

Mots-clés :	Autism Spectrum Disorder/diagnosis/genetics  Autistic Disorder  Brain  Child  Early Intervention, Educational  Humans  Neurosciences  Parents  Autism  biomarkers  ethics  genetics  infant siblings  neurodevelopment  Ltd. and Servier  and has received royalties from Sage Publications and Guilford  Publications.
Index. décimale :	PER Périodiques
Résumé :	BACKGROUND: Since the 1990s, increasing research has been devoted to the identification of biomarkers for autism to help attain more objective diagnosis; enable early prediction of prognosis; and guide individualized intervention options. Early studies focused on the identification of genetic variants associated with autism, but more recently, research has expanded to investigate neurodevelopmental markers. While ethicists have extensively discussed issues around advances in autism genomics, much less ethical scrutiny has focused on research on early neurodevelopment and on the interventions being developed as a result. OBJECTIVES: We summarize the current state of the science on the identification of early markers for autism and its potential clinical applications, before providing an overview of the ethical issues arising from increasing understanding of children's neurodevelopment in very early life. RESULTS: Advances in the understanding of brain and behavioral trajectories preceding later autism diagnosis raise ethical concerns around three themes: (a) New models for understanding autism; (b) Risks and benefits of early identification and intervention; and (c) Communication of early concerns to families. These ethical issues should be further investigated in research conducted in partnership with autistic people and their families. CONCLUSIONS: This paper highlights the need for ethical scrutiny of early neurodevelopmental research in autism. Scrutiny requires expertise and methods from the basic sciences and bioethics, as well as constructive collaborations among autistic people, their parents, and autism researchers to anticipate early interventions that serve the community's interests and accommodate the varied experiences and preferences of people on the spectrum and their families.
En ligne :	http://dx.doi.org/10.1111/jcpp.13494
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456