Comparison of three different eye-tracking tasks for distinguishing autistic from typically developing children and autistic symptom severity / Juan KOU in Autism Research, 12-10 (October 2019)  

Public ISBD [article]  inAutism Research > 12-10 (October 2019) . - p.1529-1540 Titre : Comparison of three different eye-tracking tasks for distinguishing autistic from typically developing children and autistic symptom severity Type de document : texte imprimé Auteurs : Juan KOU, Auteur ; Jiao LE, Auteur ; Meina FU, Auteur ; Chunmei LAN, Auteur ; Zhuo CHEN, Auteur ; Qiang LI, Auteur ; Weihua ZHAO, Auteur ; Lei XU, Auteur ; Benjamin BECKER, Auteur ; Keith M. KENDRICK, Auteur Article en page(s) : p.1529-1540 Langues : Anglais (eng) Mots-clés : Chinese children  attentional preference bias  autism spectrum disorder  dynamic social stimuli  eye-tracking Index. décimale : PER Périodiques Résumé : Altered patterns of visual social attention preference detected using eye-tracking and a variety of different paradigms are increasingly proposed as sensitive biomarkers for autism spectrum disorder. However, few eye-tracking studies have compared the relative efficacy of different paradigms to discriminate between autistic compared with typically developing children and their sensitivity to specific symptoms. To target this issue, the current study used three common eye-tracking protocols contrasting social versus nonsocial stimuli in young (2-7 years old) Chinese autistic (n = 35) and typically developing (n = 34) children matched for age and gender. Protocols included dancing people versus dynamic geometrical images, biological motion (dynamic light point walking human or cat) versus nonbiological motion (scrambled controls), and child playing with toy versus toy alone. Although all three paradigms differentiated autistic and typically developing children, the dancing people versus dynamic geometry pattern paradigm was the most effective, with autistic children showing marked reductions in visual preference for dancing people and correspondingly increased one for geometric patterns. Furthermore, this altered visual preference in autistic children was correlated with the Autism Diagnostic Observation Schedule social affect score and had the highest discrimination accuracy. Our results therefore indicate that decreased visual preference for dynamic social stimuli may be the most effective visual attention-based paradigm for use as a biomarker for autism in Chinese children. Clinical trial ID: NCT03286621 (clinicaltrials.gov); Clinical trial name: Development of Eye-tracking Based Markers for Autism in Young Children. Autism Res 2019, 12: 1529-1540. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Eye-tracking measures may be useful in aiding diagnosis and treatment of autism, although it is unclear which specific tasks are optimal. Here we compare the ability of three different social eye-gaze tasks to discriminate between autistic and typically developing young Chinese children and their sensitivity to specific autistic symptoms. Our results show that a dynamic task comparing visual preference for social (individuals dancing) versus geometric patterns is the most effective both for diagnosing autism and sensitivity to its social affect symptoms. En ligne : http://dx.doi.org/10.1002/aur.2174 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 [article] Comparison of three different eye-tracking tasks for distinguishing autistic from typically developing children and autistic symptom severity [texte imprimé] / Juan KOU, Auteur ; Jiao LE, Auteur ; Meina FU, Auteur ; Chunmei LAN, Auteur ; Zhuo CHEN, Auteur ; Qiang LI, Auteur ; Weihua ZHAO, Auteur ; Lei XU, Auteur ; Benjamin BECKER, Auteur ; Keith M. KENDRICK, Auteur . - p.1529-1540. Langues : Anglais (eng) in Autism Research > 12-10 (October 2019) . - p.1529-1540 Mots-clés : Chinese children  attentional preference bias  autism spectrum disorder  dynamic social stimuli  eye-tracking Index. décimale : PER Périodiques Résumé : Altered patterns of visual social attention preference detected using eye-tracking and a variety of different paradigms are increasingly proposed as sensitive biomarkers for autism spectrum disorder. However, few eye-tracking studies have compared the relative efficacy of different paradigms to discriminate between autistic compared with typically developing children and their sensitivity to specific symptoms. To target this issue, the current study used three common eye-tracking protocols contrasting social versus nonsocial stimuli in young (2-7 years old) Chinese autistic (n = 35) and typically developing (n = 34) children matched for age and gender. Protocols included dancing people versus dynamic geometrical images, biological motion (dynamic light point walking human or cat) versus nonbiological motion (scrambled controls), and child playing with toy versus toy alone. Although all three paradigms differentiated autistic and typically developing children, the dancing people versus dynamic geometry pattern paradigm was the most effective, with autistic children showing marked reductions in visual preference for dancing people and correspondingly increased one for geometric patterns. Furthermore, this altered visual preference in autistic children was correlated with the Autism Diagnostic Observation Schedule social affect score and had the highest discrimination accuracy. Our results therefore indicate that decreased visual preference for dynamic social stimuli may be the most effective visual attention-based paradigm for use as a biomarker for autism in Chinese children. Clinical trial ID: NCT03286621 (clinicaltrials.gov); Clinical trial name: Development of Eye-tracking Based Markers for Autism in Young Children. Autism Res 2019, 12: 1529-1540. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Eye-tracking measures may be useful in aiding diagnosis and treatment of autism, although it is unclear which specific tasks are optimal. Here we compare the ability of three different social eye-gaze tasks to discriminate between autistic and typically developing young Chinese children and their sensitivity to specific autistic symptoms. Our results show that a dynamic task comparing visual preference for social (individuals dancing) versus geometric patterns is the most effective both for diagnosing autism and sensitivity to its social affect symptoms. En ligne : http://dx.doi.org/10.1002/aur.2174 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408

A qualitative study exploring the attitudes toward prenatal genetic testing for autism spectrum disorders among parents of affected children in Taiwan / Shixi ZHAO in Research in Autism Spectrum Disorders, 48 (April 2018)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 48 (April 2018) . - p.36-43 Titre : A qualitative study exploring the attitudes toward prenatal genetic testing for autism spectrum disorders among parents of affected children in Taiwan Type de document : texte imprimé Auteurs : Shixi ZHAO, Auteur ; Chen-Hui WANG, Auteur ; Tse-Yang HUANG, Auteur ; Yann-Jang CHEN, Auteur ; Ching-Hua HSIAO, Auteur ; Chie-Chien TSENG, Auteur ; Lei XU, Auteur ; Lei-Shih CHEN, Auteur Article en page(s) : p.36-43 Langues : Anglais (eng) Mots-clés : Autism  Parents  Prenatal genetic testing  Abortion  Taiwan Index. décimale : PER Périodiques Résumé : Background Prenatal genetic testing (PGT) for Autism Spectrum Disorders (ASD) raises more complex ethical, legal, and social implications in Taiwan than in Western countries due to policy-related, practical, cultural, and familial reasons. This first qualitative study examines attitudes towards PGT for ASD among Taiwanese parents of children with ASD – an elevated risk group for having another affected child, and one that is mostly likely to be impacted by PGT for ASD. Methods We conducted in-depth, face-to-face, individual, semi-structured interviews with 39 parents of children with ASD from various ASD organizations in Taiwan. Results Most parents favored PGT for ASD mainly for terminating the affected pregnancy and receiving early intervention and treatment. Less than one-third of participants was against PGT for ASD due to perceived no value for this testing, contradiction with religion and/or personal beliefs, doubt of the test’s accuracy, or concerns about the negative consequences of the testing. Conclusion The majority of Taiwanese parents of children with ASD in this study supported PGT for ASD. Guidelines and regulations should be developed to regulate the provision and quality of this testing. Genetic counseling should also be recommended to parents of children with ASD in Taiwan. En ligne : https://doi.org/10.1016/j.rasd.2018.01.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=340 [article] A qualitative study exploring the attitudes toward prenatal genetic testing for autism spectrum disorders among parents of affected children in Taiwan [texte imprimé] / Shixi ZHAO, Auteur ; Chen-Hui WANG, Auteur ; Tse-Yang HUANG, Auteur ; Yann-Jang CHEN, Auteur ; Ching-Hua HSIAO, Auteur ; Chie-Chien TSENG, Auteur ; Lei XU, Auteur ; Lei-Shih CHEN, Auteur . - p.36-43. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 48 (April 2018) . - p.36-43 Mots-clés : Autism  Parents  Prenatal genetic testing  Abortion  Taiwan Index. décimale : PER Périodiques Résumé : Background Prenatal genetic testing (PGT) for Autism Spectrum Disorders (ASD) raises more complex ethical, legal, and social implications in Taiwan than in Western countries due to policy-related, practical, cultural, and familial reasons. This first qualitative study examines attitudes towards PGT for ASD among Taiwanese parents of children with ASD – an elevated risk group for having another affected child, and one that is mostly likely to be impacted by PGT for ASD. Methods We conducted in-depth, face-to-face, individual, semi-structured interviews with 39 parents of children with ASD from various ASD organizations in Taiwan. Results Most parents favored PGT for ASD mainly for terminating the affected pregnancy and receiving early intervention and treatment. Less than one-third of participants was against PGT for ASD due to perceived no value for this testing, contradiction with religion and/or personal beliefs, doubt of the test’s accuracy, or concerns about the negative consequences of the testing. Conclusion The majority of Taiwanese parents of children with ASD in this study supported PGT for ASD. Guidelines and regulations should be developed to regulate the provision and quality of this testing. Genetic counseling should also be recommended to parents of children with ASD in Taiwan. En ligne : https://doi.org/10.1016/j.rasd.2018.01.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=340

What Do Parents Think about Chromosomal Microarray Testing? A Qualitative Report from Parents of Children with Autism Spectrum Disorders / Lei XU in Autism Research and Treatment, 2016 (2016)  

Public ISBD [article]  inAutism Research and Treatment > 2016 (2016) Titre : What Do Parents Think about Chromosomal Microarray Testing? A Qualitative Report from Parents of Children with Autism Spectrum Disorders Type de document : texte imprimé Auteurs : Lei XU, Auteur ; Linda Crane MITCHELL, Auteur ; Alice R. RICHMAN, Auteur ; K. CLAWSON, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background. Chromosomal Microarray Analysis (CMA) is increasingly utilized to detect copy number variants among children and families affected with autism spectrum disorders (ASD). However, CMA is controversial due to possible ambiguous test findings, uncertain clinical implications, and other social and legal issues related to the test. Methods. Participants were parents of children with ASD residing in the North Eastern region of North Carolina, USA. We conducted individual, face-to-face interviews with 45 parents and inquired about their perceptions of CMA. Results. Three major themes dominated parents' perceptions of CMA. None of the parents had ever heard of the test before and the majority of the parents postulated positive attitudes toward the test. Parents' motivations in undergoing the test were attributed to finding a potential cause of ASD, to being better prepared for having another affected child, and to helping with future reproductive decisions. Perceived barriers included the cost of testing, risk/pain of CMA testing, and fear of test results. Conclusion. This study contributes to the understanding of psychosocial aspects and cultural influences towards adoption of genetic testing for ASD in clinical practice. Genetic education can aid informed decision-making related to CMA genetic testing among parents of children with ASD. En ligne : http://dx.doi.org/10.1155/2016/6852539 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=332 [article] What Do Parents Think about Chromosomal Microarray Testing? A Qualitative Report from Parents of Children with Autism Spectrum Disorders [texte imprimé] / Lei XU, Auteur ; Linda Crane MITCHELL, Auteur ; Alice R. RICHMAN, Auteur ; K. CLAWSON, Auteur. Langues : Anglais (eng) in Autism Research and Treatment > 2016 (2016) Index. décimale : PER Périodiques Résumé : Background. Chromosomal Microarray Analysis (CMA) is increasingly utilized to detect copy number variants among children and families affected with autism spectrum disorders (ASD). However, CMA is controversial due to possible ambiguous test findings, uncertain clinical implications, and other social and legal issues related to the test. Methods. Participants were parents of children with ASD residing in the North Eastern region of North Carolina, USA. We conducted individual, face-to-face interviews with 45 parents and inquired about their perceptions of CMA. Results. Three major themes dominated parents' perceptions of CMA. None of the parents had ever heard of the test before and the majority of the parents postulated positive attitudes toward the test. Parents' motivations in undergoing the test were attributed to finding a potential cause of ASD, to being better prepared for having another affected child, and to helping with future reproductive decisions. Perceived barriers included the cost of testing, risk/pain of CMA testing, and fear of test results. Conclusion. This study contributes to the understanding of psychosocial aspects and cultural influences towards adoption of genetic testing for ASD in clinical practice. Genetic education can aid informed decision-making related to CMA genetic testing among parents of children with ASD. En ligne : http://dx.doi.org/10.1155/2016/6852539 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=332

---

1 (1 - 3 / 3) Par page : 25 50 100 200