Atypical Visuospatial Processing in Autism: Insights from Functional Connectivity Analysis / Jane MCGRATH in Autism Research, 5-5 (October 2012)  

Public ISBD [article]  inAutism Research > 5-5 (October 2012) . - p.314-330 Titre : Atypical Visuospatial Processing in Autism: Insights from Functional Connectivity Analysis Type de document : Texte imprimé et/ou numérique Auteurs : Jane MCGRATH, Auteur ; Katherine A. JOHNSON, Auteur ; Christine ECKER, Auteur ; Erik O'HANLON, Auteur ; Michael GILL, Auteur ; Louise GALLAGHER, Auteur ; Hugh GARAVAN, Auteur Article en page(s) : p.314-330 Langues : Anglais (eng) Mots-clés : autism  functional MRI  visuospatial processing  mental rotation  functional connectivity Index. décimale : PER Périodiques Résumé : Atypical visuospatial processing is commonly described in autism spectrum disorders (ASDs); however the specific neurobiological underpinnings of this phenomenon are poorly understood. Given the extensive evidence suggesting ASDs are characterized by abnormal neural connectivity, this study aimed to investigate network connectivity during visuospatial processing in ASD. Twenty-two males with ASD without intellectual disability and 22 individually matched controls performed a mental rotation task during functional magnetic resonance imaging (MRI) in which two rotated stimuli were judged to be same (“Same Trials”) or mirror-imaged (“Mirror Trials”). Behavioral results revealed a relative advantage of mental rotation in the ASD group—controls were slower responding to the more difficult Mirror Trials than Same Trials whereas the ASD group completed Mirror Trials and Same-trials at similar speeds. In the ASD group, brain activity was reduced in frontal, temporal, occipital, striatal, and cerebellar regions and, consistent with previous literature, functional connectivity between a number of brain regions was reduced. However, some connections appeared to be conserved and were recruited in a qualitatively different way by the two groups. As task difficulty increased (on Mirror Trials), controls tended to increase connections between certain brain regions, whereas the ASD group appeared to suppress connections between these regions. There was an interesting exception to this pattern in the visual cortex, a finding that may suggest an advantage in early visual perceptual processing in ASD. Overall, this study has identified a relative advantage in mental rotation in ASD that is associated with aberrant neural connectivity and that may stem from enhanced visual perceptual processing. Autism Res 2012, 5: 314–330. © 2012 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1245 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=183 [article] Atypical Visuospatial Processing in Autism: Insights from Functional Connectivity Analysis [Texte imprimé et/ou numérique] / Jane MCGRATH, Auteur ; Katherine A. JOHNSON, Auteur ; Christine ECKER, Auteur ; Erik O'HANLON, Auteur ; Michael GILL, Auteur ; Louise GALLAGHER, Auteur ; Hugh GARAVAN, Auteur . - p.314-330. Langues : Anglais (eng) in Autism Research > 5-5 (October 2012) . - p.314-330 Mots-clés : autism  functional MRI  visuospatial processing  mental rotation  functional connectivity Index. décimale : PER Périodiques Résumé : Atypical visuospatial processing is commonly described in autism spectrum disorders (ASDs); however the specific neurobiological underpinnings of this phenomenon are poorly understood. Given the extensive evidence suggesting ASDs are characterized by abnormal neural connectivity, this study aimed to investigate network connectivity during visuospatial processing in ASD. Twenty-two males with ASD without intellectual disability and 22 individually matched controls performed a mental rotation task during functional magnetic resonance imaging (MRI) in which two rotated stimuli were judged to be same (“Same Trials”) or mirror-imaged (“Mirror Trials”). Behavioral results revealed a relative advantage of mental rotation in the ASD group—controls were slower responding to the more difficult Mirror Trials than Same Trials whereas the ASD group completed Mirror Trials and Same-trials at similar speeds. In the ASD group, brain activity was reduced in frontal, temporal, occipital, striatal, and cerebellar regions and, consistent with previous literature, functional connectivity between a number of brain regions was reduced. However, some connections appeared to be conserved and were recruited in a qualitatively different way by the two groups. As task difficulty increased (on Mirror Trials), controls tended to increase connections between certain brain regions, whereas the ASD group appeared to suppress connections between these regions. There was an interesting exception to this pattern in the visual cortex, a finding that may suggest an advantage in early visual perceptual processing in ASD. Overall, this study has identified a relative advantage in mental rotation in ASD that is associated with aberrant neural connectivity and that may stem from enhanced visual perceptual processing. Autism Res 2012, 5: 314–330. © 2012 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1245 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=183

Impaired conflict resolution and alerting in children with ADHD: evidence from the Attention Network Task (ANT) / Katherine A. JOHNSON in Journal of Child Psychology and Psychiatry, 49-12 (December 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-12 (December 2008) . - p.1339 - 1347 Titre : Impaired conflict resolution and alerting in children with ADHD: evidence from the Attention Network Task (ANT) Type de document : Texte imprimé et/ou numérique Auteurs : Katherine A. JOHNSON, Auteur ; Michael GILL, Auteur ; Aisling MULLIGAN, Auteur ; Ian H. ROBERTSON, Auteur ; Edwina BARRY, Auteur ; Aoife DAIBHIS, Auteur ; Michael DALY, Auteur ; Amy WATCHORN, Auteur ; Mark A. BELLGROVE, Auteur Année de publication : 2008 Article en page(s) : p.1339 - 1347 Langues : Anglais (eng) Mots-clés : ADD/ADHD Attention-Network-Task attention behavioural-genetics child-development executive-function Index. décimale : PER Périodiques Résumé : Background: An important theory of attention suggests that there are three separate networks that execute discrete cognitive functions. The 'alerting' network acquires and maintains an alert state, the 'orienting' network selects information from sensory input and the 'conflict' network resolves conflict that arises between potential responses. This theory holds promise for dissociating discrete patterns of cognitive impairment in disorders where attentional deficits may often be subtle, such as in attention deficit hyperactivity disorder (ADHD). Methods: The Attentional Network Test (ANT), a behavioural assay of the functional integrity of attention networks, was used to examine the performance of 73 children with ADHD and 73 controls. Results: Performance on the ANT clearly differentiated the children with and without ADHD in terms of mean and standard deviation (SD) of reaction time (RT), the number of incorrect responses made and the number of omission errors made. The ADHD group demonstrated deficits in the conflict network in terms of slower RT and a higher number of incorrect responses. The ADHD group showed deficits in the alerting network in terms of the number of omission errors made. There was no demonstration of a deficit in the orienting network in ADHD on this task. Conclusions: The children with ADHD demonstrated deficits in the alerting and conflict attention networks but normal functioning of the orienting network. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01936.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=645 [article] Impaired conflict resolution and alerting in children with ADHD: evidence from the Attention Network Task (ANT) [Texte imprimé et/ou numérique] / Katherine A. JOHNSON, Auteur ; Michael GILL, Auteur ; Aisling MULLIGAN, Auteur ; Ian H. ROBERTSON, Auteur ; Edwina BARRY, Auteur ; Aoife DAIBHIS, Auteur ; Michael DALY, Auteur ; Amy WATCHORN, Auteur ; Mark A. BELLGROVE, Auteur . - 2008 . - p.1339 - 1347. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-12 (December 2008) . - p.1339 - 1347 Mots-clés : ADD/ADHD Attention-Network-Task attention behavioural-genetics child-development executive-function Index. décimale : PER Périodiques Résumé : Background: An important theory of attention suggests that there are three separate networks that execute discrete cognitive functions. The 'alerting' network acquires and maintains an alert state, the 'orienting' network selects information from sensory input and the 'conflict' network resolves conflict that arises between potential responses. This theory holds promise for dissociating discrete patterns of cognitive impairment in disorders where attentional deficits may often be subtle, such as in attention deficit hyperactivity disorder (ADHD). Methods: The Attentional Network Test (ANT), a behavioural assay of the functional integrity of attention networks, was used to examine the performance of 73 children with ADHD and 73 controls. Results: Performance on the ANT clearly differentiated the children with and without ADHD in terms of mean and standard deviation (SD) of reaction time (RT), the number of incorrect responses made and the number of omission errors made. The ADHD group demonstrated deficits in the conflict network in terms of slower RT and a higher number of incorrect responses. The ADHD group showed deficits in the alerting network in terms of the number of omission errors made. There was no demonstration of a deficit in the orienting network in ADHD on this task. Conclusions: The children with ADHD demonstrated deficits in the alerting and conflict attention networks but normal functioning of the orienting network. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01936.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=645

Quicker Exogenous Orienting and Slower Endogenous Orienting in Autistic People / Shuting LI in Journal of Autism and Developmental Disorders, 55-4 (April 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-4 (April 2024) . - p.1495-1509 Titre : Quicker Exogenous Orienting and Slower Endogenous Orienting in Autistic People Type de document : Texte imprimé et/ou numérique Auteurs : Shuting LI, Auteur ; Keitaro MACHIDA, Auteur ; Emma L. BURROWS, Auteur ; Katherine A. JOHNSON, Auteur Article en page(s) : p.1495-1509 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Research is equivocal on whether attention orienting is atypical in autism. This study investigated two types of attention orienting in autistic people and accounted for the potential confounders of alerting level, co-occurring symptoms of attention-deficit/hyperactivity disorder (ADHD) and anxiety, age, and sex. Twenty-seven autistic participants (14 males; 9-43 years) and 22 age- and sex-matched non-autistic participants (13 males; 9-42 years) completed the exogenous and endogenous Posner tasks. Response time and pupillometric data were recorded. Autistic participants were faster at orienting attention to valid cues in the exogenous task and slower at disengaging from invalid cues in the endogenous task compared to non-autistic participants. With increasing age, autistic participants showed faster exogenous and endogenous orienting, whereas non-autistic participants showed faster exogenous orienting but stable speed of endogenous orienting. Higher ADHD symptoms were associated with slower exogenous orienting in both groups, whereas higher anxiety symptoms were associated with faster exogenous orienting only in autistic participants. No group differences were noted for alerting levels, sex, or pupillary responses. This study provides new evidence of superior exogenous orienting and inefficient endogenous orienting in autistic people and suggests that age and co-occurring symptoms are important to consider when assessing attention orienting in autism. En ligne : https://doi.org/10.1007/s10803-024-06311-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=550 [article] Quicker Exogenous Orienting and Slower Endogenous Orienting in Autistic People [Texte imprimé et/ou numérique] / Shuting LI, Auteur ; Keitaro MACHIDA, Auteur ; Emma L. BURROWS, Auteur ; Katherine A. JOHNSON, Auteur . - p.1495-1509. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-4 (April 2024) . - p.1495-1509 Index. décimale : PER Périodiques Résumé : Research is equivocal on whether attention orienting is atypical in autism. This study investigated two types of attention orienting in autistic people and accounted for the potential confounders of alerting level, co-occurring symptoms of attention-deficit/hyperactivity disorder (ADHD) and anxiety, age, and sex. Twenty-seven autistic participants (14 males; 9-43 years) and 22 age- and sex-matched non-autistic participants (13 males; 9-42 years) completed the exogenous and endogenous Posner tasks. Response time and pupillometric data were recorded. Autistic participants were faster at orienting attention to valid cues in the exogenous task and slower at disengaging from invalid cues in the endogenous task compared to non-autistic participants. With increasing age, autistic participants showed faster exogenous and endogenous orienting, whereas non-autistic participants showed faster exogenous orienting but stable speed of endogenous orienting. Higher ADHD symptoms were associated with slower exogenous orienting in both groups, whereas higher anxiety symptoms were associated with faster exogenous orienting only in autistic participants. No group differences were noted for alerting levels, sex, or pupillary responses. This study provides new evidence of superior exogenous orienting and inefficient endogenous orienting in autistic people and suggests that age and co-occurring symptoms are important to consider when assessing attention orienting in autism. En ligne : https://doi.org/10.1007/s10803-024-06311-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=550

Response time variability under slow and fast-incentive conditions in children with ASD, ADHD and ASD+ADHD / Charlotte TYE in Journal of Child Psychology and Psychiatry, 57-12 (December 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-12 (December 2016) . - p.1414-1423 Titre : Response time variability under slow and fast-incentive conditions in children with ASD, ADHD and ASD+ADHD Type de document : Texte imprimé et/ou numérique Auteurs : Charlotte TYE, Auteur ; Katherine A. JOHNSON, Auteur ; Simon P. KELLY, Auteur ; Philip ASHERSON, Auteur ; Jonna KUNTSI, Auteur ; Karen L. ASHWOOD, Auteur ; Bahare AZADI, Auteur ; Patrick BOLTON, Auteur ; Gráinne MCLOUGHLIN, Auteur Article en page(s) : p.1414-1423 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  attention deficit hyperactivity disorder  cognition  comorbidity  reaction time variability Index. décimale : PER Périodiques Résumé : Background Attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) show significant behavioural and genetic overlap. Both ADHD and ASD are characterised by poor performance on a range of cognitive tasks. In particular, increased response time variability (RTV) is a promising indicator of risk for both ADHD and ASD. However, it is not clear whether different indices of RTV and changes to RTV according to task conditions are able to discriminate between the two disorders. Methods Children with ASD (n = 19), ADHD (n = 18), ASD + ADHD (n = 29) and typically developing controls (TDC; n = 26) performed a four-choice RT task with slow-baseline and fast-incentive conditions. Performance was characterised by mean RT (MRT), standard deviation of RT (SD-RT), coefficient of variation (CV) and ex-Gaussian distribution measures of Mu, Sigma and Tau. Results In the slow-baseline condition, categorical diagnoses and trait measures converged to indicate that children with ADHD-only and ASD + ADHD demonstrated increased MRT, SD-RT, CV and Tau compared to TDC and ASD-only. Importantly, greater improvement in MRT, SD-RT and Tau was demonstrated in ADHD and ASD + ADHD from slow-baseline to fast-incentive conditions compared to TDC and ASD-only. Conclusions Slower and more variable RTs are markers of ADHD compared to ASD and typically developing controls during slow and less rewarding conditions. Energetic factors and rewards improve task performance to a greater extent in children with ADHD compared to children with ASD. These findings suggest that RTV can be distinguished in ASD, ADHD and ASD + ADHD based on the indices of variability used and the conditions in which they are elicited. Further work identifying neural processes underlying increased RTV is warranted, in order to elucidate disorder-specific and disorder-convergent aetiological pathways. En ligne : http://dx.doi.org/10.1111/jcpp.12608 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 [article] Response time variability under slow and fast-incentive conditions in children with ASD, ADHD and ASD+ADHD [Texte imprimé et/ou numérique] / Charlotte TYE, Auteur ; Katherine A. JOHNSON, Auteur ; Simon P. KELLY, Auteur ; Philip ASHERSON, Auteur ; Jonna KUNTSI, Auteur ; Karen L. ASHWOOD, Auteur ; Bahare AZADI, Auteur ; Patrick BOLTON, Auteur ; Gráinne MCLOUGHLIN, Auteur . - p.1414-1423. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-12 (December 2016) . - p.1414-1423 Mots-clés : Autism spectrum disorder  attention deficit hyperactivity disorder  cognition  comorbidity  reaction time variability Index. décimale : PER Périodiques Résumé : Background Attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) show significant behavioural and genetic overlap. Both ADHD and ASD are characterised by poor performance on a range of cognitive tasks. In particular, increased response time variability (RTV) is a promising indicator of risk for both ADHD and ASD. However, it is not clear whether different indices of RTV and changes to RTV according to task conditions are able to discriminate between the two disorders. Methods Children with ASD (n = 19), ADHD (n = 18), ASD + ADHD (n = 29) and typically developing controls (TDC; n = 26) performed a four-choice RT task with slow-baseline and fast-incentive conditions. Performance was characterised by mean RT (MRT), standard deviation of RT (SD-RT), coefficient of variation (CV) and ex-Gaussian distribution measures of Mu, Sigma and Tau. Results In the slow-baseline condition, categorical diagnoses and trait measures converged to indicate that children with ADHD-only and ASD + ADHD demonstrated increased MRT, SD-RT, CV and Tau compared to TDC and ASD-only. Importantly, greater improvement in MRT, SD-RT and Tau was demonstrated in ADHD and ASD + ADHD from slow-baseline to fast-incentive conditions compared to TDC and ASD-only. Conclusions Slower and more variable RTs are markers of ADHD compared to ASD and typically developing controls during slow and less rewarding conditions. Energetic factors and rewards improve task performance to a greater extent in children with ADHD compared to children with ASD. These findings suggest that RTV can be distinguished in ASD, ADHD and ASD + ADHD based on the indices of variability used and the conditions in which they are elicited. Further work identifying neural processes underlying increased RTV is warranted, in order to elucidate disorder-specific and disorder-convergent aetiological pathways. En ligne : http://dx.doi.org/10.1111/jcpp.12608 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297

A review of neuropsychological and neuroimaging research in autistic spectrum disorders: Attention, inhibition and cognitive flexibility / Jane SANDERS in Research in Autism Spectrum Disorders, 2-1 (January/March 2008)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 2-1 (January/March 2008) . - p.1-16 Titre : A review of neuropsychological and neuroimaging research in autistic spectrum disorders: Attention, inhibition and cognitive flexibility Type de document : Texte imprimé et/ou numérique Auteurs : Jane SANDERS, Auteur ; Katherine A. JOHNSON, Auteur ; Hugh GARAVAN, Auteur ; Michael GILL, Auteur ; Louise GALLAGHER, Auteur Année de publication : 2008 Article en page(s) : p.1-16 Langues : Anglais (eng) Mots-clés : Autism Executive-function Cognitive-flexibility Sustained-attention Orienting-attention Response-inhibition Neuropsychology Imaging Index. décimale : PER Périodiques Résumé : Autistic spectrum disorders (ASD) are devastating neurodevelopmental disorders of unknown aetiology with characteristic deficits in social interaction, communication and behaviour. Individuals with ASD show deficits in executive function (EF), which are hypothesised to underlie core repetitive, stereotyped behaviours of autism. Neuroimaging research has identified structural brain abnormalities in ASD, which coincide with brain regions involved in EF. Therefore, we reviewed the literature on four specific executive functions in ASD—sustained attention, orienting attention, response inhibition and set shifting. Medline and Embase searches were carried out using specific search terms. This task was followed by the identification of further relevant publications from papers referenced in initial search results. Discussion with experts in neuropsychology, neuroimaging and autism research yielded further publications that were reviewed. Based on these data there is evidence to suggest that deficits in orienting attention, response inhibition and set shifting exist in ASD, but sustained attention ability appears to be normal. A striking lack of research attempting to link neural correlates with these deficits in orienting attention, response inhibition and set shifting was noted. Future research should focus on understanding links between the neuropsychological deficits and structural and functional brain abnormalities. En ligne : http://dx.doi.org/10.1016/j.rasd.2007.03.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329 [article] A review of neuropsychological and neuroimaging research in autistic spectrum disorders: Attention, inhibition and cognitive flexibility [Texte imprimé et/ou numérique] / Jane SANDERS, Auteur ; Katherine A. JOHNSON, Auteur ; Hugh GARAVAN, Auteur ; Michael GILL, Auteur ; Louise GALLAGHER, Auteur . - 2008 . - p.1-16. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 2-1 (January/March 2008) . - p.1-16 Mots-clés : Autism Executive-function Cognitive-flexibility Sustained-attention Orienting-attention Response-inhibition Neuropsychology Imaging Index. décimale : PER Périodiques Résumé : Autistic spectrum disorders (ASD) are devastating neurodevelopmental disorders of unknown aetiology with characteristic deficits in social interaction, communication and behaviour. Individuals with ASD show deficits in executive function (EF), which are hypothesised to underlie core repetitive, stereotyped behaviours of autism. Neuroimaging research has identified structural brain abnormalities in ASD, which coincide with brain regions involved in EF. Therefore, we reviewed the literature on four specific executive functions in ASD—sustained attention, orienting attention, response inhibition and set shifting. Medline and Embase searches were carried out using specific search terms. This task was followed by the identification of further relevant publications from papers referenced in initial search results. Discussion with experts in neuropsychology, neuroimaging and autism research yielded further publications that were reviewed. Based on these data there is evidence to suggest that deficits in orienting attention, response inhibition and set shifting exist in ASD, but sustained attention ability appears to be normal. A striking lack of research attempting to link neural correlates with these deficits in orienting attention, response inhibition and set shifting was noted. Future research should focus on understanding links between the neuropsychological deficits and structural and functional brain abnormalities. En ligne : http://dx.doi.org/10.1016/j.rasd.2007.03.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329

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