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Auteur Michael GILL |
Documents disponibles écrits par cet auteur (13)



Atypical Visuospatial Processing in Autism: Insights from Functional Connectivity Analysis / Jane MCGRATH in Autism Research, 5-5 (October 2012)
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Titre : Atypical Visuospatial Processing in Autism: Insights from Functional Connectivity Analysis Type de document : Texte imprimé et/ou numérique Auteurs : Jane MCGRATH, Auteur ; Katherine A. JOHNSON, Auteur ; Christine ECKER, Auteur ; Erik O'HANLON, Auteur ; Michael GILL, Auteur ; Louise GALLAGHER, Auteur ; Hugh GARAVAN, Auteur Article en page(s) : p.314-330 Langues : Anglais (eng) Mots-clés : autism functional MRI visuospatial processing mental rotation functional connectivity Index. décimale : PER Périodiques Résumé : Atypical visuospatial processing is commonly described in autism spectrum disorders (ASDs); however the specific neurobiological underpinnings of this phenomenon are poorly understood. Given the extensive evidence suggesting ASDs are characterized by abnormal neural connectivity, this study aimed to investigate network connectivity during visuospatial processing in ASD. Twenty-two males with ASD without intellectual disability and 22 individually matched controls performed a mental rotation task during functional magnetic resonance imaging (MRI) in which two rotated stimuli were judged to be same (“Same Trials”) or mirror-imaged (“Mirror Trials”). Behavioral results revealed a relative advantage of mental rotation in the ASD group—controls were slower responding to the more difficult Mirror Trials than Same Trials whereas the ASD group completed Mirror Trials and Same-trials at similar speeds. In the ASD group, brain activity was reduced in frontal, temporal, occipital, striatal, and cerebellar regions and, consistent with previous literature, functional connectivity between a number of brain regions was reduced. However, some connections appeared to be conserved and were recruited in a qualitatively different way by the two groups. As task difficulty increased (on Mirror Trials), controls tended to increase connections between certain brain regions, whereas the ASD group appeared to suppress connections between these regions. There was an interesting exception to this pattern in the visual cortex, a finding that may suggest an advantage in early visual perceptual processing in ASD. Overall, this study has identified a relative advantage in mental rotation in ASD that is associated with aberrant neural connectivity and that may stem from enhanced visual perceptual processing. Autism Res 2012, 5: 314–330. © 2012 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1245 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=183
in Autism Research > 5-5 (October 2012) . - p.314-330[article] Atypical Visuospatial Processing in Autism: Insights from Functional Connectivity Analysis [Texte imprimé et/ou numérique] / Jane MCGRATH, Auteur ; Katherine A. JOHNSON, Auteur ; Christine ECKER, Auteur ; Erik O'HANLON, Auteur ; Michael GILL, Auteur ; Louise GALLAGHER, Auteur ; Hugh GARAVAN, Auteur . - p.314-330.
Langues : Anglais (eng)
in Autism Research > 5-5 (October 2012) . - p.314-330
Mots-clés : autism functional MRI visuospatial processing mental rotation functional connectivity Index. décimale : PER Périodiques Résumé : Atypical visuospatial processing is commonly described in autism spectrum disorders (ASDs); however the specific neurobiological underpinnings of this phenomenon are poorly understood. Given the extensive evidence suggesting ASDs are characterized by abnormal neural connectivity, this study aimed to investigate network connectivity during visuospatial processing in ASD. Twenty-two males with ASD without intellectual disability and 22 individually matched controls performed a mental rotation task during functional magnetic resonance imaging (MRI) in which two rotated stimuli were judged to be same (“Same Trials”) or mirror-imaged (“Mirror Trials”). Behavioral results revealed a relative advantage of mental rotation in the ASD group—controls were slower responding to the more difficult Mirror Trials than Same Trials whereas the ASD group completed Mirror Trials and Same-trials at similar speeds. In the ASD group, brain activity was reduced in frontal, temporal, occipital, striatal, and cerebellar regions and, consistent with previous literature, functional connectivity between a number of brain regions was reduced. However, some connections appeared to be conserved and were recruited in a qualitatively different way by the two groups. As task difficulty increased (on Mirror Trials), controls tended to increase connections between certain brain regions, whereas the ASD group appeared to suppress connections between these regions. There was an interesting exception to this pattern in the visual cortex, a finding that may suggest an advantage in early visual perceptual processing in ASD. Overall, this study has identified a relative advantage in mental rotation in ASD that is associated with aberrant neural connectivity and that may stem from enhanced visual perceptual processing. Autism Res 2012, 5: 314–330. © 2012 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1245 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=183 Autism symptoms in Attention-Deficit/Hyperactivity Disorder: A Familial trait which Correlates with Conduct, Oppositional Defiant, Language and Motor Disorders / Aisling MULLIGAN in Journal of Autism and Developmental Disorders, 39-2 (February 2009)
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Titre : Autism symptoms in Attention-Deficit/Hyperactivity Disorder: A Familial trait which Correlates with Conduct, Oppositional Defiant, Language and Motor Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Aisling MULLIGAN, Auteur ; Herbert ROEYERS, Auteur ; Richard ANNEY, Auteur ; Wai CHEN, Auteur ; Myra O’REGAN, Auteur ; Louise BUTLER, Auteur ; Judith NIJMEIJER, Auteur ; Pieter J. HOEKSTRA, Auteur ; Robert D. OADES, Auteur ; Hanna CHRISTIANSEN, Auteur ; Isabel GABRIELS, Auteur ; Rafaela MARCO, Auteur ; Sheera MEIDAD, Auteur ; Ueli MUELLER, Auteur ; Jacques EISENBERG, Auteur ; Iris MANOR, Auteur ; Ana MIRANDA, Auteur ; Fernando MULAS, Auteur ; Barbara FRANKE, Auteur ; Margaret J. THOMPSON, Auteur ; Ruud B. MINDERAA, Auteur ; Aribert ROTHENBERGER, Auteur ; Tobias BANASCHEWSKI, Auteur ; Henrik UEBEL, Auteur ; Joseph A. SERGEANT, Auteur ; Hans-Christoph STEINHAUSEN, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Catharina A. HARTMAN, Auteur ; Stephen V. FARAONE, Auteur ; Philip ASHERSON, Auteur ; Jonna KUNTSI, Auteur ; Jan K. BUITELAAR, Auteur ; Michael FITZGERALD, Auteur ; Nanda N. ROMMELSE, Auteur ; Cathelijne J.M. BUSCHGENS, Auteur ; Michael GILL, Auteur ; Lamprini PSYCHOGIOU, Auteur ; Richard P. EBSTEIN, Auteur Année de publication : 2009 Article en page(s) : p.197-209 Langues : Anglais (eng) Mots-clés : ADHD Autism Familiality Oppositional-disorders Motor-disorder Language-disorder Index. décimale : PER Périodiques Résumé : It is hypothesised that autism symptoms are present in Attention-Deficit/Hyperactivity Disorder (ADHD), are familial and index subtypes of ADHD. Autism symptoms were compared in 821 ADHD probands, 1050 siblings and 149 controls. Shared familiality of autism symptoms and ADHD was calculated using DeFries-Fulker analysis. Autism symptoms were higher in probands than siblings or controls, and higher in male siblings than male controls. Autism symptoms were familial, partly shared with familiality of ADHD in males. Latent class analysis using SCQ-score yielded five classes; Class 1(31%) had few autism symptoms and low comorbidity; Classes 2–4 were intermediate; Class 5(7%) had high autism symptoms and comorbidity. Thus autism symptoms in ADHD represent a familial trait associated with increased neurodevelopmental and oppositional/conduct disorders. En ligne : http://dx.doi.org/10.1007/s10803-008-0621-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=683
in Journal of Autism and Developmental Disorders > 39-2 (February 2009) . - p.197-209[article] Autism symptoms in Attention-Deficit/Hyperactivity Disorder: A Familial trait which Correlates with Conduct, Oppositional Defiant, Language and Motor Disorders [Texte imprimé et/ou numérique] / Aisling MULLIGAN, Auteur ; Herbert ROEYERS, Auteur ; Richard ANNEY, Auteur ; Wai CHEN, Auteur ; Myra O’REGAN, Auteur ; Louise BUTLER, Auteur ; Judith NIJMEIJER, Auteur ; Pieter J. HOEKSTRA, Auteur ; Robert D. OADES, Auteur ; Hanna CHRISTIANSEN, Auteur ; Isabel GABRIELS, Auteur ; Rafaela MARCO, Auteur ; Sheera MEIDAD, Auteur ; Ueli MUELLER, Auteur ; Jacques EISENBERG, Auteur ; Iris MANOR, Auteur ; Ana MIRANDA, Auteur ; Fernando MULAS, Auteur ; Barbara FRANKE, Auteur ; Margaret J. THOMPSON, Auteur ; Ruud B. MINDERAA, Auteur ; Aribert ROTHENBERGER, Auteur ; Tobias BANASCHEWSKI, Auteur ; Henrik UEBEL, Auteur ; Joseph A. SERGEANT, Auteur ; Hans-Christoph STEINHAUSEN, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Catharina A. HARTMAN, Auteur ; Stephen V. FARAONE, Auteur ; Philip ASHERSON, Auteur ; Jonna KUNTSI, Auteur ; Jan K. BUITELAAR, Auteur ; Michael FITZGERALD, Auteur ; Nanda N. ROMMELSE, Auteur ; Cathelijne J.M. BUSCHGENS, Auteur ; Michael GILL, Auteur ; Lamprini PSYCHOGIOU, Auteur ; Richard P. EBSTEIN, Auteur . - 2009 . - p.197-209.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 39-2 (February 2009) . - p.197-209
Mots-clés : ADHD Autism Familiality Oppositional-disorders Motor-disorder Language-disorder Index. décimale : PER Périodiques Résumé : It is hypothesised that autism symptoms are present in Attention-Deficit/Hyperactivity Disorder (ADHD), are familial and index subtypes of ADHD. Autism symptoms were compared in 821 ADHD probands, 1050 siblings and 149 controls. Shared familiality of autism symptoms and ADHD was calculated using DeFries-Fulker analysis. Autism symptoms were higher in probands than siblings or controls, and higher in male siblings than male controls. Autism symptoms were familial, partly shared with familiality of ADHD in males. Latent class analysis using SCQ-score yielded five classes; Class 1(31%) had few autism symptoms and low comorbidity; Classes 2–4 were intermediate; Class 5(7%) had high autism symptoms and comorbidity. Thus autism symptoms in ADHD represent a familial trait associated with increased neurodevelopmental and oppositional/conduct disorders. En ligne : http://dx.doi.org/10.1007/s10803-008-0621-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=683 Developmental psychopathology: The role of structural variation in the genome / Michael GILL in Development and Psychopathology, 24-4 (November 2012)
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Titre : Developmental psychopathology: The role of structural variation in the genome Type de document : Texte imprimé et/ou numérique Auteurs : Michael GILL, Auteur Année de publication : 2012 Article en page(s) : p.1319-1334 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : A wide range of developmental disorders present with characteristic psychopathologies and behaviors, with diagnoses including, inter alia, cognitive disorders and learning disabilities, epilepsies, autism, and schizophrenia. Each, to varying extent, has a genetic component to etiology and is associated with cytogenetic abnormalities. Technological developments, particularly array-based comparative genome hybridization and single nucleotide polymorphism chips, has revealed a wide range of rare recurrent and de novo copy number variants (CNVs) to be associated with disorder and psychopathology. It is surprising that many apparently similar CNVs are identified across two or more disorders hitherto considered unrelated. This article describes the characteristics of CNVs and current technological restrictions that make accurately identifying small events difficult. It summarizes the latest discoveries for individual diagnostic categories and considers the implications for a shared neurobiology. It examines likely developments in the knowledge base as well as addressing the clinical implications going forward. En ligne : http://dx.doi.org/10.1017/S0954579412000739 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182
in Development and Psychopathology > 24-4 (November 2012) . - p.1319-1334[article] Developmental psychopathology: The role of structural variation in the genome [Texte imprimé et/ou numérique] / Michael GILL, Auteur . - 2012 . - p.1319-1334.
Langues : Anglais (eng)
in Development and Psychopathology > 24-4 (November 2012) . - p.1319-1334
Index. décimale : PER Périodiques Résumé : A wide range of developmental disorders present with characteristic psychopathologies and behaviors, with diagnoses including, inter alia, cognitive disorders and learning disabilities, epilepsies, autism, and schizophrenia. Each, to varying extent, has a genetic component to etiology and is associated with cytogenetic abnormalities. Technological developments, particularly array-based comparative genome hybridization and single nucleotide polymorphism chips, has revealed a wide range of rare recurrent and de novo copy number variants (CNVs) to be associated with disorder and psychopathology. It is surprising that many apparently similar CNVs are identified across two or more disorders hitherto considered unrelated. This article describes the characteristics of CNVs and current technological restrictions that make accurately identifying small events difficult. It summarizes the latest discoveries for individual diagnostic categories and considers the implications for a shared neurobiology. It examines likely developments in the knowledge base as well as addressing the clinical implications going forward. En ligne : http://dx.doi.org/10.1017/S0954579412000739 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182 Emotional lability in children and adolescents with attention deficit/hyperactivity disorder (ADHD): clinical correlates and familial prevalence / Esther SOBANSKI in Journal of Child Psychology and Psychiatry, 51-8 (August 2010)
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Titre : Emotional lability in children and adolescents with attention deficit/hyperactivity disorder (ADHD): clinical correlates and familial prevalence Type de document : Texte imprimé et/ou numérique Auteurs : Esther SOBANSKI, Auteur ; Herbert ROEYERS, Auteur ; Barbara FRANKE, Auteur ; Richard ANNEY, Auteur ; Wai CHEN, Auteur ; Robert D. OADES, Auteur ; Ana MIRANDA, Auteur ; Fernando MULAS, Auteur ; Argyris STRINGARIS, Auteur ; Bertram KRUMM, Auteur ; Eric TAYLOR, Auteur ; Michael GILL, Auteur ; Aribert ROTHENBERGER, Auteur ; Tobias BANASCHEWSKI, Auteur ; Joseph A. SERGEANT, Auteur ; Hans-Christoph STEINHAUSEN, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Stephen V. FARAONE, Auteur ; Philip ASHERSON, Auteur ; Jan K. BUITELAAR, Auteur ; Martin HOLTMANN, Auteur ; Richard P. EBSTEIN, Auteur Année de publication : 2010 Article en page(s) : p.915-923 Langues : Anglais (eng) Mots-clés : Attention-deficit-hyperactivity-disorder emotional-lability affective-lability emotional-dysregulation Index. décimale : PER Périodiques Résumé : Background: The goal of this study was to investigate the occurrence, severity and clinical correlates of emotional lability (EL) in children with attention deficit/hyperactivity disorder (ADHD), and to examine factors contributing to EL and familiality of EL in youth with ADHD.
Methods: One thousand, one hundred and eighty-six children with ADHD combined type and 1827 siblings (aged 6–18 years) were assessed for symptoms of EL, ADHD, associated psychopathology and comorbid psychiatric disorders with a structured diagnostic interview (PACS) as well as parent and teacher ratings of psychopathology (SDQ; CPRS-R:L; CTRS-R:L). Analyses of variance, regression analyses, χ2-tests or loglinear models were applied.
Results: Mean age and gender-standardized ratings of EL in children with ADHD were >1.5 SD above the mean in normative samples. Severe EL (>75th percentile) was associated with more severe ADHD core symptoms, primarily hyperactive-impulsive symptoms, and more comorbid oppositional defiant, affective and substance use disorders. Age, hyperactive-impulsive, oppositional, and emotional symptoms accounted for 30% of EL variance; hyperactive-impulsive symptoms did not account for EL variance when coexisting oppositional and emotional problems were taken into account, but oppositional symptoms explained 12% of EL variance specifically. Severity of EL in probands increased the severity of EL in siblings, but not the prevalence rates of ADHD or ODD. EL and ADHD does not co-segregate within families.
Conclusion: EL is a frequent clinical problem in children with ADHD. It is associated with increased severity of ADHD core symptoms, particularly hyperactivity-impulsivity, and more symptoms of comorbid psychopathology, primarily symptoms of oppositional defiant disorder (ODD), but also affective symptoms, and substance abuse. EL in ADHD seems to be more closely related to ODD than to ADHD core symptoms, and is only partly explainable by the severity of ADHD core symptoms and associated psychopathology. Although EL symptoms are transmitted within families, EL in children with ADHD does not increase the risk of ADHD and ODD in their siblings.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02217.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108
in Journal of Child Psychology and Psychiatry > 51-8 (August 2010) . - p.915-923[article] Emotional lability in children and adolescents with attention deficit/hyperactivity disorder (ADHD): clinical correlates and familial prevalence [Texte imprimé et/ou numérique] / Esther SOBANSKI, Auteur ; Herbert ROEYERS, Auteur ; Barbara FRANKE, Auteur ; Richard ANNEY, Auteur ; Wai CHEN, Auteur ; Robert D. OADES, Auteur ; Ana MIRANDA, Auteur ; Fernando MULAS, Auteur ; Argyris STRINGARIS, Auteur ; Bertram KRUMM, Auteur ; Eric TAYLOR, Auteur ; Michael GILL, Auteur ; Aribert ROTHENBERGER, Auteur ; Tobias BANASCHEWSKI, Auteur ; Joseph A. SERGEANT, Auteur ; Hans-Christoph STEINHAUSEN, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Stephen V. FARAONE, Auteur ; Philip ASHERSON, Auteur ; Jan K. BUITELAAR, Auteur ; Martin HOLTMANN, Auteur ; Richard P. EBSTEIN, Auteur . - 2010 . - p.915-923.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 51-8 (August 2010) . - p.915-923
Mots-clés : Attention-deficit-hyperactivity-disorder emotional-lability affective-lability emotional-dysregulation Index. décimale : PER Périodiques Résumé : Background: The goal of this study was to investigate the occurrence, severity and clinical correlates of emotional lability (EL) in children with attention deficit/hyperactivity disorder (ADHD), and to examine factors contributing to EL and familiality of EL in youth with ADHD.
Methods: One thousand, one hundred and eighty-six children with ADHD combined type and 1827 siblings (aged 6–18 years) were assessed for symptoms of EL, ADHD, associated psychopathology and comorbid psychiatric disorders with a structured diagnostic interview (PACS) as well as parent and teacher ratings of psychopathology (SDQ; CPRS-R:L; CTRS-R:L). Analyses of variance, regression analyses, χ2-tests or loglinear models were applied.
Results: Mean age and gender-standardized ratings of EL in children with ADHD were >1.5 SD above the mean in normative samples. Severe EL (>75th percentile) was associated with more severe ADHD core symptoms, primarily hyperactive-impulsive symptoms, and more comorbid oppositional defiant, affective and substance use disorders. Age, hyperactive-impulsive, oppositional, and emotional symptoms accounted for 30% of EL variance; hyperactive-impulsive symptoms did not account for EL variance when coexisting oppositional and emotional problems were taken into account, but oppositional symptoms explained 12% of EL variance specifically. Severity of EL in probands increased the severity of EL in siblings, but not the prevalence rates of ADHD or ODD. EL and ADHD does not co-segregate within families.
Conclusion: EL is a frequent clinical problem in children with ADHD. It is associated with increased severity of ADHD core symptoms, particularly hyperactivity-impulsivity, and more symptoms of comorbid psychopathology, primarily symptoms of oppositional defiant disorder (ODD), but also affective symptoms, and substance abuse. EL in ADHD seems to be more closely related to ODD than to ADHD core symptoms, and is only partly explainable by the severity of ADHD core symptoms and associated psychopathology. Although EL symptoms are transmitted within families, EL in children with ADHD does not increase the risk of ADHD and ODD in their siblings.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02217.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108 Erratum : Autism Symptoms in Attention-Deficit/Hyperactivity Disorder: A Familial Trait which Correlates with Conduct, Oppositional Defiant, Language and Motor Disorders / Aisling MULLIGAN in Journal of Autism and Developmental Disorders, 39-2 (February 2009)
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Expression of glucocorticoid inducible genes is associated with reductions in cornu ammonis and dentate gyrus volumes in patients with major depressive disorder / Thomas FRODL in Development and Psychopathology, 26-4 (Part 2) (November 2014)
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PermalinkFunctionality of promoter microsatellites of arginine vasopressin receptor 1A (AVPR1A): implications for autism / Katherine E. TANSEY in Molecular Autism, (March 2011)
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PermalinkImpaired conflict resolution and alerting in children with ADHD: evidence from the Attention Network Task (ANT) / Katherine A. JOHNSON in Journal of Child Psychology and Psychiatry, 49-12 (December 2008)
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PermalinkLack of association between markers in the ITGA3, ITGAV, ITGA6 and ITGB3 and autism in an Irish sample / Lynne E. COCHRANE in Autism Research, 3-6 (December 2010)
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PermalinkNeuropsychological correlates of emotional lability in children with ADHD / Tobias BANASCHEWSKI in Journal of Child Psychology and Psychiatry, 53-11 (November 2012)
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PermalinkA review of neuropsychological and neuroimaging research in autistic spectrum disorders: Attention, inhibition and cognitive flexibility / Jane SANDERS in Research in Autism Spectrum Disorders, 2-1 (January/March 2008)
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PermalinkThe dopamine receptor D4 7-repeat allele and prenatal smoking in ADHD-affected children and their unaffected siblings: no gene–environment interaction / Marieke E. ALTINK in Journal of Child Psychology and Psychiatry, 49-10 (October 2008)
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PermalinkThe hierarchical factor model of ADHD: invariant across age and national groupings? / Maggie E. TOPLAK in Journal of Child Psychology and Psychiatry, 53-3 (March 2012)
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