Chinese children with autism: A multiple chemical elements profile in erythrocytes / J. WU in Autism Research, 11-6 (June 2018)  

Public ISBD [article]  inAutism Research > 11-6 (June 2018) . - p.834-845 Titre : Chinese children with autism: A multiple chemical elements profile in erythrocytes Type de document : Texte imprimé et/ou numérique Auteurs : J. WU, Auteur ; D. J. LIU, Auteur ; X. J. SHOU, Auteur ; J. S. ZHANG, Auteur ; F. C. MENG, Auteur ; Y. Q. LIU, Auteur ; S. P. HAN, Auteur ; R. ZHANG, Auteur ; J. Z. JIA, Auteur ; J. Y. WANG, Auteur ; J. S. HAN, Auteur Article en page(s) : p.834-845 Langues : Anglais (eng) Mots-clés : Asd  Cars  autism  erythrocyte  essential minerals  multi-elements  rare earth elements  toxic metals Index. décimale : PER Périodiques Résumé : Several lines of evidence suggested that abnormal levels of certain chemical elements may contribute to the development of autism spectrum disorders (ASD). The present work aimed to investigate the multiple chemical elements profile in the erythrocytes of autistic versus typically developing children (TDC) of China. Analyses were carried out to explore the possible association between levels of elements and the risk as well as the severity of ASD. Erythrocyte levels of 11 elements (32%) among 34 detected elements in autistic group were significantly different from those in the TDC group. To our knowledge, this is the first study which compared the levels of rare earth elements in erythrocytes between children with or without ASD. Five elements including Pb, Na, Ca, Sb, and La are associated with the Childhood Autism Rating Scale (CARS) total score. Also, a series of tendencies were found in this research which was believed to affect auditory response, taste, smell, and touch, as well as fear or nervousness. It can be concluded that Chinese autistic children suffer from multi-chemical element imbalances which involves a complex combination of genetic and environmental factors. The results showed a significant correlation between abnormal levels of several chemical elements and the severity of the autistic syndrome. LAY SUMMARY: It is suggested that abnormal levels of some chemical elements may contribute to the development of autism spectrum disorders (ASD). In this work, the impact of element imbalances on the risk and severity of ASD was investigated, focusing on the analysis of abnormal levels of the multi-chemical elements profile in erythrocytes compared with typically developing children. Furthermore, the results showed a significant correlation between abnormal levels of several chemical elements and the severity of the autistic syndrome. Autism Res 2018, 11: 834-845. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1949 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366 [article] Chinese children with autism: A multiple chemical elements profile in erythrocytes [Texte imprimé et/ou numérique] / J. WU, Auteur ; D. J. LIU, Auteur ; X. J. SHOU, Auteur ; J. S. ZHANG, Auteur ; F. C. MENG, Auteur ; Y. Q. LIU, Auteur ; S. P. HAN, Auteur ; R. ZHANG, Auteur ; J. Z. JIA, Auteur ; J. Y. WANG, Auteur ; J. S. HAN, Auteur . - p.834-845. Langues : Anglais (eng) in Autism Research > 11-6 (June 2018) . - p.834-845 Mots-clés : Asd  Cars  autism  erythrocyte  essential minerals  multi-elements  rare earth elements  toxic metals Index. décimale : PER Périodiques Résumé : Several lines of evidence suggested that abnormal levels of certain chemical elements may contribute to the development of autism spectrum disorders (ASD). The present work aimed to investigate the multiple chemical elements profile in the erythrocytes of autistic versus typically developing children (TDC) of China. Analyses were carried out to explore the possible association between levels of elements and the risk as well as the severity of ASD. Erythrocyte levels of 11 elements (32%) among 34 detected elements in autistic group were significantly different from those in the TDC group. To our knowledge, this is the first study which compared the levels of rare earth elements in erythrocytes between children with or without ASD. Five elements including Pb, Na, Ca, Sb, and La are associated with the Childhood Autism Rating Scale (CARS) total score. Also, a series of tendencies were found in this research which was believed to affect auditory response, taste, smell, and touch, as well as fear or nervousness. It can be concluded that Chinese autistic children suffer from multi-chemical element imbalances which involves a complex combination of genetic and environmental factors. The results showed a significant correlation between abnormal levels of several chemical elements and the severity of the autistic syndrome. LAY SUMMARY: It is suggested that abnormal levels of some chemical elements may contribute to the development of autism spectrum disorders (ASD). In this work, the impact of element imbalances on the risk and severity of ASD was investigated, focusing on the analysis of abnormal levels of the multi-chemical elements profile in erythrocytes compared with typically developing children. Furthermore, the results showed a significant correlation between abnormal levels of several chemical elements and the severity of the autistic syndrome. Autism Res 2018, 11: 834-845. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1949 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366

Preserved reward outcome processing in ASD as revealed by event-related potentials / J. C. MCPARTLAND in Journal of Neurodevelopmental Disorders, 4-1 (December 2012)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 4-1 (December 2012) . - p.16 Titre : Preserved reward outcome processing in ASD as revealed by event-related potentials Type de document : Texte imprimé et/ou numérique Auteurs : J. C. MCPARTLAND, Auteur ; M. J. CROWLEY, Auteur ; D. R. PERSZYK, Auteur ; C. E. MUKERJI, Auteur ; A. J. NAPLES, Auteur ; J. WU, Auteur ; L. C. MAYES, Auteur Article en page(s) : p.16 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: Problems with reward system function have been posited as a primary difficulty in autism spectrum disorders. The current study examined an electrophysiological marker of feedback monitoring, the feedback-related negativity (FRN), during a monetary reward task. The study advanced prior understanding by focusing exclusively on a developmental sample, applying rigorous diagnostic characterization and introducing an experimental paradigm providing more subtly different feedback valence (reward versus non-reward instead of reward versus loss). METHODS: Twenty-six children with autism spectrum disorder and 28 typically developing peers matched on age and full-scale IQ played a guessing game resulting in monetary gain ("win") or neutral outcome ("draw"). ERP components marking early visual processing (N1, P2) and feedback appraisal (FRN) were contrasted between groups in each condition, and their relationships to behavioral measures of social function and dysfunction, social anxiety, and autism symptomatology were explored. RESULTS: FRN was observed on draw trials relative to win trials. Consistent with prior research, children with ASD exhibited a FRN to suboptimal outcomes that was comparable to typical peers. ERP parameters were unrelated to behavioral measures. CONCLUSIONS: Results of the current study indicate typical patterns of feedback monitoring in the context of monetary reward in ASD. The study extends prior findings of normative feedback monitoring to a sample composed exclusively of children and demonstrates that, as in typical development, individuals with autism exhibit a FRN to suboptimal outcomes, irrespective of neutral or negative valence. Results do not support a pervasive problem with reward system function in ASD, instead suggesting any dysfunction lies in more specific domains, such as social perception, or in response to particular feedback-monitoring contexts, such as self-evaluation of one's errors. En ligne : http://dx.doi.org/10.1186/1866-1955-4-16 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=344 [article] Preserved reward outcome processing in ASD as revealed by event-related potentials [Texte imprimé et/ou numérique] / J. C. MCPARTLAND, Auteur ; M. J. CROWLEY, Auteur ; D. R. PERSZYK, Auteur ; C. E. MUKERJI, Auteur ; A. J. NAPLES, Auteur ; J. WU, Auteur ; L. C. MAYES, Auteur . - p.16. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 4-1 (December 2012) . - p.16 Index. décimale : PER Périodiques Résumé : BACKGROUND: Problems with reward system function have been posited as a primary difficulty in autism spectrum disorders. The current study examined an electrophysiological marker of feedback monitoring, the feedback-related negativity (FRN), during a monetary reward task. The study advanced prior understanding by focusing exclusively on a developmental sample, applying rigorous diagnostic characterization and introducing an experimental paradigm providing more subtly different feedback valence (reward versus non-reward instead of reward versus loss). METHODS: Twenty-six children with autism spectrum disorder and 28 typically developing peers matched on age and full-scale IQ played a guessing game resulting in monetary gain ("win") or neutral outcome ("draw"). ERP components marking early visual processing (N1, P2) and feedback appraisal (FRN) were contrasted between groups in each condition, and their relationships to behavioral measures of social function and dysfunction, social anxiety, and autism symptomatology were explored. RESULTS: FRN was observed on draw trials relative to win trials. Consistent with prior research, children with ASD exhibited a FRN to suboptimal outcomes that was comparable to typical peers. ERP parameters were unrelated to behavioral measures. CONCLUSIONS: Results of the current study indicate typical patterns of feedback monitoring in the context of monetary reward in ASD. The study extends prior findings of normative feedback monitoring to a sample composed exclusively of children and demonstrates that, as in typical development, individuals with autism exhibit a FRN to suboptimal outcomes, irrespective of neutral or negative valence. Results do not support a pervasive problem with reward system function in ASD, instead suggesting any dysfunction lies in more specific domains, such as social perception, or in response to particular feedback-monitoring contexts, such as self-evaluation of one's errors. En ligne : http://dx.doi.org/10.1186/1866-1955-4-16 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=344

Reliability and Validity of the Chinese Version of Modified Checklist for Autism in Toddlers, Revised, with Follow-Up (M-CHAT-R/F) / C. GUO in Journal of Autism and Developmental Disorders, 49-1 (January 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.185-196 Titre : Reliability and Validity of the Chinese Version of Modified Checklist for Autism in Toddlers, Revised, with Follow-Up (M-CHAT-R/F) Type de document : Texte imprimé et/ou numérique Auteurs : C. GUO, Auteur ; M. LUO, Auteur ; X. WANG, Auteur ; S. HUANG, Auteur ; Z. MENG, Auteur ; J. SHAO, Auteur ; X. ZHANG, Auteur ; Z. SHAO, Auteur ; J. WU, Auteur ; Diana L. ROBINS, Auteur ; J. JING, Auteur Article en page(s) : p.185-196 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  China  Early screening  Modified Checklist for Autism in Toddlers  Revised with Follow-Up (M-CHAT-R/F) Index. décimale : PER Périodiques Résumé : Although early detection of autism facilitates intervention, early detection strategies are not yet widespread in China. To improve the situation, the Chinese version of the Modified Checklist for Autism in Toddlers, Revised with Follow-Up (M-CHAT-R/F) was validated. The sample included 7928 toddlers, aged 16 to 30 months, screened during their routine care in six provinces of China. When the cut-off value was 3, the sensitivity and specificity of M-CHAT-R were 0.963 and 0.865. The inter-rater reliability and the test-retest reliability were also adequate (intraclass correlation coefficients were 0.853 and 0.759, both ps < .01). The Chinese version of M-CHAT-R/F is an effective tool for early detection of ASD and is applicable to early screening in China. En ligne : http://dx.doi.org/10.1007/s10803-018-3682-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376 [article] Reliability and Validity of the Chinese Version of Modified Checklist for Autism in Toddlers, Revised, with Follow-Up (M-CHAT-R/F) [Texte imprimé et/ou numérique] / C. GUO, Auteur ; M. LUO, Auteur ; X. WANG, Auteur ; S. HUANG, Auteur ; Z. MENG, Auteur ; J. SHAO, Auteur ; X. ZHANG, Auteur ; Z. SHAO, Auteur ; J. WU, Auteur ; Diana L. ROBINS, Auteur ; J. JING, Auteur . - p.185-196. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.185-196 Mots-clés : Autism spectrum disorder  China  Early screening  Modified Checklist for Autism in Toddlers  Revised with Follow-Up (M-CHAT-R/F) Index. décimale : PER Périodiques Résumé : Although early detection of autism facilitates intervention, early detection strategies are not yet widespread in China. To improve the situation, the Chinese version of the Modified Checklist for Autism in Toddlers, Revised with Follow-Up (M-CHAT-R/F) was validated. The sample included 7928 toddlers, aged 16 to 30 months, screened during their routine care in six provinces of China. When the cut-off value was 3, the sensitivity and specificity of M-CHAT-R were 0.963 and 0.865. The inter-rater reliability and the test-retest reliability were also adequate (intraclass correlation coefficients were 0.853 and 0.759, both ps < .01). The Chinese version of M-CHAT-R/F is an effective tool for early detection of ASD and is applicable to early screening in China. En ligne : http://dx.doi.org/10.1007/s10803-018-3682-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376

The N170 event-related potential reflects delayed neural response to faces when visual attention is directed to the eyes in youths with ASD / T. C. PARKER in Autism Research, 14-7 (July 2021)  

Public ISBD [article]  inAutism Research > 14-7 (July 2021) . - p.1347-1356 Titre : The N170 event-related potential reflects delayed neural response to faces when visual attention is directed to the eyes in youths with ASD Type de document : Texte imprimé et/ou numérique Auteurs : T. C. PARKER, Auteur ; M. J. CROWLEY, Auteur ; A. J. NAPLES, Auteur ; M. J. ROLISON, Auteur ; J. WU, Auteur ; J. A. TRAPANI, Auteur ; J. C. MCPARTLAND, Auteur Article en page(s) : p.1347-1356 Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder  Brain  Child  Evoked Potentials  Facial Recognition  Humans  Eeg  N170  autism  event-related potential  face perception  social neuroscience Index. décimale : PER Périodiques Résumé : Atypical neural response to faces is thought to contribute to social deficits in autism spectrum disorder (ASD). Compared to typically developing (TD) controls, individuals with ASD exhibit delayed brain responses to upright faces at a face-sensitive event-related potential (ERP), the N170. Given observed differences in patterns of visual attention to faces, it is not known whether slowed neural processing may simply reflect atypical looking to faces. The present study manipulated visual attention to facial features to examine whether directed attention to the eyes normalizes N170 latency in ASD. ERPs were recorded in 30 children and adolescents with ASD as well as 26 TD children and adolescents. Results replicated prior findings of shorter N170 latency to the eye region of the face in TD individuals. In contrast, those with ASD did not demonstrate modulation of N170 latency by point of regard to the face. Group differences in latency were most pronounced when attention was directed to the eyes. Results suggest that well-replicated findings of N170 delays in ASD do not simply reflect atypical patterns of visual engagement with experimental stimuli. These findings add to a body of evidence indicating that N170 delays are a promising marker of atypical neural response to social information in ASD. LAY SUMMARY: This study looks at how children's and adolescents' brains respond when looking at different parts of a face. Typically developing children and adolescents processed eyes faster than other parts of the face, whereas this pattern was not seen in ASD. Children and adolescents with ASD processed eyes more slowly than typically developing children. These findings suggest that observed inefficiencies in face processing in ASD are not simply reflective of failure to attend to the eyes. En ligne : http://dx.doi.org/10.1002/aur.2505 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] The N170 event-related potential reflects delayed neural response to faces when visual attention is directed to the eyes in youths with ASD [Texte imprimé et/ou numérique] / T. C. PARKER, Auteur ; M. J. CROWLEY, Auteur ; A. J. NAPLES, Auteur ; M. J. ROLISON, Auteur ; J. WU, Auteur ; J. A. TRAPANI, Auteur ; J. C. MCPARTLAND, Auteur . - p.1347-1356. Langues : Anglais (eng) in Autism Research > 14-7 (July 2021) . - p.1347-1356 Mots-clés : Adolescent  Autism Spectrum Disorder  Brain  Child  Evoked Potentials  Facial Recognition  Humans  Eeg  N170  autism  event-related potential  face perception  social neuroscience Index. décimale : PER Périodiques Résumé : Atypical neural response to faces is thought to contribute to social deficits in autism spectrum disorder (ASD). Compared to typically developing (TD) controls, individuals with ASD exhibit delayed brain responses to upright faces at a face-sensitive event-related potential (ERP), the N170. Given observed differences in patterns of visual attention to faces, it is not known whether slowed neural processing may simply reflect atypical looking to faces. The present study manipulated visual attention to facial features to examine whether directed attention to the eyes normalizes N170 latency in ASD. ERPs were recorded in 30 children and adolescents with ASD as well as 26 TD children and adolescents. Results replicated prior findings of shorter N170 latency to the eye region of the face in TD individuals. In contrast, those with ASD did not demonstrate modulation of N170 latency by point of regard to the face. Group differences in latency were most pronounced when attention was directed to the eyes. Results suggest that well-replicated findings of N170 delays in ASD do not simply reflect atypical patterns of visual engagement with experimental stimuli. These findings add to a body of evidence indicating that N170 delays are a promising marker of atypical neural response to social information in ASD. LAY SUMMARY: This study looks at how children's and adolescents' brains respond when looking at different parts of a face. Typically developing children and adolescents processed eyes faster than other parts of the face, whereas this pattern was not seen in ASD. Children and adolescents with ASD processed eyes more slowly than typically developing children. These findings suggest that observed inefficiencies in face processing in ASD are not simply reflective of failure to attend to the eyes. En ligne : http://dx.doi.org/10.1002/aur.2505 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

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