Childhood neurodevelopmental difficulties and risk of adolescent depression: the role of irritability / O. EYRE in Journal of Child Psychology and Psychiatry, 60-8 (August 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-8 (August 2019) . - p.866-874 Titre : Childhood neurodevelopmental difficulties and risk of adolescent depression: the role of irritability Type de document : Texte imprimé et/ou numérique Auteurs : O. EYRE, Auteur ; R. A. HUGHES, Auteur ; Ajay K. THAPAR, Auteur ; E. LEIBENLUFT, Auteur ; A. STRINGARIS, Auteur ; George DAVEY SMITH, Auteur ; E. STERGIAKOULI, Auteur ; S. COLLISHAW, Auteur ; A. THAPAR, Auteur Article en page(s) : p.866-874 Langues : Anglais (eng) Mots-clés : Alspac  attention-deficit/hyperactivity disorder  autism  depression  irritability  neurodevelopmental Index. décimale : PER Périodiques Résumé : BACKGROUND: Children with neurodevelopmental disorders are at increased risk of developing depression. Irritability predicts depression in the general population and is common in children with neurodevelopmental disorders. Thus, it is possible that irritability in children with neurodevelopmental disorders contributes to the link with later depression. This study aimed to (a) examine the association between childhood neurodevelopmental difficulties and adolescent depression and (b) test whether irritability explains this association. METHODS: Children with any neurodevelopmental difficulty at the age of 7-9 (n = 1,697) and a selected, comparison group without any neurodevelopmental difficulty (n = 3,177) were identified from a prospective, UK population-based cohort, the Avon Longitudinal Study of Parents and Children. Neurodevelopmental difficulties were defined as a score in the bottom 5% of the sample on at least one measure of cognitive ability, communication, autism spectrum symptoms, attention-deficit/hyperactivity symptoms, reading or motor coordination. The Development and Well-Being Assessment measured parent-reported child irritability at the age of 7, parent-reported adolescent depression at the age of 10 and 13, and self-reported depression at the age of 15. Depression measures were combined, deriving an outcome of major depressive disorder (MDD) in adolescence. Logistic regression examined the association between childhood neurodevelopmental difficulties and adolescent MDD, controlling for gender. Path analysis estimated the proportion of this association explained by irritability. Analyses were repeated for individual neurodevelopmental problems. RESULTS: Childhood neurodevelopmental difficulties were associated with adolescent MDD (OR = 2.11, 95% CI = 1.24, 3.60, p = .006). Childhood irritability statistically accounted for 42% of this association. On examining each neurodevelopmental difficulty separately, autistic, communication and ADHD problems were each associated with depression, with irritability explaining 29%-51% of these links. CONCLUSIONS: Childhood irritability appears to be a key contributor to the link between childhood neurodevelopmental difficulties and adolescent MDD. High rates of irritability in children with autistic and ADHD difficulties may explain elevated rates of depression in the neurodevelopmental group. En ligne : http://dx.doi.org/10.1111/jcpp.13053 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=404 [article] Childhood neurodevelopmental difficulties and risk of adolescent depression: the role of irritability [Texte imprimé et/ou numérique] / O. EYRE, Auteur ; R. A. HUGHES, Auteur ; Ajay K. THAPAR, Auteur ; E. LEIBENLUFT, Auteur ; A. STRINGARIS, Auteur ; George DAVEY SMITH, Auteur ; E. STERGIAKOULI, Auteur ; S. COLLISHAW, Auteur ; A. THAPAR, Auteur . - p.866-874. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-8 (August 2019) . - p.866-874 Mots-clés : Alspac  attention-deficit/hyperactivity disorder  autism  depression  irritability  neurodevelopmental Index. décimale : PER Périodiques Résumé : BACKGROUND: Children with neurodevelopmental disorders are at increased risk of developing depression. Irritability predicts depression in the general population and is common in children with neurodevelopmental disorders. Thus, it is possible that irritability in children with neurodevelopmental disorders contributes to the link with later depression. This study aimed to (a) examine the association between childhood neurodevelopmental difficulties and adolescent depression and (b) test whether irritability explains this association. METHODS: Children with any neurodevelopmental difficulty at the age of 7-9 (n = 1,697) and a selected, comparison group without any neurodevelopmental difficulty (n = 3,177) were identified from a prospective, UK population-based cohort, the Avon Longitudinal Study of Parents and Children. Neurodevelopmental difficulties were defined as a score in the bottom 5% of the sample on at least one measure of cognitive ability, communication, autism spectrum symptoms, attention-deficit/hyperactivity symptoms, reading or motor coordination. The Development and Well-Being Assessment measured parent-reported child irritability at the age of 7, parent-reported adolescent depression at the age of 10 and 13, and self-reported depression at the age of 15. Depression measures were combined, deriving an outcome of major depressive disorder (MDD) in adolescence. Logistic regression examined the association between childhood neurodevelopmental difficulties and adolescent MDD, controlling for gender. Path analysis estimated the proportion of this association explained by irritability. Analyses were repeated for individual neurodevelopmental problems. RESULTS: Childhood neurodevelopmental difficulties were associated with adolescent MDD (OR = 2.11, 95% CI = 1.24, 3.60, p = .006). Childhood irritability statistically accounted for 42% of this association. On examining each neurodevelopmental difficulty separately, autistic, communication and ADHD problems were each associated with depression, with irritability explaining 29%-51% of these links. CONCLUSIONS: Childhood irritability appears to be a key contributor to the link between childhood neurodevelopmental difficulties and adolescent MDD. High rates of irritability in children with autistic and ADHD difficulties may explain elevated rates of depression in the neurodevelopmental group. En ligne : http://dx.doi.org/10.1111/jcpp.13053 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=404

Editorial: Are computers going to take over: implications of machine learning and computational psychiatry for trainees and practising clinicians / A. STRINGARIS in Journal of Child Psychology and Psychiatry, 60-12 (December 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-12 (December 2019) . - p.1251-1253 Titre : Editorial: Are computers going to take over: implications of machine learning and computational psychiatry for trainees and practising clinicians Type de document : Texte imprimé et/ou numérique Auteurs : A. STRINGARIS, Auteur Article en page(s) : p.1251-1253 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Are computers going to take over? In some ways they already have, and they are bound to take over more. As clinicians and researchers, what do we need to do in order to handle, trust, and evaluate intelligent machines? En ligne : http://dx.doi.org/10.1111/jcpp.13168 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=412 [article] Editorial: Are computers going to take over: implications of machine learning and computational psychiatry for trainees and practising clinicians [Texte imprimé et/ou numérique] / A. STRINGARIS, Auteur . - p.1251-1253. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-12 (December 2019) . - p.1251-1253 Index. décimale : PER Périodiques Résumé : Are computers going to take over? In some ways they already have, and they are bound to take over more. As clinicians and researchers, what do we need to do in order to handle, trust, and evaluate intelligent machines? En ligne : http://dx.doi.org/10.1111/jcpp.13168 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=412

Editorial: Should child psychiatry be more like paediatric oncology? / A. STRINGARIS in Journal of Child Psychology and Psychiatry, 59-12 (December 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1225-1227 Titre : Editorial: Should child psychiatry be more like paediatric oncology? Type de document : Texte imprimé et/ou numérique Auteurs : A. STRINGARIS, Auteur ; K. STRINGARIS, Auteur Article en page(s) : p.1225-1227 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Looked at from a public health perspective, psychiatric disorders are devastating and cost humanity a tremendous amount of suffering as well as resources. On the other hand, childhood cancer is relatively rare and on a large scale, causes much less mortality and morbidity. Yet, when it comes to anything from public perception, to funding or to hyperbolic tabloid headlines, oncology wins hands down. Children with cancer are also better off when it comes to the quality of services and respect patients get from the health care system, treaters, and their own families. Also the cure rates for come childhood cancers, such as leukaemia, have improved dramatically. What can possibly explain such puzzling differences? En ligne : http://dx.doi.org/10.1111/jcpp.13006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 [article] Editorial: Should child psychiatry be more like paediatric oncology? [Texte imprimé et/ou numérique] / A. STRINGARIS, Auteur ; K. STRINGARIS, Auteur . - p.1225-1227. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1225-1227 Index. décimale : PER Périodiques Résumé : Looked at from a public health perspective, psychiatric disorders are devastating and cost humanity a tremendous amount of suffering as well as resources. On the other hand, childhood cancer is relatively rare and on a large scale, causes much less mortality and morbidity. Yet, when it comes to anything from public perception, to funding or to hyperbolic tabloid headlines, oncology wins hands down. Children with cancer are also better off when it comes to the quality of services and respect patients get from the health care system, treaters, and their own families. Also the cure rates for come childhood cancers, such as leukaemia, have improved dramatically. What can possibly explain such puzzling differences? En ligne : http://dx.doi.org/10.1111/jcpp.13006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371

Practitioner Review: Definition, recognition, and treatment challenges of irritability in young people / A. STRINGARIS in Journal of Child Psychology and Psychiatry, 59-7 (July 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-7 (July 2018) . - p.721-739 Titre : Practitioner Review: Definition, recognition, and treatment challenges of irritability in young people Type de document : Texte imprimé et/ou numérique Auteurs : A. STRINGARIS, Auteur ; P. VIDAL-RIBAS, Auteur ; Melissa A. BROTMAN, Auteur ; E. LEIBENLUFT, Auteur Article en page(s) : p.721-739 Langues : Anglais (eng) Mots-clés : Emotional dysregulation  assessment  intervention  mood disorder  temper tantrums Index. décimale : PER Périodiques Résumé : BACKGROUND: Irritability is one of the most common reasons for referral to child and adolescent mental health services and is the main characteristic of the new diagnosis of disruptive mood dysregulation disorder (DMDD). However, the recognition and management of irritability presents a major challenge in clinical practice and may be partly responsible for the dramatic increase in antipsychotic prescribing in recent years. METHODS: In this review, we provide up-to-date information on the definition and mechanisms underlying irritability, and its assessment in clinical practice. We aim to discuss the latest research on DMDD, and the presence of severe irritability in the context of other disorders, as well as to recommend a treatment algorithm. RESULTS: Severe irritability is associated with aberrant reward processing and bias toward threatening stimuli. Several measures are available to easily assess irritability. The recent diagnosis of DMDD captures children whose main problem is severe irritability and differ from those with bipolar disorder in longitudinal outcomes, family history, and behavioral and neural correlates. Treatment of irritability might depend on the context it appears. Indirect evidence suggests that parent management training (PMT) and cognitive behavioral therapy (CBT) are the most supported psychological treatments for irritability. CONCLUSIONS: Irritability, recognized as a mood problem rather than a purely behavioral manifestation, is a common condition for young people. Practitioners should not ignore irritability as it is associated with substantial morbidity and impairment. Although there are no trials with irritability as main outcome, clinicians can apply several existing pharmacological and psychological interventions for its treatment. Also, new promising approaches relying on pathophysiological findings, such as exposure-based cognitive behavioral therapy techniques and interpretation bias training (IBT), are being currently investigated. En ligne : http://dx.doi.org/10.1111/jcpp.12823 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] Practitioner Review: Definition, recognition, and treatment challenges of irritability in young people [Texte imprimé et/ou numérique] / A. STRINGARIS, Auteur ; P. VIDAL-RIBAS, Auteur ; Melissa A. BROTMAN, Auteur ; E. LEIBENLUFT, Auteur . - p.721-739. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-7 (July 2018) . - p.721-739 Mots-clés : Emotional dysregulation  assessment  intervention  mood disorder  temper tantrums Index. décimale : PER Périodiques Résumé : BACKGROUND: Irritability is one of the most common reasons for referral to child and adolescent mental health services and is the main characteristic of the new diagnosis of disruptive mood dysregulation disorder (DMDD). However, the recognition and management of irritability presents a major challenge in clinical practice and may be partly responsible for the dramatic increase in antipsychotic prescribing in recent years. METHODS: In this review, we provide up-to-date information on the definition and mechanisms underlying irritability, and its assessment in clinical practice. We aim to discuss the latest research on DMDD, and the presence of severe irritability in the context of other disorders, as well as to recommend a treatment algorithm. RESULTS: Severe irritability is associated with aberrant reward processing and bias toward threatening stimuli. Several measures are available to easily assess irritability. The recent diagnosis of DMDD captures children whose main problem is severe irritability and differ from those with bipolar disorder in longitudinal outcomes, family history, and behavioral and neural correlates. Treatment of irritability might depend on the context it appears. Indirect evidence suggests that parent management training (PMT) and cognitive behavioral therapy (CBT) are the most supported psychological treatments for irritability. CONCLUSIONS: Irritability, recognized as a mood problem rather than a purely behavioral manifestation, is a common condition for young people. Practitioners should not ignore irritability as it is associated with substantial morbidity and impairment. Although there are no trials with irritability as main outcome, clinicians can apply several existing pharmacological and psychological interventions for its treatment. Also, new promising approaches relying on pathophysiological findings, such as exposure-based cognitive behavioral therapy techniques and interpretation bias training (IBT), are being currently investigated. En ligne : http://dx.doi.org/10.1111/jcpp.12823 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

Special Editorial: Open science and the Journal of Child Psychology & Psychiatry - next steps? / J. ASARNOW in Journal of Child Psychology and Psychiatry, 59-7 (July 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-7 (July 2018) . - p.826-827 Titre : Special Editorial: Open science and the Journal of Child Psychology & Psychiatry - next steps? Type de document : Texte imprimé et/ou numérique Auteurs : J. ASARNOW, Auteur ; Michael H. BLOCH, Auteur ; Daniel BRANDEIS, Auteur ; S. Alexandra BURT, Auteur ; P. FEARON, Auteur ; E. FOMBONNE, Auteur ; J. GREEN, Auteur ; A. GREGORY, Auteur ; M. GUNNAR, Auteur ; J. M. HALPERIN, Auteur ; C. HOLLIS, Auteur ; Sara JAFFEE, Auteur ; K. KLUMP, Auteur ; S. LANDAU, Auteur ; K. P. LESCH, Auteur ; A. J. T. OLDEHINKEL, Auteur ; B. PETERSON, Auteur ; P. RAMCHANDANI, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; A. STRINGARIS, Auteur ; C. H. ZEANAH, Auteur Article en page(s) : p.826-827 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The JCPP works at the cutting edge of clinical science to publish ground-breaking research across the full range of topics in the field of child psychology and psychiatry. As JCPP editors, who are also active researchers in our own right, we are conscious of the threat posed to our field by what has come to be known as the reproducibility crisis - the fact that many published findings, initially trumpeted as important developments in the field, cannot be replicated and are therefore likely to be spurious (Nature Human Behaviour, 1, 2017, 21). The JCPP is conscious of its responsibility to play its part in addressing this issue as best it can. The roots of the problem are complex and its causes multifaceted. As one part of its response, the JCPP embraces the principles of open science and encourage preregistration of study protocols. Furthermore, we are working towards implementing new systems to promote preregistration with the hope of increasing scientific transparency and accountability and reducing the risks of selective reporting and posthoc rationalisation of findings (Journal of Child Psychology & Psychiatry, 59, 2018, 1). En ligne : http://dx.doi.org/10.1111/jcpp.12929 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] Special Editorial: Open science and the Journal of Child Psychology & Psychiatry - next steps? [Texte imprimé et/ou numérique] / J. ASARNOW, Auteur ; Michael H. BLOCH, Auteur ; Daniel BRANDEIS, Auteur ; S. Alexandra BURT, Auteur ; P. FEARON, Auteur ; E. FOMBONNE, Auteur ; J. GREEN, Auteur ; A. GREGORY, Auteur ; M. GUNNAR, Auteur ; J. M. HALPERIN, Auteur ; C. HOLLIS, Auteur ; Sara JAFFEE, Auteur ; K. KLUMP, Auteur ; S. LANDAU, Auteur ; K. P. LESCH, Auteur ; A. J. T. OLDEHINKEL, Auteur ; B. PETERSON, Auteur ; P. RAMCHANDANI, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; A. STRINGARIS, Auteur ; C. H. ZEANAH, Auteur . - p.826-827. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-7 (July 2018) . - p.826-827 Index. décimale : PER Périodiques Résumé : The JCPP works at the cutting edge of clinical science to publish ground-breaking research across the full range of topics in the field of child psychology and psychiatry. As JCPP editors, who are also active researchers in our own right, we are conscious of the threat posed to our field by what has come to be known as the reproducibility crisis - the fact that many published findings, initially trumpeted as important developments in the field, cannot be replicated and are therefore likely to be spurious (Nature Human Behaviour, 1, 2017, 21). The JCPP is conscious of its responsibility to play its part in addressing this issue as best it can. The roots of the problem are complex and its causes multifaceted. As one part of its response, the JCPP embraces the principles of open science and encourage preregistration of study protocols. Furthermore, we are working towards implementing new systems to promote preregistration with the hope of increasing scientific transparency and accountability and reducing the risks of selective reporting and posthoc rationalisation of findings (Journal of Child Psychology & Psychiatry, 59, 2018, 1). En ligne : http://dx.doi.org/10.1111/jcpp.12929 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

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