
- <Centre d'Information et de documentation du CRA Rhône-Alpes
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Mention de date : December 2018
Paru le : 01/12/2018 |
[n° ou bulletin]
[n° ou bulletin]
59-12 - December 2018 [Texte imprimé et/ou numérique] . - 2018. Langues : Anglais (eng)
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Exemplaires (1)
Code-barres | Cote | Support | Localisation | Section | Disponibilité |
---|---|---|---|---|---|
PER0001666 | PER JCP | Périodique | Centre d'Information et de Documentation du CRA Rhône-Alpes | PER - Périodiques | Exclu du prêt |
Dépouillements


Editorial: Should child psychiatry be more like paediatric oncology? / A. STRINGARIS in Journal of Child Psychology and Psychiatry, 59-12 (December 2018)
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Titre : Editorial: Should child psychiatry be more like paediatric oncology? Type de document : Texte imprimé et/ou numérique Auteurs : A. STRINGARIS, Auteur ; K. STRINGARIS, Auteur Article en page(s) : p.1225-1227 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Looked at from a public health perspective, psychiatric disorders are devastating and cost humanity a tremendous amount of suffering as well as resources. On the other hand, childhood cancer is relatively rare and on a large scale, causes much less mortality and morbidity. Yet, when it comes to anything from public perception, to funding or to hyperbolic tabloid headlines, oncology wins hands down. Children with cancer are also better off when it comes to the quality of services and respect patients get from the health care system, treaters, and their own families. Also the cure rates for come childhood cancers, such as leukaemia, have improved dramatically. What can possibly explain such puzzling differences? En ligne : http://dx.doi.org/10.1111/jcpp.13006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371
in Journal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1225-1227[article] Editorial: Should child psychiatry be more like paediatric oncology? [Texte imprimé et/ou numérique] / A. STRINGARIS, Auteur ; K. STRINGARIS, Auteur . - p.1225-1227.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1225-1227
Index. décimale : PER Périodiques Résumé : Looked at from a public health perspective, psychiatric disorders are devastating and cost humanity a tremendous amount of suffering as well as resources. On the other hand, childhood cancer is relatively rare and on a large scale, causes much less mortality and morbidity. Yet, when it comes to anything from public perception, to funding or to hyperbolic tabloid headlines, oncology wins hands down. Children with cancer are also better off when it comes to the quality of services and respect patients get from the health care system, treaters, and their own families. Also the cure rates for come childhood cancers, such as leukaemia, have improved dramatically. What can possibly explain such puzzling differences? En ligne : http://dx.doi.org/10.1111/jcpp.13006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 Research Review: Gender identity in youth: treatment paradigms and controversies / J. L. TURBAN in Journal of Child Psychology and Psychiatry, 59-12 (December 2018)
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Titre : Research Review: Gender identity in youth: treatment paradigms and controversies Type de document : Texte imprimé et/ou numérique Auteurs : J. L. TURBAN, Auteur ; D. EHRENSAFT, Auteur Article en page(s) : p.1228-1243 Langues : Anglais (eng) Mots-clés : Gender dysphoria anxiety depression gender identity suicidal behavior Index. décimale : PER Périodiques Résumé : BACKGROUND: Pediatric gender identity has gained increased attention over the past several years in the popular media, political arena, and medical literature. This article reviews terminology in this evolving field, traditional models of gender identity development and their limitations, epidemiology and natural history of cross-gender identification among children and adolescents, co-occurring conditions and behaviors, research into the biological and psychosocial determinants of cross-gender identification, and research into the options regarding and benefits of clinical approaches to gender incongruent youth. METHODS: Based on a critical review of the extant literature, both theoretical and empirical, that addresses the issue of pediatric gender identity, the authors synthesized what is presently known and what is in need of further research in order to elucidate the developmental trajectory and clinical needs of gender diverse youth. RESULTS: The field of pediatric gender identity has evolved substantially over the past several years. New research suggests that cross-gender identification is prevalent (approximately 1% of youth). These youth suffer disproportionately high rates of anxiety, depression, and suicidality. Although research into the etiology of cross-gender identification is limited, emerging data have shown that affirmative treatment protocols may improve the high rates of mental health difficulties seen among these patients. CONCLUSIONS: The field of pediatric gender identity has evolved dramatically. Emerging data suggest that these patients' high rates of anxiety, depression, and suicidality appear to be improved with affirmative protocols, although future longitudinal data are needed. En ligne : http://dx.doi.org/10.1111/jcpp.12833 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371
in Journal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1228-1243[article] Research Review: Gender identity in youth: treatment paradigms and controversies [Texte imprimé et/ou numérique] / J. L. TURBAN, Auteur ; D. EHRENSAFT, Auteur . - p.1228-1243.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1228-1243
Mots-clés : Gender dysphoria anxiety depression gender identity suicidal behavior Index. décimale : PER Périodiques Résumé : BACKGROUND: Pediatric gender identity has gained increased attention over the past several years in the popular media, political arena, and medical literature. This article reviews terminology in this evolving field, traditional models of gender identity development and their limitations, epidemiology and natural history of cross-gender identification among children and adolescents, co-occurring conditions and behaviors, research into the biological and psychosocial determinants of cross-gender identification, and research into the options regarding and benefits of clinical approaches to gender incongruent youth. METHODS: Based on a critical review of the extant literature, both theoretical and empirical, that addresses the issue of pediatric gender identity, the authors synthesized what is presently known and what is in need of further research in order to elucidate the developmental trajectory and clinical needs of gender diverse youth. RESULTS: The field of pediatric gender identity has evolved substantially over the past several years. New research suggests that cross-gender identification is prevalent (approximately 1% of youth). These youth suffer disproportionately high rates of anxiety, depression, and suicidality. Although research into the etiology of cross-gender identification is limited, emerging data have shown that affirmative treatment protocols may improve the high rates of mental health difficulties seen among these patients. CONCLUSIONS: The field of pediatric gender identity has evolved dramatically. Emerging data suggest that these patients' high rates of anxiety, depression, and suicidality appear to be improved with affirmative protocols, although future longitudinal data are needed. En ligne : http://dx.doi.org/10.1111/jcpp.12833 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 Evidence needed to understand gender identity: Commentary on Turban & Ehrensaft (2018) / Sheri A. BERENBAUM in Journal of Child Psychology and Psychiatry, 59-12 (December 2018)
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Titre : Evidence needed to understand gender identity: Commentary on Turban & Ehrensaft (2018) Type de document : Texte imprimé et/ou numérique Auteurs : Sheri A. BERENBAUM, Auteur Article en page(s) : p.1244-1247 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Turban and Ehrensaft (2018) have provided a thoughtful review of transgender identity in children and adolescents, emphasizing the benefits of the affirmative approach in maintaining positive psychological health in transgender individuals. The review reveals significant gaps in our understanding of gender identity regarding its nature, development, plasticity, causes, and links with other aspects of gender, and of the long-term benefits and costs of childhood social transitions. A full understanding of transgender identity requires studying cisgender identity too, and recognition that gender identity is continuous, develops across time and is not synonymous with gender expression or variations in gender-typed characteristics. Considerable evidence is needed before we can be confident that we are providing optimal treatment for children who are gender variant. En ligne : http://dx.doi.org/10.1111/jcpp.12997 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371
in Journal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1244-1247[article] Evidence needed to understand gender identity: Commentary on Turban & Ehrensaft (2018) [Texte imprimé et/ou numérique] / Sheri A. BERENBAUM, Auteur . - p.1244-1247.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1244-1247
Index. décimale : PER Périodiques Résumé : Turban and Ehrensaft (2018) have provided a thoughtful review of transgender identity in children and adolescents, emphasizing the benefits of the affirmative approach in maintaining positive psychological health in transgender individuals. The review reveals significant gaps in our understanding of gender identity regarding its nature, development, plasticity, causes, and links with other aspects of gender, and of the long-term benefits and costs of childhood social transitions. A full understanding of transgender identity requires studying cisgender identity too, and recognition that gender identity is continuous, develops across time and is not synonymous with gender expression or variations in gender-typed characteristics. Considerable evidence is needed before we can be confident that we are providing optimal treatment for children who are gender variant. En ligne : http://dx.doi.org/10.1111/jcpp.12997 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 Editorial Perspective: Delayed circadian rhythm phase: a cause of late-onset attention-deficit/hyperactivity disorder among adolescents? / J. R. LUNSFORD-AVERY in Journal of Child Psychology and Psychiatry, 59-12 (December 2018)
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Titre : Editorial Perspective: Delayed circadian rhythm phase: a cause of late-onset attention-deficit/hyperactivity disorder among adolescents? Type de document : Texte imprimé et/ou numérique Auteurs : J. R. LUNSFORD-AVERY, Auteur ; S. H. KOLLINS, Auteur Article en page(s) : p.1248-1251 Langues : Anglais (eng) Mots-clés : Adhd circadian rhythm sleep Index. décimale : PER Périodiques Résumé : Late-onset attention-deficit/hyperactivity disorder (ADHD) has been a topic of significant debate within our field. One question focuses on whether there may be alternative explanations for the onset of inattentive and/or hyperactive symptoms in adolescence. Adolescence is a developmental period associated with a normative circadian rhythm phase delay, and there is significant overlap in the behavioral and cognitive manifestations and genetic underpinnings of ADHD and circadian misalignment. Delayed circadian rhythm phase is also common among individuals with traditionally diagnosed ADHD, and exposure to bright light may be protective against ADHD, a process potentially mediated by improved circadian timing. In addition, daytime sleepiness is prevalent in late-onset ADHD. Despite these converging lines of evidence, circadian misalignment is yet to be considered in the context of late-onset ADHD - a glaring gap. It is imperative for future research in late-onset ADHD to consider a possible causal role of delayed circadian rhythm phase in adolescence. Clarification of this issue has significant implications for research, clinical care, and public health. En ligne : http://dx.doi.org/10.1111/jcpp.12956 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371
in Journal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1248-1251[article] Editorial Perspective: Delayed circadian rhythm phase: a cause of late-onset attention-deficit/hyperactivity disorder among adolescents? [Texte imprimé et/ou numérique] / J. R. LUNSFORD-AVERY, Auteur ; S. H. KOLLINS, Auteur . - p.1248-1251.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1248-1251
Mots-clés : Adhd circadian rhythm sleep Index. décimale : PER Périodiques Résumé : Late-onset attention-deficit/hyperactivity disorder (ADHD) has been a topic of significant debate within our field. One question focuses on whether there may be alternative explanations for the onset of inattentive and/or hyperactive symptoms in adolescence. Adolescence is a developmental period associated with a normative circadian rhythm phase delay, and there is significant overlap in the behavioral and cognitive manifestations and genetic underpinnings of ADHD and circadian misalignment. Delayed circadian rhythm phase is also common among individuals with traditionally diagnosed ADHD, and exposure to bright light may be protective against ADHD, a process potentially mediated by improved circadian timing. In addition, daytime sleepiness is prevalent in late-onset ADHD. Despite these converging lines of evidence, circadian misalignment is yet to be considered in the context of late-onset ADHD - a glaring gap. It is imperative for future research in late-onset ADHD to consider a possible causal role of delayed circadian rhythm phase in adolescence. Clarification of this issue has significant implications for research, clinical care, and public health. En ligne : http://dx.doi.org/10.1111/jcpp.12956 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 Police contacts, arrests and decreasing self-control and personal responsibility among female adolescents / A. E. HIPWELL in Journal of Child Psychology and Psychiatry, 59-12 (December 2018)
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Titre : Police contacts, arrests and decreasing self-control and personal responsibility among female adolescents Type de document : Texte imprimé et/ou numérique Auteurs : A. E. HIPWELL, Auteur ; Joseph E. BEENEY, Auteur ; F. YE, Auteur ; S. H. GEBRESELASSIE, Auteur ; M. R. STALTER, Auteur ; D. GANESH, Auteur ; Kate KEENAN, Auteur ; Stephanie D. STEPP, Auteur Article en page(s) : p.1252-1260 Langues : Anglais (eng) Mots-clés : Females adolescents arrest police contacts responsibility self-control Index. décimale : PER Périodiques Résumé : BACKGROUND: Female involvement in the juvenile justice system (JJS) has increased rapidly in recent years. Although deficits in self-control and responsibility are associated with delinquency and higher rates of police contacts and arrests, much of this research has focused on males and/or selected samples of youth who already have a history of JJS involvement. Furthermore, little is known about the extent to which police contacts and arrests may disrupt normative psychosocial maturation. METHODS: Police contacts, arrests, levels of self-control and personal responsibility were assessed annually between 12 and 17 years in a population-based sample of 2,450 adolescent females. Fixed-effects regression models, which control for stable individual characteristics, were used to examine whether within-adolescent changes in self-control, and responsibility were associated concurrently and prospectively with police contacts and arrests, and vice versa. RESULTS: Across adolescence, 5%-12% participants reported police contacts and 1%-4% were arrested. After adjusting for covariates, within-person increases in self-control and responsibility were associated concurrently with decreased odds of police contact. Increasing responsibility also predicted lower likelihood of police contact in the following year. When testing reverse causation, results showed that police contact predicted next year decreases in personal responsibility, and that being arrested predicted decreasing levels of self-control and responsibility in the following year. CONCLUSIONS: The study shows more clearly than previous work that increasing levels of responsibility precede decreased police contact in nonselected adolescent females, and that contacts with the justice system during adolescence may delay or undermine normative psychosocial maturation, highlighting important targets for intervention. En ligne : http://dx.doi.org/10.1111/jcpp.12914 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371
in Journal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1252-1260[article] Police contacts, arrests and decreasing self-control and personal responsibility among female adolescents [Texte imprimé et/ou numérique] / A. E. HIPWELL, Auteur ; Joseph E. BEENEY, Auteur ; F. YE, Auteur ; S. H. GEBRESELASSIE, Auteur ; M. R. STALTER, Auteur ; D. GANESH, Auteur ; Kate KEENAN, Auteur ; Stephanie D. STEPP, Auteur . - p.1252-1260.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1252-1260
Mots-clés : Females adolescents arrest police contacts responsibility self-control Index. décimale : PER Périodiques Résumé : BACKGROUND: Female involvement in the juvenile justice system (JJS) has increased rapidly in recent years. Although deficits in self-control and responsibility are associated with delinquency and higher rates of police contacts and arrests, much of this research has focused on males and/or selected samples of youth who already have a history of JJS involvement. Furthermore, little is known about the extent to which police contacts and arrests may disrupt normative psychosocial maturation. METHODS: Police contacts, arrests, levels of self-control and personal responsibility were assessed annually between 12 and 17 years in a population-based sample of 2,450 adolescent females. Fixed-effects regression models, which control for stable individual characteristics, were used to examine whether within-adolescent changes in self-control, and responsibility were associated concurrently and prospectively with police contacts and arrests, and vice versa. RESULTS: Across adolescence, 5%-12% participants reported police contacts and 1%-4% were arrested. After adjusting for covariates, within-person increases in self-control and responsibility were associated concurrently with decreased odds of police contact. Increasing responsibility also predicted lower likelihood of police contact in the following year. When testing reverse causation, results showed that police contact predicted next year decreases in personal responsibility, and that being arrested predicted decreasing levels of self-control and responsibility in the following year. CONCLUSIONS: The study shows more clearly than previous work that increasing levels of responsibility precede decreased police contact in nonselected adolescent females, and that contacts with the justice system during adolescence may delay or undermine normative psychosocial maturation, highlighting important targets for intervention. En ligne : http://dx.doi.org/10.1111/jcpp.12914 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 Predicting suicide attempts in adolescents with longitudinal clinical data and machine learning / C. G. WALSH in Journal of Child Psychology and Psychiatry, 59-12 (December 2018)
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Titre : Predicting suicide attempts in adolescents with longitudinal clinical data and machine learning Type de document : Texte imprimé et/ou numérique Auteurs : C. G. WALSH, Auteur ; J. D. RIBEIRO, Auteur ; J. C. FRANKLIN, Auteur Article en page(s) : p.1261-1270 Langues : Anglais (eng) Mots-clés : Suicide adolescent attempted decision support techniques electronic health records machine learning Index. décimale : PER Périodiques Résumé : BACKGROUND: Adolescents have high rates of nonfatal suicide attempts, but clinically practical risk prediction remains a challenge. Screening can be time consuming to implement at scale, if it is done at all. Computational algorithms may predict suicide risk using only routinely collected clinical data. We used a machine learning approach validated on longitudinal clinical data in adults to address this challenge in adolescents. METHODS: This is a retrospective, longitudinal cohort study. Data were collected from the Vanderbilt Synthetic Derivative from January 1998 to December 2015 and included 974 adolescents with nonfatal suicide attempts and multiple control comparisons: 496 adolescents with other self-injury (OSI), 7,059 adolescents with depressive symptoms, and 25,081 adolescent general hospital controls. Candidate predictors included diagnostic, demographic, medication, and socioeconomic factors. Outcome was determined by multiexpert review of electronic health records. Random forests were validated with optimism adjustment at multiple time points (from 1 week to 2 years). Recalibration was done via isotonic regression. Evaluation metrics included discrimination (AUC, sensitivity/specificity, precision/recall) and calibration (calibration plots, slope/intercept, Brier score). RESULTS: Computational models performed well and did not require face-to-face screening. Performance improved as suicide attempts became more imminent. Discrimination was good in comparison with OSI controls (AUC = 0.83 [0.82-0.84] at 720 days; AUC = 0.85 [0.84-0.87] at 7 days) and depressed controls (AUC = 0.87 [95% CI 0.85-0.90] at 720 days; 0.90 [0.85-0.94] at 7 days) and best in comparison with general hospital controls (AUC 0.94 [0.92-0.96] at 720 days; 0.97 [0.95-0.98] at 7 days). Random forests significantly outperformed logistic regression in every comparison. Recalibration improved performance as much as ninefold - clinical recommendations with poorly calibrated predictions can lead to decision errors. CONCLUSIONS: Machine learning on longitudinal clinical data may provide a scalable approach to broaden screening for risk of nonfatal suicide attempts in adolescents. En ligne : http://dx.doi.org/10.1111/jcpp.12916 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371
in Journal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1261-1270[article] Predicting suicide attempts in adolescents with longitudinal clinical data and machine learning [Texte imprimé et/ou numérique] / C. G. WALSH, Auteur ; J. D. RIBEIRO, Auteur ; J. C. FRANKLIN, Auteur . - p.1261-1270.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1261-1270
Mots-clés : Suicide adolescent attempted decision support techniques electronic health records machine learning Index. décimale : PER Périodiques Résumé : BACKGROUND: Adolescents have high rates of nonfatal suicide attempts, but clinically practical risk prediction remains a challenge. Screening can be time consuming to implement at scale, if it is done at all. Computational algorithms may predict suicide risk using only routinely collected clinical data. We used a machine learning approach validated on longitudinal clinical data in adults to address this challenge in adolescents. METHODS: This is a retrospective, longitudinal cohort study. Data were collected from the Vanderbilt Synthetic Derivative from January 1998 to December 2015 and included 974 adolescents with nonfatal suicide attempts and multiple control comparisons: 496 adolescents with other self-injury (OSI), 7,059 adolescents with depressive symptoms, and 25,081 adolescent general hospital controls. Candidate predictors included diagnostic, demographic, medication, and socioeconomic factors. Outcome was determined by multiexpert review of electronic health records. Random forests were validated with optimism adjustment at multiple time points (from 1 week to 2 years). Recalibration was done via isotonic regression. Evaluation metrics included discrimination (AUC, sensitivity/specificity, precision/recall) and calibration (calibration plots, slope/intercept, Brier score). RESULTS: Computational models performed well and did not require face-to-face screening. Performance improved as suicide attempts became more imminent. Discrimination was good in comparison with OSI controls (AUC = 0.83 [0.82-0.84] at 720 days; AUC = 0.85 [0.84-0.87] at 7 days) and depressed controls (AUC = 0.87 [95% CI 0.85-0.90] at 720 days; 0.90 [0.85-0.94] at 7 days) and best in comparison with general hospital controls (AUC 0.94 [0.92-0.96] at 720 days; 0.97 [0.95-0.98] at 7 days). Random forests significantly outperformed logistic regression in every comparison. Recalibration improved performance as much as ninefold - clinical recommendations with poorly calibrated predictions can lead to decision errors. CONCLUSIONS: Machine learning on longitudinal clinical data may provide a scalable approach to broaden screening for risk of nonfatal suicide attempts in adolescents. En ligne : http://dx.doi.org/10.1111/jcpp.12916 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 How do stimulant treatments for ADHD work? Evidence for mediation by improved cognition / L. W. HAWK in Journal of Child Psychology and Psychiatry, 59-12 (December 2018)
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Titre : How do stimulant treatments for ADHD work? Evidence for mediation by improved cognition Type de document : Texte imprimé et/ou numérique Auteurs : L. W. HAWK, Auteur ; W. D. FOSCO, Auteur ; Craig R. COLDER, Auteur ; J. G. WAXMONSKY, Auteur ; W. E. PELHAM, Auteur ; K. S. ROSCH, Auteur Article en page(s) : p.1271-1281 Langues : Anglais (eng) Mots-clés : Attention-Deficit/Hyperactivity Disorder cognition mediation methylphenidate Index. décimale : PER Périodiques Résumé : BACKGROUND: Stimulant medications such as methylphenidate (MPH) are the frontline treatment for Attention-Deficit/Hyperactivity Disorder (ADHD). Despite their well-documented efficacy, the mechanisms by which stimulants improve clinical outcomes are not clear. The current study evaluated whether MPH effects on classroom behavior were mediated by improved cognitive functioning. METHODS: Children with ADHD (n = 82; 9-12 years old) participated in a week-long summer research camp, consisting of cognitive testing, classroom periods, and recreational activities. After a baseline day, participants completed a 3-day randomized, double-blind, placebo-controlled trial of MPH (at doses approximating 0.3 and 0.6 mg/kg of immediate-release MPH dosed TID). Cognitive domains included inhibitory control (Stop Signal Task and prepulse inhibition of startle), attention (Continuous Performance Task and reaction time variability), and working memory (forward and backward spatial span). Clinical outcomes included math seatwork productivity and teacher-rated classroom behavior. A within-subjects path-analytic approach was used to test mediation. MPH-placebo and dose-response contrasts were used to evaluate drug effects. RESULTS: Methylphenidate improved seatwork productivity and teacher ratings (ds = 1.4 and 1.1) and all domains of cognition (ds = 0.3-1.1). Inhibitory control (Stop Signal Task, SST) and working memory backward uniquely mediated the effect of MPH (vs. placebo) on productivity. Only working memory backward mediated the impact of MPH on teacher-rated behavior. The dose-response (0.6 vs. 0.3 mg/kg) effects were more modest for clinical outcomes (ds = 0.4 and 0.2) and cognition (ds = 0-0.3); there was no evidence of cognitive mediation of the clinical dose-response effects. CONCLUSIONS: These findings are novel in demonstrating that specific cognitive processes mediate clinical improvement with stimulant treatment for ADHD. They converge with work on ADHD theory, neurobiology, and treatment development in suggesting that inhibitory control and working memory may be mechanisms of stimulant treatment response in ADHD. More work is necessary to evaluate the degree to which these findings generalize to chronic treatment, a broader array of clinical outcomes, and nonstimulant treatments. En ligne : http://dx.doi.org/10.1111/jcpp.12917 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371
in Journal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1271-1281[article] How do stimulant treatments for ADHD work? Evidence for mediation by improved cognition [Texte imprimé et/ou numérique] / L. W. HAWK, Auteur ; W. D. FOSCO, Auteur ; Craig R. COLDER, Auteur ; J. G. WAXMONSKY, Auteur ; W. E. PELHAM, Auteur ; K. S. ROSCH, Auteur . - p.1271-1281.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1271-1281
Mots-clés : Attention-Deficit/Hyperactivity Disorder cognition mediation methylphenidate Index. décimale : PER Périodiques Résumé : BACKGROUND: Stimulant medications such as methylphenidate (MPH) are the frontline treatment for Attention-Deficit/Hyperactivity Disorder (ADHD). Despite their well-documented efficacy, the mechanisms by which stimulants improve clinical outcomes are not clear. The current study evaluated whether MPH effects on classroom behavior were mediated by improved cognitive functioning. METHODS: Children with ADHD (n = 82; 9-12 years old) participated in a week-long summer research camp, consisting of cognitive testing, classroom periods, and recreational activities. After a baseline day, participants completed a 3-day randomized, double-blind, placebo-controlled trial of MPH (at doses approximating 0.3 and 0.6 mg/kg of immediate-release MPH dosed TID). Cognitive domains included inhibitory control (Stop Signal Task and prepulse inhibition of startle), attention (Continuous Performance Task and reaction time variability), and working memory (forward and backward spatial span). Clinical outcomes included math seatwork productivity and teacher-rated classroom behavior. A within-subjects path-analytic approach was used to test mediation. MPH-placebo and dose-response contrasts were used to evaluate drug effects. RESULTS: Methylphenidate improved seatwork productivity and teacher ratings (ds = 1.4 and 1.1) and all domains of cognition (ds = 0.3-1.1). Inhibitory control (Stop Signal Task, SST) and working memory backward uniquely mediated the effect of MPH (vs. placebo) on productivity. Only working memory backward mediated the impact of MPH on teacher-rated behavior. The dose-response (0.6 vs. 0.3 mg/kg) effects were more modest for clinical outcomes (ds = 0.4 and 0.2) and cognition (ds = 0-0.3); there was no evidence of cognitive mediation of the clinical dose-response effects. CONCLUSIONS: These findings are novel in demonstrating that specific cognitive processes mediate clinical improvement with stimulant treatment for ADHD. They converge with work on ADHD theory, neurobiology, and treatment development in suggesting that inhibitory control and working memory may be mechanisms of stimulant treatment response in ADHD. More work is necessary to evaluate the degree to which these findings generalize to chronic treatment, a broader array of clinical outcomes, and nonstimulant treatments. En ligne : http://dx.doi.org/10.1111/jcpp.12917 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 Early warm-rewarding parenting moderates the genetic contributions to callous-unemotional traits in childhood / J. HENRY in Journal of Child Psychology and Psychiatry, 59-12 (December 2018)
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Titre : Early warm-rewarding parenting moderates the genetic contributions to callous-unemotional traits in childhood Type de document : Texte imprimé et/ou numérique Auteurs : J. HENRY, Auteur ; G. DIONNE, Auteur ; E. VIDING, Auteur ; F. VITARO, Auteur ; M. BRENDGEN, Auteur ; R. E. TREMBLAY, Auteur ; Michel BOIVIN, Auteur Article en page(s) : p.1282-1288 Langues : Anglais (eng) Mots-clés : Callous-unemotional traits gene-environment interaction twin studies warm/rewarding parenting Index. décimale : PER Périodiques Résumé : BACKGROUND: Previous gene-environment interaction studies of CU traits have relied on the candidate gene approach, which does not account for the entire genetic load of complex phenotypes. Moreover, these studies have not examined the role of positive environmental factors such as warm/rewarding parenting. The aim of the present study was to determine whether early warm/rewarding parenting moderates the genetic contributions (i.e., heritability) to callous-unemotional (CU) traits at school age. METHODS: Data were collected in a population sample of 662 twin pairs (Quebec Newborn Twin Study - QNTS). Mothers reported on their warm/rewarding parenting. Teachers assessed children's CU traits. These reports were subjected to twin modeling. RESULTS: Callous-unemotional traits were highly heritable, with the remaining variance accounted for by nonshared environmental factors. Warm/rewarding parenting significantly moderated the role of genes in CU traits; heritability was lower when children received high warm/rewarding parenting than when they were exposed to low warm/rewarding parenting. CONCLUSIONS: High warm/rewarding parenting may partly impede the genetic expression of CU traits. Developmental models of CU traits need to account for such gene-environment processes. En ligne : http://dx.doi.org/10.1111/jcpp.12918 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371
in Journal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1282-1288[article] Early warm-rewarding parenting moderates the genetic contributions to callous-unemotional traits in childhood [Texte imprimé et/ou numérique] / J. HENRY, Auteur ; G. DIONNE, Auteur ; E. VIDING, Auteur ; F. VITARO, Auteur ; M. BRENDGEN, Auteur ; R. E. TREMBLAY, Auteur ; Michel BOIVIN, Auteur . - p.1282-1288.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1282-1288
Mots-clés : Callous-unemotional traits gene-environment interaction twin studies warm/rewarding parenting Index. décimale : PER Périodiques Résumé : BACKGROUND: Previous gene-environment interaction studies of CU traits have relied on the candidate gene approach, which does not account for the entire genetic load of complex phenotypes. Moreover, these studies have not examined the role of positive environmental factors such as warm/rewarding parenting. The aim of the present study was to determine whether early warm/rewarding parenting moderates the genetic contributions (i.e., heritability) to callous-unemotional (CU) traits at school age. METHODS: Data were collected in a population sample of 662 twin pairs (Quebec Newborn Twin Study - QNTS). Mothers reported on their warm/rewarding parenting. Teachers assessed children's CU traits. These reports were subjected to twin modeling. RESULTS: Callous-unemotional traits were highly heritable, with the remaining variance accounted for by nonshared environmental factors. Warm/rewarding parenting significantly moderated the role of genes in CU traits; heritability was lower when children received high warm/rewarding parenting than when they were exposed to low warm/rewarding parenting. CONCLUSIONS: High warm/rewarding parenting may partly impede the genetic expression of CU traits. Developmental models of CU traits need to account for such gene-environment processes. En ligne : http://dx.doi.org/10.1111/jcpp.12918 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 Neural reward responsiveness in children who engage in nonsuicidal self-injury: an ERP study / A. TSYPES in Journal of Child Psychology and Psychiatry, 59-12 (December 2018)
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[article]
Titre : Neural reward responsiveness in children who engage in nonsuicidal self-injury: an ERP study Type de document : Texte imprimé et/ou numérique Auteurs : A. TSYPES, Auteur ; M. OWENS, Auteur ; G. HAJCAK, Auteur ; B. E. GIBB, Auteur Article en page(s) : p.1289-1297 Langues : Anglais (eng) Mots-clés : Nonsuicidal self-injury children event-related potential feedback negativity rewards Index. décimale : PER Périodiques Résumé : BACKGROUND: A better understanding of the correlates of nonsuicidal self-injury (NSSI) in children is important for the identification and prevention of future suicide risk. However, although abnormalities in reward responsiveness might constitute one potential transdiagnostic mechanism of risk for NSSI, no studies have examined initial response to reward in children with a history of NSSI. The goal of the present study was to address this important gap in the literature. To objectively assess initial response to reward, we utilized the feedback negativity (FN) event-related potential, a well-established psychophysiological marker of reward responsiveness. METHODS: Participants were 57 children (19 with a history of NSSI and 38 demographically matched controls) between the ages of 7 and 11. Diagnostic interviews were used to assess for current and past DSM-IV mood and anxiety diagnoses and NSSI history. Children also completed a guessing task, during which continuous electroencephalography was recorded. RESULTS: Children with a history of NSSI exhibited significantly more negative DeltaFN (i.e., FN to losses minus FN to gains) than children without NSSI. These findings appeared to be at least partially independent of children's history of psychopathology and current symptoms, suggesting their specificity to NSSI. CONCLUSIONS: These results provide initial evidence for heightened neural initial reward responsiveness to losses versus rewards in children with a history of NSSI. Pending replications and longitudinal studies, the DeltaFN might represent a psychophysiological marker of risk for self-harm. En ligne : http://dx.doi.org/10.1111/jcpp.12919 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371
in Journal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1289-1297[article] Neural reward responsiveness in children who engage in nonsuicidal self-injury: an ERP study [Texte imprimé et/ou numérique] / A. TSYPES, Auteur ; M. OWENS, Auteur ; G. HAJCAK, Auteur ; B. E. GIBB, Auteur . - p.1289-1297.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1289-1297
Mots-clés : Nonsuicidal self-injury children event-related potential feedback negativity rewards Index. décimale : PER Périodiques Résumé : BACKGROUND: A better understanding of the correlates of nonsuicidal self-injury (NSSI) in children is important for the identification and prevention of future suicide risk. However, although abnormalities in reward responsiveness might constitute one potential transdiagnostic mechanism of risk for NSSI, no studies have examined initial response to reward in children with a history of NSSI. The goal of the present study was to address this important gap in the literature. To objectively assess initial response to reward, we utilized the feedback negativity (FN) event-related potential, a well-established psychophysiological marker of reward responsiveness. METHODS: Participants were 57 children (19 with a history of NSSI and 38 demographically matched controls) between the ages of 7 and 11. Diagnostic interviews were used to assess for current and past DSM-IV mood and anxiety diagnoses and NSSI history. Children also completed a guessing task, during which continuous electroencephalography was recorded. RESULTS: Children with a history of NSSI exhibited significantly more negative DeltaFN (i.e., FN to losses minus FN to gains) than children without NSSI. These findings appeared to be at least partially independent of children's history of psychopathology and current symptoms, suggesting their specificity to NSSI. CONCLUSIONS: These results provide initial evidence for heightened neural initial reward responsiveness to losses versus rewards in children with a history of NSSI. Pending replications and longitudinal studies, the DeltaFN might represent a psychophysiological marker of risk for self-harm. En ligne : http://dx.doi.org/10.1111/jcpp.12919 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 The impact of a computerised test of attention and activity (QbTest) on diagnostic decision-making in children and young people with suspected attention deficit hyperactivity disorder: single-blind randomised controlled trial / C. HOLLIS in Journal of Child Psychology and Psychiatry, 59-12 (December 2018)
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[article]
Titre : The impact of a computerised test of attention and activity (QbTest) on diagnostic decision-making in children and young people with suspected attention deficit hyperactivity disorder: single-blind randomised controlled trial Type de document : Texte imprimé et/ou numérique Auteurs : C. HOLLIS, Auteur ; C. L. HALL, Auteur ; B. GUO, Auteur ; M. JAMES, Auteur ; J. BOADU, Auteur ; M. J. GROOM, Auteur ; N. BROWN, Auteur ; C. KAYLOR-HUGHES, Auteur ; M. MOLDAVSKY, Auteur ; A. Z. VALENTINE, Auteur ; G. M. WALKER, Auteur ; D. DALEY, Auteur ; K. SAYAL, Auteur ; R. MORRISS, Auteur Article en page(s) : p.1298-1308 Langues : Anglais (eng) Mots-clés : QbTest assessment attention deficit hyperactivity disorder continuous performance test Index. décimale : PER Périodiques Résumé : BACKGROUND: Diagnosis of attention deficit hyperactivity disorder (ADHD) relies on subjective methods which can lead to diagnostic uncertainty and delay. This trial evaluated the impact of providing a computerised test of attention and activity (QbTest) report on the speed and accuracy of diagnostic decision-making in children with suspected ADHD. METHODS: Randomised, parallel, single-blind controlled trial in mental health and community paediatric clinics in England. Participants were 6-17 years-old and referred for ADHD diagnostic assessment; all underwent assessment-as-usual, plus QbTest. Participants and their clinician were randomised to either receive the QbTest report immediately (QbOpen group) or the report was withheld (QbBlind group). The primary outcome was number of consultations until a diagnostic decision confirming/excluding ADHD within 6-months from baseline. Health economic cost-effectiveness and cost utility analysis was conducted. Assessing QbTest Utility in ADHD: A Randomised Controlled Trial was registered at ClinicalTrials.gov (https://clinicaltrials.gov/ct2/show/NCT02209116). RESULTS: One hundred and thirty-two participants were randomised to QbOpen group (123 analysed) and 135 to QbBlind group (127 analysed). Clinicians with access to the QbTest report (QbOpen) were more likely to reach a diagnostic decision about ADHD (hazard ratio 1.44, 95% CI 1.04-2.01). At 6-months, 76% of those with a QbTest report had received a diagnostic decision, compared with 50% without. QbTest reduced appointment length by 15% (time ratio 0.85, 95% CI 0.77-0.93), increased clinicians' confidence in their diagnostic decisions (odds ratio 1.77, 95% CI 1.09-2.89) and doubled the likelihood of excluding ADHD. There was no difference in diagnostic accuracy. Health economic analysis showed a position of strict dominance; however, cost savings were small suggesting that the impact of providing the QbTest report within this trial can best be viewed as 'cost neutral'. CONCLUSIONS: QbTest may increase the efficiency of ADHD assessment pathway allowing greater patient throughput with clinicians reaching diagnostic decisions faster without compromising diagnostic accuracy. En ligne : http://dx.doi.org/10.1111/jcpp.12921 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371
in Journal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1298-1308[article] The impact of a computerised test of attention and activity (QbTest) on diagnostic decision-making in children and young people with suspected attention deficit hyperactivity disorder: single-blind randomised controlled trial [Texte imprimé et/ou numérique] / C. HOLLIS, Auteur ; C. L. HALL, Auteur ; B. GUO, Auteur ; M. JAMES, Auteur ; J. BOADU, Auteur ; M. J. GROOM, Auteur ; N. BROWN, Auteur ; C. KAYLOR-HUGHES, Auteur ; M. MOLDAVSKY, Auteur ; A. Z. VALENTINE, Auteur ; G. M. WALKER, Auteur ; D. DALEY, Auteur ; K. SAYAL, Auteur ; R. MORRISS, Auteur . - p.1298-1308.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1298-1308
Mots-clés : QbTest assessment attention deficit hyperactivity disorder continuous performance test Index. décimale : PER Périodiques Résumé : BACKGROUND: Diagnosis of attention deficit hyperactivity disorder (ADHD) relies on subjective methods which can lead to diagnostic uncertainty and delay. This trial evaluated the impact of providing a computerised test of attention and activity (QbTest) report on the speed and accuracy of diagnostic decision-making in children with suspected ADHD. METHODS: Randomised, parallel, single-blind controlled trial in mental health and community paediatric clinics in England. Participants were 6-17 years-old and referred for ADHD diagnostic assessment; all underwent assessment-as-usual, plus QbTest. Participants and their clinician were randomised to either receive the QbTest report immediately (QbOpen group) or the report was withheld (QbBlind group). The primary outcome was number of consultations until a diagnostic decision confirming/excluding ADHD within 6-months from baseline. Health economic cost-effectiveness and cost utility analysis was conducted. Assessing QbTest Utility in ADHD: A Randomised Controlled Trial was registered at ClinicalTrials.gov (https://clinicaltrials.gov/ct2/show/NCT02209116). RESULTS: One hundred and thirty-two participants were randomised to QbOpen group (123 analysed) and 135 to QbBlind group (127 analysed). Clinicians with access to the QbTest report (QbOpen) were more likely to reach a diagnostic decision about ADHD (hazard ratio 1.44, 95% CI 1.04-2.01). At 6-months, 76% of those with a QbTest report had received a diagnostic decision, compared with 50% without. QbTest reduced appointment length by 15% (time ratio 0.85, 95% CI 0.77-0.93), increased clinicians' confidence in their diagnostic decisions (odds ratio 1.77, 95% CI 1.09-2.89) and doubled the likelihood of excluding ADHD. There was no difference in diagnostic accuracy. Health economic analysis showed a position of strict dominance; however, cost savings were small suggesting that the impact of providing the QbTest report within this trial can best be viewed as 'cost neutral'. CONCLUSIONS: QbTest may increase the efficiency of ADHD assessment pathway allowing greater patient throughput with clinicians reaching diagnostic decisions faster without compromising diagnostic accuracy. En ligne : http://dx.doi.org/10.1111/jcpp.12921 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 Vigilant attention to threat, sleep patterns, and anxiety in peripubertal youth / E. J. RICKETTS in Journal of Child Psychology and Psychiatry, 59-12 (December 2018)
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[article]
Titre : Vigilant attention to threat, sleep patterns, and anxiety in peripubertal youth Type de document : Texte imprimé et/ou numérique Auteurs : E. J. RICKETTS, Auteur ; R. B. PRICE, Auteur ; G. J. SIEGLE, Auteur ; J. S. SILK, Auteur ; E. E. FORBES, Auteur ; Cecile D. LADOUCEUR, Auteur ; A. G. HARVEY, Auteur ; N. D. RYAN, Auteur ; Ronald E. DAHL, Auteur ; D. L. MCMAKIN, Auteur Article en page(s) : p.1309-1322 Langues : Anglais (eng) Mots-clés : Sleep adolescence anxiety Index. décimale : PER Périodiques Résumé : BACKGROUND: Vigilant attention to threat is commonly observed in anxiety, undergoes developmental changes in early adolescence, and has been proposed to interfere with sleep initiation and maintenance. We present one of the first studies to use objective measures to examine associations between vigilant attention to threat and difficulties initiating and maintaining sleep in an early adolescent anxious sample. We also explore the moderating role of development (age, puberty) and sex. METHODS: Participants were 66 peripubertal youth (ages 9-14) with a primary anxiety disorder and 24 healthy control subjects. A dot-probe task was used to assess attentional bias to fearful relative to neutral face stimuli. Eye-tracking indexed selective attentional bias to threat, and reaction time bias indexed action readiness to threat. Sleep was assessed via actigraphy (e.g. sleep onset delay, wake after sleep onset, etc.), parent report (Children's Sleep Habits Questionnaire), and child report (Sleep Self-Report). The Pediatric Anxiety Rating Scale assessed anxiety severity. RESULTS: Eye-tracking initial threat fixation bias (beta = .33, p = .001) and threat dwell time bias (beta = .22, p = .041) were positively associated with sleep onset latency. Reaction time bias was positively associated with wake after sleep onset (beta = .24, p = .026) and parent-reported sleep disturbance (beta = .25, p = .019). Anxiety (severity, diagnosis) was not associated with these outcomes. Sex (beta = -.32, p = .036) moderated the relation between initial threat fixation bias and sleep onset latency, with a positive association for males (p = .005), but not for females (p = .289). Age and pubertal status did not moderate effects. CONCLUSIONS: Vigilant attention to threat is related to longer sleep onset and reduced sleep maintenance. These associations are not stronger in early adolescents with anxiety. Implications for early intervention or prevention that targets vigilant attention to threat to impact sleep disturbance, and vice versa, are discussed. En ligne : http://dx.doi.org/10.1111/jcpp.12923 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371
in Journal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1309-1322[article] Vigilant attention to threat, sleep patterns, and anxiety in peripubertal youth [Texte imprimé et/ou numérique] / E. J. RICKETTS, Auteur ; R. B. PRICE, Auteur ; G. J. SIEGLE, Auteur ; J. S. SILK, Auteur ; E. E. FORBES, Auteur ; Cecile D. LADOUCEUR, Auteur ; A. G. HARVEY, Auteur ; N. D. RYAN, Auteur ; Ronald E. DAHL, Auteur ; D. L. MCMAKIN, Auteur . - p.1309-1322.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1309-1322
Mots-clés : Sleep adolescence anxiety Index. décimale : PER Périodiques Résumé : BACKGROUND: Vigilant attention to threat is commonly observed in anxiety, undergoes developmental changes in early adolescence, and has been proposed to interfere with sleep initiation and maintenance. We present one of the first studies to use objective measures to examine associations between vigilant attention to threat and difficulties initiating and maintaining sleep in an early adolescent anxious sample. We also explore the moderating role of development (age, puberty) and sex. METHODS: Participants were 66 peripubertal youth (ages 9-14) with a primary anxiety disorder and 24 healthy control subjects. A dot-probe task was used to assess attentional bias to fearful relative to neutral face stimuli. Eye-tracking indexed selective attentional bias to threat, and reaction time bias indexed action readiness to threat. Sleep was assessed via actigraphy (e.g. sleep onset delay, wake after sleep onset, etc.), parent report (Children's Sleep Habits Questionnaire), and child report (Sleep Self-Report). The Pediatric Anxiety Rating Scale assessed anxiety severity. RESULTS: Eye-tracking initial threat fixation bias (beta = .33, p = .001) and threat dwell time bias (beta = .22, p = .041) were positively associated with sleep onset latency. Reaction time bias was positively associated with wake after sleep onset (beta = .24, p = .026) and parent-reported sleep disturbance (beta = .25, p = .019). Anxiety (severity, diagnosis) was not associated with these outcomes. Sex (beta = -.32, p = .036) moderated the relation between initial threat fixation bias and sleep onset latency, with a positive association for males (p = .005), but not for females (p = .289). Age and pubertal status did not moderate effects. CONCLUSIONS: Vigilant attention to threat is related to longer sleep onset and reduced sleep maintenance. These associations are not stronger in early adolescents with anxiety. Implications for early intervention or prevention that targets vigilant attention to threat to impact sleep disturbance, and vice versa, are discussed. En ligne : http://dx.doi.org/10.1111/jcpp.12923 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 Does perinatal exposure to exogenous oxytocin influence child behavioural problems and autistic-like behaviours to 20 years of age? / A. J. GUASTELLA in Journal of Child Psychology and Psychiatry, 59-12 (December 2018)
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[article]
Titre : Does perinatal exposure to exogenous oxytocin influence child behavioural problems and autistic-like behaviours to 20 years of age? Type de document : Texte imprimé et/ou numérique Auteurs : A. J. GUASTELLA, Auteur ; Matthew N. COOPER, Auteur ; C. R. H. WHITE, Auteur ; M. K. WHITE, Auteur ; C. E. PENNELL, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Article en page(s) : p.1323-1332 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders behaviour problems developmental psychopathology empathy public health Index. décimale : PER Périodiques Résumé : BACKGROUND: The neuropeptide and hormone oxytocin is known to have a significant impact on social cognition and behaviour in humans. There is growing concern regarding the influence of exogenous oxytocin (OT) administration in early life on later social and emotional development, including autism spectrum disorder (ASD). No study has examined offspring development in relation to the dose of exogenous oxytocin administered during labour. METHODS: Between 1989 and 1992, 2,900 mothers were recruited prior to the 18th week of pregnancy, delivering 2,868 live offspring. The Child Behaviour Checklist was used to measure offspring behavioural difficulties at ages 5, 8, 10, 14 and 17 years. Autism spectrum disorder was formally diagnosed by consensus of a team of specialists. At 20 years, offspring completed a measure of autistic-like traits, the Autism Spectrum Quotient (AQ). Oxytocin exposure prior to birth was analysed using categorical and continuous approaches (maternal oxytocin dose) with univariate and multivariate statistical techniques. RESULTS: Categorical analyses of oxytocin exposure prior to birth demonstrated no group differences in any measures of child behaviour. A small in magnitude dose-response association was observed for clinically significant total behaviour symptoms (adjusted odds ratio 1.03; 95% CI: 1.01-1.06, p < .01). Exogenous oxytocin administration prior to birth was not associated with ASD (OR: 0.64; 95% CI: 0.15-2.12, p = .46) or high levels of autistic-like traits (p = .93), as assessed by the AQ. CONCLUSIONS: This study is the first to investigate longitudinal mental health outcomes associated with the use of oxytocin-based medications during labour. The results do not provide evidence to support the theory that exogenous OT has a clinically significant negative impact on the long-term mental health of children. En ligne : http://dx.doi.org/10.1111/jcpp.12924 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371
in Journal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1323-1332[article] Does perinatal exposure to exogenous oxytocin influence child behavioural problems and autistic-like behaviours to 20 years of age? [Texte imprimé et/ou numérique] / A. J. GUASTELLA, Auteur ; Matthew N. COOPER, Auteur ; C. R. H. WHITE, Auteur ; M. K. WHITE, Auteur ; C. E. PENNELL, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - p.1323-1332.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.1323-1332
Mots-clés : Autism spectrum disorders behaviour problems developmental psychopathology empathy public health Index. décimale : PER Périodiques Résumé : BACKGROUND: The neuropeptide and hormone oxytocin is known to have a significant impact on social cognition and behaviour in humans. There is growing concern regarding the influence of exogenous oxytocin (OT) administration in early life on later social and emotional development, including autism spectrum disorder (ASD). No study has examined offspring development in relation to the dose of exogenous oxytocin administered during labour. METHODS: Between 1989 and 1992, 2,900 mothers were recruited prior to the 18th week of pregnancy, delivering 2,868 live offspring. The Child Behaviour Checklist was used to measure offspring behavioural difficulties at ages 5, 8, 10, 14 and 17 years. Autism spectrum disorder was formally diagnosed by consensus of a team of specialists. At 20 years, offspring completed a measure of autistic-like traits, the Autism Spectrum Quotient (AQ). Oxytocin exposure prior to birth was analysed using categorical and continuous approaches (maternal oxytocin dose) with univariate and multivariate statistical techniques. RESULTS: Categorical analyses of oxytocin exposure prior to birth demonstrated no group differences in any measures of child behaviour. A small in magnitude dose-response association was observed for clinically significant total behaviour symptoms (adjusted odds ratio 1.03; 95% CI: 1.01-1.06, p < .01). Exogenous oxytocin administration prior to birth was not associated with ASD (OR: 0.64; 95% CI: 0.15-2.12, p = .46) or high levels of autistic-like traits (p = .93), as assessed by the AQ. CONCLUSIONS: This study is the first to investigate longitudinal mental health outcomes associated with the use of oxytocin-based medications during labour. The results do not provide evidence to support the theory that exogenous OT has a clinically significant negative impact on the long-term mental health of children. En ligne : http://dx.doi.org/10.1111/jcpp.12924 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371
[article]
Titre : Corrigendum Type de document : Texte imprimé et/ou numérique Article en page(s) : p.e1 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1111/jcpp.13008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371
in Journal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.e1[article] Corrigendum [Texte imprimé et/ou numérique] . - p.e1.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-12 (December 2018) . - p.e1
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1111/jcpp.13008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371