Deactivation in anterior cingulate cortex during facial processing in young individuals with high familial risk and early development of depression: fMRI findings from the Scottish Bipolar Family Study / Stella W.Y. CHAN in Journal of Child Psychology and Psychiatry, 57-11 (November 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-11 (November 2016) . - p.1277-1286 Titre : Deactivation in anterior cingulate cortex during facial processing in young individuals with high familial risk and early development of depression: fMRI findings from the Scottish Bipolar Family Study Type de document : texte imprimé Auteurs : Stella W.Y. CHAN, Auteur ; Jessika E. SUSSMANN, Auteur ; Liana ROMANIUK, Auteur ; Tiffany STEWART, Auteur ; Stephen M. LAWRIE, Auteur ; Jeremy HALL, Auteur ; Andrew M. MCINTOSH, Auteur ; Heather C. WHALLEY, Auteur Article en page(s) : p.1277-1286 Langues : Anglais (eng) Mots-clés : Mood disorder  major depressive disorder  fMRI  anterior cingulate  facial recognition  familial risk Index. décimale : PER Périodiques Résumé : Background Studies have identified perturbations in facial processing in bipolar disorder and major depressive disorder (MDD), but their relationship to genetic risk and early development of illness is unclear. Methods The Scottish Bipolar Family Study is a prospective longitudinal investigation examining young individuals (age 16–25) at familial risk of mood disorder. Participants underwent functional MRI using an implicit facial processing task employing angry and neutral faces. An explicit facial expression recognition task was completed outside the scanner. Clinical outcomes obtained 2 years after the scan were used to categorise participants into controls (n = 54), high-risk individuals who had developed MDD (HR MDD; n = 30) and high-risk individuals who remained well (HR Well, n = 43). Results All groups demonstrated activation patterns typically observed during facial processing, including activation of the amygdala, hippocampus, fusiform gyrus and middle frontal regions. Notably, the HR MDD group showed reduced activation of the anterior cingulate gyrus versus both the control and HR Well group for angry faces, and versus the HR Well group for neutral faces. Outside the scanner, the HR MDD group was less accurate in recognising fearful expressions than the HR Well group. Conclusions Here, we demonstrate functional abnormalities of the anterior cingulate cortex alongside facial emotional recognition deficits in high-risk individuals in the early stages of depression compared with both controls and at-risk individuals who remained well. These neural changes were associated with a current or future diagnosis of MDD and were not simply associated with increased familial risk. En ligne : http://dx.doi.org/10.1111/jcpp.12591 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295 [article] Deactivation in anterior cingulate cortex during facial processing in young individuals with high familial risk and early development of depression: fMRI findings from the Scottish Bipolar Family Study [texte imprimé] / Stella W.Y. CHAN, Auteur ; Jessika E. SUSSMANN, Auteur ; Liana ROMANIUK, Auteur ; Tiffany STEWART, Auteur ; Stephen M. LAWRIE, Auteur ; Jeremy HALL, Auteur ; Andrew M. MCINTOSH, Auteur ; Heather C. WHALLEY, Auteur . - p.1277-1286. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-11 (November 2016) . - p.1277-1286 Mots-clés : Mood disorder  major depressive disorder  fMRI  anterior cingulate  facial recognition  familial risk Index. décimale : PER Périodiques Résumé : Background Studies have identified perturbations in facial processing in bipolar disorder and major depressive disorder (MDD), but their relationship to genetic risk and early development of illness is unclear. Methods The Scottish Bipolar Family Study is a prospective longitudinal investigation examining young individuals (age 16–25) at familial risk of mood disorder. Participants underwent functional MRI using an implicit facial processing task employing angry and neutral faces. An explicit facial expression recognition task was completed outside the scanner. Clinical outcomes obtained 2 years after the scan were used to categorise participants into controls (n = 54), high-risk individuals who had developed MDD (HR MDD; n = 30) and high-risk individuals who remained well (HR Well, n = 43). Results All groups demonstrated activation patterns typically observed during facial processing, including activation of the amygdala, hippocampus, fusiform gyrus and middle frontal regions. Notably, the HR MDD group showed reduced activation of the anterior cingulate gyrus versus both the control and HR Well group for angry faces, and versus the HR Well group for neutral faces. Outside the scanner, the HR MDD group was less accurate in recognising fearful expressions than the HR Well group. Conclusions Here, we demonstrate functional abnormalities of the anterior cingulate cortex alongside facial emotional recognition deficits in high-risk individuals in the early stages of depression compared with both controls and at-risk individuals who remained well. These neural changes were associated with a current or future diagnosis of MDD and were not simply associated with increased familial risk. En ligne : http://dx.doi.org/10.1111/jcpp.12591 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295

Diffusion tensor imaging correlates of early markers of depression in youth at high-familial risk for bipolar disorder / Rossana GANZOLA in Journal of Child Psychology and Psychiatry, 59-8 (August 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.917-927 Titre : Diffusion tensor imaging correlates of early markers of depression in youth at high-familial risk for bipolar disorder Type de document : texte imprimé Auteurs : Rossana GANZOLA, Auteur ; Andrew M. MCINTOSH, Auteur ; Thomas NICKSON, Auteur ; E. SPROOTEN, Auteur ; Mark E. BASTIN, Auteur ; Stephen GILES, Auteur ; Alix MACDONALD, Auteur ; Jessika SUSSMANN, Auteur ; Simon DUCHESNE, Auteur ; Heather C. WHALLEY, Auteur Article en page(s) : p.917-927 Langues : Anglais (eng) Mots-clés : Bipolar disorder  fractional anisotropy  high-familial risk  major depressive disorder  white matter integrity Index. décimale : PER Périodiques Résumé : BACKGROUND: Mood disorders are familial psychiatric diseases, in which patients show reduced white matter (WM) integrity. We sought to determine whether WM integrity was affected in young offspring at high-familial risk of mood disorder before they go on to develop major depressive disorder (MDD). METHODS: The Bipolar Family study is a prospective longitudinal study examining young individuals (age 16-25 years) at familial risk of mood disorder on three occasions 2 years apart. This study used baseline imaging data, categorizing groups according to clinical outcome at follow-up. Diffusion tensor MRI data were acquired for 61 controls and 106 high-risk individuals, the latter divided into 78 high-risk subjects who remained well throughout the study ('high-risk well') and 28 individuals who subsequently developed MDD ('high-risk MDD'). Voxel-wise between-group comparison of fractional anisotropy (FA) based on diagnostic status was performed using tract-based spatial statistics (TBSS). RESULTS: Compared to controls, both high-risk groups showed widespread decreases in FA (pcorr < .05) at baseline. Although FA in the high-risk MDD group negatively correlated with subthreshold depressive symptoms at the time of scanning (pcorr < .05), there were no statistically significant differences at p-corrected levels between the two high-risk groups. CONCLUSIONS: These results suggest that decreased FA is related to the presence of familial risk for mood disorder along with subdiagnostic symptoms at the time of scanning rather than predictive of subsequent diagnosis. Due to the difficulties performing such longitudinal prospective studies, we note, however, that this latter analysis may be underpowered due to sample size within the high-risk MDD group. Further clinical follow-up may clarify these findings. En ligne : http://dx.doi.org/10.1111/jcpp.12879 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] Diffusion tensor imaging correlates of early markers of depression in youth at high-familial risk for bipolar disorder [texte imprimé] / Rossana GANZOLA, Auteur ; Andrew M. MCINTOSH, Auteur ; Thomas NICKSON, Auteur ; E. SPROOTEN, Auteur ; Mark E. BASTIN, Auteur ; Stephen GILES, Auteur ; Alix MACDONALD, Auteur ; Jessika SUSSMANN, Auteur ; Simon DUCHESNE, Auteur ; Heather C. WHALLEY, Auteur . - p.917-927. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.917-927 Mots-clés : Bipolar disorder  fractional anisotropy  high-familial risk  major depressive disorder  white matter integrity Index. décimale : PER Périodiques Résumé : BACKGROUND: Mood disorders are familial psychiatric diseases, in which patients show reduced white matter (WM) integrity. We sought to determine whether WM integrity was affected in young offspring at high-familial risk of mood disorder before they go on to develop major depressive disorder (MDD). METHODS: The Bipolar Family study is a prospective longitudinal study examining young individuals (age 16-25 years) at familial risk of mood disorder on three occasions 2 years apart. This study used baseline imaging data, categorizing groups according to clinical outcome at follow-up. Diffusion tensor MRI data were acquired for 61 controls and 106 high-risk individuals, the latter divided into 78 high-risk subjects who remained well throughout the study ('high-risk well') and 28 individuals who subsequently developed MDD ('high-risk MDD'). Voxel-wise between-group comparison of fractional anisotropy (FA) based on diagnostic status was performed using tract-based spatial statistics (TBSS). RESULTS: Compared to controls, both high-risk groups showed widespread decreases in FA (pcorr < .05) at baseline. Although FA in the high-risk MDD group negatively correlated with subthreshold depressive symptoms at the time of scanning (pcorr < .05), there were no statistically significant differences at p-corrected levels between the two high-risk groups. CONCLUSIONS: These results suggest that decreased FA is related to the presence of familial risk for mood disorder along with subdiagnostic symptoms at the time of scanning rather than predictive of subsequent diagnosis. Due to the difficulties performing such longitudinal prospective studies, we note, however, that this latter analysis may be underpowered due to sample size within the high-risk MDD group. Further clinical follow-up may clarify these findings. En ligne : http://dx.doi.org/10.1111/jcpp.12879 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

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