Maternal Alcohol Consumption During Pregnancy and the Risk of Autism Spectrum Disorders in Offspring: A Retrospective Analysis of the Millennium Cohort Study / C. GALLAGHER in Journal of Autism and Developmental Disorders, 48-11 (November 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-11 (November 2018) . - p.3773-3782 Titre : Maternal Alcohol Consumption During Pregnancy and the Risk of Autism Spectrum Disorders in Offspring: A Retrospective Analysis of the Millennium Cohort Study Type de document : Texte imprimé et/ou numérique Auteurs : C. GALLAGHER, Auteur ; F. P. MCCARTHY, Auteur ; R. M. RYAN, Auteur ; A. S. KHASHAN, Auteur Article en page(s) : p.3773-3782 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Maternal alcohol consumption  Pregnancy Index. décimale : PER Périodiques Résumé : The objective of this retrospective analysis of the longitudinal Millennium Cohort Study was to examine whether maternal alcohol consumption in pregnancy (MACP) is associated with the development of childhood autism spectrum disorders (ASD). Data on MACP and ASD were obtained from parental questionnaires. There were 18,168 singleton mother-child pairs with data on MACP, and 12,595 answered the question on ASD when the children were 11 years old. No statistically significant association was found between MACP and ASD for light (OR 0.78, 95% CI 0.48-1.29), moderate (OR 0.89, 95% CI 0.35-2.27), or heavy (OR 1.54, 95% CI 0.56-4.21) MACP. Alcohol consumption during pregnancy was not associated with the risk of developing ASD in this study cohort. En ligne : http://dx.doi.org/10.1007/s10803-018-3626-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370 [article] Maternal Alcohol Consumption During Pregnancy and the Risk of Autism Spectrum Disorders in Offspring: A Retrospective Analysis of the Millennium Cohort Study [Texte imprimé et/ou numérique] / C. GALLAGHER, Auteur ; F. P. MCCARTHY, Auteur ; R. M. RYAN, Auteur ; A. S. KHASHAN, Auteur . - p.3773-3782. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-11 (November 2018) . - p.3773-3782 Mots-clés : Autism spectrum disorder  Maternal alcohol consumption  Pregnancy Index. décimale : PER Périodiques Résumé : The objective of this retrospective analysis of the longitudinal Millennium Cohort Study was to examine whether maternal alcohol consumption in pregnancy (MACP) is associated with the development of childhood autism spectrum disorders (ASD). Data on MACP and ASD were obtained from parental questionnaires. There were 18,168 singleton mother-child pairs with data on MACP, and 12,595 answered the question on ASD when the children were 11 years old. No statistically significant association was found between MACP and ASD for light (OR 0.78, 95% CI 0.48-1.29), moderate (OR 0.89, 95% CI 0.35-2.27), or heavy (OR 1.54, 95% CI 0.56-4.21) MACP. Alcohol consumption during pregnancy was not associated with the risk of developing ASD in this study cohort. En ligne : http://dx.doi.org/10.1007/s10803-018-3626-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370

Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder / S. CASEY in Journal of Autism and Developmental Disorders, 52-9 (September 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-9 (September 2022) . - p.3919-3932 Titre : Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : S. CASEY, Auteur ; M. CARTER, Auteur ; A. M. LOONEY, Auteur ; V. LIVINGSTONE, Auteur ; G. MOLONEY, Auteur ; G. W. O'KEEFFE, Auteur ; Rebecca S. TAYLOR, Auteur ; L. C. KENNY, Auteur ; F. P. MCCARTHY, Auteur ; L. M. E. MCCOWAN, Auteur ; J. M. D. THOMPSON, Auteur ; D. M. MURRAY, Auteur ; SCOPE CONSORTIUM, Auteur Article en page(s) : p.3919-3932 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Child  Cytokines  Female  Humans  Mothers  Pregnancy  Autism spectrum disorder  Cytokine  Il-17a  Inflammation  Maternal immune activation Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a developmental disorder characterised by deficits in social interactions and communication, with stereotypical and repetitive behaviours. Recent evidence suggests that maternal immune dysregulation may predispose offspring to ASD. Independent samples t-tests revealed downregulation of IL-17A concentrations in cases, when compared to controls, at both 15 weeks (p=0.02), and 20 weeks (p=0.02), which persisted at 20 weeks following adjustment for confounding variables. This adds to the growing body of evidence that maternal immune regulation may play a role in foetal neurodevelopment. En ligne : http://dx.doi.org/10.1007/s10803-021-05271-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485 [article] Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / S. CASEY, Auteur ; M. CARTER, Auteur ; A. M. LOONEY, Auteur ; V. LIVINGSTONE, Auteur ; G. MOLONEY, Auteur ; G. W. O'KEEFFE, Auteur ; Rebecca S. TAYLOR, Auteur ; L. C. KENNY, Auteur ; F. P. MCCARTHY, Auteur ; L. M. E. MCCOWAN, Auteur ; J. M. D. THOMPSON, Auteur ; D. M. MURRAY, Auteur ; SCOPE CONSORTIUM, Auteur . - p.3919-3932. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-9 (September 2022) . - p.3919-3932 Mots-clés : Autism Spectrum Disorder  Child  Cytokines  Female  Humans  Mothers  Pregnancy  Autism spectrum disorder  Cytokine  Il-17a  Inflammation  Maternal immune activation Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a developmental disorder characterised by deficits in social interactions and communication, with stereotypical and repetitive behaviours. Recent evidence suggests that maternal immune dysregulation may predispose offspring to ASD. Independent samples t-tests revealed downregulation of IL-17A concentrations in cases, when compared to controls, at both 15 weeks (p=0.02), and 20 weeks (p=0.02), which persisted at 20 weeks following adjustment for confounding variables. This adds to the growing body of evidence that maternal immune regulation may play a role in foetal neurodevelopment. En ligne : http://dx.doi.org/10.1007/s10803-021-05271-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485

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