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Cytokine levels and associations with symptom severity in male and female children with autism spectrum disorder / A. MASI in Molecular Autism, 8 (2017)
[article]
Titre : Cytokine levels and associations with symptom severity in male and female children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : A. MASI, Auteur ; E. J. BREEN, Auteur ; Gail A. ALVARES, Auteur ; N. GLOZIER, Auteur ; I. B. HICKIE, Auteur ; A. HUNT, Auteur ; J. HUI, Auteur ; J. BEILBY, Auteur ; D. RAVINE, Auteur ; J. WRAY, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; A. J. GUASTELLA, Auteur Article en page(s) : 63p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Behavior Cytokine Pediatric Severity Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorders (ASDs) are complex, pervasive, and heterogeneous neurodevelopmental conditions with varying trajectories, significant male bias and largely unknown etiology. However, an understanding of the biological mechanisms driving pathophysiology is evolving. Immune system aberrations, as identified through cytokine profiles, are believed to have a role in ASD. Altered cytokine levels may facilitate identification of ASD subtypes as well as provide biological markers of response to effective treatments. Research exploring the relationship between cytokine profiles and ASD symptoms is, however, in its infancy. The objective of this study was to explore relationships between cytokine levels and the severity of ASD and other clinical traits. Methods: Multiplex assay techniques were used to measure levels of 27 cytokines in plasma samples from a cohort of 144 children diagnosed with ASD. Results: Overall, results showed a significant negative association between platelet-derived growth factor (PDGF)-BB, and the severity of ASD symptoms. Furthermore, a significant interaction with sex suggested a different immune profile for females compared to males. ASD symptom severity was negatively associated with levels of 4 cytokines, IL-1beta, IL-8, MIP-1beta, and VEGF, in females, but not in males. Conclusions: Results of the present study suggest that an altered cytokine response or profile is associated with the severity of ASD-related symptoms, with sex a potential modifier of this relationship. Further research in larger populations which recognizes the importance of sex comparisons and longitudinal assessments are now required to extend and further describe the role of the immune system in ASD. En ligne : http://dx.doi.org/10.1186/s13229-017-0176-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330
in Molecular Autism > 8 (2017) . - 63p.[article] Cytokine levels and associations with symptom severity in male and female children with autism spectrum disorder [Texte imprimé et/ou numérique] / A. MASI, Auteur ; E. J. BREEN, Auteur ; Gail A. ALVARES, Auteur ; N. GLOZIER, Auteur ; I. B. HICKIE, Auteur ; A. HUNT, Auteur ; J. HUI, Auteur ; J. BEILBY, Auteur ; D. RAVINE, Auteur ; J. WRAY, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; A. J. GUASTELLA, Auteur . - 63p.
Langues : Anglais (eng)
in Molecular Autism > 8 (2017) . - 63p.
Mots-clés : Autism spectrum disorder Behavior Cytokine Pediatric Severity Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorders (ASDs) are complex, pervasive, and heterogeneous neurodevelopmental conditions with varying trajectories, significant male bias and largely unknown etiology. However, an understanding of the biological mechanisms driving pathophysiology is evolving. Immune system aberrations, as identified through cytokine profiles, are believed to have a role in ASD. Altered cytokine levels may facilitate identification of ASD subtypes as well as provide biological markers of response to effective treatments. Research exploring the relationship between cytokine profiles and ASD symptoms is, however, in its infancy. The objective of this study was to explore relationships between cytokine levels and the severity of ASD and other clinical traits. Methods: Multiplex assay techniques were used to measure levels of 27 cytokines in plasma samples from a cohort of 144 children diagnosed with ASD. Results: Overall, results showed a significant negative association between platelet-derived growth factor (PDGF)-BB, and the severity of ASD symptoms. Furthermore, a significant interaction with sex suggested a different immune profile for females compared to males. ASD symptom severity was negatively associated with levels of 4 cytokines, IL-1beta, IL-8, MIP-1beta, and VEGF, in females, but not in males. Conclusions: Results of the present study suggest that an altered cytokine response or profile is associated with the severity of ASD-related symptoms, with sex a potential modifier of this relationship. Further research in larger populations which recognizes the importance of sex comparisons and longitudinal assessments are now required to extend and further describe the role of the immune system in ASD. En ligne : http://dx.doi.org/10.1186/s13229-017-0176-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330 Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder / S. CASEY in Journal of Autism and Developmental Disorders, 52-9 (September 2022)
[article]
Titre : Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : S. CASEY, Auteur ; M. CARTER, Auteur ; A. M. LOONEY, Auteur ; V. LIVINGSTONE, Auteur ; G. MOLONEY, Auteur ; G. W. O'KEEFFE, Auteur ; Rebecca S. TAYLOR, Auteur ; L. C. KENNY, Auteur ; F. P. MCCARTHY, Auteur ; L. M. E. MCCOWAN, Auteur ; J. M. D. THOMPSON, Auteur ; D. M. MURRAY, Auteur ; SCOPE CONSORTIUM, Auteur Article en page(s) : p.3919-3932 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder Child Cytokines Female Humans Mothers Pregnancy Autism spectrum disorder Cytokine Il-17a Inflammation Maternal immune activation Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a developmental disorder characterised by deficits in social interactions and communication, with stereotypical and repetitive behaviours. Recent evidence suggests that maternal immune dysregulation may predispose offspring to ASD. Independent samples t-tests revealed downregulation of IL-17A concentrations in cases, when compared to controls, at both 15 weeks (p=0.02), and 20 weeks (p=0.02), which persisted at 20 weeks following adjustment for confounding variables. This adds to the growing body of evidence that maternal immune regulation may play a role in foetal neurodevelopment. En ligne : http://dx.doi.org/10.1007/s10803-021-05271-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485
in Journal of Autism and Developmental Disorders > 52-9 (September 2022) . - p.3919-3932[article] Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / S. CASEY, Auteur ; M. CARTER, Auteur ; A. M. LOONEY, Auteur ; V. LIVINGSTONE, Auteur ; G. MOLONEY, Auteur ; G. W. O'KEEFFE, Auteur ; Rebecca S. TAYLOR, Auteur ; L. C. KENNY, Auteur ; F. P. MCCARTHY, Auteur ; L. M. E. MCCOWAN, Auteur ; J. M. D. THOMPSON, Auteur ; D. M. MURRAY, Auteur ; SCOPE CONSORTIUM, Auteur . - p.3919-3932.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-9 (September 2022) . - p.3919-3932
Mots-clés : Autism Spectrum Disorder Child Cytokines Female Humans Mothers Pregnancy Autism spectrum disorder Cytokine Il-17a Inflammation Maternal immune activation Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a developmental disorder characterised by deficits in social interactions and communication, with stereotypical and repetitive behaviours. Recent evidence suggests that maternal immune dysregulation may predispose offspring to ASD. Independent samples t-tests revealed downregulation of IL-17A concentrations in cases, when compared to controls, at both 15 weeks (p=0.02), and 20 weeks (p=0.02), which persisted at 20 weeks following adjustment for confounding variables. This adds to the growing body of evidence that maternal immune regulation may play a role in foetal neurodevelopment. En ligne : http://dx.doi.org/10.1007/s10803-021-05271-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485 Alterations in plasma cytokine levels in chinese children with autism spectrum disorder / C. C. HU in Autism Research, 11-7 (July 2018)
[article]
Titre : Alterations in plasma cytokine levels in chinese children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : C. C. HU, Auteur ; X. XU, Auteur ; G. L. XIONG, Auteur ; Q. XU, Auteur ; B. R. ZHOU, Auteur ; C. Y. LI, Auteur ; Q. QIN, Auteur ; C. X. LIU, Auteur ; H. P. LI, Auteur ; Y. J. SUN, Auteur ; X. YU, Auteur Article en page(s) : p.989-999 Langues : Anglais (eng) Mots-clés : TGF-beta1 TNF-alpha cytokine eotaxin immune neuroinflammation Index. décimale : PER Périodiques Résumé : Genetic alterations, together with environmental risk factors during infancy and childhood, contribute significantly to the etiology of autism spectrum disorder (ASD), a heterogeneous neurodevelopmental condition characterized by impairments in social interaction and restricted, repetitive behaviors. Mounting evidence points to a critical contribution of immunological risk factors to the development of ASD. By affecting multiple neurodevelopmental processes, immune system dysfunction could act as a point of convergence between genetics and environmental factors in ASD. Previous studies have shown altered cytokine levels in individuals with ASD, but research in Asian populations are limited. Here, we measured the plasma levels of 11 candidate cytokines in ASD and typically developing (TD) children. The cohort included 41 TD children and 87 children with ASD, aged 1-6 years. We found that as compared to the TD group, children with ASD had higher plasma levels of Eotaxin, TGF-beta1 and TNF-alpha. The increase in TGF-beta1 level was most significant in males, while the increase in Eotaxin was most significant in females. Eotaxin level negatively correlated with the social affect score (SA) in ADOS, while TNF-alpha level positively correlated with total development quotient (DQ), measured using GMDS. These pilot findings suggest potentially important roles of Eotaxin, TGF-beta1 and TNF-alpha in ASD in the Chinese population. Autism Res 2018, 11: 989-999. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Alteration of immune system function is an important risk factor for autism spectrum disorder (ASD). Here we found that the levels of cytokines, including Eotaxin, TGF-beta1 and TNF-alpha, are elevated in Chinese children with ASD, as compared to typically developing children. The change in TGF-beta1 level was most prominent in boys, while that of Eotaxin was more significant in girls. These results provide evidence for changes in cytokine profile in Chinese children with ASD. En ligne : http://dx.doi.org/10.1002/aur.1940 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366
in Autism Research > 11-7 (July 2018) . - p.989-999[article] Alterations in plasma cytokine levels in chinese children with autism spectrum disorder [Texte imprimé et/ou numérique] / C. C. HU, Auteur ; X. XU, Auteur ; G. L. XIONG, Auteur ; Q. XU, Auteur ; B. R. ZHOU, Auteur ; C. Y. LI, Auteur ; Q. QIN, Auteur ; C. X. LIU, Auteur ; H. P. LI, Auteur ; Y. J. SUN, Auteur ; X. YU, Auteur . - p.989-999.
Langues : Anglais (eng)
in Autism Research > 11-7 (July 2018) . - p.989-999
Mots-clés : TGF-beta1 TNF-alpha cytokine eotaxin immune neuroinflammation Index. décimale : PER Périodiques Résumé : Genetic alterations, together with environmental risk factors during infancy and childhood, contribute significantly to the etiology of autism spectrum disorder (ASD), a heterogeneous neurodevelopmental condition characterized by impairments in social interaction and restricted, repetitive behaviors. Mounting evidence points to a critical contribution of immunological risk factors to the development of ASD. By affecting multiple neurodevelopmental processes, immune system dysfunction could act as a point of convergence between genetics and environmental factors in ASD. Previous studies have shown altered cytokine levels in individuals with ASD, but research in Asian populations are limited. Here, we measured the plasma levels of 11 candidate cytokines in ASD and typically developing (TD) children. The cohort included 41 TD children and 87 children with ASD, aged 1-6 years. We found that as compared to the TD group, children with ASD had higher plasma levels of Eotaxin, TGF-beta1 and TNF-alpha. The increase in TGF-beta1 level was most significant in males, while the increase in Eotaxin was most significant in females. Eotaxin level negatively correlated with the social affect score (SA) in ADOS, while TNF-alpha level positively correlated with total development quotient (DQ), measured using GMDS. These pilot findings suggest potentially important roles of Eotaxin, TGF-beta1 and TNF-alpha in ASD in the Chinese population. Autism Res 2018, 11: 989-999. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Alteration of immune system function is an important risk factor for autism spectrum disorder (ASD). Here we found that the levels of cytokines, including Eotaxin, TGF-beta1 and TNF-alpha, are elevated in Chinese children with ASD, as compared to typically developing children. The change in TGF-beta1 level was most prominent in boys, while that of Eotaxin was more significant in girls. These results provide evidence for changes in cytokine profile in Chinese children with ASD. En ligne : http://dx.doi.org/10.1002/aur.1940 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366 Can Neuroinflammation Influence the Development of Autism Spectrum Disorders? / Carlos A. PARDO-VIILLAMIZAR
Titre : Can Neuroinflammation Influence the Development of Autism Spectrum Disorders? Type de document : Texte imprimé et/ou numérique Auteurs : Carlos A. PARDO-VIILLAMIZAR, Auteur Année de publication : 2008 Importance : p.329-346 Langues : Anglais (eng) Mots-clés : Neuroimmunité Neuroinflammation Neurodéveloppement Astrocyte Microglie Neuroglie Cytokine Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=704 Can Neuroinflammation Influence the Development of Autism Spectrum Disorders? [Texte imprimé et/ou numérique] / Carlos A. PARDO-VIILLAMIZAR, Auteur . - 2008 . - p.329-346.
Langues : Anglais (eng)
Mots-clés : Neuroimmunité Neuroinflammation Neurodéveloppement Astrocyte Microglie Neuroglie Cytokine Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=704 Exemplaires
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