[article]
| Titre : |
White matter as a monitoring biomarker for neurodevelopmental disorder intervention studies |
| Type de document : |
texte imprimé |
| Auteurs : |
Meghan R. SWANSON, Auteur ; Heather C. HAZLETT, Auteur |
| Article en page(s) : |
33 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Animals Autism Spectrum Disorder/diagnostic imaging/pathology/therapy Biomarkers Brain/diagnostic imaging/growth & development/pathology Early Medical Intervention Fragile X Syndrome/diagnostic imaging/pathology/therapy Humans Neurodevelopmental Disorders/diagnostic imaging/pathology/therapy White Matter/diagnostic imaging/growth & development/pathology Autism spectrum disorder Brain Clinical trial Fragile X syndrome Intervention Myelin Neurodevelopment Treatment White matter |
| Index. décimale : |
PER Périodiques |
| Résumé : |
BACKGROUND: Early intervention is a valuable tool to support the development of toddlers with neurodevelopmental disorders. With recent research advances in early identification that allow for pre-symptomatic detection of autism in infancy, scientists are looking forward to intervention during infancy. These advances may be supported by the identification of biologically based treatment and outcome measures that are sensitive and dimensional. The purpose of this review is to evaluate white matter neurodevelopment as a monitoring biomarker for early treatment of neurodevelopmental disorders. Fragile X syndrome (FXS) and autism spectrum disorder (ASD) as used as exemplars. White matter has unique neurobiology, including a prolonged period of dynamic development. This developmental pattern may make white matter especially responsive to treatment. White matter develops aberrantly in children with ASD and FXS. Histologic studies in rodents have provided targets for FXS pharmacological intervention. However, pharmaceutical clinical trials in humans failed to garner positive clinical results. In this article, we argue that the use of neurobiological monitoring biomarkers may overcome some of these limitations, as they are objective, not susceptible to placebo effects, and are dimensional in nature. SHORT CONCLUSION: As the field moves towards earlier detection and early intervention for neurodevelopmental disorders, we encourage scientists to consider the advantages of using neurobiological features as monitoring biomarkers. |
| En ligne : |
https://dx.doi.org/10.1186/s11689-019-9295-8 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573 |
in Journal of Neurodevelopmental Disorders > 11-1 (December 2019) . - 33
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White matter as a monitoring biomarker for neurodevelopmental disorder intervention studies in Journal of Neurodevelopmental Disorders, 11-1 (December 2019)
