ADHD and risk for subsequent adverse childhood experiences: understanding the cycle of adversity / C. LUGO-CANDELAS in Journal of Child Psychology and Psychiatry, 62-8 (August 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-8 (August 2021) . - p.971-978 Titre : ADHD and risk for subsequent adverse childhood experiences: understanding the cycle of adversity Type de document : Texte imprimé et/ou numérique Auteurs : C. LUGO-CANDELAS, Auteur ; T. CORBEIL, Auteur ; M. WALL, Auteur ; J. POSNER, Auteur ; Héctor R. BIRD, Auteur ; Glorisa CANINO, Auteur ; P. W. FISHER, Auteur ; S. F. SUGLIA, Auteur ; C. S. DUARTE, Auteur Article en page(s) : p.971-978 Langues : Anglais (eng) Mots-clés : Adolescent  Adverse Childhood Experiences  Attention Deficit Disorder with Hyperactivity/epidemiology/etiology  Attention Deficit and Disruptive Behavior Disorders  Child  Child Abuse  Family  Female  Humans  Male  Attention-deficit  Boricua Youth Study  adversity  hyperactivity disorder Index. décimale : PER Périodiques Résumé : BACKGROUND: Children with adverse childhood experiences (ACEs) are more likely to develop Attention-Deficit/Hyperactivity Disorder (ADHD). The reverse relationship - ADHD predicting subsequent ACEs - is vastly understudied, although it may be of great relevance to underserved populations highly exposed to ACEs. METHODS: Participants were 5- to 15-year-olds (48% females) with (9.9%) and without ADHD (DSM-IV criteria except age of onset) in a longitudinal population-based study of Puerto Rican youth. In each wave (3 yearly assessments, W1-3), ten ACEs (covering parental loss and maladjustment and child maltreatment) were examined, plus exposure to violence. Logistic regression models examined ADHD (including subtypes) and subsequent risk for ACEs. Also considered were interactions by age, sex, number of W1 ACEs, and recruitment site. RESULTS: Children with W1 ADHD were more likely to experience subsequent adversity (OR: 1.63; 95% CI: 1.12-2.37) accounting for child age, sex, public assistance, maternal education, site, disruptive behavior disorders, and W1 ACEs. Inattentive (OR: 2.00; 95% CI: 1.09-3.66), but not hyperactive/impulsive or combined ADHD, predicted future ACEs. CONCLUSIONS: ADHD predicts subsequent risk for ACEs, and the inattentive presentation may confer the most risk. Inattentive presentations could pose a bigger risk given differences in symptom persistence, latency to access to treatment, and treatment duration. The present study suggests a pathway for the perpetuation of adversity, where bidirectional relationships between ADHD and ACEs may ensnare children in developmental pathways predictive of poor outcomes. Understanding the mechanism underlying this association can help the development of interventions that interrupt the cycle of adversity exposure and improve the lives of children with ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.13352 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] ADHD and risk for subsequent adverse childhood experiences: understanding the cycle of adversity [Texte imprimé et/ou numérique] / C. LUGO-CANDELAS, Auteur ; T. CORBEIL, Auteur ; M. WALL, Auteur ; J. POSNER, Auteur ; Héctor R. BIRD, Auteur ; Glorisa CANINO, Auteur ; P. W. FISHER, Auteur ; S. F. SUGLIA, Auteur ; C. S. DUARTE, Auteur . - p.971-978. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-8 (August 2021) . - p.971-978 Mots-clés : Adolescent  Adverse Childhood Experiences  Attention Deficit Disorder with Hyperactivity/epidemiology/etiology  Attention Deficit and Disruptive Behavior Disorders  Child  Child Abuse  Family  Female  Humans  Male  Attention-deficit  Boricua Youth Study  adversity  hyperactivity disorder Index. décimale : PER Périodiques Résumé : BACKGROUND: Children with adverse childhood experiences (ACEs) are more likely to develop Attention-Deficit/Hyperactivity Disorder (ADHD). The reverse relationship - ADHD predicting subsequent ACEs - is vastly understudied, although it may be of great relevance to underserved populations highly exposed to ACEs. METHODS: Participants were 5- to 15-year-olds (48% females) with (9.9%) and without ADHD (DSM-IV criteria except age of onset) in a longitudinal population-based study of Puerto Rican youth. In each wave (3 yearly assessments, W1-3), ten ACEs (covering parental loss and maladjustment and child maltreatment) were examined, plus exposure to violence. Logistic regression models examined ADHD (including subtypes) and subsequent risk for ACEs. Also considered were interactions by age, sex, number of W1 ACEs, and recruitment site. RESULTS: Children with W1 ADHD were more likely to experience subsequent adversity (OR: 1.63; 95% CI: 1.12-2.37) accounting for child age, sex, public assistance, maternal education, site, disruptive behavior disorders, and W1 ACEs. Inattentive (OR: 2.00; 95% CI: 1.09-3.66), but not hyperactive/impulsive or combined ADHD, predicted future ACEs. CONCLUSIONS: ADHD predicts subsequent risk for ACEs, and the inattentive presentation may confer the most risk. Inattentive presentations could pose a bigger risk given differences in symptom persistence, latency to access to treatment, and treatment duration. The present study suggests a pathway for the perpetuation of adversity, where bidirectional relationships between ADHD and ACEs may ensnare children in developmental pathways predictive of poor outcomes. Understanding the mechanism underlying this association can help the development of interventions that interrupt the cycle of adversity exposure and improve the lives of children with ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.13352 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Research Review: Intergenerational transmission of disadvantage: epigenetics and parents' childhoods as the first exposure / P. SCORZA in Journal of Child Psychology and Psychiatry, 60-2 (February 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-2 (February 2019) . - p.119-132 Titre : Research Review: Intergenerational transmission of disadvantage: epigenetics and parents' childhoods as the first exposure Type de document : Texte imprimé et/ou numérique Auteurs : P. SCORZA, Auteur ; C. S. DUARTE, Auteur ; A. E. HIPWELL, Auteur ; J. POSNER, Auteur ; A. ORTIN, Auteur ; Glorisa CANINO, Auteur ; C. MONK, Auteur Article en page(s) : p.119-132 Langues : Anglais (eng) Mots-clés : Development  adversity  early life experience  endocrinology  epigenetics  gene-environment interaction  stress Index. décimale : PER Périodiques Résumé : BACKGROUND: For decades, economists and sociologists have documented intergenerational transmission of socioeconomic disadvantage, demonstrating that economic, political, and social factors contribute to 'inherited hardship'. Drawing on biological factors, the developmental origins of adult health and disease model posits that fetal exposure to maternal prenatal distress associated with socioeconomic disadvantage compromises offspring's neurodevelopment, affecting short- and long-term physical and mental health, and thereby psychosocial standing and resources. Increasing evidence suggests that mother-to-child influence occurs prenatally, in part via maternal and offspring atypical HPA axis regulation, with negative effects on the maturation of prefrontal and subcortical neural circuits in the offspring. However, even this in utero timeframe may be insufficient to understand biological aspects of the transmission of factors contributing to disadvantage across generations. METHODS: We review animal studies and emerging human research indicating that parents' childhood experiences may transfer epigenetic marks that could impact the development of their offspring independently of and in interaction with their offspring's perinatal and early childhood direct exposures to stress stemming from socioeconomic disadvantage and adversity. RESULTS: Animal models point to epigenetic mechanisms by which traits that could contribute to disadvantage may be transmitted across generations. However, epigenetic pathways of parental childhood experiences influencing child outcomes in the next generation are only beginning to be studied in humans. With a focus on translational research, we point to design features and methodological considerations for human cohort studies to be able to test the intergenerational transmission hypothesis, and we illustrate this with existing longitudinal studies. CONCLUSIONS: Epigenetic intergenerational transmission, if at play in human populations, could have policy implications in terms of reducing the continuation of disadvantage across generations. Further research is needed to address this gap in the understanding of the perpetuation of compromised lives across generations. En ligne : http://dx.doi.org/10.1111/jcpp.12877 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=381 [article] Research Review: Intergenerational transmission of disadvantage: epigenetics and parents' childhoods as the first exposure [Texte imprimé et/ou numérique] / P. SCORZA, Auteur ; C. S. DUARTE, Auteur ; A. E. HIPWELL, Auteur ; J. POSNER, Auteur ; A. ORTIN, Auteur ; Glorisa CANINO, Auteur ; C. MONK, Auteur . - p.119-132. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-2 (February 2019) . - p.119-132 Mots-clés : Development  adversity  early life experience  endocrinology  epigenetics  gene-environment interaction  stress Index. décimale : PER Périodiques Résumé : BACKGROUND: For decades, economists and sociologists have documented intergenerational transmission of socioeconomic disadvantage, demonstrating that economic, political, and social factors contribute to 'inherited hardship'. Drawing on biological factors, the developmental origins of adult health and disease model posits that fetal exposure to maternal prenatal distress associated with socioeconomic disadvantage compromises offspring's neurodevelopment, affecting short- and long-term physical and mental health, and thereby psychosocial standing and resources. Increasing evidence suggests that mother-to-child influence occurs prenatally, in part via maternal and offspring atypical HPA axis regulation, with negative effects on the maturation of prefrontal and subcortical neural circuits in the offspring. However, even this in utero timeframe may be insufficient to understand biological aspects of the transmission of factors contributing to disadvantage across generations. METHODS: We review animal studies and emerging human research indicating that parents' childhood experiences may transfer epigenetic marks that could impact the development of their offspring independently of and in interaction with their offspring's perinatal and early childhood direct exposures to stress stemming from socioeconomic disadvantage and adversity. RESULTS: Animal models point to epigenetic mechanisms by which traits that could contribute to disadvantage may be transmitted across generations. However, epigenetic pathways of parental childhood experiences influencing child outcomes in the next generation are only beginning to be studied in humans. With a focus on translational research, we point to design features and methodological considerations for human cohort studies to be able to test the intergenerational transmission hypothesis, and we illustrate this with existing longitudinal studies. CONCLUSIONS: Epigenetic intergenerational transmission, if at play in human populations, could have policy implications in terms of reducing the continuation of disadvantage across generations. Further research is needed to address this gap in the understanding of the perpetuation of compromised lives across generations. En ligne : http://dx.doi.org/10.1111/jcpp.12877 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=381

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