33 recherche sur le mot-clé 'Adverse Childhood Experiences'

Adverse childhood experiences and transcriptional response in school-age children / A. MARIE-MITCHELL in Development and Psychopathology, 34-3 (August 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-3 (August 2022) . - p.875-881 Titre : Adverse childhood experiences and transcriptional response in school-age children Type de document : Texte imprimé et/ou numérique Auteurs : A. MARIE-MITCHELL, Auteur ; S. W. COLE, Auteur Article en page(s) : p.875-881 Langues : Anglais (eng) Mots-clés : adverse childhood experiences  adversity  biomarkers  immunology  inflammation Index. décimale : PER Périodiques Résumé : This study evaluated whether children with higher adverse childhood experiences (ACE) scores had alterations in immune cell gene expression profiles. RNA sequencing was conducted on dried blood spot samples from 37 generally healthy English-speaking children (age 5 “11) who were recruited from well-child visits at a university-affiliated pediatric practice. The Whole Child Assessment was used to assess ACE exposure. Primary analyses examined an a priori-specified composite of 19 pro-inflammatory gene transcripts. Secondary analyses examined a 34-gene composite assessing Type I interferon response, and used Transcript Origin Analyses to identify cellular mechanisms. After controlling for age, body mass index percentile, sex, race/ethnicity, current insurance status, and household smoking exposure, pro-inflammatory gene expression was elevated by 0.094 log2 RNA expression units with each Child-ACE total score point (p = .019). Type I interferon gene expression was similarly upregulated (0.103; p = .008). Transcript origin analyses implicated CD8+ T cell as the primary sources of gene transcripts upregulated, and nonclassical (CD16+) monocytes as sources of downregulated transcripts. These preliminary analyses suggest that parent-reported ACE exposures are associated with increased expression of both inflammatory and interferon gene transcripts in children's circulating blood cells. En ligne : http://dx.doi.org/10.1017/S095457942000187X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484 [article] Adverse childhood experiences and transcriptional response in school-age children [Texte imprimé et/ou numérique] / A. MARIE-MITCHELL, Auteur ; S. W. COLE, Auteur . - p.875-881. Langues : Anglais (eng) in Development and Psychopathology > 34-3 (August 2022) . - p.875-881 Mots-clés : adverse childhood experiences  adversity  biomarkers  immunology  inflammation Index. décimale : PER Périodiques Résumé : This study evaluated whether children with higher adverse childhood experiences (ACE) scores had alterations in immune cell gene expression profiles. RNA sequencing was conducted on dried blood spot samples from 37 generally healthy English-speaking children (age 5 “11) who were recruited from well-child visits at a university-affiliated pediatric practice. The Whole Child Assessment was used to assess ACE exposure. Primary analyses examined an a priori-specified composite of 19 pro-inflammatory gene transcripts. Secondary analyses examined a 34-gene composite assessing Type I interferon response, and used Transcript Origin Analyses to identify cellular mechanisms. After controlling for age, body mass index percentile, sex, race/ethnicity, current insurance status, and household smoking exposure, pro-inflammatory gene expression was elevated by 0.094 log2 RNA expression units with each Child-ACE total score point (p = .019). Type I interferon gene expression was similarly upregulated (0.103; p = .008). Transcript origin analyses implicated CD8+ T cell as the primary sources of gene transcripts upregulated, and nonclassical (CD16+) monocytes as sources of downregulated transcripts. These preliminary analyses suggest that parent-reported ACE exposures are associated with increased expression of both inflammatory and interferon gene transcripts in children's circulating blood cells. En ligne : http://dx.doi.org/10.1017/S095457942000187X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484

Adverse childhood experiences, sleep problems, low self-control, and adolescent delinquency: A longitudinal serial mediation analysis / Ryan C. MELDRUM ; Michelle G. VILLAR ; Robert A. ZUCKER ; Elisa M. TRUCCO in Development and Psychopathology, 35-4 (October 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-4 (October 2023) . - p.1868-1877 Titre : Adverse childhood experiences, sleep problems, low self-control, and adolescent delinquency: A longitudinal serial mediation analysis Type de document : Texte imprimé et/ou numérique Auteurs : Ryan C. MELDRUM, Auteur ; Michelle G. VILLAR, Auteur ; Robert A. ZUCKER, Auteur ; Elisa M. TRUCCO, Auteur Article en page(s) : p.1868-1877 Langues : Anglais (eng) Mots-clés : adverse childhood experiences  delinquency  low self-control  sleep Index. décimale : PER Périodiques Résumé : Several studies link adverse childhood experiences (ACEs) to delinquency. Yet, developmental sequalae accounting for this association remain unclear, with previous research limited by cross-sectional research designs and investigations of singular mediating processes. To redress these shortcomings, this study examines the longitudinal association between ACEs and delinquency as mediated by both sleep problems and low self-control, two factors which past research implicates as potentially important for understanding how ACEs contribute to antisocial behavior. Data collected from 480 adolescents (71.3% boys; 86.3% White) and their parents participating in the Michigan Longitudinal Study was used to conduct a serial mediation analysis. The association between ACEs (prior to age 11) and delinquency in late adolescence was found to operate indirectly via sleep problems in early adolescence and low self-control in middle adolescence. Nonetheless, a direct association between ACEs and later delinquency remained. Pathways through which ACEs contribute to later delinquency are complex and multiply determined. Findings indicate that early behavioral interventions, including improving sleep and self-control, could reduce later delinquency. Still, more research is needed to identify additional avenues through which the ACEs-delinquency association unfolds across development. En ligne : https://dx.doi.org/10.1017/S0954579422000530 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=515 [article] Adverse childhood experiences, sleep problems, low self-control, and adolescent delinquency: A longitudinal serial mediation analysis [Texte imprimé et/ou numérique] / Ryan C. MELDRUM, Auteur ; Michelle G. VILLAR, Auteur ; Robert A. ZUCKER, Auteur ; Elisa M. TRUCCO, Auteur . - p.1868-1877. Langues : Anglais (eng) in Development and Psychopathology > 35-4 (October 2023) . - p.1868-1877 Mots-clés : adverse childhood experiences  delinquency  low self-control  sleep Index. décimale : PER Périodiques Résumé : Several studies link adverse childhood experiences (ACEs) to delinquency. Yet, developmental sequalae accounting for this association remain unclear, with previous research limited by cross-sectional research designs and investigations of singular mediating processes. To redress these shortcomings, this study examines the longitudinal association between ACEs and delinquency as mediated by both sleep problems and low self-control, two factors which past research implicates as potentially important for understanding how ACEs contribute to antisocial behavior. Data collected from 480 adolescents (71.3% boys; 86.3% White) and their parents participating in the Michigan Longitudinal Study was used to conduct a serial mediation analysis. The association between ACEs (prior to age 11) and delinquency in late adolescence was found to operate indirectly via sleep problems in early adolescence and low self-control in middle adolescence. Nonetheless, a direct association between ACEs and later delinquency remained. Pathways through which ACEs contribute to later delinquency are complex and multiply determined. Findings indicate that early behavioral interventions, including improving sleep and self-control, could reduce later delinquency. Still, more research is needed to identify additional avenues through which the ACEs-delinquency association unfolds across development. En ligne : https://dx.doi.org/10.1017/S0954579422000530 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=515

Brief Report: Examining the Association of Autism and Adverse Childhood Experiences in the National Survey of Children’s Health: The Important Role of Income and Co-occurring Mental Health Conditions / Connor M. KERNS in Journal of Autism and Developmental Disorders, 47-7 (July 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-7 (July 2017) . - p.2275-2281 Titre : Brief Report: Examining the Association of Autism and Adverse Childhood Experiences in the National Survey of Children’s Health: The Important Role of Income and Co-occurring Mental Health Conditions Type de document : Texte imprimé et/ou numérique Auteurs : Connor M. KERNS, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Steven J. BERKOWITZ, Auteur ; Brian K. LEE, Auteur Article en page(s) : p.2275-2281 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Adverse childhood experiences  Comorbidity  Anxiety  Depression  Attention problems  Behavioral problems Index. décimale : PER Périodiques Résumé : Adverse childhood experiences (ACEs) are risk factors for mental and physical illness and more likely to occur for children with autism spectrum disorder (ASD). The present study aimed to clarify the contribution of poverty, intellectual disability and mental health conditions to this disparity. Data on child and family characteristics, mental health conditions and ACEs were analyzed in 67,067 youth from the 2011–2012 National Survey of Children’s Health. In an income-stratified sample, the association of ASD and ACEs was greater for lower income children and significantly diminished after controlling for child mental health conditions, but not intellectual disability. Findings suggest that the association of ACEs and ASD is moderated by family income and contingent on co-occurring mental health conditions. En ligne : https://doi.org/10.1007/s10803-017-3111-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=314 [article] Brief Report: Examining the Association of Autism and Adverse Childhood Experiences in the National Survey of Children’s Health: The Important Role of Income and Co-occurring Mental Health Conditions [Texte imprimé et/ou numérique] / Connor M. KERNS, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Steven J. BERKOWITZ, Auteur ; Brian K. LEE, Auteur . - p.2275-2281. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-7 (July 2017) . - p.2275-2281 Mots-clés : Autism spectrum disorder  Adverse childhood experiences  Comorbidity  Anxiety  Depression  Attention problems  Behavioral problems Index. décimale : PER Périodiques Résumé : Adverse childhood experiences (ACEs) are risk factors for mental and physical illness and more likely to occur for children with autism spectrum disorder (ASD). The present study aimed to clarify the contribution of poverty, intellectual disability and mental health conditions to this disparity. Data on child and family characteristics, mental health conditions and ACEs were analyzed in 67,067 youth from the 2011–2012 National Survey of Children’s Health. In an income-stratified sample, the association of ASD and ACEs was greater for lower income children and significantly diminished after controlling for child mental health conditions, but not intellectual disability. Findings suggest that the association of ACEs and ASD is moderated by family income and contingent on co-occurring mental health conditions. En ligne : https://doi.org/10.1007/s10803-017-3111-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=314

ADHD and risk for subsequent adverse childhood experiences: understanding the cycle of adversity / C. LUGO-CANDELAS in Journal of Child Psychology and Psychiatry, 62-8 (August 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-8 (August 2021) . - p.971-978 Titre : ADHD and risk for subsequent adverse childhood experiences: understanding the cycle of adversity Type de document : Texte imprimé et/ou numérique Auteurs : C. LUGO-CANDELAS, Auteur ; T. CORBEIL, Auteur ; M. WALL, Auteur ; J. POSNER, Auteur ; Héctor R. BIRD, Auteur ; Glorisa CANINO, Auteur ; P. W. FISHER, Auteur ; S. F. SUGLIA, Auteur ; C. S. DUARTE, Auteur Article en page(s) : p.971-978 Langues : Anglais (eng) Mots-clés : Adolescent  Adverse Childhood Experiences  Attention Deficit Disorder with Hyperactivity/epidemiology/etiology  Attention Deficit and Disruptive Behavior Disorders  Child  Child Abuse  Family  Female  Humans  Male  Attention-deficit  Boricua Youth Study  adversity  hyperactivity disorder Index. décimale : PER Périodiques Résumé : BACKGROUND: Children with adverse childhood experiences (ACEs) are more likely to develop Attention-Deficit/Hyperactivity Disorder (ADHD). The reverse relationship - ADHD predicting subsequent ACEs - is vastly understudied, although it may be of great relevance to underserved populations highly exposed to ACEs. METHODS: Participants were 5- to 15-year-olds (48% females) with (9.9%) and without ADHD (DSM-IV criteria except age of onset) in a longitudinal population-based study of Puerto Rican youth. In each wave (3 yearly assessments, W1-3), ten ACEs (covering parental loss and maladjustment and child maltreatment) were examined, plus exposure to violence. Logistic regression models examined ADHD (including subtypes) and subsequent risk for ACEs. Also considered were interactions by age, sex, number of W1 ACEs, and recruitment site. RESULTS: Children with W1 ADHD were more likely to experience subsequent adversity (OR: 1.63; 95% CI: 1.12-2.37) accounting for child age, sex, public assistance, maternal education, site, disruptive behavior disorders, and W1 ACEs. Inattentive (OR: 2.00; 95% CI: 1.09-3.66), but not hyperactive/impulsive or combined ADHD, predicted future ACEs. CONCLUSIONS: ADHD predicts subsequent risk for ACEs, and the inattentive presentation may confer the most risk. Inattentive presentations could pose a bigger risk given differences in symptom persistence, latency to access to treatment, and treatment duration. The present study suggests a pathway for the perpetuation of adversity, where bidirectional relationships between ADHD and ACEs may ensnare children in developmental pathways predictive of poor outcomes. Understanding the mechanism underlying this association can help the development of interventions that interrupt the cycle of adversity exposure and improve the lives of children with ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.13352 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] ADHD and risk for subsequent adverse childhood experiences: understanding the cycle of adversity [Texte imprimé et/ou numérique] / C. LUGO-CANDELAS, Auteur ; T. CORBEIL, Auteur ; M. WALL, Auteur ; J. POSNER, Auteur ; Héctor R. BIRD, Auteur ; Glorisa CANINO, Auteur ; P. W. FISHER, Auteur ; S. F. SUGLIA, Auteur ; C. S. DUARTE, Auteur . - p.971-978. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-8 (August 2021) . - p.971-978 Mots-clés : Adolescent  Adverse Childhood Experiences  Attention Deficit Disorder with Hyperactivity/epidemiology/etiology  Attention Deficit and Disruptive Behavior Disorders  Child  Child Abuse  Family  Female  Humans  Male  Attention-deficit  Boricua Youth Study  adversity  hyperactivity disorder Index. décimale : PER Périodiques Résumé : BACKGROUND: Children with adverse childhood experiences (ACEs) are more likely to develop Attention-Deficit/Hyperactivity Disorder (ADHD). The reverse relationship - ADHD predicting subsequent ACEs - is vastly understudied, although it may be of great relevance to underserved populations highly exposed to ACEs. METHODS: Participants were 5- to 15-year-olds (48% females) with (9.9%) and without ADHD (DSM-IV criteria except age of onset) in a longitudinal population-based study of Puerto Rican youth. In each wave (3 yearly assessments, W1-3), ten ACEs (covering parental loss and maladjustment and child maltreatment) were examined, plus exposure to violence. Logistic regression models examined ADHD (including subtypes) and subsequent risk for ACEs. Also considered were interactions by age, sex, number of W1 ACEs, and recruitment site. RESULTS: Children with W1 ADHD were more likely to experience subsequent adversity (OR: 1.63; 95% CI: 1.12-2.37) accounting for child age, sex, public assistance, maternal education, site, disruptive behavior disorders, and W1 ACEs. Inattentive (OR: 2.00; 95% CI: 1.09-3.66), but not hyperactive/impulsive or combined ADHD, predicted future ACEs. CONCLUSIONS: ADHD predicts subsequent risk for ACEs, and the inattentive presentation may confer the most risk. Inattentive presentations could pose a bigger risk given differences in symptom persistence, latency to access to treatment, and treatment duration. The present study suggests a pathway for the perpetuation of adversity, where bidirectional relationships between ADHD and ACEs may ensnare children in developmental pathways predictive of poor outcomes. Understanding the mechanism underlying this association can help the development of interventions that interrupt the cycle of adversity exposure and improve the lives of children with ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.13352 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Association of adverse childhood experiences and precuneus volume with intrusive reexperiencing in autism spectrum disorder / S. KITAMURA in Autism Research, 14-9 (September 2021)  

Public ISBD [article]  inAutism Research > 14-9 (September 2021) . - p.1886-1895 Titre : Association of adverse childhood experiences and precuneus volume with intrusive reexperiencing in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : S. KITAMURA, Auteur ; M. MAKINODAN, Auteur ; K. MATSUOKA, Auteur ; M. TAKAHASHI, Auteur ; H. YOSHIKAWA, Auteur ; R. ISHIDA, Auteur ; N. KISHIMOTO, Auteur ; F. YASUNO, Auteur ; Y. YASUDA, Auteur ; R. HASHIMOTO, Auteur ; T. MIYASAKA, Auteur ; K. KICHIKAWA, Auteur ; T. KISHIMOTO, Auteur Article en page(s) : p.1886-1895 Langues : Anglais (eng) Mots-clés : Adult  Adverse Childhood Experiences  Autism Spectrum Disorder/diagnostic imaging  Brain/diagnostic imaging  Child  Gray Matter/diagnostic imaging  Humans  Magnetic Resonance Imaging  Parietal Lobe/diagnostic imaging  autism spectrum disorder  gray matter  parietal lobe  post-traumatic stress disorder Index. décimale : PER Périodiques Résumé : Compared to typically developing (TD) children, people with autism spectrum disorder (ASD) have an increased risk of adverse childhood experiences (ACEs). Exposure to ACEs is associated with adult ASD psychological comorbidities, such as posttraumatic stress disorder (PTSD). Occurrence of intrusive event reexperiencing, characteristic of PTSD, often causes social dysfunction in adults with ASD, but its pathological basis is unclear. This study examined brain regions related to the severity of intrusive reexperiencing and explored whether ACE severity was associated with that of intrusive reexperiencing and/or extracted regional gray matter volume. Forty-six individuals with ASD and 41 TD subjects underwent T1-weighted magnetic resonance imaging and evaluation of ACEs and intrusive reexperiencing. Brain regions related to the severity of intrusive reexperiencing in both groups were identified by voxel-based whole brain analyses. Associations among the severity of intrusive reexperiencing, that of ACEs, and gray matter volume were examined in both groups. The severities of intrusive reexperiencing and ACEs were significantly associated with reduced gray matter volume in the right precuneus in individuals with ASD but not in TD subjects. Although the right precuneus gray matter volume was smaller in individuals with ASD and severe ACEs than in those with mild ACEs or TD subjects, it was similar in the latter two groups. However, ACE-dependent gray matter volume reduction in the right precuneus led to intrusive reexperiencing in individuals with ASD. This suggests that exposure to ACEs is associated with right precuneus gray matter reduction, which is critical for intrusive reexperiencing in adults with ASD. LAY SUMMARY: Individuals with autism spectrum disorder (ASD) are at increased risk of adverse childhood experiences (ACEs) and of subsequent manifestation of intrusive reexperiencing of stressful life events. The present study found that reduced gray matter volume in the right precuneus of the brain was associated with more severe intrusive reexperiencing of ACEs by individuals with ASD. These results suggest that ACEs affect neural development in the precuneus, which is the pathological basis of intrusive event reexperiencing in ASD. En ligne : http://dx.doi.org/10.1002/aur.2558 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Association of adverse childhood experiences and precuneus volume with intrusive reexperiencing in autism spectrum disorder [Texte imprimé et/ou numérique] / S. KITAMURA, Auteur ; M. MAKINODAN, Auteur ; K. MATSUOKA, Auteur ; M. TAKAHASHI, Auteur ; H. YOSHIKAWA, Auteur ; R. ISHIDA, Auteur ; N. KISHIMOTO, Auteur ; F. YASUNO, Auteur ; Y. YASUDA, Auteur ; R. HASHIMOTO, Auteur ; T. MIYASAKA, Auteur ; K. KICHIKAWA, Auteur ; T. KISHIMOTO, Auteur . - p.1886-1895. Langues : Anglais (eng) in Autism Research > 14-9 (September 2021) . - p.1886-1895 Mots-clés : Adult  Adverse Childhood Experiences  Autism Spectrum Disorder/diagnostic imaging  Brain/diagnostic imaging  Child  Gray Matter/diagnostic imaging  Humans  Magnetic Resonance Imaging  Parietal Lobe/diagnostic imaging  autism spectrum disorder  gray matter  parietal lobe  post-traumatic stress disorder Index. décimale : PER Périodiques Résumé : Compared to typically developing (TD) children, people with autism spectrum disorder (ASD) have an increased risk of adverse childhood experiences (ACEs). Exposure to ACEs is associated with adult ASD psychological comorbidities, such as posttraumatic stress disorder (PTSD). Occurrence of intrusive event reexperiencing, characteristic of PTSD, often causes social dysfunction in adults with ASD, but its pathological basis is unclear. This study examined brain regions related to the severity of intrusive reexperiencing and explored whether ACE severity was associated with that of intrusive reexperiencing and/or extracted regional gray matter volume. Forty-six individuals with ASD and 41 TD subjects underwent T1-weighted magnetic resonance imaging and evaluation of ACEs and intrusive reexperiencing. Brain regions related to the severity of intrusive reexperiencing in both groups were identified by voxel-based whole brain analyses. Associations among the severity of intrusive reexperiencing, that of ACEs, and gray matter volume were examined in both groups. The severities of intrusive reexperiencing and ACEs were significantly associated with reduced gray matter volume in the right precuneus in individuals with ASD but not in TD subjects. Although the right precuneus gray matter volume was smaller in individuals with ASD and severe ACEs than in those with mild ACEs or TD subjects, it was similar in the latter two groups. However, ACE-dependent gray matter volume reduction in the right precuneus led to intrusive reexperiencing in individuals with ASD. This suggests that exposure to ACEs is associated with right precuneus gray matter reduction, which is critical for intrusive reexperiencing in adults with ASD. LAY SUMMARY: Individuals with autism spectrum disorder (ASD) are at increased risk of adverse childhood experiences (ACEs) and of subsequent manifestation of intrusive reexperiencing of stressful life events. The present study found that reduced gray matter volume in the right precuneus of the brain was associated with more severe intrusive reexperiencing of ACEs by individuals with ASD. These results suggest that ACEs affect neural development in the precuneus, which is the pathological basis of intrusive event reexperiencing in ASD. En ligne : http://dx.doi.org/10.1002/aur.2558 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

Lest we forget: comparing retrospective and prospective assessments of adverse childhood experiences in the prediction of adult health / Aaron REUBEN in Journal of Child Psychology and Psychiatry, 57-10 (October 2016)  

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Parents' adverse childhood experiences and parent-child emotional availability in an American Indian community: Relations with young children's social-emotional development / Hannah E. WURSTER in Development and Psychopathology, 32-2 (May 2020)  

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The role of HPA-axis function during pregnancy in the intergenerational transmission of maternal adverse childhood experiences to child behavior problems / Jenna C. THOMAS-ARGYRIOU in Development and Psychopathology, 33-1 (February 2021)  

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Trajectories of adverse childhood experiences among children with autism / Bethany RIGLES in Research in Autism Spectrum Disorders, 89 (November 2021)  

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Associations of perceived adverse lifetime experiences with brain structure in UK Biobank participants / D. A. GHEORGHE in Journal of Child Psychology and Psychiatry, 62-7 (July 2021)  

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