[article] 
inJournal of Neurodevelopmental Disorders > 17 (2025)

Titre :	Disrupted visual attention relates to cognitive development in infants with Neurofibromatosis Type 1
Type de document :	texte imprimé
Auteurs :	Jannath BEGUM-ALI, Auteur ; Luke MASON, Auteur ; Tony CHARMAN, Auteur ; Mark H. JOHNSON, Auteur ; Jonathan GREEN, Auteur ; Shruti GARG, Auteur ; Emily J.H. JONES, Auteur ; THE STAARS AND EDEN TEAMS, Auteur
Langues :	Anglais (eng)
Mots-clés :	Humans  Neurofibromatosis 1/complications/physiopathology  Infant  Attention/physiology  Male  Female  Child Development/physiology  Longitudinal Studies  Visual Perception/physiology  Attention Deficit Disorder with Hyperactivity/physiopathology  Cognition/physiology  Autism Spectrum Disorder/physiopathology  Attention deficit hyperactivity disorder  Autism spectrum disorder  Eye tracking  Longitudinal  Neurofibromatosis Type 1  Visual attention  consent was provided by the parent(s) prior to the commencement of the study. The  testing only took place if the infants were in a content and alert state. Ethical  approval was granted by the National Research Ethics Service and the Research  Ethics Committee of the Department of Psychological Sciences, Birkbeck,  University of London. Consent for publication: Not applicable. Competing  interests: Dr Jannath Begum Ali declares no conflict of interest. Dr Luke Mason  declares no conflict of interest. Professor Tony Charman has served as a paid  consultant to F. Hoffmann-La Roche Ltd and Servier. He has received royalties  from Sage Publications and Guildford Publications. . Dr Shruti Garg declares no  conflict of interest. Professor Jonathan Green declares no conflict of interest.  Professor Mark H. Johnson declares no conflict of interest. Professor Emily J.H.  Jones declares no conflict of interest. The STAARS team declares no conflict of  interest. The EDEN team declares no conflict of interest.
Index. décimale :	PER Périodiques
Résumé :	BACKGROUND: Neurofibromatosis Type 1 is a genetic condition diagnosed in infancy that substantially increases the likelihood of a child experiencing cognitive and developmental difficulties, including Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD). Children with NF1 show clear differences in attention, but whether these differences emerge in early development and how they relate to broader difficulties with cognitive and learning skills is unclear. To address this question requires longitudinal prospective studies from infancy, where the relation between domains of visual attention (including exogenous and endogenous shifting) and cognitive development can be mapped over time. METHODS: We report data from 28 infants with NF1 tested longitudinally at 5, 10 and 14 months compared to cohorts of 29 typical likelihood infants (with no history of NF1 or ASD and/or ADHD), and 123 infants with a family history of ASD and/or ADHD. We used an eyetracking battery to measure both exogenous and endogenous control of visual attention. RESULTS: Infants with NF1 demonstrated intact social orienting, but slower development of endogenous visual foraging. This slower development presented as prolonged engagement with a salient stimulus in a static display relative to typically developing infants. In terms of exogenous attention shifting, NF1 infants showed faster saccadic reaction times than typical likelihood infants. However, the NF1 group demonstrated a slower developmental improvement from 5 to 14 months of age. Individual differences in foraging and saccade times were concurrently related to visual reception abilities within the full infant cohort (NF1, typical likelihood and those with a family history of ASD/ADHD). CONCLUSIONS: Our results provide preliminary evidence that alterations in saccadic reaction time and visual foraging may contribute to learning difficulties in infants with NF1.
En ligne :	https://dx.doi.org/10.1186/s11689-025-09599-4
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576

[article] Disrupted visual attention relates to cognitive development in infants with Neurofibromatosis Type 1 [texte imprimé] / Jannath BEGUM-ALI, Auteur ; Luke MASON, Auteur ; Tony CHARMAN, Auteur ; Mark H. JOHNSON, Auteur ; Jonathan GREEN, Auteur ; Shruti GARG, Auteur ; Emily J.H. JONES, Auteur ; THE STAARS AND EDEN TEAMS, Auteur.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 17 (2025)

Mots-clés :	Humans  Neurofibromatosis 1/complications/physiopathology  Infant  Attention/physiology  Male  Female  Child Development/physiology  Longitudinal Studies  Visual Perception/physiology  Attention Deficit Disorder with Hyperactivity/physiopathology  Cognition/physiology  Autism Spectrum Disorder/physiopathology  Attention deficit hyperactivity disorder  Autism spectrum disorder  Eye tracking  Longitudinal  Neurofibromatosis Type 1  Visual attention  consent was provided by the parent(s) prior to the commencement of the study. The  testing only took place if the infants were in a content and alert state. Ethical  approval was granted by the National Research Ethics Service and the Research  Ethics Committee of the Department of Psychological Sciences, Birkbeck,  University of London. Consent for publication: Not applicable. Competing  interests: Dr Jannath Begum Ali declares no conflict of interest. Dr Luke Mason  declares no conflict of interest. Professor Tony Charman has served as a paid  consultant to F. Hoffmann-La Roche Ltd and Servier. He has received royalties  from Sage Publications and Guildford Publications. . Dr Shruti Garg declares no  conflict of interest. Professor Jonathan Green declares no conflict of interest.  Professor Mark H. Johnson declares no conflict of interest. Professor Emily J.H.  Jones declares no conflict of interest. The STAARS team declares no conflict of  interest. The EDEN team declares no conflict of interest.
Index. décimale :	PER Périodiques
Résumé :	BACKGROUND: Neurofibromatosis Type 1 is a genetic condition diagnosed in infancy that substantially increases the likelihood of a child experiencing cognitive and developmental difficulties, including Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD). Children with NF1 show clear differences in attention, but whether these differences emerge in early development and how they relate to broader difficulties with cognitive and learning skills is unclear. To address this question requires longitudinal prospective studies from infancy, where the relation between domains of visual attention (including exogenous and endogenous shifting) and cognitive development can be mapped over time. METHODS: We report data from 28 infants with NF1 tested longitudinally at 5, 10 and 14 months compared to cohorts of 29 typical likelihood infants (with no history of NF1 or ASD and/or ADHD), and 123 infants with a family history of ASD and/or ADHD. We used an eyetracking battery to measure both exogenous and endogenous control of visual attention. RESULTS: Infants with NF1 demonstrated intact social orienting, but slower development of endogenous visual foraging. This slower development presented as prolonged engagement with a salient stimulus in a static display relative to typically developing infants. In terms of exogenous attention shifting, NF1 infants showed faster saccadic reaction times than typical likelihood infants. However, the NF1 group demonstrated a slower developmental improvement from 5 to 14 months of age. Individual differences in foraging and saccade times were concurrently related to visual reception abilities within the full infant cohort (NF1, typical likelihood and those with a family history of ASD/ADHD). CONCLUSIONS: Our results provide preliminary evidence that alterations in saccadic reaction time and visual foraging may contribute to learning difficulties in infants with NF1.
En ligne :	https://dx.doi.org/10.1186/s11689-025-09599-4
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576