18 recherche sur le mot-clé 'Autism Spectrum Disorder/physiopathology'

Initial eye gaze to faces and its functional consequence on face identification abilities in autism spectrum disorder / Kimberly B. SCHAUDER in Journal of Neurodevelopmental Disorders, 11-1 (December 2019)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 11-1 (December 2019) . - 42 Titre : Initial eye gaze to faces and its functional consequence on face identification abilities in autism spectrum disorder Type de document : texte imprimé Auteurs : Kimberly B. SCHAUDER, Auteur ; Woon Ju PARK, Auteur ; Yuliy TSANK, Auteur ; Miguel P. ECKSTEIN, Auteur ; Duje TADIN, Auteur ; Loisa BENNETTO, Auteur Article en page(s) : 42 Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder/physiopathology  Child  Eye Movement Measurements  Facial Recognition/physiology  Female  Fixation, Ocular/physiology  Humans  Male  Social Perception  Autism spectrum disorder  Eye gaze  Face identification Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disorder defined and diagnosed by core deficits in social communication and the presence of restricted and repetitive behaviors. Research on face processing suggests deficits in this domain in ASD but includes many mixed findings regarding the nature and extent of these differences. The first eye movement to a face has been shown to be highly informative and sufficient to achieve high performance in face identification in neurotypical adults. The current study focused on this critical moment shown to be essential in the process of face identification. METHODS: We applied an established eye-tracking and face identification paradigm to comprehensively characterize the initial eye movement to a face and test its functional consequence on face identification performance in adolescents with and without ASD (n = 21 per group), and in neurotypical adults. Specifically, we presented a series of faces and measured the landing location of the first saccade to each face, while simultaneously measuring their face identification abilities. Then, individuals were guided to look at specific locations on the face, and we measured how face identification performance varied as a function of that location. Adolescent participants also completed a more traditional measure of face identification which allowed us to more fully characterize face identification abilities in ASD. RESULTS: Our results indicate that the location of the initial look to faces and face identification performance for briefly presented faces are intact in ASD, ruling out the possibility that deficits in face perception, at least in adolescents with ASD, begin with the initial eye movement to the face. However, individuals with ASD showed impairments on the more traditional measure of face identification. CONCLUSION: Together, the observed dissociation between initial, rapid face perception processes, and other measures of face perception offers new insights and hypotheses related to the timing and perceptual complexity of face processing and how these specific aspects of face identification may be disrupted in ASD. En ligne : https://dx.doi.org/10.1186/s11689-019-9303-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573 [article] Initial eye gaze to faces and its functional consequence on face identification abilities in autism spectrum disorder [texte imprimé] / Kimberly B. SCHAUDER, Auteur ; Woon Ju PARK, Auteur ; Yuliy TSANK, Auteur ; Miguel P. ECKSTEIN, Auteur ; Duje TADIN, Auteur ; Loisa BENNETTO, Auteur . - 42. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 11-1 (December 2019) . - 42 Mots-clés : Adolescent  Autism Spectrum Disorder/physiopathology  Child  Eye Movement Measurements  Facial Recognition/physiology  Female  Fixation, Ocular/physiology  Humans  Male  Social Perception  Autism spectrum disorder  Eye gaze  Face identification Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disorder defined and diagnosed by core deficits in social communication and the presence of restricted and repetitive behaviors. Research on face processing suggests deficits in this domain in ASD but includes many mixed findings regarding the nature and extent of these differences. The first eye movement to a face has been shown to be highly informative and sufficient to achieve high performance in face identification in neurotypical adults. The current study focused on this critical moment shown to be essential in the process of face identification. METHODS: We applied an established eye-tracking and face identification paradigm to comprehensively characterize the initial eye movement to a face and test its functional consequence on face identification performance in adolescents with and without ASD (n = 21 per group), and in neurotypical adults. Specifically, we presented a series of faces and measured the landing location of the first saccade to each face, while simultaneously measuring their face identification abilities. Then, individuals were guided to look at specific locations on the face, and we measured how face identification performance varied as a function of that location. Adolescent participants also completed a more traditional measure of face identification which allowed us to more fully characterize face identification abilities in ASD. RESULTS: Our results indicate that the location of the initial look to faces and face identification performance for briefly presented faces are intact in ASD, ruling out the possibility that deficits in face perception, at least in adolescents with ASD, begin with the initial eye movement to the face. However, individuals with ASD showed impairments on the more traditional measure of face identification. CONCLUSION: Together, the observed dissociation between initial, rapid face perception processes, and other measures of face perception offers new insights and hypotheses related to the timing and perceptual complexity of face processing and how these specific aspects of face identification may be disrupted in ASD. En ligne : https://dx.doi.org/10.1186/s11689-019-9303-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573

Postural control processes during standing and step initiation in autism spectrum disorder / Erin K. BOJANEK in Journal of Neurodevelopmental Disorders, 12 (2020)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 12 (2020) Titre : Postural control processes during standing and step initiation in autism spectrum disorder Type de document : texte imprimé Auteurs : Erin K. BOJANEK, Auteur ; Zheng WANG, Auteur ; Stormi P. WHITE, Auteur ; Matthew W. MOSCONI, Auteur Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder/physiopathology  Case-Control Studies  Child  Female  Gait/physiology  Humans  Male  Postural Balance/physiology  Standing Position  Young Adult  Anticipatory postural adjustments  Autism Spectrum disorder  Mutual information  Postural control  Stepping Index. décimale : PER Périodiques Résumé : BACKGROUND: Individuals with autism spectrum disorder (ASD) show a reduced ability to maintain postural stability, though motor control mechanisms contributing to these issues and the extent to which they are associated with other gross motor activities (e.g., stepping) are not yet known. METHODS: Seventeen individuals with ASD and 20 typically developing (TD) controls (ages 6-19 years) completed three tests of postural control during standing. During the neutral stance, individuals stood with their feet shoulder width apart. During the Romberg one stance, they stood with feet close together. During the circular sway, participants stood with feet shoulder width apart and swayed in a circular motion. The standard deviation (SD) of their center of pressure (COP) in the mediolateral (ML) and anteroposterior (AP) directions and the COP trajectory length were examined for each stance. We also assessed mutual information (MI), or the shared dependencies between COP in the ML and AP directions. Participants also completed a stepping task in which they stepped forward from one force platform to an adjacent platform. The amplitude and duration of anticipatory postural adjustments (APAs) were examined, as were the maximum lateral sway, duration, and velocity of COP adjustments following the initial step. We examined stepping variables using separate one-way ANCOVAs with height as a covariate. The relationships between postural control and stepping measures and ASD symptom severity were assessed using Spearman correlations with scores on the Autism Diagnostic Observation Schedule-Second Edition (ADOS-2) and the Autism Diagnostic Interview-Revised (ADI-R). RESULTS: Individuals with ASD showed increased COP trajectory length across stance conditions (p = 0.05) and reduced MI during circular sway relative to TD controls (p = 0.02). During stepping, groups did not differ on APA amplitude (p = 0.97) or duration (p = 0.41), but during their initial step, individuals with ASD showed reduced ML sway (p = 0.06), reduced body transfer duration (p < 0.01), and increased body transfer velocity (p = 0.02) compared to controls. Greater neutral stance COP(ML) variability (r = 0.55, p = 0.02) and decreased lateral sway (r = - 0.55, p = 0.02) when stepping were associated with more severe restricted and repetitive behaviors in participants with ASD. CONCLUSIONS: We found that individuals with ASD showed reduced MI during circular sway suggesting a reduced ability to effectively coordinate joint movements during dynamic postural adjustments. Additionally, individuals with ASD showed reduced lateral sway when stepping indicating that motor rigidity may interfere with balance and gait. Postural control and stepping deficits were related to repetitive behaviors in individuals with ASD indicating that motor rigidity and key clinical issues in ASD may represent overlapping pathological processes. En ligne : https://dx.doi.org/10.1186/s11689-019-9305-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573 [article] Postural control processes during standing and step initiation in autism spectrum disorder [texte imprimé] / Erin K. BOJANEK, Auteur ; Zheng WANG, Auteur ; Stormi P. WHITE, Auteur ; Matthew W. MOSCONI, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 12 (2020) Mots-clés : Adolescent  Autism Spectrum Disorder/physiopathology  Case-Control Studies  Child  Female  Gait/physiology  Humans  Male  Postural Balance/physiology  Standing Position  Young Adult  Anticipatory postural adjustments  Autism Spectrum disorder  Mutual information  Postural control  Stepping Index. décimale : PER Périodiques Résumé : BACKGROUND: Individuals with autism spectrum disorder (ASD) show a reduced ability to maintain postural stability, though motor control mechanisms contributing to these issues and the extent to which they are associated with other gross motor activities (e.g., stepping) are not yet known. METHODS: Seventeen individuals with ASD and 20 typically developing (TD) controls (ages 6-19 years) completed three tests of postural control during standing. During the neutral stance, individuals stood with their feet shoulder width apart. During the Romberg one stance, they stood with feet close together. During the circular sway, participants stood with feet shoulder width apart and swayed in a circular motion. The standard deviation (SD) of their center of pressure (COP) in the mediolateral (ML) and anteroposterior (AP) directions and the COP trajectory length were examined for each stance. We also assessed mutual information (MI), or the shared dependencies between COP in the ML and AP directions. Participants also completed a stepping task in which they stepped forward from one force platform to an adjacent platform. The amplitude and duration of anticipatory postural adjustments (APAs) were examined, as were the maximum lateral sway, duration, and velocity of COP adjustments following the initial step. We examined stepping variables using separate one-way ANCOVAs with height as a covariate. The relationships between postural control and stepping measures and ASD symptom severity were assessed using Spearman correlations with scores on the Autism Diagnostic Observation Schedule-Second Edition (ADOS-2) and the Autism Diagnostic Interview-Revised (ADI-R). RESULTS: Individuals with ASD showed increased COP trajectory length across stance conditions (p = 0.05) and reduced MI during circular sway relative to TD controls (p = 0.02). During stepping, groups did not differ on APA amplitude (p = 0.97) or duration (p = 0.41), but during their initial step, individuals with ASD showed reduced ML sway (p = 0.06), reduced body transfer duration (p < 0.01), and increased body transfer velocity (p = 0.02) compared to controls. Greater neutral stance COP(ML) variability (r = 0.55, p = 0.02) and decreased lateral sway (r = - 0.55, p = 0.02) when stepping were associated with more severe restricted and repetitive behaviors in participants with ASD. CONCLUSIONS: We found that individuals with ASD showed reduced MI during circular sway suggesting a reduced ability to effectively coordinate joint movements during dynamic postural adjustments. Additionally, individuals with ASD showed reduced lateral sway when stepping indicating that motor rigidity may interfere with balance and gait. Postural control and stepping deficits were related to repetitive behaviors in individuals with ASD indicating that motor rigidity and key clinical issues in ASD may represent overlapping pathological processes. En ligne : https://dx.doi.org/10.1186/s11689-019-9305-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573

Pubertal developmental, body mass index, and cardiovascular autonomic function in children and adolescents with and without autism spectrum disorder: a four-time point accelerated longitudinal study / Rachael A. MUSCATELLO in Journal of Neurodevelopmental Disorders, 17 (2025)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 17 (2025) Titre : Pubertal developmental, body mass index, and cardiovascular autonomic function in children and adolescents with and without autism spectrum disorder: a four-time point accelerated longitudinal study Type de document : texte imprimé Auteurs : Rachael A. MUSCATELLO, Auteur ; Meredith COLA, Auteur ; Simon VANDEKAR, Auteur ; Blythe A. CORBETT, Auteur Langues : Anglais (eng) Mots-clés : Humans  Adolescent  Child  Male  Female  Autism Spectrum Disorder/physiopathology  Longitudinal Studies  Body Mass Index  Autonomic Nervous System/physiopathology  Puberty/physiology  Heart Rate/physiology  Respiratory Sinus Arrhythmia/physiology  Autism  Autonomic  Cardiovascular  Health  Heart rate  Physical  Pubertal development  Variability  out in accordance with the Code of Ethics of the World Medical Association  (Declaration of Helsinki). The Vanderbilt Institutional Review Board approved all  study procedures. In compliance with the Institutional Review Board, informed  written consent and verbal assent was obtained from all parent/guardians and  children, respectively, prior to inclusion in the study. Consent for publication:  Not Applicable. Competing interests: The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: The Autonomic Nervous System (ANS) regulates 'automatic' functions such as heart rate, and alterations may have significant impacts on health outcomes. Cardiovascular measures of autonomic function such as heart rate variability are of interest as biological markers in autism spectrum disorder (ASD). The interplay between the ANS and physical health establishes a need to examine cardiovascular autonomic functioning in youth with and without ASD over development. The current study aimed to identify change in autonomic function and balance across the parasympathetic and sympathetic branches over time as a function of diagnosis, age, pubertal development, and physical health status. METHODS: The study included 244 ASD (N = 140) or neurotypical (NT) (N = 104) youth, ages 10 to 13 years at enrollment and followed over four years. Resting state autonomic functioning was measured using respiratory sinus arrhythmia (RSA; parasympathetic) and pre-ejection period (PEP; sympathetic). Autonomic balance and regulation were also examined as outcomes. Linear mixed models tested between- and within-group differences in the primary autonomic outcomes as well as the influence of pubertal development, body weight, and medication use. RESULTS: Baseline models showed diagnostic differences, with lower parasympathetic regulation, in youth with ASD, but no differences were observed for the other three outcomes. Adding body mass index (BMI) percentile and medication use removed the statistically significant diagnostic effect, while both variables were significantly related to lower RSA and overall autonomic regulation. Parasympathetic function (RSA) was stable over age and pubertal stage, while a notable decrease in sympathetic control (increased PEP) was found for age and pubertal stage. BMI percentile at enrollment significantly predicted autonomic function, while change in BMI over time did not. CONCLUSIONS: Minimal research to date has explored physical health (e.g., BMI) and autonomic outcomes in ASD. The current study observed few group differences yet demonstrates important effects of physical health on ANS function in both ASD and neurotypical youth. Findings further emphasize a need to focus on individual traits such as BMI and medication use to elucidate the extent to which autonomic differences are related to health status, irrespective of diagnostic category, across the lifespan. En ligne : https://dx.doi.org/10.1186/s11689-025-09602-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 [article] Pubertal developmental, body mass index, and cardiovascular autonomic function in children and adolescents with and without autism spectrum disorder: a four-time point accelerated longitudinal study [texte imprimé] / Rachael A. MUSCATELLO, Auteur ; Meredith COLA, Auteur ; Simon VANDEKAR, Auteur ; Blythe A. CORBETT, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 17 (2025) Mots-clés : Humans  Adolescent  Child  Male  Female  Autism Spectrum Disorder/physiopathology  Longitudinal Studies  Body Mass Index  Autonomic Nervous System/physiopathology  Puberty/physiology  Heart Rate/physiology  Respiratory Sinus Arrhythmia/physiology  Autism  Autonomic  Cardiovascular  Health  Heart rate  Physical  Pubertal development  Variability  out in accordance with the Code of Ethics of the World Medical Association  (Declaration of Helsinki). The Vanderbilt Institutional Review Board approved all  study procedures. In compliance with the Institutional Review Board, informed  written consent and verbal assent was obtained from all parent/guardians and  children, respectively, prior to inclusion in the study. Consent for publication:  Not Applicable. Competing interests: The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: The Autonomic Nervous System (ANS) regulates 'automatic' functions such as heart rate, and alterations may have significant impacts on health outcomes. Cardiovascular measures of autonomic function such as heart rate variability are of interest as biological markers in autism spectrum disorder (ASD). The interplay between the ANS and physical health establishes a need to examine cardiovascular autonomic functioning in youth with and without ASD over development. The current study aimed to identify change in autonomic function and balance across the parasympathetic and sympathetic branches over time as a function of diagnosis, age, pubertal development, and physical health status. METHODS: The study included 244 ASD (N = 140) or neurotypical (NT) (N = 104) youth, ages 10 to 13 years at enrollment and followed over four years. Resting state autonomic functioning was measured using respiratory sinus arrhythmia (RSA; parasympathetic) and pre-ejection period (PEP; sympathetic). Autonomic balance and regulation were also examined as outcomes. Linear mixed models tested between- and within-group differences in the primary autonomic outcomes as well as the influence of pubertal development, body weight, and medication use. RESULTS: Baseline models showed diagnostic differences, with lower parasympathetic regulation, in youth with ASD, but no differences were observed for the other three outcomes. Adding body mass index (BMI) percentile and medication use removed the statistically significant diagnostic effect, while both variables were significantly related to lower RSA and overall autonomic regulation. Parasympathetic function (RSA) was stable over age and pubertal stage, while a notable decrease in sympathetic control (increased PEP) was found for age and pubertal stage. BMI percentile at enrollment significantly predicted autonomic function, while change in BMI over time did not. CONCLUSIONS: Minimal research to date has explored physical health (e.g., BMI) and autonomic outcomes in ASD. The current study observed few group differences yet demonstrates important effects of physical health on ANS function in both ASD and neurotypical youth. Findings further emphasize a need to focus on individual traits such as BMI and medication use to elucidate the extent to which autonomic differences are related to health status, irrespective of diagnostic category, across the lifespan. En ligne : https://dx.doi.org/10.1186/s11689-025-09602-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576

Does a high threshold of sensory responsiveness affect the development of pretend play in children on the autism spectrum? / Karolina KRZYSZTOFIK in Journal of Neurodevelopmental Disorders, 16 (2024)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 16 (2024) Titre : Does a high threshold of sensory responsiveness affect the development of pretend play in children on the autism spectrum? Type de document : texte imprimé Auteurs : Karolina KRZYSZTOFIK, Auteur Langues : Anglais (eng) Mots-clés : Humans  Autism Spectrum Disorder/physiopathology  Male  Female  Child, Preschool  Play and Playthings  Child  Child Development/physiology  Theory of Mind/physiology  Autism spectrum  Level of sensory responsiveness  Pretend play  relationships with other people or organizations within three years of beginning  the submitted work that could inappropriately influence, or be perceived to  influence, their work. The author declares that they have no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Among the current avenues of research into the origins and development of the autism spectrum, those concerning atypical levels of sensory responsiveness are gaining increasing relevance. Researchers note the relationship of sensory responsiveness in children on the autism spectrum to their motor, cognitive and social development. Current research reports combines the responsiveness to sensory stimuli also with the development of pretend play. Aim of this study was to verify the relationship between the level of development of pretend play and the level of sensory responsiveness in children on the autism spectrum. METHODS: A study was conducted in a group of 63 children with a diagnosis of autism spectrum aged from 3 years and 7 months to 9 years and 3 months using: Pretend Play subscale from the Theory of Mind Mechanism Scale and Sensory Experiences Questionnaire version 2.1. RESULTS: The results revealed that elevated sensory hyporesponsiveness predicted low pretend play skills in the group of participating children. CONCLUSION: The study verified the contribution of the level of sensory hyporesponsiveness to explaining the atypical development of pretend play in children on the autism spectrum. En ligne : https://dx.doi.org/10.1186/s11689-024-09551-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] Does a high threshold of sensory responsiveness affect the development of pretend play in children on the autism spectrum? [texte imprimé] / Karolina KRZYSZTOFIK, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 16 (2024) Mots-clés : Humans  Autism Spectrum Disorder/physiopathology  Male  Female  Child, Preschool  Play and Playthings  Child  Child Development/physiology  Theory of Mind/physiology  Autism spectrum  Level of sensory responsiveness  Pretend play  relationships with other people or organizations within three years of beginning  the submitted work that could inappropriately influence, or be perceived to  influence, their work. The author declares that they have no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Among the current avenues of research into the origins and development of the autism spectrum, those concerning atypical levels of sensory responsiveness are gaining increasing relevance. Researchers note the relationship of sensory responsiveness in children on the autism spectrum to their motor, cognitive and social development. Current research reports combines the responsiveness to sensory stimuli also with the development of pretend play. Aim of this study was to verify the relationship between the level of development of pretend play and the level of sensory responsiveness in children on the autism spectrum. METHODS: A study was conducted in a group of 63 children with a diagnosis of autism spectrum aged from 3 years and 7 months to 9 years and 3 months using: Pretend Play subscale from the Theory of Mind Mechanism Scale and Sensory Experiences Questionnaire version 2.1. RESULTS: The results revealed that elevated sensory hyporesponsiveness predicted low pretend play skills in the group of participating children. CONCLUSION: The study verified the contribution of the level of sensory hyporesponsiveness to explaining the atypical development of pretend play in children on the autism spectrum. En ligne : https://dx.doi.org/10.1186/s11689-024-09551-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

Event-related potential (ERP) correlates of face processing in verbal children with autism spectrum disorders (ASD) and their first-degree relatives: a family study / Olga V. SYSOEVA in Molecular Autism, 9 (2018)  

Public ISBD [article]  inMolecular Autism > 9 (2018) . - 41p. Titre : Event-related potential (ERP) correlates of face processing in verbal children with autism spectrum disorders (ASD) and their first-degree relatives: a family study Type de document : texte imprimé Auteurs : Olga V. SYSOEVA, Auteur ; John N. CONSTANTINO, Auteur ; Andrey P. ANOKHIN, Auteur Article en page(s) : 41p. Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/physiopathology  Child  Electroencephalography  Evoked Potentials  Face  Fathers  Humans  Male  Middle Aged  Pattern Recognition, Visual  Siblings  Young Adult  Autistic disorder  erp  Electrophysiology  Endophenotype  N170 Index. décimale : PER Périodiques Résumé : Background: Inherited abnormalities of perception, recognition, and attention to faces have been implicated in the etiology of autism spectrum disorders (ASD) including abnormal components of event-related brain potentials (ERP) elicited by faces. Methods: We examined familial aggregation of face processing ERP abnormalities previously implicated in ASD in 49 verbal individuals with ASD, 36 unaffected siblings (US), 18 unaffected fathers (UF), and 53 unrelated controls (UC). The ASD, US, and UC groups ranged in age from 12 to 21 years, the UF group ranged in age from 30 to 56 years. ERP responses to images of upright and inverted faces and houses were analyzed under disparate EEG reference schemes. Results: Face-sensitive features of N170 and P1 were readily observed in all groups. Differences between ASD and control groups depended upon the EEG reference scheme. Notably, the superiority of face over object for N170 latency was attenuated in ASD subjects, but not their relatives; this occurred exclusively with the average reference. The difference in N170 amplitude between inverted and upright faces was reduced in both ASD and US groups relative to UC, but this effect was significant only with the vertex reference. Furthermore, similar group differences were observed for both inverted faces and inverted houses, suggesting a lack of face specificity for the attenuation of the N170 inversion effect in ASD. Conclusion: The present findings refine understanding of face processing ERPs in ASD. These data provide only modest evidence for highly-selective ASD-sensitive ERP features, and underscore the sensitivity of these biomarkers to ERP reference scheme. These schemes have varied across published studies and must be accounted for in future studies of the relationship between these commonly acquired ERP characteristics, genotype, and ASD. En ligne : https://dx.doi.org/10.1186/s13229-018-0220-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 [article] Event-related potential (ERP) correlates of face processing in verbal children with autism spectrum disorders (ASD) and their first-degree relatives: a family study [texte imprimé] / Olga V. SYSOEVA, Auteur ; John N. CONSTANTINO, Auteur ; Andrey P. ANOKHIN, Auteur . - 41p. Langues : Anglais (eng) in Molecular Autism > 9 (2018) . - 41p. Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/physiopathology  Child  Electroencephalography  Evoked Potentials  Face  Fathers  Humans  Male  Middle Aged  Pattern Recognition, Visual  Siblings  Young Adult  Autistic disorder  erp  Electrophysiology  Endophenotype  N170 Index. décimale : PER Périodiques Résumé : Background: Inherited abnormalities of perception, recognition, and attention to faces have been implicated in the etiology of autism spectrum disorders (ASD) including abnormal components of event-related brain potentials (ERP) elicited by faces. Methods: We examined familial aggregation of face processing ERP abnormalities previously implicated in ASD in 49 verbal individuals with ASD, 36 unaffected siblings (US), 18 unaffected fathers (UF), and 53 unrelated controls (UC). The ASD, US, and UC groups ranged in age from 12 to 21 years, the UF group ranged in age from 30 to 56 years. ERP responses to images of upright and inverted faces and houses were analyzed under disparate EEG reference schemes. Results: Face-sensitive features of N170 and P1 were readily observed in all groups. Differences between ASD and control groups depended upon the EEG reference scheme. Notably, the superiority of face over object for N170 latency was attenuated in ASD subjects, but not their relatives; this occurred exclusively with the average reference. The difference in N170 amplitude between inverted and upright faces was reduced in both ASD and US groups relative to UC, but this effect was significant only with the vertex reference. Furthermore, similar group differences were observed for both inverted faces and inverted houses, suggesting a lack of face specificity for the attenuation of the N170 inversion effect in ASD. Conclusion: The present findings refine understanding of face processing ERPs in ASD. These data provide only modest evidence for highly-selective ASD-sensitive ERP features, and underscore the sensitivity of these biomarkers to ERP reference scheme. These schemes have varied across published studies and must be accounted for in future studies of the relationship between these commonly acquired ERP characteristics, genotype, and ASD. En ligne : https://dx.doi.org/10.1186/s13229-018-0220-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371

Intact priors for gaze direction in adults with high-functioning autism spectrum conditions / Philip J. PELL in Molecular Autism, 7 (2016)  

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Physiological and communicative emotional disconcordance in children on the autism spectrum / Emma FINKEL in Journal of Neurodevelopmental Disorders, 16 (2024)  

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Atypical audio-visual neural synchrony and speech processing in early autism / Xiaoyue WANG in Journal of Neurodevelopmental Disorders, 17 (2025)  

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Visual preference for social stimuli in individuals with autism or neurodevelopmental disorders: an eye-tracking study / Hayley CRAWFORD in Molecular Autism, 7 (2016)  

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Atypical lateralization of motor circuit functional connectivity in children with autism is associated with motor deficits / Dorothea L. FLORIS in Molecular Autism, 7 (2016)  

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