Genetic susceptibility for major depressive disorder associates with trajectories of depressive symptoms across childhood and adolescence / A. A. LUSSIER in Journal of Child Psychology and Psychiatry, 62-7 (July 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-7 (July 2021) . - p.895-904 Titre : Genetic susceptibility for major depressive disorder associates with trajectories of depressive symptoms across childhood and adolescence Type de document : Texte imprimé et/ou numérique Auteurs : A. A. LUSSIER, Auteur ; M. HAWRILENKO, Auteur ; M. J. WANG, Auteur ; Karmel W. CHOI, Auteur ; J. CERUTTI, Auteur ; Y. ZHU, Auteur ; E. C. DUNN, Auteur Article en page(s) : p.895-904 Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Child  Depression  Depressive Disorder, Major/epidemiology/genetics  Genetic Predisposition to Disease/genetics  Genome-Wide Association Study  Humans  Longitudinal Studies  Prospective Studies  Alspac  Depression trajectories  development  longitudinal  polygenic risk scores Index. décimale : PER Périodiques Résumé : BACKGROUND: Early-onset depression during childhood and adolescence is associated with a worse course of illness and outcome than adult onset. However, the genetic factors that influence risk for early-onset depression remain mostly unknown. Using data collected over 13 years, we examined whether polygenic risk scores (PRS) that capture genetic risk for depression were associated with depressive symptom trajectories assessed from childhood to adolescence. METHODS: Data came from the Avon Longitudinal Study of Parents and Children, a prospective, longitudinal birth cohort (analytic sample = 7,308 youth). We analyzed the relationship between genetic susceptibility to depression and three time-dependent measures of depressive symptoms trajectories spanning 4-16.5 years of age (class, onset, and cumulative burden). Trajectories were constructed using a growth mixture model with structured residuals. PRS were generated from the summary statistics of a genome-wide association study of depression risk using data from the Psychiatric Genomics Consortium, UK Biobank, and 23andMe, Inc. We used MAGMA to identify gene-level associations with these measures. RESULTS: Youth were classified into six classes of depressive symptom trajectories: high/renitent (27.9% of youth), high/reversing (9.1%), childhood decrease (7.3%), late childhood peak (3.3%), adolescent spike (2.5%), and minimal symptoms (49.9%). PRS discriminated between youth in the late childhood peak, high/reversing, and high/renitent classes compared to the minimal symptoms and childhood decrease classes. No significant associations were detected at the gene level. CONCLUSIONS: This study highlights differences in polygenic loading for depressive symptoms across childhood and adolescence, particularly among youths with high symptoms in early adolescence, regardless of age-independent patterns. En ligne : http://dx.doi.org/10.1111/jcpp.13342 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Genetic susceptibility for major depressive disorder associates with trajectories of depressive symptoms across childhood and adolescence [Texte imprimé et/ou numérique] / A. A. LUSSIER, Auteur ; M. HAWRILENKO, Auteur ; M. J. WANG, Auteur ; Karmel W. CHOI, Auteur ; J. CERUTTI, Auteur ; Y. ZHU, Auteur ; E. C. DUNN, Auteur . - p.895-904. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-7 (July 2021) . - p.895-904 Mots-clés : Adolescent  Adult  Child  Depression  Depressive Disorder, Major/epidemiology/genetics  Genetic Predisposition to Disease/genetics  Genome-Wide Association Study  Humans  Longitudinal Studies  Prospective Studies  Alspac  Depression trajectories  development  longitudinal  polygenic risk scores Index. décimale : PER Périodiques Résumé : BACKGROUND: Early-onset depression during childhood and adolescence is associated with a worse course of illness and outcome than adult onset. However, the genetic factors that influence risk for early-onset depression remain mostly unknown. Using data collected over 13 years, we examined whether polygenic risk scores (PRS) that capture genetic risk for depression were associated with depressive symptom trajectories assessed from childhood to adolescence. METHODS: Data came from the Avon Longitudinal Study of Parents and Children, a prospective, longitudinal birth cohort (analytic sample = 7,308 youth). We analyzed the relationship between genetic susceptibility to depression and three time-dependent measures of depressive symptoms trajectories spanning 4-16.5 years of age (class, onset, and cumulative burden). Trajectories were constructed using a growth mixture model with structured residuals. PRS were generated from the summary statistics of a genome-wide association study of depression risk using data from the Psychiatric Genomics Consortium, UK Biobank, and 23andMe, Inc. We used MAGMA to identify gene-level associations with these measures. RESULTS: Youth were classified into six classes of depressive symptom trajectories: high/renitent (27.9% of youth), high/reversing (9.1%), childhood decrease (7.3%), late childhood peak (3.3%), adolescent spike (2.5%), and minimal symptoms (49.9%). PRS discriminated between youth in the late childhood peak, high/reversing, and high/renitent classes compared to the minimal symptoms and childhood decrease classes. No significant associations were detected at the gene level. CONCLUSIONS: This study highlights differences in polygenic loading for depressive symptoms across childhood and adolescence, particularly among youths with high symptoms in early adolescence, regardless of age-independent patterns. En ligne : http://dx.doi.org/10.1111/jcpp.13342 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Integrative analysis of genomic and exposomic influences on youth mental health / Karmel W. CHOI in Journal of Child Psychology and Psychiatry, 63-10 (October 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-10 (October 2022) . - p.1196-1205 Titre : Integrative analysis of genomic and exposomic influences on youth mental health Type de document : Texte imprimé et/ou numérique Auteurs : Karmel W. CHOI, Auteur ; Marina WILSON, Auteur ; Tian GE, Auteur ; Aaron KANDOLA, Auteur ; Chirag J. PATEL, Auteur ; S. Hong LEE, Auteur ; Jordan W. SMOLLER, Auteur Année de publication : 2022 Article en page(s) : p.1196-1205 Langues : Anglais (eng) Mots-clés : Adolescent  Genomics  Humans  Mental Health  Psychopathology  Schools  Exposome  G×e  depression  gene-environment interaction  genetics  heritability  youth mental health Index. décimale : PER Périodiques Résumé : BACKGROUND: Understanding complex influences on mental health problems in young people is needed to inform early prevention strategies. Both genetic and environmental factors are known to influence youth mental health, but a more comprehensive picture of their interplay, including wide-ranging environmental exposures - that is, the exposome - is needed. We perform an integrative analysis of genomic and exposomic data in relation to internalizing and externalizing symptoms in a cohort of 4,314 unrelated youth from the Adolescent Brain and Cognitive Development (ABCD) Study. METHODS: Using novel GREML-based approaches, we model the variance in internalizing and externalizing symptoms explained by additive and interactive influences from the genome (G) and modeled exposome (E) consisting of up to 133 variables at the family, peer, school, neighborhood, life event, and broader environmental levels, including genome-by-exposome (G×E) and exposome-by-exposome (E×E) effects. RESULTS: A best-fitting integrative model with G, E, and G×E components explained 35% and 63% of variance in youth internalizing and externalizing symptoms, respectively. Youth in the top quintile of model-predicted risk accounted for the majority of individuals with clinically elevated symptoms at follow-up (60% for internalizing; 72% for externalizing). Of note, different domains of environmental exposures were most impactful for internalizing (life events) and externalizing (contextual including family, school, and peer-level factors) symptoms. In addition, variance explained by G×E contributions was substantially larger for externalizing (33%) than internalizing (13%) symptoms. CONCLUSIONS: Advanced statistical genetic methods in a longitudinal cohort of youth can be leveraged to address fundamental questions about the role of 'nature and nurture' in developmental psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.13664 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 [article] Integrative analysis of genomic and exposomic influences on youth mental health [Texte imprimé et/ou numérique] / Karmel W. CHOI, Auteur ; Marina WILSON, Auteur ; Tian GE, Auteur ; Aaron KANDOLA, Auteur ; Chirag J. PATEL, Auteur ; S. Hong LEE, Auteur ; Jordan W. SMOLLER, Auteur . - 2022 . - p.1196-1205. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-10 (October 2022) . - p.1196-1205 Mots-clés : Adolescent  Genomics  Humans  Mental Health  Psychopathology  Schools  Exposome  G×e  depression  gene-environment interaction  genetics  heritability  youth mental health Index. décimale : PER Périodiques Résumé : BACKGROUND: Understanding complex influences on mental health problems in young people is needed to inform early prevention strategies. Both genetic and environmental factors are known to influence youth mental health, but a more comprehensive picture of their interplay, including wide-ranging environmental exposures - that is, the exposome - is needed. We perform an integrative analysis of genomic and exposomic data in relation to internalizing and externalizing symptoms in a cohort of 4,314 unrelated youth from the Adolescent Brain and Cognitive Development (ABCD) Study. METHODS: Using novel GREML-based approaches, we model the variance in internalizing and externalizing symptoms explained by additive and interactive influences from the genome (G) and modeled exposome (E) consisting of up to 133 variables at the family, peer, school, neighborhood, life event, and broader environmental levels, including genome-by-exposome (G×E) and exposome-by-exposome (E×E) effects. RESULTS: A best-fitting integrative model with G, E, and G×E components explained 35% and 63% of variance in youth internalizing and externalizing symptoms, respectively. Youth in the top quintile of model-predicted risk accounted for the majority of individuals with clinically elevated symptoms at follow-up (60% for internalizing; 72% for externalizing). Of note, different domains of environmental exposures were most impactful for internalizing (life events) and externalizing (contextual including family, school, and peer-level factors) symptoms. In addition, variance explained by G×E contributions was substantially larger for externalizing (33%) than internalizing (13%) symptoms. CONCLUSIONS: Advanced statistical genetic methods in a longitudinal cohort of youth can be leveraged to address fundamental questions about the role of 'nature and nurture' in developmental psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.13664 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486

Maternal depression in the intergenerational transmission of childhood maltreatment and its sequelae: Testing postpartum effects in a longitudinal birth cohort / Karmel W. CHOI in Development and Psychopathology, 31-1 (February 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-1 (February 2019) . - p.143-156 Titre : Maternal depression in the intergenerational transmission of childhood maltreatment and its sequelae: Testing postpartum effects in a longitudinal birth cohort Type de document : Texte imprimé et/ou numérique Auteurs : Karmel W. CHOI, Auteur ; Renate HOUTS, Auteur ; Louise ARSENEAULT, Auteur ; Carmine PARIANTE, Auteur ; Kathleen J. SIKKEMA, Auteur ; Terrie E. MOFFITT, Auteur Article en page(s) : p.143-156 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Mothers who have experienced childhood maltreatment are more likely to have children also exposed to maltreatment, a phenomenon known as intergenerational transmission. Factors in the perinatal period may contribute uniquely to this transmission, but timing effects have not been ascertained. Using structural equation modeling with 1,016 mothers and their 2,032 children in the Environmental Risk Longitudinal Twin Study, we tested the mediating role of postpartum depression between maternal childhood maltreatment and a cascade of negative child outcomes, specifically child exposure to maltreatment, internalizing symptoms, and externalizing symptoms: (a) adjusting for later maternal depression, (b) comparing across sex differences, and (c) examining the relative role of maltreatment subtypes. Mothers who had been maltreated as children, especially those who had experienced emotional or sexual abuse, were at increased risk for postpartum depression. In turn, postpartum depression predicted children’s exposure to maltreatment, followed by emotional and behavioral problems. Indirect effects from maternal childhood maltreatment to child outcomes were robust across child sex and supported significant mediation through postpartum depression; however, this appeared to be carried by mothers’ depression beyond the postpartum period. Identifying and treating postpartum depression, and preventing its recurrence, may help interrupt the intergenerational transmission of maltreatment and its sequelae. En ligne : http://dx.doi.org/10.1017/S0954579418000032 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383 [article] Maternal depression in the intergenerational transmission of childhood maltreatment and its sequelae: Testing postpartum effects in a longitudinal birth cohort [Texte imprimé et/ou numérique] / Karmel W. CHOI, Auteur ; Renate HOUTS, Auteur ; Louise ARSENEAULT, Auteur ; Carmine PARIANTE, Auteur ; Kathleen J. SIKKEMA, Auteur ; Terrie E. MOFFITT, Auteur . - p.143-156. Langues : Anglais (eng) in Development and Psychopathology > 31-1 (February 2019) . - p.143-156 Index. décimale : PER Périodiques Résumé : Mothers who have experienced childhood maltreatment are more likely to have children also exposed to maltreatment, a phenomenon known as intergenerational transmission. Factors in the perinatal period may contribute uniquely to this transmission, but timing effects have not been ascertained. Using structural equation modeling with 1,016 mothers and their 2,032 children in the Environmental Risk Longitudinal Twin Study, we tested the mediating role of postpartum depression between maternal childhood maltreatment and a cascade of negative child outcomes, specifically child exposure to maltreatment, internalizing symptoms, and externalizing symptoms: (a) adjusting for later maternal depression, (b) comparing across sex differences, and (c) examining the relative role of maltreatment subtypes. Mothers who had been maltreated as children, especially those who had experienced emotional or sexual abuse, were at increased risk for postpartum depression. In turn, postpartum depression predicted children’s exposure to maltreatment, followed by emotional and behavioral problems. Indirect effects from maternal childhood maltreatment to child outcomes were robust across child sex and supported significant mediation through postpartum depression; however, this appeared to be carried by mothers’ depression beyond the postpartum period. Identifying and treating postpartum depression, and preventing its recurrence, may help interrupt the intergenerational transmission of maltreatment and its sequelae. En ligne : http://dx.doi.org/10.1017/S0954579418000032 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383

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