Abnormal Transient Pupillary Light Reflex in Individuals with Autism Spectrum Disorders / Xiaofei FAN in Journal of Autism and Developmental Disorders, 39-11 (November 2009)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 39-11 (November 2009) . - p.1499-1508 Titre : Abnormal Transient Pupillary Light Reflex in Individuals with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Xiaofei FAN, Auteur ; T. Nicole TAKAHASHI, Auteur ; Judith H. MILES, Auteur ; Gang YAO, Auteur Année de publication : 2009 Article en page(s) : p.1499-1508 Langues : Anglais (eng) Mots-clés : Autism Pupillary-light-reflex Biomarker Index. décimale : PER Périodiques Résumé : Computerized binocular infrared pupillography was used to measure the transient pupillary light reflex (PLR) in both children with autism spectrum disorders (ASDs) and children with typical development. We found that participants with ASDs showed significantly longer PLR latency, smaller constriction amplitude and lower constriction velocity than children with typical development. The PLR latency alone can be used to discriminate the ASD group from the control group with a cross-validated success rate of 89.6%. By adding the constriction amplitude, the percentage of correct classification can be further improved to 92.5%. In addition, the right-lateralization of contraction anisocoria that was observed in participants with typical development was not observed in those with ASDs. Further studies are necessary to understand the origin and implications of these observations. It is anticipated that as potential biomarkers, these pupillary light reflex measurements will advance our understanding of neurodevelopmental differences in the autism brain. En ligne : http://dx.doi.org/10.1007/s10803-009-0767-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=849 [article] Abnormal Transient Pupillary Light Reflex in Individuals with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Xiaofei FAN, Auteur ; T. Nicole TAKAHASHI, Auteur ; Judith H. MILES, Auteur ; Gang YAO, Auteur . - 2009 . - p.1499-1508. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 39-11 (November 2009) . - p.1499-1508 Mots-clés : Autism Pupillary-light-reflex Biomarker Index. décimale : PER Périodiques Résumé : Computerized binocular infrared pupillography was used to measure the transient pupillary light reflex (PLR) in both children with autism spectrum disorders (ASDs) and children with typical development. We found that participants with ASDs showed significantly longer PLR latency, smaller constriction amplitude and lower constriction velocity than children with typical development. The PLR latency alone can be used to discriminate the ASD group from the control group with a cross-validated success rate of 89.6%. By adding the constriction amplitude, the percentage of correct classification can be further improved to 92.5%. In addition, the right-lateralization of contraction anisocoria that was observed in participants with typical development was not observed in those with ASDs. Further studies are necessary to understand the origin and implications of these observations. It is anticipated that as potential biomarkers, these pupillary light reflex measurements will advance our understanding of neurodevelopmental differences in the autism brain. En ligne : http://dx.doi.org/10.1007/s10803-009-0767-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=849

Atypical Pupillary Light Reflex and Heart Rate Variability in Children with Autism Spectrum Disorder / Chathuri DALUWATTE in Journal of Autism and Developmental Disorders, 43-8 (August 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-8 (August 2013) . - p.1910-1925 Titre : Atypical Pupillary Light Reflex and Heart Rate Variability in Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Chathuri DALUWATTE, Auteur ; Judith H. MILES, Auteur ; Shawn E. CHRIST, Auteur ; David Q. BEVERSDORF, Auteur ; T. Nicole TAKAHASHI, Auteur ; Gang YAO, Auteur Article en page(s) : p.1910-1925 Langues : Anglais (eng) Mots-clés : Pupillary light reflex  Heart rate variability  Autism  Autonomic nervous system Index. décimale : PER Périodiques Résumé : We investigated pupillary light reflex (PLR) in 152 children with ASD, 116 typically developing (TD) children, and 36 children with non-ASD neurodevelopmental disorders (NDDs). Heart rate variability (HRV) was measured simultaneously to study potential impairments in the autonomic nervous system (ANS) associated with ASD. The results showed that the ASD group had significantly longer PLR latency, reduced relative constriction amplitude, and shorter constriction/redilation time than those of the TD group. Similar atypical PLR parameters were observed in the NDD group. A significant age effect on PLR latency was observed in children younger than 9 years in the TD group, but not in the ASD and NDD groups. Atypical HRV parameters were observed in the ASD and NDD groups. A significant negative correlation existed between the PLR constriction amplitude and average heart rate in children with an ASD, but not in children with typical development. En ligne : http://dx.doi.org/10.1007/s10803-012-1741-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=205 [article] Atypical Pupillary Light Reflex and Heart Rate Variability in Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Chathuri DALUWATTE, Auteur ; Judith H. MILES, Auteur ; Shawn E. CHRIST, Auteur ; David Q. BEVERSDORF, Auteur ; T. Nicole TAKAHASHI, Auteur ; Gang YAO, Auteur . - p.1910-1925. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-8 (August 2013) . - p.1910-1925 Mots-clés : Pupillary light reflex  Heart rate variability  Autism  Autonomic nervous system Index. décimale : PER Périodiques Résumé : We investigated pupillary light reflex (PLR) in 152 children with ASD, 116 typically developing (TD) children, and 36 children with non-ASD neurodevelopmental disorders (NDDs). Heart rate variability (HRV) was measured simultaneously to study potential impairments in the autonomic nervous system (ANS) associated with ASD. The results showed that the ASD group had significantly longer PLR latency, reduced relative constriction amplitude, and shorter constriction/redilation time than those of the TD group. Similar atypical PLR parameters were observed in the NDD group. A significant age effect on PLR latency was observed in children younger than 9 years in the TD group, but not in the ASD and NDD groups. Atypical HRV parameters were observed in the ASD and NDD groups. A significant negative correlation existed between the PLR constriction amplitude and average heart rate in children with an ASD, but not in children with typical development. En ligne : http://dx.doi.org/10.1007/s10803-012-1741-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=205

Atypical pupillary light reflex in 2–6-year-old children with autism spectrum disorders / Dinalankara M. R. DINALANKARA in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.829-838 Titre : Atypical pupillary light reflex in 2–6-year-old children with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Dinalankara M. R. DINALANKARA, Auteur ; Judith H. MILES, Auteur ; T. NICOLE TAKAHASHI, Auteur ; Gang YAO, Auteur Article en page(s) : p.829-838 Langues : Anglais (eng) Mots-clés : pupillary light reflex  autism  age  latency  pupil size  autonomic dysfunction Index. décimale : PER Périodiques Résumé : The purpose of this study was to investigate pupillary light reflex (PLR) in 2–6-years-old children with autism spectrum disorders (ASD). A total of 117 medication-free 2–6-year-old boys participated in this study. Sixty participants were diagnosed with ASD (the “ASD group”) and the other 57 were in the control group of typical development (the “TD group”). A questionnaire was completed by the parent/guardian for assessing potential dysfunctions in the autonomic nervous system (ANS). The base pupil radius, PLR latency, and constriction time showed a significant age-related trend in both the ASD and TD groups. The base pupil size increased with age in the typically developing children, but not in the ASD group. The ASD group showed more symptoms related to ANS dysfunctions. An association between abnormal sweating with base pupil radius and PLR constriction was observed in the TD group but not the ASD group. The different association of PLR parameters with ANS dysfunction may suggest disrupted autonomic controls in children with ASD. En ligne : http://dx.doi.org/10.1002/aur.1745 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Atypical pupillary light reflex in 2–6-year-old children with autism spectrum disorders [Texte imprimé et/ou numérique] / Dinalankara M. R. DINALANKARA, Auteur ; Judith H. MILES, Auteur ; T. NICOLE TAKAHASHI, Auteur ; Gang YAO, Auteur . - p.829-838. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.829-838 Mots-clés : pupillary light reflex  autism  age  latency  pupil size  autonomic dysfunction Index. décimale : PER Périodiques Résumé : The purpose of this study was to investigate pupillary light reflex (PLR) in 2–6-years-old children with autism spectrum disorders (ASD). A total of 117 medication-free 2–6-year-old boys participated in this study. Sixty participants were diagnosed with ASD (the “ASD group”) and the other 57 were in the control group of typical development (the “TD group”). A questionnaire was completed by the parent/guardian for assessing potential dysfunctions in the autonomic nervous system (ANS). The base pupil radius, PLR latency, and constriction time showed a significant age-related trend in both the ASD and TD groups. The base pupil size increased with age in the typically developing children, but not in the ASD group. The ASD group showed more symptoms related to ANS dysfunctions. An association between abnormal sweating with base pupil radius and PLR constriction was observed in the TD group but not the ASD group. The different association of PLR parameters with ANS dysfunction may suggest disrupted autonomic controls in children with ASD. En ligne : http://dx.doi.org/10.1002/aur.1745 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Autism Subgroups from a Medical Genetics Perspective / Judith H. MILES

Public ISBD in Autism Spectrum Disorders / David G. AMARAL Titre : Autism Subgroups from a Medical Genetics Perspective Type de document : Texte imprimé et/ou numérique Auteurs : Judith H. MILES, Auteur Année de publication : 2011 Importance : p.705-721 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139 in Autism Spectrum Disorders / David G. AMARAL Autism Subgroups from a Medical Genetics Perspective [Texte imprimé et/ou numérique] / Judith H. MILES, Auteur . - 2011 . - p.705-721. Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139

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Brief Report: A Preliminary Study of the Relationship between Repetitive Behaviors and Concurrent Executive Function Demands in Children with Autism Spectrum Disorder / Mackenzie N. CISSNE in Journal of Autism and Developmental Disorders, 52-4 (April 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-4 (April 2022) . - p.1896-1902 Titre : Brief Report: A Preliminary Study of the Relationship between Repetitive Behaviors and Concurrent Executive Function Demands in Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Mackenzie N. CISSNE, Auteur ; Lindsay E. KESTER, Auteur ; Amanda J. MOFFITT GUNN, Auteur ; Kimberly E. BODNER, Auteur ; Judith H. MILES, Auteur ; Shawn E. CHRIST, Auteur Article en page(s) : p.1896-1902 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis  Child  Cognition  Executive Function/physiology  Humans  Inhibition, Psychological  Antisaccade  Autism Spectrum Disorder  Cognitive flexibility  Executive function  Inhibitory control  Repetitive behaviors Index. décimale : PER Périodiques Résumé : The present study evaluated the hypothesis that the strength of the relationship between executive function (EF) and repetitive behaviors and restricted interests (RBRI) symptomatology is moderated by the degree to which concurrent demands are placed on multiple aspects of EF. An eye movement task was used to evaluate inhibition and task switching ability (both together and in isolation) in a sample of 22 children with autism spectrum disorder (ASD). The Repetitive Behavior Scale-Revised (RBS-R) was used to assess the severity of RBRI symptoms. Results provide preliminary support for the aforementioned hypothesis. RBS-R scores were significantly correlated with task performance when simultaneous demands were placed on switching and inhibition; however, no such relationship was found for inhibition-only or switching-only task conditions. En ligne : http://dx.doi.org/10.1007/s10803-021-05071-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 [article] Brief Report: A Preliminary Study of the Relationship between Repetitive Behaviors and Concurrent Executive Function Demands in Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Mackenzie N. CISSNE, Auteur ; Lindsay E. KESTER, Auteur ; Amanda J. MOFFITT GUNN, Auteur ; Kimberly E. BODNER, Auteur ; Judith H. MILES, Auteur ; Shawn E. CHRIST, Auteur . - p.1896-1902. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-4 (April 2022) . - p.1896-1902 Mots-clés : Autism Spectrum Disorder/diagnosis  Child  Cognition  Executive Function/physiology  Humans  Inhibition, Psychological  Antisaccade  Autism Spectrum Disorder  Cognitive flexibility  Executive function  Inhibitory control  Repetitive behaviors Index. décimale : PER Périodiques Résumé : The present study evaluated the hypothesis that the strength of the relationship between executive function (EF) and repetitive behaviors and restricted interests (RBRI) symptomatology is moderated by the degree to which concurrent demands are placed on multiple aspects of EF. An eye movement task was used to evaluate inhibition and task switching ability (both together and in isolation) in a sample of 22 children with autism spectrum disorder (ASD). The Repetitive Behavior Scale-Revised (RBS-R) was used to assess the severity of RBRI symptoms. Results provide preliminary support for the aforementioned hypothesis. RBS-R scores were significantly correlated with task performance when simultaneous demands were placed on switching and inhibition; however, no such relationship was found for inhibition-only or switching-only task conditions. En ligne : http://dx.doi.org/10.1007/s10803-021-05071-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476

Defining Autism Subgroups: A Taxometric Solution / David G. INGRAM in Journal of Autism and Developmental Disorders, 38-5 (May 2008)  

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Facial phenotypes in subgroups of prepubertal boys with autism spectrum disorders are correlated with clinical phenotypes / Kristina ALDRIDGE in Molecular Autism, (October 2011)  

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Facial Structure Analysis Separates Autism Spectrum Disorders into Meaningful Clinical Subgroups / Tayo OBAFEMI-AJAYI in Journal of Autism and Developmental Disorders, 45-5 (May 2015)  

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Predicting improvement in social–communication symptoms of autism spectrum disorders using retrospective treatment data / Micah O. MAZUREK in Research in Autism Spectrum Disorders, 6-1 (January-March 2012)  

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