Association of cumulative prenatal adversity with infant subcortical structure volumes and child problem behavior and its moderation by a coexpression polygenic risk score of the serotonin system / Henriette ACOSTA in Development and Psychopathology, 36-3 (August 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-3 (August 2024) . - p.1027-1042 Titre : Association of cumulative prenatal adversity with infant subcortical structure volumes and child problem behavior and its moderation by a coexpression polygenic risk score of the serotonin system Type de document : Texte imprimé et/ou numérique Auteurs : Henriette ACOSTA, Auteur ; Katri KANTOJARVI, Auteur ; Jetro J. TUULARI, Auteur ; John D. LEWIS, Auteur ; Niloofar HASHEMPOUR, Auteur ; Noora M. SCHEININ, Auteur ; Satu J. LEHTOLA, Auteur ; Saara NOLVI, Auteur ; Vladimir S. FONOV, Auteur ; D. Louis COLLINS, Auteur ; Alan C. EVANS, Auteur ; Riitta PARKKOLA, Auteur ; Tuire LÄHDESMÄKI, Auteur ; Jani SAUNAVAARA, Auteur ; Harri MERISAARI, Auteur ; Linnea KARLSSON, Auteur ; Tiina PAUNIO, Auteur ; Hasse KARLSSON, Auteur Article en page(s) : p.1027-1042 Langues : Anglais (eng) Mots-clés : MRI  SDQ  amygdala  hyperactivity  prenatal stress Index. décimale : PER Périodiques Résumé : Prenatal adversity has been linked to later psychopathology. Yet, research on cumulative prenatal adversity, as well as its interaction with offspring genotype, on brain and behavioral development is scarce. With this study, we aimed to address this gap. In Finnish mother-infant dyads, we investigated the association of a cumulative prenatal adversity sum score (PRE-AS) with (a) child emotional and behavioral problems assessed with the Strengths and Difficulties Questionnaire at 4 and 5 years (N = 1568, 45.3% female), (b) infant amygdalar and hippocampal volumes (subsample N = 122), and (c) its moderation by a hippocampal-specific coexpression polygenic risk score based on the serotonin transporter (SLC6A4) gene. We found that higher PRE-AS was linked to greater child emotional and behavioral problems at both time points, with partly stronger associations in boys than in girls. Higher PRE-AS was associated with larger bilateral infant amygdalar volumes in girls compared to boys, while no associations were found for hippocampal volumes. Further, hyperactivity/inattention in 4-year-old girls was related to both genotype and PRE-AS, the latter partially mediated by right amygdalar volumes as preliminary evidence suggests. Our study is the first to demonstrate a dose-dependent sexually dimorphic relationship between cumulative prenatal adversity and infant amygdalar volumes. En ligne : https://dx.doi.org/10.1017/S0954579423000275 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538 [article] Association of cumulative prenatal adversity with infant subcortical structure volumes and child problem behavior and its moderation by a coexpression polygenic risk score of the serotonin system [Texte imprimé et/ou numérique] / Henriette ACOSTA, Auteur ; Katri KANTOJARVI, Auteur ; Jetro J. TUULARI, Auteur ; John D. LEWIS, Auteur ; Niloofar HASHEMPOUR, Auteur ; Noora M. SCHEININ, Auteur ; Satu J. LEHTOLA, Auteur ; Saara NOLVI, Auteur ; Vladimir S. FONOV, Auteur ; D. Louis COLLINS, Auteur ; Alan C. EVANS, Auteur ; Riitta PARKKOLA, Auteur ; Tuire LÄHDESMÄKI, Auteur ; Jani SAUNAVAARA, Auteur ; Harri MERISAARI, Auteur ; Linnea KARLSSON, Auteur ; Tiina PAUNIO, Auteur ; Hasse KARLSSON, Auteur . - p.1027-1042. Langues : Anglais (eng) in Development and Psychopathology > 36-3 (August 2024) . - p.1027-1042 Mots-clés : MRI  SDQ  amygdala  hyperactivity  prenatal stress Index. décimale : PER Périodiques Résumé : Prenatal adversity has been linked to later psychopathology. Yet, research on cumulative prenatal adversity, as well as its interaction with offspring genotype, on brain and behavioral development is scarce. With this study, we aimed to address this gap. In Finnish mother-infant dyads, we investigated the association of a cumulative prenatal adversity sum score (PRE-AS) with (a) child emotional and behavioral problems assessed with the Strengths and Difficulties Questionnaire at 4 and 5 years (N = 1568, 45.3% female), (b) infant amygdalar and hippocampal volumes (subsample N = 122), and (c) its moderation by a hippocampal-specific coexpression polygenic risk score based on the serotonin transporter (SLC6A4) gene. We found that higher PRE-AS was linked to greater child emotional and behavioral problems at both time points, with partly stronger associations in boys than in girls. Higher PRE-AS was associated with larger bilateral infant amygdalar volumes in girls compared to boys, while no associations were found for hippocampal volumes. Further, hyperactivity/inattention in 4-year-old girls was related to both genotype and PRE-AS, the latter partially mediated by right amygdalar volumes as preliminary evidence suggests. Our study is the first to demonstrate a dose-dependent sexually dimorphic relationship between cumulative prenatal adversity and infant amygdalar volumes. En ligne : https://dx.doi.org/10.1017/S0954579423000275 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538

Maternal and paternal depressive symptoms and children's emotional problems at the age of 2 and 5 years: a longitudinal study / Johanna T. PIETIKAINEN in Journal of Child Psychology and Psychiatry, 61-2 (February 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.195-204 Titre : Maternal and paternal depressive symptoms and children's emotional problems at the age of 2 and 5 years: a longitudinal study Type de document : Texte imprimé et/ou numérique Auteurs : Johanna T. PIETIKAINEN, Auteur ; Olli KIVIRUUSU, Auteur ; Anneli KYLLIAINEN, Auteur ; Pirjo POLKKI, Auteur ; Outi SAARENPAA-HEIKKILA, Auteur ; Tiina PAUNIO, Auteur ; E. Juulia PAAVONEN, Auteur Article en page(s) : p.195-204 Langues : Anglais (eng) Mots-clés : Depression  child development  longitudinal studies  maternal depression  perinatal Index. décimale : PER Périodiques Résumé : BACKGROUND: Maternal and paternal depressive symptoms are related to children's emotional problems, but their combined effect remains unclear. Here, we constructed four parental longitudinal depressive symptom trajectory groups and studied their associations with children's emotional problems at the age of 2 and 5 years. METHODS: We did an assessment of maternal and paternal depressive symptoms (gestational week 32, as well as 3, 8 and 24 months postnatally) and children's emotional problems at ages two (N = 939) and five (N = 700) in the CHILD-SLEEP cohort. Three separate maternal and paternal depressive symptom trajectories based on latent profile analysis were combined to form four parental depressive symptom trajectory groups. We compared groups with a general linear model, with children's emotional (total, internalizing and externalizing) - problem scores serving as the dependent variables. RESULTS: At both ages, combined parental depressive symptom trajectories were associated with children's emotional problems: effect sizes were medium for total and small for other domains. According to post hoc comparisons, children whose mothers or both parents had persistent depressive symptoms had significantly more total, externalizing and internalizing problems than did children who had neither parent nor only the father showing depressive symptoms. A higher (and persistent) level of maternal depressive symptoms was related to a higher level of these children's emotional problems, a pattern not evident with paternal depressive symptoms. In all analyses, the interaction effect was nonsignificant between parental trajectories and child gender. CONCLUSIONS: Findings suggest that an absence of depressive symptoms in their fathers cannot compensate for the adverse effects of maternal depressive symptoms upon their children. Moreover, paternal depressive symptoms alone do not lead to increased risk for emotional problems in these 2- and 5-year-old children. In contrast, even subclinical levels of maternal depressive symptoms in late pregnancy are associated with increased risk for their children's experiencing internalizing and externalizing emotional problems. En ligne : http://dx.doi.org/10.1111/jcpp.13126 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415 [article] Maternal and paternal depressive symptoms and children's emotional problems at the age of 2 and 5 years: a longitudinal study [Texte imprimé et/ou numérique] / Johanna T. PIETIKAINEN, Auteur ; Olli KIVIRUUSU, Auteur ; Anneli KYLLIAINEN, Auteur ; Pirjo POLKKI, Auteur ; Outi SAARENPAA-HEIKKILA, Auteur ; Tiina PAUNIO, Auteur ; E. Juulia PAAVONEN, Auteur . - p.195-204. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.195-204 Mots-clés : Depression  child development  longitudinal studies  maternal depression  perinatal Index. décimale : PER Périodiques Résumé : BACKGROUND: Maternal and paternal depressive symptoms are related to children's emotional problems, but their combined effect remains unclear. Here, we constructed four parental longitudinal depressive symptom trajectory groups and studied their associations with children's emotional problems at the age of 2 and 5 years. METHODS: We did an assessment of maternal and paternal depressive symptoms (gestational week 32, as well as 3, 8 and 24 months postnatally) and children's emotional problems at ages two (N = 939) and five (N = 700) in the CHILD-SLEEP cohort. Three separate maternal and paternal depressive symptom trajectories based on latent profile analysis were combined to form four parental depressive symptom trajectory groups. We compared groups with a general linear model, with children's emotional (total, internalizing and externalizing) - problem scores serving as the dependent variables. RESULTS: At both ages, combined parental depressive symptom trajectories were associated with children's emotional problems: effect sizes were medium for total and small for other domains. According to post hoc comparisons, children whose mothers or both parents had persistent depressive symptoms had significantly more total, externalizing and internalizing problems than did children who had neither parent nor only the father showing depressive symptoms. A higher (and persistent) level of maternal depressive symptoms was related to a higher level of these children's emotional problems, a pattern not evident with paternal depressive symptoms. In all analyses, the interaction effect was nonsignificant between parental trajectories and child gender. CONCLUSIONS: Findings suggest that an absence of depressive symptoms in their fathers cannot compensate for the adverse effects of maternal depressive symptoms upon their children. Moreover, paternal depressive symptoms alone do not lead to increased risk for emotional problems in these 2- and 5-year-old children. In contrast, even subclinical levels of maternal depressive symptoms in late pregnancy are associated with increased risk for their children's experiencing internalizing and externalizing emotional problems. En ligne : http://dx.doi.org/10.1111/jcpp.13126 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415

Paternal perinatal stress is associated with children's emotional problems at 2 years / Fiona L. CHALLACOMBE in Journal of Child Psychology and Psychiatry, 64-2 (February 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-2 (February 2023) . - p.277-288 Titre : Paternal perinatal stress is associated with children's emotional problems at 2 years Type de document : Texte imprimé et/ou numérique Auteurs : Fiona L. CHALLACOMBE, Auteur ; Johanna T. PIETIKAINEN, Auteur ; Olli KIVIRUUSU, Auteur ; Outi SAARENPAA-HEIKKILA, Auteur ; Tiina PAUNIO, Auteur ; E. Juulia PAAVONEN, Auteur Article en page(s) : p.277-288 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Paternal mental health in pregnancy and postpartum has been increasingly highlighted as important both in its own right, but also as crucial for the development of children. Rates of help-seeking among fathers is low, possibly due to conceptualising their own difficulties as stress rather than problems with mood. The relationship between paternal stress and child outcomes has not been investigated. Methods This study used data from the Finnish CHILD-SLEEP birth cohort. Data were available for 901 fathers and 939 mothers who completed questionnaires on demographics, stress, anxiety and depression at 32 weeks gestation, 3 months, 8 months and 24 months postpartum. Parental report of child emotional and behavioural problems was collected at 24 months. Results Around 7% of fathers experienced high stress (over 90% percentile) at each timepoint measured in the perinatal period, rising to 10% at 2 years postpartum. Paternal stress measured antenatally, at 3 and 24 months was associated with child total problems at 24 months, while paternal depression and anxiety were not related to child outcomes when in the same model. After adjusting for concurrent maternal depression, anxiety and stress, an association remained between paternal stress at each timepoint and child total problem scores at 24 months. The strongest association was with paternal stress at 3 months (OR 3.17; 95% CI 1.63-6.16). There were stronger relationships between paternal stress and boys' rather than girls' total problem scores, although the interactions were not statistically significant. Conclusions Paternal stress is an important manifestation of perinatal distress and is related to child mental health, particularly when present in the early postpartum months. Paternal stress should therefore be assessed in the perinatal period, which presents opportunities for early intervention and prevention of difficulties for both father and child. En ligne : https://doi.org/10.1111/jcpp.13695 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 [article] Paternal perinatal stress is associated with children's emotional problems at 2 years [Texte imprimé et/ou numérique] / Fiona L. CHALLACOMBE, Auteur ; Johanna T. PIETIKAINEN, Auteur ; Olli KIVIRUUSU, Auteur ; Outi SAARENPAA-HEIKKILA, Auteur ; Tiina PAUNIO, Auteur ; E. Juulia PAAVONEN, Auteur . - p.277-288. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-2 (February 2023) . - p.277-288 Index. décimale : PER Périodiques Résumé : Background Paternal mental health in pregnancy and postpartum has been increasingly highlighted as important both in its own right, but also as crucial for the development of children. Rates of help-seeking among fathers is low, possibly due to conceptualising their own difficulties as stress rather than problems with mood. The relationship between paternal stress and child outcomes has not been investigated. Methods This study used data from the Finnish CHILD-SLEEP birth cohort. Data were available for 901 fathers and 939 mothers who completed questionnaires on demographics, stress, anxiety and depression at 32 weeks gestation, 3 months, 8 months and 24 months postpartum. Parental report of child emotional and behavioural problems was collected at 24 months. Results Around 7% of fathers experienced high stress (over 90% percentile) at each timepoint measured in the perinatal period, rising to 10% at 2 years postpartum. Paternal stress measured antenatally, at 3 and 24 months was associated with child total problems at 24 months, while paternal depression and anxiety were not related to child outcomes when in the same model. After adjusting for concurrent maternal depression, anxiety and stress, an association remained between paternal stress at each timepoint and child total problem scores at 24 months. The strongest association was with paternal stress at 3 months (OR 3.17; 95% CI 1.63-6.16). There were stronger relationships between paternal stress and boys' rather than girls' total problem scores, although the interactions were not statistically significant. Conclusions Paternal stress is an important manifestation of perinatal distress and is related to child mental health, particularly when present in the early postpartum months. Paternal stress should therefore be assessed in the perinatal period, which presents opportunities for early intervention and prevention of difficulties for both father and child. En ligne : https://doi.org/10.1111/jcpp.13695 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492

---

1 (1 - 3 / 3)