Infant epigenetic aging moderates the link between Black maternal childhood trauma and offspring symptoms of psychopathology / Brooke G. MCKENNA in Development and Psychopathology, 36-4 (October 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-4 (October 2024) . - p.1890-1902 Titre : Infant epigenetic aging moderates the link between Black maternal childhood trauma and offspring symptoms of psychopathology Type de document : Texte imprimé et/ou numérique Auteurs : Brooke G. MCKENNA, Auteur ; Anna K. KNIGHT, Auteur ; Alicia K. SMITH, Auteur ; Elizabeth J. CORWIN, Auteur ; Sierra E. CARTER, Auteur ; Rohan H. C. PALMER, Auteur ; Anne L. DUNLOP, Auteur ; Patricia A. BRENNAN, Auteur Article en page(s) : p.1890-1902 Langues : Anglais (eng) Mots-clés : child psychopathology  epigenetic aging  intergenerational  trauma Index. décimale : PER Périodiques Résumé : Although offspring of women exposed to childhood trauma exhibit elevated rates of psychopathology, many children demonstrate resilience to these intergenerational impacts. Among the variety of factors that likely contribute to resilience, epigenetic processes have been suggested to play an important role. The current study used a prospective design to test the novel hypothesis that offspring epigenetic aging - a measure of methylation differences that are associated with infant health outcomes - moderates the relationship between maternal exposure to childhood adversity and offspring symptomatology. Maternal childhood adversity was self-reported during pregnancy via the ACEs survey and the CTQ, which assessed total childhood trauma as well as maltreatment subtypes (i.e., emotional, physical, and sexual abuse). Offspring blood samples were collected at or shortly after birth and assayed on a DNA methylation microarray, and offspring symptomatology was assessed with the CBCL/1.5-5 when offspring were 2-4 years old. Results indicated that maternal childhood trauma, particularly sexual abuse, was predictive of offspring symptoms (ps = 0.003-0.03). However, the associations between maternal sexual abuse and offspring symptomatology were significantly attenuated in offspring with accelerated epigenetic aging. These findings further our understanding of how epigenetic processes may contribute to and attenuate the intergenerational link between stress and psychopathology. En ligne : https://dx.doi.org/10.1017/S0954579423001232 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539 [article] Infant epigenetic aging moderates the link between Black maternal childhood trauma and offspring symptoms of psychopathology [Texte imprimé et/ou numérique] / Brooke G. MCKENNA, Auteur ; Anna K. KNIGHT, Auteur ; Alicia K. SMITH, Auteur ; Elizabeth J. CORWIN, Auteur ; Sierra E. CARTER, Auteur ; Rohan H. C. PALMER, Auteur ; Anne L. DUNLOP, Auteur ; Patricia A. BRENNAN, Auteur . - p.1890-1902. Langues : Anglais (eng) in Development and Psychopathology > 36-4 (October 2024) . - p.1890-1902 Mots-clés : child psychopathology  epigenetic aging  intergenerational  trauma Index. décimale : PER Périodiques Résumé : Although offspring of women exposed to childhood trauma exhibit elevated rates of psychopathology, many children demonstrate resilience to these intergenerational impacts. Among the variety of factors that likely contribute to resilience, epigenetic processes have been suggested to play an important role. The current study used a prospective design to test the novel hypothesis that offspring epigenetic aging - a measure of methylation differences that are associated with infant health outcomes - moderates the relationship between maternal exposure to childhood adversity and offspring symptomatology. Maternal childhood adversity was self-reported during pregnancy via the ACEs survey and the CTQ, which assessed total childhood trauma as well as maltreatment subtypes (i.e., emotional, physical, and sexual abuse). Offspring blood samples were collected at or shortly after birth and assayed on a DNA methylation microarray, and offspring symptomatology was assessed with the CBCL/1.5-5 when offspring were 2-4 years old. Results indicated that maternal childhood trauma, particularly sexual abuse, was predictive of offspring symptoms (ps = 0.003-0.03). However, the associations between maternal sexual abuse and offspring symptomatology were significantly attenuated in offspring with accelerated epigenetic aging. These findings further our understanding of how epigenetic processes may contribute to and attenuate the intergenerational link between stress and psychopathology. En ligne : https://dx.doi.org/10.1017/S0954579423001232 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539

School-age social behavior and pragmatic language ability in children with prenatal serotonin reuptake inhibitor exposure / Erica L. SMEARMAN in Development and Psychopathology, 32-1 (February 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-1 (February 2020) . - p.21-30 Titre : School-age social behavior and pragmatic language ability in children with prenatal serotonin reuptake inhibitor exposure Type de document : Texte imprimé et/ou numérique Auteurs : Erica L. SMEARMAN, Auteur ; Cassandra L. HENDRIX, Auteur ; Dominika A. WINIARSKI, Auteur ; Katrina C. JOHNSON, Auteur ; Alicia K. SMITH, Auteur ; Opal Y. OUSLEY, Auteur ; Zachary N. STOWE, Auteur ; D. Jeffrey NEWPORT, Auteur ; Patricia A. BRENNAN, Auteur Article en page(s) : p.21-30 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  language  neurodevelopment  prenatal exposure  serotonin Index. décimale : PER Périodiques Résumé : Studies examining associations between fetal serotonin reuptake inhibitor (SRI) exposure and child autism spectrum disorder (ASD) diagnoses or delayed language remain mixed and rarely prospectively follow children or employ gold-standard assessments. We prospectively followed a cohort of mother-child dyads from pregnancy through early elementary school (N = 178), and obtained maternal and alternate-caregiver ratings of behaviors related to ASD (N = 137), as well as direct, gold-standard assessments of child ASD symptoms and pragmatic language among dyads who experienced prenatal depression and either took SRIs or were medication free during pregnancy (N = 44). Prenatal SRI exposure was related to maternal ratings of ASD-related behaviors (beta = 0.24 95% confidence interval; CI [0.07, 0.48]), and, among boys, alternative caregiver ratings (males-only beta = 0.28 95% CI [0.02, 0.55], females-only beta = -0.21 95% CI [-0.63, 0.08]). However, results of our direct assessments suggest an association between SRI exposure and reduced pragmatic language scores (beta = -0.27, 95% CI [-0.53, -0.01], but not ASD (Autism Diagnostic Observation Schedule beta = 0.14 95% CI [-0.15, 0.41]; Social Responsiveness Scale beta = 0.08 95% CI [-0.25, 0.40]). These discrepancies point to issues regarding how ASD is assessed, and the possibility that SRIs may be more strongly associated with language or other broader behaviors that coincide with ASD. Larger prospective studies that incorporate thorough, gold-standard assessments of ASD, language, and other ASD-related behaviors are needed. En ligne : http://dx.doi.org/10.1017/s0954579418001372 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415 [article] School-age social behavior and pragmatic language ability in children with prenatal serotonin reuptake inhibitor exposure [Texte imprimé et/ou numérique] / Erica L. SMEARMAN, Auteur ; Cassandra L. HENDRIX, Auteur ; Dominika A. WINIARSKI, Auteur ; Katrina C. JOHNSON, Auteur ; Alicia K. SMITH, Auteur ; Opal Y. OUSLEY, Auteur ; Zachary N. STOWE, Auteur ; D. Jeffrey NEWPORT, Auteur ; Patricia A. BRENNAN, Auteur . - p.21-30. Langues : Anglais (eng) in Development and Psychopathology > 32-1 (February 2020) . - p.21-30 Mots-clés : Autism Spectrum Disorder  language  neurodevelopment  prenatal exposure  serotonin Index. décimale : PER Périodiques Résumé : Studies examining associations between fetal serotonin reuptake inhibitor (SRI) exposure and child autism spectrum disorder (ASD) diagnoses or delayed language remain mixed and rarely prospectively follow children or employ gold-standard assessments. We prospectively followed a cohort of mother-child dyads from pregnancy through early elementary school (N = 178), and obtained maternal and alternate-caregiver ratings of behaviors related to ASD (N = 137), as well as direct, gold-standard assessments of child ASD symptoms and pragmatic language among dyads who experienced prenatal depression and either took SRIs or were medication free during pregnancy (N = 44). Prenatal SRI exposure was related to maternal ratings of ASD-related behaviors (beta = 0.24 95% confidence interval; CI [0.07, 0.48]), and, among boys, alternative caregiver ratings (males-only beta = 0.28 95% CI [0.02, 0.55], females-only beta = -0.21 95% CI [-0.63, 0.08]). However, results of our direct assessments suggest an association between SRI exposure and reduced pragmatic language scores (beta = -0.27, 95% CI [-0.53, -0.01], but not ASD (Autism Diagnostic Observation Schedule beta = 0.14 95% CI [-0.15, 0.41]; Social Responsiveness Scale beta = 0.08 95% CI [-0.25, 0.40]). These discrepancies point to issues regarding how ASD is assessed, and the possibility that SRIs may be more strongly associated with language or other broader behaviors that coincide with ASD. Larger prospective studies that incorporate thorough, gold-standard assessments of ASD, language, and other ASD-related behaviors are needed. En ligne : http://dx.doi.org/10.1017/s0954579418001372 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415

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