Commentary: Microbial panaceas: does development have the answer? - reflections on Cowan, Dinan, & Cryan (2020) / Bridget L. CALLAGHAN in Journal of Child Psychology and Psychiatry, 61-3 (March 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-3 (March 2020) . - p.372-375 Titre : Commentary: Microbial panaceas: does development have the answer? - reflections on Cowan, Dinan, & Cryan (2020) Type de document : Texte imprimé et/ou numérique Auteurs : Bridget L. CALLAGHAN, Auteur Article en page(s) : p.372-375 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Is the microbiome a promising adjunct, a potential panacea, or a distraction from feasible treatments for neurodevelopmental disorders? Taking a developmental approach may get us closer to understanding the data and give us pause in trying to translate this nascent field to the clinic right now. En ligne : http://dx.doi.org/10.1111/jcpp.13192 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=420 [article] Commentary: Microbial panaceas: does development have the answer? - reflections on Cowan, Dinan, & Cryan (2020) [Texte imprimé et/ou numérique] / Bridget L. CALLAGHAN, Auteur . - p.372-375. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-3 (March 2020) . - p.372-375 Index. décimale : PER Périodiques Résumé : Is the microbiome a promising adjunct, a potential panacea, or a distraction from feasible treatments for neurodevelopmental disorders? Taking a developmental approach may get us closer to understanding the data and give us pause in trying to translate this nascent field to the clinic right now. En ligne : http://dx.doi.org/10.1111/jcpp.13192 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=420

Effects of maternal childhood trauma on child emotional health: maternal mental health and frontoamygdala pathways / Jessica P. UY in Journal of Child Psychology and Psychiatry, 64-3 (March 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.426-436 Titre : Effects of maternal childhood trauma on child emotional health: maternal mental health and frontoamygdala pathways Type de document : Texte imprimé et/ou numérique Auteurs : Jessica P. UY, Auteur ; Ai Peng TAN, Auteur ; Birit B.F.P. BROECKMAN, Auteur ; Peter D. GLUCKMAN, Auteur ; Yap Seng CHONG, Auteur ; Helen CHEN, Auteur ; Marielle V. FORTIER, Auteur ; Michael J. MEANEY, Auteur ; Bridget L. CALLAGHAN, Auteur Article en page(s) : p.426-436 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Experiences of early life adversity pose significant psychological and physical health risks to exposed individuals. Emerging evidence suggests that these health risks can be transmitted across generations; however, the mechanisms underlying the intergenerational impacts of maternal early-life trauma on child health remain unknown. Methods The current study used a prospective longitudinal design to determine the unique and joint contributions of maternal childhood trauma (neglect and abuse) and maternal prenatal and postnatal mental health (anxiety and depressive symptoms) (N = 541) to children's resting frontoamygdala functional connectivity at 6 years (N = 89) and emotional health at 7-8 years, as indexed by parent-reported internalizing problems and child self-reported anxiety and depressive symptoms (N = 268-418). Results Greater maternal childhood neglect was indirectly associated with greater internalizing problems serially through a pathway of worse maternal prenatal and postnatal mental health (greater maternal anxiety and depressive symptoms). Worse maternal postnatal mental health was also uniquely associated with more negative child frontoamygdala resting-state functional connectivity, over and above maternal childhood trauma (both neglect and abuse) and prenatal mental health. More negative frontoamygdala functional connectivity was, in turn, associated with poorer child emotional health outcomes. Conclusions Findings from the current study provide support for the existence of intergenerational influences of parental exposure to childhood trauma on childhood risk for psychopathology in the next generation and point to the importance of maternal factors proximal to the second generation (maternal prenatal and postnatal mental health) in determining the intergenerational impact of maternal early experiences. En ligne : https://doi.org/10.1111/jcpp.13721 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493 [article] Effects of maternal childhood trauma on child emotional health: maternal mental health and frontoamygdala pathways [Texte imprimé et/ou numérique] / Jessica P. UY, Auteur ; Ai Peng TAN, Auteur ; Birit B.F.P. BROECKMAN, Auteur ; Peter D. GLUCKMAN, Auteur ; Yap Seng CHONG, Auteur ; Helen CHEN, Auteur ; Marielle V. FORTIER, Auteur ; Michael J. MEANEY, Auteur ; Bridget L. CALLAGHAN, Auteur . - p.426-436. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.426-436 Index. décimale : PER Périodiques Résumé : Background Experiences of early life adversity pose significant psychological and physical health risks to exposed individuals. Emerging evidence suggests that these health risks can be transmitted across generations; however, the mechanisms underlying the intergenerational impacts of maternal early-life trauma on child health remain unknown. Methods The current study used a prospective longitudinal design to determine the unique and joint contributions of maternal childhood trauma (neglect and abuse) and maternal prenatal and postnatal mental health (anxiety and depressive symptoms) (N = 541) to children's resting frontoamygdala functional connectivity at 6 years (N = 89) and emotional health at 7-8 years, as indexed by parent-reported internalizing problems and child self-reported anxiety and depressive symptoms (N = 268-418). Results Greater maternal childhood neglect was indirectly associated with greater internalizing problems serially through a pathway of worse maternal prenatal and postnatal mental health (greater maternal anxiety and depressive symptoms). Worse maternal postnatal mental health was also uniquely associated with more negative child frontoamygdala resting-state functional connectivity, over and above maternal childhood trauma (both neglect and abuse) and prenatal mental health. More negative frontoamygdala functional connectivity was, in turn, associated with poorer child emotional health outcomes. Conclusions Findings from the current study provide support for the existence of intergenerational influences of parental exposure to childhood trauma on childhood risk for psychopathology in the next generation and point to the importance of maternal factors proximal to the second generation (maternal prenatal and postnatal mental health) in determining the intergenerational impact of maternal early experiences. En ligne : https://doi.org/10.1111/jcpp.13721 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493

Mind and gut: Associations between mood and gastrointestinal distress in children exposed to adversity / Bridget L. CALLAGHAN in Development and Psychopathology, 32-1 (February 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-1 (February 2020) . - p.309-328 Titre : Mind and gut: Associations between mood and gastrointestinal distress in children exposed to adversity Type de document : Texte imprimé et/ou numérique Auteurs : Bridget L. CALLAGHAN, Auteur ; Andrea FIELDS, Auteur ; Dylan G. GEE, Auteur ; Laurel GABARD-DURNAM, Auteur ; Christina CALDERA, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Bonnie GOFF, Auteur ; Jessica FLANNERY, Auteur ; Eva H. TELZER, Auteur ; Mor SHAPIRO, Auteur ; Nim TOTTENHAM, Auteur Article en page(s) : p.309-328 Langues : Anglais (eng) Mots-clés : anxiety  development  functional magnetic resonance imaging  gastrointestinal distress  microbiome Index. décimale : PER Périodiques Résumé : Gastrointestinal and mental disorders are highly comorbid, and animal models have shown that both can be caused by early adversity (e.g., parental deprivation). Interactions between the brain and bacteria that live within the gastrointestinal system (the microbiome) underlie adversity-gastrointestinal-anxiety interactions, but these links have not been investigated during human development. In this study, we utilized data from a population of 344 youth (3-18 years old) who were raised with their biological parents or were exposed to early adverse caregiving experiences (i.e., institutional or foster care followed by international adoption) to explore adversity-gastrointestinal-anxiety associations. In Study 1, we demonstrated that previous adverse care experiences were associated with increased incidence of gastrointestinal symptoms in youth. Gastrointestinal symptoms were also associated with concurrent and future anxiety (measured across 5 years), and those gastrointestinal symptoms mediated the adversity-anxiety association at Time 1. In a subsample of children who provided both stool samples and functional magnetic resonance imaging of the brain (Study 2, which was a "proof-of-principle"), adversity was associated with changes in diversity (both alpha and beta) of microbial communities, and bacteria levels (adversity-associated and adversity-independent) were correlated with prefrontal cortex activation to emotional faces. Implications of these data for supporting youth mental health are discussed. En ligne : http://dx.doi.org/10.1017/s0954579419000087 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=416 [article] Mind and gut: Associations between mood and gastrointestinal distress in children exposed to adversity [Texte imprimé et/ou numérique] / Bridget L. CALLAGHAN, Auteur ; Andrea FIELDS, Auteur ; Dylan G. GEE, Auteur ; Laurel GABARD-DURNAM, Auteur ; Christina CALDERA, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Bonnie GOFF, Auteur ; Jessica FLANNERY, Auteur ; Eva H. TELZER, Auteur ; Mor SHAPIRO, Auteur ; Nim TOTTENHAM, Auteur . - p.309-328. Langues : Anglais (eng) in Development and Psychopathology > 32-1 (February 2020) . - p.309-328 Mots-clés : anxiety  development  functional magnetic resonance imaging  gastrointestinal distress  microbiome Index. décimale : PER Périodiques Résumé : Gastrointestinal and mental disorders are highly comorbid, and animal models have shown that both can be caused by early adversity (e.g., parental deprivation). Interactions between the brain and bacteria that live within the gastrointestinal system (the microbiome) underlie adversity-gastrointestinal-anxiety interactions, but these links have not been investigated during human development. In this study, we utilized data from a population of 344 youth (3-18 years old) who were raised with their biological parents or were exposed to early adverse caregiving experiences (i.e., institutional or foster care followed by international adoption) to explore adversity-gastrointestinal-anxiety associations. In Study 1, we demonstrated that previous adverse care experiences were associated with increased incidence of gastrointestinal symptoms in youth. Gastrointestinal symptoms were also associated with concurrent and future anxiety (measured across 5 years), and those gastrointestinal symptoms mediated the adversity-anxiety association at Time 1. In a subsample of children who provided both stool samples and functional magnetic resonance imaging of the brain (Study 2, which was a "proof-of-principle"), adversity was associated with changes in diversity (both alpha and beta) of microbial communities, and bacteria levels (adversity-associated and adversity-independent) were correlated with prefrontal cortex activation to emotional faces. Implications of these data for supporting youth mental health are discussed. En ligne : http://dx.doi.org/10.1017/s0954579419000087 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=416

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