6 recherche sur le mot-clé 'microbiome'

Development of the infant gut microbiome predicts temperament across the first year of life / Molly FOX in Development and Psychopathology, 34-5 (December 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-5 (December 2022) . - p.1914-1925 Titre : Development of the infant gut microbiome predicts temperament across the first year of life Type de document : Texte imprimé et/ou numérique Auteurs : Molly FOX, Auteur ; S. Melanie LEE, Auteur ; Kyle S. WILEY, Auteur ; Venu LAGISHETTY, Auteur ; Curt A. SANDMAN, Auteur ; Jonathan P. JACOBS, Auteur ; Laura M. GLYNN, Auteur Article en page(s) : p.1914-1925 Langues : Anglais (eng) Mots-clés : emotion regulation  gut–brain axis  infant development  microbiome  temperament Index. décimale : PER Périodiques Résumé : Perturbations to the gut microbiome are implicated in altered neurodevelopmental trajectories that may shape life span risk for emotion dysregulation and affective disorders. However, the sensitive periods during which the microbiome may influence neurodevelopment remain understudied. We investigated relationships between gut microbiome composition across infancy and temperament at 12 months of age. In 67 infants, we examined if gut microbiome composition assessed at 1 “3 weeks, 2, 6, and 12 months of age was associated with temperament at age 12 months. Stool samples were sequenced using the 16S Illumina MiSeq platform. Temperament was assessed using the Infant Behavior Questionnaire-Revised (IBQ-R). Beta diversity at age 1 “3 weeks was associated with surgency/extraversion at age 12 months. Bifidobacterium and Lachnospiraceae abundance at 1 “3 weeks of age was positively associated with surgency/extraversion at age 12 months. Klebsiella abundance at 1 “3 weeks was negatively associated with surgency/extraversion at 12 months. Concurrent composition was associated with negative affectivity at 12 months, including a positive association with Ruminococcus-1 and a negative association with Lactobacillus. Our findings support a relationship between gut microbiome composition and infant temperament. While exploratory due to the small sample size, these results point to early and late infancy as sensitive periods during which the gut microbiome may exert effects on neurodevelopment. En ligne : http://dx.doi.org/10.1017/S0954579421000456 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 [article] Development of the infant gut microbiome predicts temperament across the first year of life [Texte imprimé et/ou numérique] / Molly FOX, Auteur ; S. Melanie LEE, Auteur ; Kyle S. WILEY, Auteur ; Venu LAGISHETTY, Auteur ; Curt A. SANDMAN, Auteur ; Jonathan P. JACOBS, Auteur ; Laura M. GLYNN, Auteur . - p.1914-1925. Langues : Anglais (eng) in Development and Psychopathology > 34-5 (December 2022) . - p.1914-1925 Mots-clés : emotion regulation  gut–brain axis  infant development  microbiome  temperament Index. décimale : PER Périodiques Résumé : Perturbations to the gut microbiome are implicated in altered neurodevelopmental trajectories that may shape life span risk for emotion dysregulation and affective disorders. However, the sensitive periods during which the microbiome may influence neurodevelopment remain understudied. We investigated relationships between gut microbiome composition across infancy and temperament at 12 months of age. In 67 infants, we examined if gut microbiome composition assessed at 1 “3 weeks, 2, 6, and 12 months of age was associated with temperament at age 12 months. Stool samples were sequenced using the 16S Illumina MiSeq platform. Temperament was assessed using the Infant Behavior Questionnaire-Revised (IBQ-R). Beta diversity at age 1 “3 weeks was associated with surgency/extraversion at age 12 months. Bifidobacterium and Lachnospiraceae abundance at 1 “3 weeks of age was positively associated with surgency/extraversion at age 12 months. Klebsiella abundance at 1 “3 weeks was negatively associated with surgency/extraversion at 12 months. Concurrent composition was associated with negative affectivity at 12 months, including a positive association with Ruminococcus-1 and a negative association with Lactobacillus. Our findings support a relationship between gut microbiome composition and infant temperament. While exploratory due to the small sample size, these results point to early and late infancy as sensitive periods during which the gut microbiome may exert effects on neurodevelopment. En ligne : http://dx.doi.org/10.1017/S0954579421000456 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492

Mitochondria, Microbiome and Their Potential Psychiatric Modulation / Christopher SNYDER in Autism - Open Access, 5-2 ([01/03/2015])  

Public ISBD [article]  inAutism - Open Access > 5-2 [01/03/2015] . - 4 p. Titre : Mitochondria, Microbiome and Their Potential Psychiatric Modulation Type de document : Texte imprimé et/ou numérique Auteurs : Christopher SNYDER, Auteur ; Richard M. KREAM, Auteur ; Radek PTACEK, Auteur ; George B. STEFAN, Auteur Article en page(s) : 4 p. Langues : Anglais (eng) Mots-clés : Gut  Microbiome  Mitochondria  Metabolic Syndrome  Autism Index. décimale : PER Périodiques Résumé : Pervasive developmental disorders, or autism spectrum disorders, are multifaceted and have a high rate of occurrence. Additionally, the origin of Autism appears to be multidimensional and largely unknown. Thus, it would appear novel approaches and concepts are needed in this area of scientific endeavor. In this regard, microbial cells harbored within the human gut and elsewhere are being studied to understand their multi-functional properties and their ability to affect physiological activities in their “host” organism. The communities of approximately 10 trillion microbial cells that live within the gut are involved in functions such as metabolism, nutrition and immune regulation. We and others surmise this microbiota can contribute to disruption of normal activities, causing harmful pathologies such as gastrointestinal complications, obesity, and diabetes and autism. They have the ability to trigger inappropriate immune activation, especially macrophages, which can travel from the gut and penetrate the blood brain barrier and communicate inappropriately with neural cells, altering behavior. Normally these immune cells can enter the brain and become microglia. However, being abnormally stimulated, many more can enter the brain, awakening the sentinel microglia and establishing a pro inflammatory state, inducing hypoxia (altering mitochondrial performance). Thus, the microbiome has the potential to extend its influence into the brain, suggesting this may also take place within the parameters of normal activity. In part, the behavioral outcome of such an inappropriate invasion would depend on the region(s) penetrated, manifesting itself with a multidimensional behavioral profile such as occurs in autism. En ligne : https://dx.doi.org/10.4172/2165-7890.1000144 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 [article] Mitochondria, Microbiome and Their Potential Psychiatric Modulation [Texte imprimé et/ou numérique] / Christopher SNYDER, Auteur ; Richard M. KREAM, Auteur ; Radek PTACEK, Auteur ; George B. STEFAN, Auteur . - 4 p. Langues : Anglais (eng) in Autism - Open Access > 5-2 [01/03/2015] . - 4 p. Mots-clés : Gut  Microbiome  Mitochondria  Metabolic Syndrome  Autism Index. décimale : PER Périodiques Résumé : Pervasive developmental disorders, or autism spectrum disorders, are multifaceted and have a high rate of occurrence. Additionally, the origin of Autism appears to be multidimensional and largely unknown. Thus, it would appear novel approaches and concepts are needed in this area of scientific endeavor. In this regard, microbial cells harbored within the human gut and elsewhere are being studied to understand their multi-functional properties and their ability to affect physiological activities in their “host” organism. The communities of approximately 10 trillion microbial cells that live within the gut are involved in functions such as metabolism, nutrition and immune regulation. We and others surmise this microbiota can contribute to disruption of normal activities, causing harmful pathologies such as gastrointestinal complications, obesity, and diabetes and autism. They have the ability to trigger inappropriate immune activation, especially macrophages, which can travel from the gut and penetrate the blood brain barrier and communicate inappropriately with neural cells, altering behavior. Normally these immune cells can enter the brain and become microglia. However, being abnormally stimulated, many more can enter the brain, awakening the sentinel microglia and establishing a pro inflammatory state, inducing hypoxia (altering mitochondrial performance). Thus, the microbiome has the potential to extend its influence into the brain, suggesting this may also take place within the parameters of normal activity. In part, the behavioral outcome of such an inappropriate invasion would depend on the region(s) penetrated, manifesting itself with a multidimensional behavioral profile such as occurs in autism. En ligne : https://dx.doi.org/10.4172/2165-7890.1000144 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409

Oral microbiome activity in children with autism spectrum disorder / S. D. HICKS in Autism Research, 11-9 (September 2018)  

Public ISBD [article]  inAutism Research > 11-9 (September 2018) . - p.1286-1299 Titre : Oral microbiome activity in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : S. D. HICKS, Auteur ; R. UHLIG, Auteur ; P. AFSHARI, Auteur ; J. WILLIAMS, Auteur ; M. CHRONEOS, Auteur ; C. TIERNEY-AVES, Auteur ; K. WAGNER, Auteur ; F. A. MIDDLETON, Auteur Article en page(s) : p.1286-1299 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  developmental delay  gastrointestinal disturbance  microbiome  oropharynx  saliva Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is associated with several oropharyngeal abnormalities, including buccal sensory sensitivity, taste and texture aversions, speech apraxia, and salivary transcriptome alterations. Furthermore, the oropharynx represents the sole entry point to the gastrointestinal (GI) tract. GI disturbances and alterations in the GI microbiome are established features of ASD, and may impact behavior through the "microbial-gut-brain axis." Most studies of the ASD microbiome have used fecal samples. Here, we identified changes in the salivary microbiome of children aged 2-6 years across three developmental profiles: ASD (n = 180), nonautistic developmental delay (DD; n = 60), and typically developing (TD; n = 106) children. After RNA extraction and shotgun sequencing, actively transcribing taxa were quantified and tested for differences between groups and within ASD endophenotypes. A total of 12 taxa were altered between the developmental groups and 28 taxa were identified that distinguished ASD patients with and without GI disturbance, providing further evidence for the role of the gut-brain axis in ASD. Group classification accuracy was visualized with receiver operating characteristic curves and validated using a 50/50 hold-out procedure. Five microbial ratios distinguished ASD from TD participants (79.5% accuracy), three distinguished ASD from DD (76.5%), and three distinguished ASD children with/without GI disturbance (85.7%). Taxonomic pathways were assessed using the Kyoto Encyclopedia of Genes and Genomes microbial database and compared with one-way analysis of variance, revealing significant differences within energy metabolism and lysine degradation. Together, these results indicate that GI microbiome disruption in ASD extends to the oropharynx, and suggests oral microbiome profiling as a potential tool to evaluate ASD status. Autism Res 2018, 11: 1286-1299. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Previous research suggests that the bacteria living in the human gut may influence autistic behavior. This study examined genetic activity of microbes living in the mouth of over 300 children. The microbes with differences in children with autism were involved in energy processing and showed potential for identifying autism status. En ligne : http://dx.doi.org/10.1002/aur.1972 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369 [article] Oral microbiome activity in children with autism spectrum disorder [Texte imprimé et/ou numérique] / S. D. HICKS, Auteur ; R. UHLIG, Auteur ; P. AFSHARI, Auteur ; J. WILLIAMS, Auteur ; M. CHRONEOS, Auteur ; C. TIERNEY-AVES, Auteur ; K. WAGNER, Auteur ; F. A. MIDDLETON, Auteur . - p.1286-1299. Langues : Anglais (eng) in Autism Research > 11-9 (September 2018) . - p.1286-1299 Mots-clés : autism spectrum disorder  developmental delay  gastrointestinal disturbance  microbiome  oropharynx  saliva Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is associated with several oropharyngeal abnormalities, including buccal sensory sensitivity, taste and texture aversions, speech apraxia, and salivary transcriptome alterations. Furthermore, the oropharynx represents the sole entry point to the gastrointestinal (GI) tract. GI disturbances and alterations in the GI microbiome are established features of ASD, and may impact behavior through the "microbial-gut-brain axis." Most studies of the ASD microbiome have used fecal samples. Here, we identified changes in the salivary microbiome of children aged 2-6 years across three developmental profiles: ASD (n = 180), nonautistic developmental delay (DD; n = 60), and typically developing (TD; n = 106) children. After RNA extraction and shotgun sequencing, actively transcribing taxa were quantified and tested for differences between groups and within ASD endophenotypes. A total of 12 taxa were altered between the developmental groups and 28 taxa were identified that distinguished ASD patients with and without GI disturbance, providing further evidence for the role of the gut-brain axis in ASD. Group classification accuracy was visualized with receiver operating characteristic curves and validated using a 50/50 hold-out procedure. Five microbial ratios distinguished ASD from TD participants (79.5% accuracy), three distinguished ASD from DD (76.5%), and three distinguished ASD children with/without GI disturbance (85.7%). Taxonomic pathways were assessed using the Kyoto Encyclopedia of Genes and Genomes microbial database and compared with one-way analysis of variance, revealing significant differences within energy metabolism and lysine degradation. Together, these results indicate that GI microbiome disruption in ASD extends to the oropharynx, and suggests oral microbiome profiling as a potential tool to evaluate ASD status. Autism Res 2018, 11: 1286-1299. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Previous research suggests that the bacteria living in the human gut may influence autistic behavior. This study examined genetic activity of microbes living in the mouth of over 300 children. The microbes with differences in children with autism were involved in energy processing and showed potential for identifying autism status. En ligne : http://dx.doi.org/10.1002/aur.1972 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369

Mind and gut: Associations between mood and gastrointestinal distress in children exposed to adversity / Bridget L. CALLAGHAN in Development and Psychopathology, 32-1 (February 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-1 (February 2020) . - p.309-328 Titre : Mind and gut: Associations between mood and gastrointestinal distress in children exposed to adversity Type de document : Texte imprimé et/ou numérique Auteurs : Bridget L. CALLAGHAN, Auteur ; Andrea FIELDS, Auteur ; Dylan G. GEE, Auteur ; Laurel GABARD-DURNAM, Auteur ; Christina CALDERA, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Bonnie GOFF, Auteur ; Jessica FLANNERY, Auteur ; Eva H. TELZER, Auteur ; Mor SHAPIRO, Auteur ; Nim TOTTENHAM, Auteur Article en page(s) : p.309-328 Langues : Anglais (eng) Mots-clés : anxiety  development  functional magnetic resonance imaging  gastrointestinal distress  microbiome Index. décimale : PER Périodiques Résumé : Gastrointestinal and mental disorders are highly comorbid, and animal models have shown that both can be caused by early adversity (e.g., parental deprivation). Interactions between the brain and bacteria that live within the gastrointestinal system (the microbiome) underlie adversity-gastrointestinal-anxiety interactions, but these links have not been investigated during human development. In this study, we utilized data from a population of 344 youth (3-18 years old) who were raised with their biological parents or were exposed to early adverse caregiving experiences (i.e., institutional or foster care followed by international adoption) to explore adversity-gastrointestinal-anxiety associations. In Study 1, we demonstrated that previous adverse care experiences were associated with increased incidence of gastrointestinal symptoms in youth. Gastrointestinal symptoms were also associated with concurrent and future anxiety (measured across 5 years), and those gastrointestinal symptoms mediated the adversity-anxiety association at Time 1. In a subsample of children who provided both stool samples and functional magnetic resonance imaging of the brain (Study 2, which was a "proof-of-principle"), adversity was associated with changes in diversity (both alpha and beta) of microbial communities, and bacteria levels (adversity-associated and adversity-independent) were correlated with prefrontal cortex activation to emotional faces. Implications of these data for supporting youth mental health are discussed. En ligne : http://dx.doi.org/10.1017/s0954579419000087 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=416 [article] Mind and gut: Associations between mood and gastrointestinal distress in children exposed to adversity [Texte imprimé et/ou numérique] / Bridget L. CALLAGHAN, Auteur ; Andrea FIELDS, Auteur ; Dylan G. GEE, Auteur ; Laurel GABARD-DURNAM, Auteur ; Christina CALDERA, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Bonnie GOFF, Auteur ; Jessica FLANNERY, Auteur ; Eva H. TELZER, Auteur ; Mor SHAPIRO, Auteur ; Nim TOTTENHAM, Auteur . - p.309-328. Langues : Anglais (eng) in Development and Psychopathology > 32-1 (February 2020) . - p.309-328 Mots-clés : anxiety  development  functional magnetic resonance imaging  gastrointestinal distress  microbiome Index. décimale : PER Périodiques Résumé : Gastrointestinal and mental disorders are highly comorbid, and animal models have shown that both can be caused by early adversity (e.g., parental deprivation). Interactions between the brain and bacteria that live within the gastrointestinal system (the microbiome) underlie adversity-gastrointestinal-anxiety interactions, but these links have not been investigated during human development. In this study, we utilized data from a population of 344 youth (3-18 years old) who were raised with their biological parents or were exposed to early adverse caregiving experiences (i.e., institutional or foster care followed by international adoption) to explore adversity-gastrointestinal-anxiety associations. In Study 1, we demonstrated that previous adverse care experiences were associated with increased incidence of gastrointestinal symptoms in youth. Gastrointestinal symptoms were also associated with concurrent and future anxiety (measured across 5 years), and those gastrointestinal symptoms mediated the adversity-anxiety association at Time 1. In a subsample of children who provided both stool samples and functional magnetic resonance imaging of the brain (Study 2, which was a "proof-of-principle"), adversity was associated with changes in diversity (both alpha and beta) of microbial communities, and bacteria levels (adversity-associated and adversity-independent) were correlated with prefrontal cortex activation to emotional faces. Implications of these data for supporting youth mental health are discussed. En ligne : http://dx.doi.org/10.1017/s0954579419000087 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=416

Association of Rigid-Compulsive Behavior with Functional Constipation in Autism Spectrum Disorder / Sarah MARLER in Journal of Autism and Developmental Disorders, 47-6 (June 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-6 (June 2017) . - p.1673-1681 Titre : Association of Rigid-Compulsive Behavior with Functional Constipation in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Sarah MARLER, Auteur ; Bradley J. FERGUSON, Auteur ; Evon BATEY LEE, Auteur ; Brittany PETERS, Auteur ; Kent C. WILLIAMS, Auteur ; Erin MCDONNELL, Auteur ; Eric A. MACKLIN, Auteur ; Pat LEVITT, Auteur ; Kara GROSS MARGOLIS, Auteur ; David Q. BEVERSDORF, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur Article en page(s) : p.1673-1681 Langues : Anglais (eng) Mots-clés : Developmental  Gut  Enteric Medical comorbidity  Obsessive compulsive disorder  Serotonin  Microbiome Index. décimale : PER Périodiques Résumé : Based upon checklist data from the Autism Speaks Autism Treatment Network, we hypothesized that functional constipation (FC) would be associated with rigid-compulsive behavior in children with autism spectrum disorder (ASD). We used the Questionnaire on Pediatric Gastrointestinal Symptoms—Rome III to assess FC symptoms in 108 children with ASD. As hypothesized, FC was associated with parent ratings on the Repetitive Behavior Scales—Revised (RBS-R) Compulsive, Ritualistic, and Sameness subscales in the overall population. Of note, FC was less common in children who were not taking medications that target behavior or treat FC. In the medication-free children, rigid-compulsive behavior was not significantly associated with FC. More research is needed to understand the mechanisms underlying these associations. En ligne : http://dx.doi.org/10.1007/s10803-017-3084-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308 [article] Association of Rigid-Compulsive Behavior with Functional Constipation in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Sarah MARLER, Auteur ; Bradley J. FERGUSON, Auteur ; Evon BATEY LEE, Auteur ; Brittany PETERS, Auteur ; Kent C. WILLIAMS, Auteur ; Erin MCDONNELL, Auteur ; Eric A. MACKLIN, Auteur ; Pat LEVITT, Auteur ; Kara GROSS MARGOLIS, Auteur ; David Q. BEVERSDORF, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur . - p.1673-1681. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-6 (June 2017) . - p.1673-1681 Mots-clés : Developmental  Gut  Enteric Medical comorbidity  Obsessive compulsive disorder  Serotonin  Microbiome Index. décimale : PER Périodiques Résumé : Based upon checklist data from the Autism Speaks Autism Treatment Network, we hypothesized that functional constipation (FC) would be associated with rigid-compulsive behavior in children with autism spectrum disorder (ASD). We used the Questionnaire on Pediatric Gastrointestinal Symptoms—Rome III to assess FC symptoms in 108 children with ASD. As hypothesized, FC was associated with parent ratings on the Repetitive Behavior Scales—Revised (RBS-R) Compulsive, Ritualistic, and Sameness subscales in the overall population. Of note, FC was less common in children who were not taking medications that target behavior or treat FC. In the medication-free children, rigid-compulsive behavior was not significantly associated with FC. More research is needed to understand the mechanisms underlying these associations. En ligne : http://dx.doi.org/10.1007/s10803-017-3084-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308

Gut Microbiota and Autism: Key Concepts and Findings / Helen T. DING in Journal of Autism and Developmental Disorders, 47-2 (February 2017)  

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