Autism Heterogeneity in a Densely Sampled U.S. Population: Results From the First 1,000 Participants in the RI-CART Study / Carolyn MCCORMICK in Autism Research, 13-3 (March 2020)  

Public ISBD [article]  inAutism Research > 13-3 (March 2020) . - p.474-488 Titre : Autism Heterogeneity in a Densely Sampled U.S. Population: Results From the First 1,000 Participants in the RI-CART Study Type de document : texte imprimé Auteurs : Carolyn MCCORMICK, Auteur ; Brian C. KAVANAUGH, Auteur ; Danielle SIPSOCK, Auteur ; Giulia RIGHI, Auteur ; Lindsay M. OBERMAN, Auteur ; Daniel MORENO DE LUCA, Auteur ; Ece D. GAMSIZ UZUN, Auteur ; Carrie R. BEST, Auteur ; Beth A. JERSKEY, Auteur ; Joanne G. QUINN, Auteur ; Susan B. JEWEL, Auteur ; Pei-Chi WU, Auteur ; Rebecca L. MCLEAN, Auteur ; Todd P. LEVINE, Auteur ; Hasmik TOKADJIAN, Auteur ; Kayla A. PERKINS, Auteur ; Elaine B. CLARKE, Auteur ; Brittany DUNN, Auteur ; Alan H. GERBER, Auteur ; Elena J. TENENBAUM, Auteur ; Thomas F. ANDERS, Auteur Article en page(s) : p.474-488 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  comorbidity  female autism  population study  registry Index. décimale : PER Périodiques Résumé : The objective of this study was to establish a large, densely sampled, U.S. population-based cohort of people with autism spectrum disorder (ASD). The Rhode Island Consortium for Autism Research and Treatment (RI-CART) represents a unique public-private-academic collaboration involving all major points of service for families in Rhode Island affected by ASD. Diagnosis was based on direct behavioral observation via the Autism Diagnostic Observation Schedule, Second Edition. For the first 1,000 participants, ages ranged from 21 months to 64 years. Using Geographic Information System and published prevalence rates, the overall cohort is estimated to represent between 20% and 49% of pediatric age persons in Rhode Island with ASD, with demographics representative of U.S. Census. We observed a high rate of co-occurring medical and psychiatric conditions in affected individuals. Among the most prominent findings of immediate clinical importance, we found that females received a first diagnosis of ASD at a later age than males, potentially due to more advanced language abilities in females with ASD. In summary, this is the first analysis of a large, population-based U.S. cohort with ASD. Given the depth of sampling, the RI-CART study reflects an important new resource for studying ASD in a representative U.S. population. Psychiatric and medical comorbidities in ASD constitute a substantial burden and warrant adequate attention as part of overall treatment. Our study also suggests that new strategies for earlier diagnosis of ASD in females may be warranted. Autism Res 2020, 13: 474-488. (c) 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The Rhode Island Consortium for Autism Research and Treatment (RI-CART) represents a unique public-private-academic collaboration involving all major points of service for families in Rhode Island affected by autism spectrum disorder (ASD). In this article, we provide results from the first 1,000 participants, estimated to represent >20% of affected families in the state. Importantly, we find a later age at first diagnosis of ASD in females, which potentially calls attention to the need for improved early diagnosis in girls. Also, we report a high rate of co-occurring medical and psychiatric conditions in affected individuals. En ligne : http://dx.doi.org/10.1002/aur.2261 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421 [article] Autism Heterogeneity in a Densely Sampled U.S. Population: Results From the First 1,000 Participants in the RI-CART Study [texte imprimé] / Carolyn MCCORMICK, Auteur ; Brian C. KAVANAUGH, Auteur ; Danielle SIPSOCK, Auteur ; Giulia RIGHI, Auteur ; Lindsay M. OBERMAN, Auteur ; Daniel MORENO DE LUCA, Auteur ; Ece D. GAMSIZ UZUN, Auteur ; Carrie R. BEST, Auteur ; Beth A. JERSKEY, Auteur ; Joanne G. QUINN, Auteur ; Susan B. JEWEL, Auteur ; Pei-Chi WU, Auteur ; Rebecca L. MCLEAN, Auteur ; Todd P. LEVINE, Auteur ; Hasmik TOKADJIAN, Auteur ; Kayla A. PERKINS, Auteur ; Elaine B. CLARKE, Auteur ; Brittany DUNN, Auteur ; Alan H. GERBER, Auteur ; Elena J. TENENBAUM, Auteur ; Thomas F. ANDERS, Auteur . - p.474-488. Langues : Anglais (eng) in Autism Research > 13-3 (March 2020) . - p.474-488 Mots-clés : autism spectrum disorder  comorbidity  female autism  population study  registry Index. décimale : PER Périodiques Résumé : The objective of this study was to establish a large, densely sampled, U.S. population-based cohort of people with autism spectrum disorder (ASD). The Rhode Island Consortium for Autism Research and Treatment (RI-CART) represents a unique public-private-academic collaboration involving all major points of service for families in Rhode Island affected by ASD. Diagnosis was based on direct behavioral observation via the Autism Diagnostic Observation Schedule, Second Edition. For the first 1,000 participants, ages ranged from 21 months to 64 years. Using Geographic Information System and published prevalence rates, the overall cohort is estimated to represent between 20% and 49% of pediatric age persons in Rhode Island with ASD, with demographics representative of U.S. Census. We observed a high rate of co-occurring medical and psychiatric conditions in affected individuals. Among the most prominent findings of immediate clinical importance, we found that females received a first diagnosis of ASD at a later age than males, potentially due to more advanced language abilities in females with ASD. In summary, this is the first analysis of a large, population-based U.S. cohort with ASD. Given the depth of sampling, the RI-CART study reflects an important new resource for studying ASD in a representative U.S. population. Psychiatric and medical comorbidities in ASD constitute a substantial burden and warrant adequate attention as part of overall treatment. Our study also suggests that new strategies for earlier diagnosis of ASD in females may be warranted. Autism Res 2020, 13: 474-488. (c) 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The Rhode Island Consortium for Autism Research and Treatment (RI-CART) represents a unique public-private-academic collaboration involving all major points of service for families in Rhode Island affected by autism spectrum disorder (ASD). In this article, we provide results from the first 1,000 participants, estimated to represent >20% of affected families in the state. Importantly, we find a later age at first diagnosis of ASD in females, which potentially calls attention to the need for improved early diagnosis in girls. Also, we report a high rate of co-occurring medical and psychiatric conditions in affected individuals. En ligne : http://dx.doi.org/10.1002/aur.2261 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421

Early childhood trauma exposure and neurocognitive and emotional processes: Associations in young children in a partial hospital program / Lindsay HUFFHINES in Development and Psychopathology, 37-2 (May 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-2 (May 2025) . - p.1108-1124 Titre : Early childhood trauma exposure and neurocognitive and emotional processes: Associations in young children in a partial hospital program Type de document : texte imprimé Auteurs : Lindsay HUFFHINES, Auteur ; Stephanie H. PARADE, Auteur ; Sarah E. MARTIN, Auteur ; Anjali GOTTIPATY, Auteur ; Brian C. KAVANAUGH, Auteur ; Anthony SPIRITO, Auteur ; John R. BOEKAMP, Auteur Article en page(s) : p.1108-1124 Langues : Anglais (eng) Mots-clés : adverse childhood experiences  early childhood trauma  emotion reactivity  emotion regulation  executive functioning Index. décimale : PER Périodiques Résumé : Early childhood trauma has been linked to neurocognitive and emotional processing deficits in older children, yet much less is known about these associations in young children. Early childhood is an important developmental period in which to examine relations between trauma and executive functioning/emotion reactivity, given that these capacities are rapidly developing and are potential transdiagnostic factors implicated in the development of psychopathology. This cross-sectional study examined associations between cumulative trauma, interpersonal trauma, and components of executive functioning, episodic memory, and emotion reactivity, conceptualized using the RDoC framework and assessed with observational and performance-based measures, in a sample of 90 children (ages 4-7) admitted to a partial hospital program. Children who had experienced two or more categories of trauma had lower scores in episodic memory, global cognition, and inhibitory control as measured in a relational (but not computerized) task, when compared to children with less or no trauma. Interpersonal trauma was similarly associated with global cognition and relational inhibitory control. Family contextual factors did not moderate associations. Findings support examining inhibitory control in both relationally significant and decontextualized paradigms in early childhood, and underscore the importance of investigating multiple neurocognitive and emotional processes simultaneously to identify potential targets for early intervention. En ligne : https://dx.doi.org/10.1017/S0954579424000956 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=552 [article] Early childhood trauma exposure and neurocognitive and emotional processes: Associations in young children in a partial hospital program [texte imprimé] / Lindsay HUFFHINES, Auteur ; Stephanie H. PARADE, Auteur ; Sarah E. MARTIN, Auteur ; Anjali GOTTIPATY, Auteur ; Brian C. KAVANAUGH, Auteur ; Anthony SPIRITO, Auteur ; John R. BOEKAMP, Auteur . - p.1108-1124. Langues : Anglais (eng) in Development and Psychopathology > 37-2 (May 2025) . - p.1108-1124 Mots-clés : adverse childhood experiences  early childhood trauma  emotion reactivity  emotion regulation  executive functioning Index. décimale : PER Périodiques Résumé : Early childhood trauma has been linked to neurocognitive and emotional processing deficits in older children, yet much less is known about these associations in young children. Early childhood is an important developmental period in which to examine relations between trauma and executive functioning/emotion reactivity, given that these capacities are rapidly developing and are potential transdiagnostic factors implicated in the development of psychopathology. This cross-sectional study examined associations between cumulative trauma, interpersonal trauma, and components of executive functioning, episodic memory, and emotion reactivity, conceptualized using the RDoC framework and assessed with observational and performance-based measures, in a sample of 90 children (ages 4-7) admitted to a partial hospital program. Children who had experienced two or more categories of trauma had lower scores in episodic memory, global cognition, and inhibitory control as measured in a relational (but not computerized) task, when compared to children with less or no trauma. Interpersonal trauma was similarly associated with global cognition and relational inhibitory control. Family contextual factors did not moderate associations. Findings support examining inhibitory control in both relationally significant and decontextualized paradigms in early childhood, and underscore the importance of investigating multiple neurocognitive and emotional processes simultaneously to identify potential targets for early intervention. En ligne : https://dx.doi.org/10.1017/S0954579424000956 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=552

Parental age and autism severity in the Rhode Island Consortium for Autism Research and Treatment (RI-CART) study / Brian C. KAVANAUGH in Autism Research, 15-1 (January 2022)  

Public ISBD [article]  inAutism Research > 15-1 (January 2022) . - p.86-92 Titre : Parental age and autism severity in the Rhode Island Consortium for Autism Research and Treatment (RI-CART) study Type de document : texte imprimé Auteurs : Brian C. KAVANAUGH, Auteur ; Tess GABERT, Auteur ; Richard N. JONES, Auteur ; Stephen J. SHEINKOPF, Auteur ; Eric M. MORROW, Auteur Article en page(s) : p.86-92 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Female  Humans  Mothers  Parents  Rhode Island  neuropsychiatric disorders  parental age  repetitive behaviors  restricted Index. décimale : PER Périodiques Résumé : Advanced parental age at offspring birth has been associated with autism spectrum disorder (ASD). The objective of the current study was to investigate associations between parental age at birth and autism severity. The Rhode Island Consortium for Autism Research and Treatment (RI-CART) study represents a community-based sample with a range of autism severity, including participants with and without ASD. This study involved participants (n = 1178) enrolled in RI-CART with available mother and father ages at birth. Primary data points included the age of mother and father at the participant's birth and results from the Autism Diagnostic Observation Schedule - Second Edition (ADOS-2). Mothers were 1.7 years older at the time of birth of the child with ASD, as compared to mothers of offspring without ASD. Fathers of children with ASD were 1.6 years older at the time of birth than fathers of children without ASD. The age of both parents at offspring birth displayed a positive, statistically significant association with overall ASD severity and the severity of restricted/repetitive behaviors. This finding was driven by the association between parental age and the severity of compulsions or rituals. Intelligence and adaptive functioning did not moderate the relationship between parental age and ASD severity. This study extends prior research to show that advanced parental age at birth is associated with the severity as well as the presence of ASD in offspring. En ligne : http://dx.doi.org/10.1002/aur.2648 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Parental age and autism severity in the Rhode Island Consortium for Autism Research and Treatment (RI-CART) study [texte imprimé] / Brian C. KAVANAUGH, Auteur ; Tess GABERT, Auteur ; Richard N. JONES, Auteur ; Stephen J. SHEINKOPF, Auteur ; Eric M. MORROW, Auteur . - p.86-92. Langues : Anglais (eng) in Autism Research > 15-1 (January 2022) . - p.86-92 Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Female  Humans  Mothers  Parents  Rhode Island  neuropsychiatric disorders  parental age  repetitive behaviors  restricted Index. décimale : PER Périodiques Résumé : Advanced parental age at offspring birth has been associated with autism spectrum disorder (ASD). The objective of the current study was to investigate associations between parental age at birth and autism severity. The Rhode Island Consortium for Autism Research and Treatment (RI-CART) study represents a community-based sample with a range of autism severity, including participants with and without ASD. This study involved participants (n = 1178) enrolled in RI-CART with available mother and father ages at birth. Primary data points included the age of mother and father at the participant's birth and results from the Autism Diagnostic Observation Schedule - Second Edition (ADOS-2). Mothers were 1.7 years older at the time of birth of the child with ASD, as compared to mothers of offspring without ASD. Fathers of children with ASD were 1.6 years older at the time of birth than fathers of children without ASD. The age of both parents at offspring birth displayed a positive, statistically significant association with overall ASD severity and the severity of restricted/repetitive behaviors. This finding was driven by the association between parental age and the severity of compulsions or rituals. Intelligence and adaptive functioning did not moderate the relationship between parental age and ASD severity. This study extends prior research to show that advanced parental age at birth is associated with the severity as well as the presence of ASD in offspring. En ligne : http://dx.doi.org/10.1002/aur.2648 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

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