Behavioral problems in children with autism spectrum disorder with and without co-occurring intellectual disability / Margaret KURZIUS-SPENCER in Research in Autism Spectrum Disorders, 56 (December 2018)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 56 (December 2018) . - p.61-71 Titre : Behavioral problems in children with autism spectrum disorder with and without co-occurring intellectual disability Type de document : Texte imprimé et/ou numérique Auteurs : Margaret KURZIUS-SPENCER, Auteur ; Sydney PETTYGROVE, Auteur ; Deborah CHRISTENSEN, Auteur ; Anita L. PEDERSEN, Auteur ; Christopher CUNNIFF, Auteur ; F. John MEANEY, Auteur ; Gnakub Norbert SOKE, Auteur ; Rebecca A. HARRINGTON, Auteur ; Maureen DURKIN, Auteur ; Sydney RICE, Auteur Article en page(s) : p.61-71 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Intellectual disability  Self-injurious behavior  Problem behaviors  Autism and developmental disabilities monitoring network  Children Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorder (ASD), intellectual disability (ID), and behavioral problems commonly co-occur, leading to increased impairment, diagnostic confusion, and treatment delays. Using data from a large surveillance population of children with ASD, the objectives of the present study were to compare the relative risk of common behavioral problems in children with ASD, with and without co-occurring intellectual disability. Methods Data from the Autism and Developmental Disabilities Monitoring (ADDM) Network (2006–2010) on 9378 8-year-old children who met case definition for ASD and had cognitive test scores and information on behavioral problems were analyzed using frequency measures, risk ratios, chi-squared tests, and trend tests. Results Children with ASD with and without ID had on average six co-occurring behavioral problems. The relative risk (RR) of self-injurious behaviors, unusual fear responses, and eating abnormalities increased with increasing cognitive impairment among children with ASD and ID (all p<0.001). Conversely, RR of mood (p<0.001) and sleep abnormalities (p=0.013) declined with increasing levels of cognitive impairment. Conclusions Children with ASD and ID are at greater risk of some behavioral problems and lower risk of others as compared to children with ASD only. Successful interventions depend on understanding the complex interactions between co-occurring neurodevelopmental and behavioral problems. En ligne : https://doi.org/10.1016/j.rasd.2018.09.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369 [article] Behavioral problems in children with autism spectrum disorder with and without co-occurring intellectual disability [Texte imprimé et/ou numérique] / Margaret KURZIUS-SPENCER, Auteur ; Sydney PETTYGROVE, Auteur ; Deborah CHRISTENSEN, Auteur ; Anita L. PEDERSEN, Auteur ; Christopher CUNNIFF, Auteur ; F. John MEANEY, Auteur ; Gnakub Norbert SOKE, Auteur ; Rebecca A. HARRINGTON, Auteur ; Maureen DURKIN, Auteur ; Sydney RICE, Auteur . - p.61-71. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 56 (December 2018) . - p.61-71 Mots-clés : Autism spectrum disorder  Intellectual disability  Self-injurious behavior  Problem behaviors  Autism and developmental disabilities monitoring network  Children Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorder (ASD), intellectual disability (ID), and behavioral problems commonly co-occur, leading to increased impairment, diagnostic confusion, and treatment delays. Using data from a large surveillance population of children with ASD, the objectives of the present study were to compare the relative risk of common behavioral problems in children with ASD, with and without co-occurring intellectual disability. Methods Data from the Autism and Developmental Disabilities Monitoring (ADDM) Network (2006–2010) on 9378 8-year-old children who met case definition for ASD and had cognitive test scores and information on behavioral problems were analyzed using frequency measures, risk ratios, chi-squared tests, and trend tests. Results Children with ASD with and without ID had on average six co-occurring behavioral problems. The relative risk (RR) of self-injurious behaviors, unusual fear responses, and eating abnormalities increased with increasing cognitive impairment among children with ASD and ID (all p<0.001). Conversely, RR of mood (p<0.001) and sleep abnormalities (p=0.013) declined with increasing levels of cognitive impairment. Conclusions Children with ASD and ID are at greater risk of some behavioral problems and lower risk of others as compared to children with ASD only. Successful interventions depend on understanding the complex interactions between co-occurring neurodevelopmental and behavioral problems. En ligne : https://doi.org/10.1016/j.rasd.2018.09.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369

Children with Autism: Quality of Life and Parental Concerns / Li-Ching LEE in Journal of Autism and Developmental Disorders, 38-6 (July 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-6 (July 2008) . - p.1147-1160 Titre : Children with Autism: Quality of Life and Parental Concerns Type de document : Texte imprimé et/ou numérique Auteurs : Li-Ching LEE, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Rebecca A. HARRINGTON, Auteur ; Brian B. LOUIE, Auteur Année de publication : 2008 Article en page(s) : p.1147-1160 Langues : Anglais (eng) Mots-clés : Autism ADD ADHD Quality-of-life Parental-concern Index. décimale : PER Périodiques Résumé : Past research has shown that children with autism and their families have compromised quality of life (QOL) in several domains. This study examined QOL and parental concerns in children with autism during early childhood, childhood, and adolescence compared to children with Attention Deficit Disorder/Attention Deficit Hyperactivity Disorder (ADD/ADHD) and to typical controls from a US national sample. Families with children diagnosed with autism reported more profound QOL effects than families of children with ADD/ADHD or unaffected controls. Children with autism were significantly less likely to attend religious services, more likely to miss school, and less likely to participate in organized activities. Parental concerns over learning difficulty, being bullied, stress-coping, and achievement were overwhelming in the autism group relative to the comparison groups. En ligne : http://dx.doi.org/10.1007/s10803-007-0491-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474 [article] Children with Autism: Quality of Life and Parental Concerns [Texte imprimé et/ou numérique] / Li-Ching LEE, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Rebecca A. HARRINGTON, Auteur ; Brian B. LOUIE, Auteur . - 2008 . - p.1147-1160. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-6 (July 2008) . - p.1147-1160 Mots-clés : Autism ADD ADHD Quality-of-life Parental-concern Index. décimale : PER Périodiques Résumé : Past research has shown that children with autism and their families have compromised quality of life (QOL) in several domains. This study examined QOL and parental concerns in children with autism during early childhood, childhood, and adolescence compared to children with Attention Deficit Disorder/Attention Deficit Hyperactivity Disorder (ADD/ADHD) and to typical controls from a US national sample. Families with children diagnosed with autism reported more profound QOL effects than families of children with ADD/ADHD or unaffected controls. Children with autism were significantly less likely to attend religious services, more likely to miss school, and less likely to participate in organized activities. Parental concerns over learning difficulty, being bullied, stress-coping, and achievement were overwhelming in the autism group relative to the comparison groups. En ligne : http://dx.doi.org/10.1007/s10803-007-0491-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474

Disparity in report of autism-related behaviors by social demographic characteristics: Findings from a community-based study in Taiwan / Peng-Chou TSAI in Autism, 21-5 (July 2017)  

Public ISBD [article]  inAutism > 21-5 (July 2017) . - p.540-551 Titre : Disparity in report of autism-related behaviors by social demographic characteristics: Findings from a community-based study in Taiwan Type de document : Texte imprimé et/ou numérique Auteurs : Peng-Chou TSAI, Auteur ; Rebecca A. HARRINGTON, Auteur ; For-Wey LUNG, Auteur ; Li-Ching LEE, Auteur Article en page(s) : p.540-551 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The Social Communication Questionnaire is one of the most commonly used screening tools for autism spectrum disorder. The Social Communication Questionnaire is a caregiver-reported questionnaire with 40 items based on questions from the Autism Diagnostic Interview?Revised. This study collected Social Communication Questionnaire data from a community-based, multi-stage case identification design epidemiologic study in one socioeconomically disadvantaged county in Taiwan. The Social Communication Questionnaire was distributed to 3034 school children, aged 6?8?years. Item prevalence results indicate males were reported to have more autism-related behaviors than females (higher prevalence on most items), in the whole study sample as well as in children meeting Social Communication Questionnaire clinical cut-offs (?15). Children whose biological fathers completed the Social Communication Questionnaire were reported to have more behavioral issues than children whose biological mothers were the respondent. Lower respondent education levels were associated with reports of clinically concerning autism-related behaviors. However, males were not at higher risk of meeting Social Communication Questionnaire clinical cut-offs than females in this study population. Findings from this study help to better understand reporting patterns on children?s autism-related behaviors potentially due to social demographic characteristics and child sex, which may lead to improved identification of these behaviors. En ligne : http://dx.doi.org/10.1177/1362361316677024 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=310 [article] Disparity in report of autism-related behaviors by social demographic characteristics: Findings from a community-based study in Taiwan [Texte imprimé et/ou numérique] / Peng-Chou TSAI, Auteur ; Rebecca A. HARRINGTON, Auteur ; For-Wey LUNG, Auteur ; Li-Ching LEE, Auteur . - p.540-551. Langues : Anglais (eng) in Autism > 21-5 (July 2017) . - p.540-551 Index. décimale : PER Périodiques Résumé : The Social Communication Questionnaire is one of the most commonly used screening tools for autism spectrum disorder. The Social Communication Questionnaire is a caregiver-reported questionnaire with 40 items based on questions from the Autism Diagnostic Interview?Revised. This study collected Social Communication Questionnaire data from a community-based, multi-stage case identification design epidemiologic study in one socioeconomically disadvantaged county in Taiwan. The Social Communication Questionnaire was distributed to 3034 school children, aged 6?8?years. Item prevalence results indicate males were reported to have more autism-related behaviors than females (higher prevalence on most items), in the whole study sample as well as in children meeting Social Communication Questionnaire clinical cut-offs (?15). Children whose biological fathers completed the Social Communication Questionnaire were reported to have more behavioral issues than children whose biological mothers were the respondent. Lower respondent education levels were associated with reports of clinically concerning autism-related behaviors. However, males were not at higher risk of meeting Social Communication Questionnaire clinical cut-offs than females in this study population. Findings from this study help to better understand reporting patterns on children?s autism-related behaviors potentially due to social demographic characteristics and child sex, which may lead to improved identification of these behaviors. En ligne : http://dx.doi.org/10.1177/1362361316677024 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=310

Serotonin Hypothesis of Autism: Implications for Selective Serotonin Reuptake Inhibitor Use during Pregnancy / Rebecca A. HARRINGTON in Autism Research, 6-3 (June 2013)  

Public ISBD [article]  inAutism Research > 6-3 (June 2013) . - p.149-168 Titre : Serotonin Hypothesis of Autism: Implications for Selective Serotonin Reuptake Inhibitor Use during Pregnancy Type de document : Texte imprimé et/ou numérique Auteurs : Rebecca A. HARRINGTON, Auteur ; Li-Ching LEE, Auteur ; Rosa M. CRUM, Auteur ; Andrew W. ZIMMERMAN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur Année de publication : 2013 Article en page(s) : p.149-168 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  serotonin  selective serotonin reuptake inhibitors  pregnancy Index. décimale : PER Périodiques Résumé : Serotonin, a neurotransmitter found throughout the brain and body, has long been of interest in autism. Repeated findings of elevated platelet serotonin levels in approximately one third of children with autism has led some to believe that dysfunctional serotonin signaling may be a causal mechanism for the disorder. Because serotonin is critical to fetal brain development, concerns have arisen regarding prenatal exposure to substances that manipulate serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs). This review examines evidence regarding the serotonin system and autism spectrum disorders (ASD), as well as what the literature has reported thus far on developmental effects of prenatal exposure to SSRIs. Possible mechanisms by which SSRIs could affect the fetus during pregnancy and clinical implications are also discussed. Though the majority of studies conducted in infants and children suggest prenatal exposure to SSRIs does not affect neurodevelopment, interpretation must be tempered given small sample sizes. The only published study that focused on prenatal SSRI exposure and ASD found an increased risk with exposure to SSRIs, especially during the first trimester. Obstacles that will be faced in future research are isolating medication effects from maternal depression and, given the infrequent occurrence of exposure and outcome, obtaining an adequate sample size. Whether serotonin is an etiologic factor in ASD, and what it points to as a marker for subgrouping, remains unclear. Understanding how the development of ASD might be affected by prenatal factors that influence serotonin levels, such as SSRIs, could identify modifiable targets for prevention. En ligne : http://dx.doi.org/10.1002/aur.1288 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202 [article] Serotonin Hypothesis of Autism: Implications for Selective Serotonin Reuptake Inhibitor Use during Pregnancy [Texte imprimé et/ou numérique] / Rebecca A. HARRINGTON, Auteur ; Li-Ching LEE, Auteur ; Rosa M. CRUM, Auteur ; Andrew W. ZIMMERMAN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur . - 2013 . - p.149-168. Langues : Anglais (eng) in Autism Research > 6-3 (June 2013) . - p.149-168 Mots-clés : autism spectrum disorders  serotonin  selective serotonin reuptake inhibitors  pregnancy Index. décimale : PER Périodiques Résumé : Serotonin, a neurotransmitter found throughout the brain and body, has long been of interest in autism. Repeated findings of elevated platelet serotonin levels in approximately one third of children with autism has led some to believe that dysfunctional serotonin signaling may be a causal mechanism for the disorder. Because serotonin is critical to fetal brain development, concerns have arisen regarding prenatal exposure to substances that manipulate serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs). This review examines evidence regarding the serotonin system and autism spectrum disorders (ASD), as well as what the literature has reported thus far on developmental effects of prenatal exposure to SSRIs. Possible mechanisms by which SSRIs could affect the fetus during pregnancy and clinical implications are also discussed. Though the majority of studies conducted in infants and children suggest prenatal exposure to SSRIs does not affect neurodevelopment, interpretation must be tempered given small sample sizes. The only published study that focused on prenatal SSRI exposure and ASD found an increased risk with exposure to SSRIs, especially during the first trimester. Obstacles that will be faced in future research are isolating medication effects from maternal depression and, given the infrequent occurrence of exposure and outcome, obtaining an adequate sample size. Whether serotonin is an etiologic factor in ASD, and what it points to as a marker for subgrouping, remains unclear. Understanding how the development of ASD might be affected by prenatal factors that influence serotonin levels, such as SSRIs, could identify modifiable targets for prevention. En ligne : http://dx.doi.org/10.1002/aur.1288 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202

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