Developmental-behavioral profiles in children with autism spectrum disorder and co-occurring gastrointestinal symptoms / Bibiana RESTREPO in Autism Research, 13-10 (October 2020)  

Public ISBD [article]  inAutism Research > 13-10 (October 2020) . - p.1778-1789 Titre : Developmental-behavioral profiles in children with autism spectrum disorder and co-occurring gastrointestinal symptoms Type de document : texte imprimé Auteurs : Bibiana RESTREPO, Auteur ; Kathleen ANGKUSTSIRI, Auteur ; Sandra L. TAYLOR, Auteur ; Sally J ROGERS, Auteur ; Jacqueline CABRAL, Auteur ; Brianna HEATH, Auteur ; Alexa HECHTMAN, Auteur ; Marjorie SOLOMON, Auteur ; Paul ASHWOOD, Auteur ; David G. AMARAL, Auteur ; Christine W. NORDAHL, Auteur Article en page(s) : p.1778-1789 Langues : Anglais (eng) Mots-clés : GI dysfunction  GI symptoms  autism  autism spectrum disorder  co-occurring  coexisting  comorbidities  gastrointestinal problems  repetitive behavior Index. décimale : PER Périodiques Résumé : Gastrointestinal (GI) symptoms are frequently reported in children with autism spectrum disorder (ASD). We evaluated the frequency and severity of GI symptoms in preschool-aged children with ASD compared to participants with typical development (TD). Our goal was to ascertain whether GI symptoms are associated with differences in sex or developmental and behavioral measures. Participants were between 2 and 3.5 years of age and included 255 children with ASD (184 males/71 females) and 129 age-matched TD controls (75 males/54 females). A parent interview was used to assess GI symptoms (abdominal pain, gaseousness/bloating, diarrhea, constipation, pain on stooling, vomiting, difficulty swallowing, blood in stool or in vomit). Children with GI symptoms in each diagnostic group were compared to children without GI symptoms on measures of developmental, behavioral, and adaptive functioning. GI symptoms were reported more frequently in children with ASD compared to the TD group (47.8% vs. 17.8%, respectively). Children with ASD were also more likely to experience multiple GI symptoms (30.6% vs. 5.4%). GI symptoms were equally common in males and females across both diagnostic groups. There were no statistically significant differences in developmental or adaptive measures based on presence of GI symptoms in either ASD or TD children. Co-occurring GI symptoms were, however, associated with increased self-injurious behaviors, restricted stereotyped behaviors, aggressive behaviors, sleep problems and attention problems in both ASD and TD children. In children with ASD, a higher number of GI symptoms was associated with an increase in self-injurious behaviors, somatic complaints, reduced sleep duration, and increased parasomnias. LAY SUMMARY: ASD is characterized by challenges in social communication and repetitive behaviors. But, people with autism have many other difficulties including gastrointestinal problems. Children with ASD were three times more likely to experience GI symptoms than typically developing peers. Increased GI symptoms are associated with increased problem behaviors such as sleep problems, self-injury, and body aches. Since GI symptoms are often treatable, it is important to recognize them as soon as possible. Both clinicians and parents should become more aware of the high occurrence of GI problems in autistic people. Autism Res 2020, 13: 1778-1789. © 2020 International Society for Autism Research and Wiley Periodicals LLC. En ligne : http://dx.doi.org/10.1002/aur.2354 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431 [article] Developmental-behavioral profiles in children with autism spectrum disorder and co-occurring gastrointestinal symptoms [texte imprimé] / Bibiana RESTREPO, Auteur ; Kathleen ANGKUSTSIRI, Auteur ; Sandra L. TAYLOR, Auteur ; Sally J ROGERS, Auteur ; Jacqueline CABRAL, Auteur ; Brianna HEATH, Auteur ; Alexa HECHTMAN, Auteur ; Marjorie SOLOMON, Auteur ; Paul ASHWOOD, Auteur ; David G. AMARAL, Auteur ; Christine W. NORDAHL, Auteur . - p.1778-1789. Langues : Anglais (eng) in Autism Research > 13-10 (October 2020) . - p.1778-1789 Mots-clés : GI dysfunction  GI symptoms  autism  autism spectrum disorder  co-occurring  coexisting  comorbidities  gastrointestinal problems  repetitive behavior Index. décimale : PER Périodiques Résumé : Gastrointestinal (GI) symptoms are frequently reported in children with autism spectrum disorder (ASD). We evaluated the frequency and severity of GI symptoms in preschool-aged children with ASD compared to participants with typical development (TD). Our goal was to ascertain whether GI symptoms are associated with differences in sex or developmental and behavioral measures. Participants were between 2 and 3.5 years of age and included 255 children with ASD (184 males/71 females) and 129 age-matched TD controls (75 males/54 females). A parent interview was used to assess GI symptoms (abdominal pain, gaseousness/bloating, diarrhea, constipation, pain on stooling, vomiting, difficulty swallowing, blood in stool or in vomit). Children with GI symptoms in each diagnostic group were compared to children without GI symptoms on measures of developmental, behavioral, and adaptive functioning. GI symptoms were reported more frequently in children with ASD compared to the TD group (47.8% vs. 17.8%, respectively). Children with ASD were also more likely to experience multiple GI symptoms (30.6% vs. 5.4%). GI symptoms were equally common in males and females across both diagnostic groups. There were no statistically significant differences in developmental or adaptive measures based on presence of GI symptoms in either ASD or TD children. Co-occurring GI symptoms were, however, associated with increased self-injurious behaviors, restricted stereotyped behaviors, aggressive behaviors, sleep problems and attention problems in both ASD and TD children. In children with ASD, a higher number of GI symptoms was associated with an increase in self-injurious behaviors, somatic complaints, reduced sleep duration, and increased parasomnias. LAY SUMMARY: ASD is characterized by challenges in social communication and repetitive behaviors. But, people with autism have many other difficulties including gastrointestinal problems. Children with ASD were three times more likely to experience GI symptoms than typically developing peers. Increased GI symptoms are associated with increased problem behaviors such as sleep problems, self-injury, and body aches. Since GI symptoms are often treatable, it is important to recognize them as soon as possible. Both clinicians and parents should become more aware of the high occurrence of GI problems in autistic people. Autism Res 2020, 13: 1778-1789. © 2020 International Society for Autism Research and Wiley Periodicals LLC. En ligne : http://dx.doi.org/10.1002/aur.2354 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431

Examining the association between prenatal cannabis exposure and child autism traits: A multi-cohort investigation in the environmental influences on child health outcome program / Aisha S. DICKERSON ; Tingju HSU ; Aseel AL-JADIRI ; Carlos A. CAMARGO ; Julie B. SCHWEITZER ; Coral L. SHUSTER ; Margaret R. KARAGAS ; Juliette C. MADAN ; Bibiana RESTREPO ; Rebecca J. SCHMIDT ; Claudia LUGO-CANDELAS ; Jenae NEIDERHISER ; Sheela SATHYANARAYANA ; Anne L. DUNLOP ; Patricia A. BRENNAN ; program collaborators for Environmental influences on Child Health OUTCOMES in Autism Research, 17-8 (August 2024)  

Public ISBD [article]  inAutism Research > 17-8 (August 2024) . - p.1651-1664 Titre : Examining the association between prenatal cannabis exposure and child autism traits: A multi-cohort investigation in the environmental influences on child health outcome program Type de document : texte imprimé Auteurs : Aisha S. DICKERSON, Auteur ; Tingju HSU, Auteur ; Aseel AL-JADIRI, Auteur ; Carlos A. CAMARGO, Auteur ; Julie B. SCHWEITZER, Auteur ; Coral L. SHUSTER, Auteur ; Margaret R. KARAGAS, Auteur ; Juliette C. MADAN, Auteur ; Bibiana RESTREPO, Auteur ; Rebecca J. SCHMIDT, Auteur ; Claudia LUGO-CANDELAS, Auteur ; Jenae NEIDERHISER, Auteur ; Sheela SATHYANARAYANA, Auteur ; Anne L. DUNLOP, Auteur ; Patricia A. BRENNAN, Auteur ; program collaborators for Environmental influences on Child Health OUTCOMES, Auteur Article en page(s) : p.1651-1664 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract This study examined the association between prenatal cannabis exposure and autism spectrum disorder (ASD) diagnoses and traits. A total sample of 11,570 children (ages 1-18; 53% male; 25% Hispanic; 60% White) from 34 cohorts of the National Institutes of Health-funded environmental influences on child health outcomes consortium were included in analyses. Results from generalized linear mixed models replicated previous studies showing that associations between prenatal cannabis exposure and ASD traits in children are not significant when controlling for relevant covariates, particularly tobacco exposure. Child biological sex did not moderate the association between prenatal cannabis exposure and ASD. In a large sample and measuring ASD traits continuously, there was no evidence that prenatal cannabis exposure increases the risk for ASD. This work helps to clarify previous mixed findings by addressing concerns about statistical power and ASD measurement. En ligne : https://doi.org/10.1002/aur.3185 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Examining the association between prenatal cannabis exposure and child autism traits: A multi-cohort investigation in the environmental influences on child health outcome program [texte imprimé] / Aisha S. DICKERSON, Auteur ; Tingju HSU, Auteur ; Aseel AL-JADIRI, Auteur ; Carlos A. CAMARGO, Auteur ; Julie B. SCHWEITZER, Auteur ; Coral L. SHUSTER, Auteur ; Margaret R. KARAGAS, Auteur ; Juliette C. MADAN, Auteur ; Bibiana RESTREPO, Auteur ; Rebecca J. SCHMIDT, Auteur ; Claudia LUGO-CANDELAS, Auteur ; Jenae NEIDERHISER, Auteur ; Sheela SATHYANARAYANA, Auteur ; Anne L. DUNLOP, Auteur ; Patricia A. BRENNAN, Auteur ; program collaborators for Environmental influences on Child Health OUTCOMES, Auteur . - p.1651-1664. Langues : Anglais (eng) in Autism Research > 17-8 (August 2024) . - p.1651-1664 Index. décimale : PER Périodiques Résumé : Abstract This study examined the association between prenatal cannabis exposure and autism spectrum disorder (ASD) diagnoses and traits. A total sample of 11,570 children (ages 1-18; 53% male; 25% Hispanic; 60% White) from 34 cohorts of the National Institutes of Health-funded environmental influences on child health outcomes consortium were included in analyses. Results from generalized linear mixed models replicated previous studies showing that associations between prenatal cannabis exposure and ASD traits in children are not significant when controlling for relevant covariates, particularly tobacco exposure. Child biological sex did not moderate the association between prenatal cannabis exposure and ASD. In a large sample and measuring ASD traits continuously, there was no evidence that prenatal cannabis exposure increases the risk for ASD. This work helps to clarify previous mixed findings by addressing concerns about statistical power and ASD measurement. En ligne : https://doi.org/10.1002/aur.3185 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

A longitudinal evaluation of gastrointestinal symptoms in children with autism spectrum disorder / Bibiana RESTREPO in Autism, 29-11 (November 2025)  

Public ISBD [article]  inAutism > 29-11 (November 2025) . - p.2832-2845 Titre : A longitudinal evaluation of gastrointestinal symptoms in children with autism spectrum disorder Type de document : texte imprimé Auteurs : Bibiana RESTREPO, Auteur ; Sandra L TAYLOR, Auteur ; Matthew DOMINIC PONZINI, Auteur ; Kathleen ANGKUSTSIRI, Auteur ; Marjorie SOLOMON, Auteur ; Sally J ROGERS, Auteur ; Paul ASHWOOD, Auteur ; Daphne S SAY, Auteur ; Sonny CACERES, Auteur ; Shayan M ALAVYNEJAD, Auteur ; Brianna HEATH, Auteur ; David G. AMARAL, Auteur ; Christine WU NORDAHL, Auteur Article en page(s) : p.2832-2845 Langues : Anglais (eng) Mots-clés : chronic GI  GI dysfunction  GI issues  GI symptoms  impaired behavior  longitudinal  medical problems Index. décimale : PER Périodiques Résumé : Gastrointestinal symptoms are frequently reported in children diagnosed with autism spectrum disorder. This study sought to determine the longitudinal trajectory of gastrointestinal symptoms without a medical etiology in children with autism compared to similar aged participants with typical development. A total of 475 children enrolled in this longitudinal study (322 autism spectrum disorder and 153 typical development groups) were evaluated at up to three time points between 2 and 12 years of age. Nine common gastrointestinal symptoms and formal medical gastrointestinal diagnosis were assessed using a physician-administered parent interview. A rigorous symptom classification was performed by physicians via clinical consensus. The frequency and persistence of gastrointestinal symptoms across childhood were compared between groups. Associations between gastrointestinal symptoms and measures of internalizing and externalizing behaviors, sleep problems, sensory problems, restricted and repetitive behaviors, and social communication were also evaluated. Children with autism presented with more gastrointestinal symptoms at each time point, and they were also more likely to experience multiple and persistent gastrointestinal symptoms. The presence and number of gastrointestinal symptoms were associated with greater impairment in internalizing behaviors, sleep, communication, sensory processing, and repetitive behaviors. Participants in the autism spectrum disorder group reported more gastrointestinal symptoms without known etiology throughout childhood in this longitudinal well-characterized sample.Lay Abstract Children with autism have been found to experience more medical issues including gastrointestinal symptoms. In this study, participants in the autism group were more likely to experience gastrointestinal symptoms than their typically developing peers. They were also more likely to experience multiple gastrointestinal symptoms at the same time and more likely to have persistent gastrointestinal symptoms throughout their childhood. Increased gastrointestinal symptoms were associated with more challenges with sleep, communication, sensory processing, and repetitive behaviors. Clinicians and parents should become more aware of the high occurrence of gastrointestinal problems in children with autism. If identified, these symptoms are often treatable which may improve their well-being. En ligne : https://dx.doi.org/10.1177/13623613251362349 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=570 [article] A longitudinal evaluation of gastrointestinal symptoms in children with autism spectrum disorder [texte imprimé] / Bibiana RESTREPO, Auteur ; Sandra L TAYLOR, Auteur ; Matthew DOMINIC PONZINI, Auteur ; Kathleen ANGKUSTSIRI, Auteur ; Marjorie SOLOMON, Auteur ; Sally J ROGERS, Auteur ; Paul ASHWOOD, Auteur ; Daphne S SAY, Auteur ; Sonny CACERES, Auteur ; Shayan M ALAVYNEJAD, Auteur ; Brianna HEATH, Auteur ; David G. AMARAL, Auteur ; Christine WU NORDAHL, Auteur . - p.2832-2845. Langues : Anglais (eng) in Autism > 29-11 (November 2025) . - p.2832-2845 Mots-clés : chronic GI  GI dysfunction  GI issues  GI symptoms  impaired behavior  longitudinal  medical problems Index. décimale : PER Périodiques Résumé : Gastrointestinal symptoms are frequently reported in children diagnosed with autism spectrum disorder. This study sought to determine the longitudinal trajectory of gastrointestinal symptoms without a medical etiology in children with autism compared to similar aged participants with typical development. A total of 475 children enrolled in this longitudinal study (322 autism spectrum disorder and 153 typical development groups) were evaluated at up to three time points between 2 and 12 years of age. Nine common gastrointestinal symptoms and formal medical gastrointestinal diagnosis were assessed using a physician-administered parent interview. A rigorous symptom classification was performed by physicians via clinical consensus. The frequency and persistence of gastrointestinal symptoms across childhood were compared between groups. Associations between gastrointestinal symptoms and measures of internalizing and externalizing behaviors, sleep problems, sensory problems, restricted and repetitive behaviors, and social communication were also evaluated. Children with autism presented with more gastrointestinal symptoms at each time point, and they were also more likely to experience multiple and persistent gastrointestinal symptoms. The presence and number of gastrointestinal symptoms were associated with greater impairment in internalizing behaviors, sleep, communication, sensory processing, and repetitive behaviors. Participants in the autism spectrum disorder group reported more gastrointestinal symptoms without known etiology throughout childhood in this longitudinal well-characterized sample.Lay Abstract Children with autism have been found to experience more medical issues including gastrointestinal symptoms. In this study, participants in the autism group were more likely to experience gastrointestinal symptoms than their typically developing peers. They were also more likely to experience multiple gastrointestinal symptoms at the same time and more likely to have persistent gastrointestinal symptoms throughout their childhood. Increased gastrointestinal symptoms were associated with more challenges with sleep, communication, sensory processing, and repetitive behaviors. Clinicians and parents should become more aware of the high occurrence of gastrointestinal problems in children with autism. If identified, these symptoms are often treatable which may improve their well-being. En ligne : https://dx.doi.org/10.1177/13623613251362349 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=570

Prediction of internalizing and externalizing symptoms in late childhood from attention-deficit/hyperactivity disorder symptoms in early childhood / Agnieszka MLODNICKA in Development and Psychopathology, 37-2 (May 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-2 (May 2025) . - p.815-824 Titre : Prediction of internalizing and externalizing symptoms in late childhood from attention-deficit/hyperactivity disorder symptoms in early childhood Type de document : texte imprimé Auteurs : Agnieszka MLODNICKA, Auteur ; Maxwell MANSOLF, Auteur ; Aruna CHANDRAN, Auteur ; Izzuddin M. ARIS, Auteur ; Catrina A. CALUB, Auteur ; Shaikh I. Ahmad, Auteur ; Allison SHAPIRO, Auteur ; David COCHRAN, Auteur ; Bibiana RESTREPO, Auteur ; Rebecca SCHMIDT, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Deborah BENNETT, Auteur ; Diane R. GOLD, Auteur ; T. Michael O'SHEA, Auteur ; Leslie LEVE, Auteur ; Julie B. SCHWEITZER, Auteur Article en page(s) : p.815-824 Langues : Anglais (eng) Mots-clés : ADHD  conduct symptoms  depression  puberty  sex Index. décimale : PER Périodiques Résumé : Limited analyses based on national samples have assessed whether early attention-deficit/hyperactivity disorder (ADHD) symptoms predict later internalizing and externalizing symptoms in youth and the influence of sex and pubertal timing on subsequent psychiatric symptoms. This study analyzed data (n = 2818) from the Environmental influences on Child Health Outcomes Program national cohort. Analyses used data from early childhood (mean age = 5.3 years) utilizing parent-reported ADHD symptoms to predict rates of internalizing and externalizing symptoms from late childhood/adolescence (mean age = 11.9 years). Within a subsample age at peak height velocity (APHV) acted as a proxy to assess pubertal timing from early childhood (mean age = 5.4 years) to adolescence (mean age = 12.3 years). Early-childhood ADHD symptoms predicted later psychiatric symptoms, including anxiety, depression, aggressive behavior, conduct problems, oppositional defiant disorder, and rule-breaking behavior. Earlier APHV was associated with increased Conduct Disorder symptoms from late childhood to adolescence for females only. A stronger relation between ADHD symptoms and later aggression was observed in females with earlier APHV, whereas this same pattern with aggression, conduct problems and depression was observed in males with later APHV. Clinicians should consider that both young girls and boys with elevated ADHD symptoms, particularly with off-set pubertal timing, may be at risk for later psychiatric symptoms. En ligne : https://dx.doi.org/10.1017/S0954579424000695 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=552 [article] Prediction of internalizing and externalizing symptoms in late childhood from attention-deficit/hyperactivity disorder symptoms in early childhood [texte imprimé] / Agnieszka MLODNICKA, Auteur ; Maxwell MANSOLF, Auteur ; Aruna CHANDRAN, Auteur ; Izzuddin M. ARIS, Auteur ; Catrina A. CALUB, Auteur ; Shaikh I. Ahmad, Auteur ; Allison SHAPIRO, Auteur ; David COCHRAN, Auteur ; Bibiana RESTREPO, Auteur ; Rebecca SCHMIDT, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Deborah BENNETT, Auteur ; Diane R. GOLD, Auteur ; T. Michael O'SHEA, Auteur ; Leslie LEVE, Auteur ; Julie B. SCHWEITZER, Auteur . - p.815-824. Langues : Anglais (eng) in Development and Psychopathology > 37-2 (May 2025) . - p.815-824 Mots-clés : ADHD  conduct symptoms  depression  puberty  sex Index. décimale : PER Périodiques Résumé : Limited analyses based on national samples have assessed whether early attention-deficit/hyperactivity disorder (ADHD) symptoms predict later internalizing and externalizing symptoms in youth and the influence of sex and pubertal timing on subsequent psychiatric symptoms. This study analyzed data (n = 2818) from the Environmental influences on Child Health Outcomes Program national cohort. Analyses used data from early childhood (mean age = 5.3 years) utilizing parent-reported ADHD symptoms to predict rates of internalizing and externalizing symptoms from late childhood/adolescence (mean age = 11.9 years). Within a subsample age at peak height velocity (APHV) acted as a proxy to assess pubertal timing from early childhood (mean age = 5.4 years) to adolescence (mean age = 12.3 years). Early-childhood ADHD symptoms predicted later psychiatric symptoms, including anxiety, depression, aggressive behavior, conduct problems, oppositional defiant disorder, and rule-breaking behavior. Earlier APHV was associated with increased Conduct Disorder symptoms from late childhood to adolescence for females only. A stronger relation between ADHD symptoms and later aggression was observed in females with earlier APHV, whereas this same pattern with aggression, conduct problems and depression was observed in males with later APHV. Clinicians should consider that both young girls and boys with elevated ADHD symptoms, particularly with off-set pubertal timing, may be at risk for later psychiatric symptoms. En ligne : https://dx.doi.org/10.1017/S0954579424000695 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=552

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