Factors associated with enrollment into a clinical trial of caregiver-implemented intervention for infants at risk for autism spectrum disorder / Jessica BRADSHAW in Autism, 24-7 (October 2020)  

Public ISBD [article]  inAutism > 24-7 (October 2020) . - p.1874-1884 Titre : Factors associated with enrollment into a clinical trial of caregiver-implemented intervention for infants at risk for autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Jessica BRADSHAW, Auteur ; Ashley TRUMBULL, Auteur ; Jennifer STAPEL-WAX, Auteur ; Scott GILLESPIE, Auteur ; Nisha GEORGE, Auteur ; Celine A. SAULNIER, Auteur ; Cheryl KLAIMAN, Auteur ; Juliann WOODS, Auteur ; Nathan A. CALL, Auteur ; Ami KLIN, Auteur ; Amy M. WETHERBY, Auteur Article en page(s) : p.1874-1884 Langues : Anglais (eng) Mots-clés : *autism spectrum disorders  *clinical trial  *communication and language  *infant  *interventions—psychosocial/behavioral Index. décimale : PER Périodiques Résumé : Early intervention helps to address developmental delays in young children with autism spectrum disorder. Yet, research suggests there are barriers to enrollment into research studies that test the effectiveness of these interventions for infants at risk. This study identifies family characteristics that were associated with agreement to enroll in a clinical trial of early intervention for 12-month-old infants at risk for autism spectrum disorder. As part of a large longitudinal study, infants were evaluated for early signs of autism spectrum disorder at 1?year of age. Of the fifty-seven infants who were showing signs of autism and deemed eligible for the early intervention trial, 44% declined enrollment. Results suggest that families were more likely to decline enrolling into the intervention study if the mother was working full time, the total household income was between US$60,000 and US$100,000, and they lived further from the clinic. In contrast, infant autism symptoms and parental concern at 12?months were not significantly associated with enrollment. These findings highlight the need for intervention studies that are more accessible to parents, for example, intervention that takes place in the home, in addition to more research on how parental understanding of, and willingness to act on, early social-communication delays impact intervention study enrollment. Future research can then examine how to address these barriers to enrollment in early intervention studies. Such findings will shed light on best practices for dissemination of early identification and intervention strategies. En ligne : http://dx.doi.org/10.1177/1362361320928829 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431 [article] Factors associated with enrollment into a clinical trial of caregiver-implemented intervention for infants at risk for autism spectrum disorder [Texte imprimé et/ou numérique] / Jessica BRADSHAW, Auteur ; Ashley TRUMBULL, Auteur ; Jennifer STAPEL-WAX, Auteur ; Scott GILLESPIE, Auteur ; Nisha GEORGE, Auteur ; Celine A. SAULNIER, Auteur ; Cheryl KLAIMAN, Auteur ; Juliann WOODS, Auteur ; Nathan A. CALL, Auteur ; Ami KLIN, Auteur ; Amy M. WETHERBY, Auteur . - p.1874-1884. Langues : Anglais (eng) in Autism > 24-7 (October 2020) . - p.1874-1884 Mots-clés : *autism spectrum disorders  *clinical trial  *communication and language  *infant  *interventions—psychosocial/behavioral Index. décimale : PER Périodiques Résumé : Early intervention helps to address developmental delays in young children with autism spectrum disorder. Yet, research suggests there are barriers to enrollment into research studies that test the effectiveness of these interventions for infants at risk. This study identifies family characteristics that were associated with agreement to enroll in a clinical trial of early intervention for 12-month-old infants at risk for autism spectrum disorder. As part of a large longitudinal study, infants were evaluated for early signs of autism spectrum disorder at 1?year of age. Of the fifty-seven infants who were showing signs of autism and deemed eligible for the early intervention trial, 44% declined enrollment. Results suggest that families were more likely to decline enrolling into the intervention study if the mother was working full time, the total household income was between US$60,000 and US$100,000, and they lived further from the clinic. In contrast, infant autism symptoms and parental concern at 12?months were not significantly associated with enrollment. These findings highlight the need for intervention studies that are more accessible to parents, for example, intervention that takes place in the home, in addition to more research on how parental understanding of, and willingness to act on, early social-communication delays impact intervention study enrollment. Future research can then examine how to address these barriers to enrollment in early intervention studies. Such findings will shed light on best practices for dissemination of early identification and intervention strategies. En ligne : http://dx.doi.org/10.1177/1362361320928829 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431

The earlier the better: An RCT of treatment timing effects for toddlers on the autism spectrum / Whitney GUTHRIE in Autism, 27-8 (November 2023)  

Public ISBD [article]  inAutism > 27-8 (November 2023) . - p.2295-2309 Titre : The earlier the better: An RCT of treatment timing effects for toddlers on the autism spectrum Type de document : Texte imprimé et/ou numérique Auteurs : Whitney GUTHRIE, Auteur ; Amy M WETHERBY, Auteur ; Juliann WOODS, Auteur ; Christopher SCHATSCHNEIDER, Auteur ; Renee D HOLLAND, Auteur ; Lindee MORGAN, Auteur ; Catherine E LORD, Auteur Article en page(s) : p.2295-2309 Mots-clés : autism  early intervention  Early Social Interaction  parent coaching  toddlers Index. décimale : PER Périodiques Résumé : Robust evidence supports the efficacy of early autism intervention. Despite broad consensus that earlier intervention leads to better outcomes, evidence for this has been limited to correlational studies. This study examined timing effects of the Early Social Interaction (ESI) model, a parent-implemented intervention, using a complete crossover randomized controlled trial (RCT). Effects of Individual-ESI were compared when initiated at 18 or 27?months of age, and also contrasted with effects of the less intensive Group-ESI as an active control condition. Participants included 82 autistic toddlers who received 9?months of Individual-ESI and 9?months of Group-ESI, with the timing/order randomized. Blinded clinicians completed assessments at baseline (18?months of age), end of Condition 1 (27?months), and end of Condition 2 (36?months). Toddlers randomized to Individual-ESI at 18?months showed greater gains during treatment than those starting Individual-ESI at 27?months in receptive/expressive language, social communication, and daily living skills. This pattern was not observed for Group-ESI, demonstrating that timing effects were specific to Individual-ESI and ruling out maturation effects. This RCT demonstrated that earlier intensive, individualized intervention led to greater improvements, and suggests that even a narrow window of 18 versus 27?months may impact child outcomes.Lay abstractBehavioral interventions that incorporate naturalistic, developmental strategies have been shown to improve outcomes for young children who receive an autism spectrum disorder (ASD) diagnosis. Although there is broad consensus that children on the spectrum should begin supports as soon as possible, the empirical evidence for this is relatively limited and little is known about the optimal age to start autism-specific interventions. Our team conducted a randomized controlled trial (RCT) to test the effects of starting intervention at different ages, using the Early Social Interaction (ESI) model, a parent-implemented intervention for toddlers on the spectrum. Participants included 82 autistic toddlers and their caregiver(s) who received 9 months of Individual-ESI and 9 months of Group-ESI, with the timing/order of these two treatment conditions randomized. Thus, families received the more intensive and individualized Individual-ESI at either 18 or 27?months of age. Results revealed that children who received Individual-ESI earlier showed greater treatment gains than those who received this intervention later. Gains were demonstrated in several areas, which included the use and understanding of language, social use of communication skills, and self-help skills. Importantly, these findings were specific to the intensive and individualized parent coaching model compared to group-based treatment, allowing us to rule out the possibility that these timing effects were due to children getting older rather than the treatment itself. Our results suggest that even a narrow window of 18 versus 27?months may have an impact on outcomes and underscore the importance of screening and evaluation as young as possible. En ligne : http://dx.doi.org/10.1177/13623613231159153 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513 [article] The earlier the better: An RCT of treatment timing effects for toddlers on the autism spectrum [Texte imprimé et/ou numérique] / Whitney GUTHRIE, Auteur ; Amy M WETHERBY, Auteur ; Juliann WOODS, Auteur ; Christopher SCHATSCHNEIDER, Auteur ; Renee D HOLLAND, Auteur ; Lindee MORGAN, Auteur ; Catherine E LORD, Auteur . - p.2295-2309. in Autism > 27-8 (November 2023) . - p.2295-2309 Mots-clés : autism  early intervention  Early Social Interaction  parent coaching  toddlers Index. décimale : PER Périodiques Résumé : Robust evidence supports the efficacy of early autism intervention. Despite broad consensus that earlier intervention leads to better outcomes, evidence for this has been limited to correlational studies. This study examined timing effects of the Early Social Interaction (ESI) model, a parent-implemented intervention, using a complete crossover randomized controlled trial (RCT). Effects of Individual-ESI were compared when initiated at 18 or 27?months of age, and also contrasted with effects of the less intensive Group-ESI as an active control condition. Participants included 82 autistic toddlers who received 9?months of Individual-ESI and 9?months of Group-ESI, with the timing/order randomized. Blinded clinicians completed assessments at baseline (18?months of age), end of Condition 1 (27?months), and end of Condition 2 (36?months). Toddlers randomized to Individual-ESI at 18?months showed greater gains during treatment than those starting Individual-ESI at 27?months in receptive/expressive language, social communication, and daily living skills. This pattern was not observed for Group-ESI, demonstrating that timing effects were specific to Individual-ESI and ruling out maturation effects. This RCT demonstrated that earlier intensive, individualized intervention led to greater improvements, and suggests that even a narrow window of 18 versus 27?months may impact child outcomes.Lay abstractBehavioral interventions that incorporate naturalistic, developmental strategies have been shown to improve outcomes for young children who receive an autism spectrum disorder (ASD) diagnosis. Although there is broad consensus that children on the spectrum should begin supports as soon as possible, the empirical evidence for this is relatively limited and little is known about the optimal age to start autism-specific interventions. Our team conducted a randomized controlled trial (RCT) to test the effects of starting intervention at different ages, using the Early Social Interaction (ESI) model, a parent-implemented intervention for toddlers on the spectrum. Participants included 82 autistic toddlers and their caregiver(s) who received 9 months of Individual-ESI and 9 months of Group-ESI, with the timing/order of these two treatment conditions randomized. Thus, families received the more intensive and individualized Individual-ESI at either 18 or 27?months of age. Results revealed that children who received Individual-ESI earlier showed greater treatment gains than those who received this intervention later. Gains were demonstrated in several areas, which included the use and understanding of language, social use of communication skills, and self-help skills. Importantly, these findings were specific to the intensive and individualized parent coaching model compared to group-based treatment, allowing us to rule out the possibility that these timing effects were due to children getting older rather than the treatment itself. Our results suggest that even a narrow window of 18 versus 27?months may have an impact on outcomes and underscore the importance of screening and evaluation as young as possible. En ligne : http://dx.doi.org/10.1177/13623613231159153 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513

The Early Screening for Autism and Communication Disorders: Field-testing an autism-specific screening tool for children 12 to 36 months of age / Amy M. WETHERBY in Autism, 26-7 (October 2022)  

Public ISBD [article]  inAutism > 26-7 (October 2022) . - p.2112-2123 Titre : The Early Screening for Autism and Communication Disorders: Field-testing an autism-specific screening tool for children 12 to 36 months of age Type de document : Texte imprimé et/ou numérique Auteurs : Amy M. WETHERBY, Auteur ; Whitney GUTHRIE, Auteur ; Jessica L HOOKER, Auteur ; Abigail D. DELEHANTY, Auteur ; Taylor N. DAY, Auteur ; Juliann WOODS, Auteur ; Karen PIERCE, Auteur ; Stacy S. MANWARING, Auteur ; Audrey THURM, Auteur ; Sally OZONOFF, Auteur ; Eva PETKOVA, Auteur ; Catherine LORD, Auteur Article en page(s) : p.2112-2123 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder  Child  Child, Preschool  Communication Disorders/diagnosis  Humans  Infant  Mass Screening  Sensitivity and Specificity  Early Screening for Autism and Communication Disorders  autism spectrum disorder  field-testing  screening  validation  potential conflicts of interest with respect to the research, authorship, and/or  publication of this article: A.M.W. is co-author of the Communication and  Symbolic Behavior Scales and receives royalties but not from this study.  Catherine Lord is author of the Autism Diagnostic Observation Schedule–Second  Edition (ADOS-2). C.L. and W.G. are authors of the ADOS Toddler Module (ADOS-T).  They receive royalties from use of the ADOS-2/ADOS-T, but not from this study.  The remaining authors have no financial relationships relevant to this article to  disclose. Index. décimale : PER Périodiques Résumé : There is a critical need for accurate screening tools for autism spectrum disorder in very young children so families can access tailored intervention services as early as possible. However, there are few screeners designed for children 18-24months. Developing screeners that pick up on the signs of autism spectrum disorder in very young children has proved even more challenging. In this study, we examined a new autism-specific parent-report screening tool, the Early Screening for Autism and Communication Disorders for children between 12 and 36months of age. Field-testing was done in five sites with 471 children screened for communication delays in primary care or referred for familial risk or concern for autism spectrum disorder. The Early Screening for Autism and Communication Disorders was tested in three age groups: 12-17, 18-23, and 24-36months. A best-estimate diagnosis of autism spectrum disorder, developmental delay, or typical development was made. Analyses examined all 46 items and identified 30 items that best discriminated autism spectrum disorder from the non-spectrum groups. Cutoffs were established for each age group with good sensitivity and specificity. Results provide preliminary support for the accuracy of the Early Screening for Autism and Communication Disorders as an autism-specific screener in children 12-36months with elevated risk of communication delay or autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/13623613211012526 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484 [article] The Early Screening for Autism and Communication Disorders: Field-testing an autism-specific screening tool for children 12 to 36 months of age [Texte imprimé et/ou numérique] / Amy M. WETHERBY, Auteur ; Whitney GUTHRIE, Auteur ; Jessica L HOOKER, Auteur ; Abigail D. DELEHANTY, Auteur ; Taylor N. DAY, Auteur ; Juliann WOODS, Auteur ; Karen PIERCE, Auteur ; Stacy S. MANWARING, Auteur ; Audrey THURM, Auteur ; Sally OZONOFF, Auteur ; Eva PETKOVA, Auteur ; Catherine LORD, Auteur . - p.2112-2123. Langues : Anglais (eng) in Autism > 26-7 (October 2022) . - p.2112-2123 Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder  Child  Child, Preschool  Communication Disorders/diagnosis  Humans  Infant  Mass Screening  Sensitivity and Specificity  Early Screening for Autism and Communication Disorders  autism spectrum disorder  field-testing  screening  validation  potential conflicts of interest with respect to the research, authorship, and/or  publication of this article: A.M.W. is co-author of the Communication and  Symbolic Behavior Scales and receives royalties but not from this study.  Catherine Lord is author of the Autism Diagnostic Observation Schedule–Second  Edition (ADOS-2). C.L. and W.G. are authors of the ADOS Toddler Module (ADOS-T).  They receive royalties from use of the ADOS-2/ADOS-T, but not from this study.  The remaining authors have no financial relationships relevant to this article to  disclose. Index. décimale : PER Périodiques Résumé : There is a critical need for accurate screening tools for autism spectrum disorder in very young children so families can access tailored intervention services as early as possible. However, there are few screeners designed for children 18-24months. Developing screeners that pick up on the signs of autism spectrum disorder in very young children has proved even more challenging. In this study, we examined a new autism-specific parent-report screening tool, the Early Screening for Autism and Communication Disorders for children between 12 and 36months of age. Field-testing was done in five sites with 471 children screened for communication delays in primary care or referred for familial risk or concern for autism spectrum disorder. The Early Screening for Autism and Communication Disorders was tested in three age groups: 12-17, 18-23, and 24-36months. A best-estimate diagnosis of autism spectrum disorder, developmental delay, or typical development was made. Analyses examined all 46 items and identified 30 items that best discriminated autism spectrum disorder from the non-spectrum groups. Cutoffs were established for each age group with good sensitivity and specificity. Results provide preliminary support for the accuracy of the Early Screening for Autism and Communication Disorders as an autism-specific screener in children 12-36months with elevated risk of communication delay or autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/13623613211012526 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484

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