Affording autism an early brain development re-definition / Ami KLIN in Development and Psychopathology, 32-4 (October 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-4 (October 2020) . - p.1175-1189 Titre : Affording autism an early brain development re-definition Type de document : texte imprimé Auteurs : Ami KLIN, Auteur ; Megan MICHELETTI, Auteur ; Cheryl KLAIMAN, Auteur ; Sarah SHULTZ, Auteur ; John N. CONSTANTINO, Auteur ; Warren JONES, Auteur Article en page(s) : p.1175-1189 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  brain development  definition  early diagnosis  early intervention Index. décimale : PER Périodiques Résumé : The national priority to advance early detection and intervention for children with autism spectrum disorder (ASD) has not reduced the late age of ASD diagnosis in the US over several consecutive Centers for Disease Control and Prevention (CDC) surveillance cohorts, with traditionally under-served populations accessing diagnosis later still. In this review, we explore a potential perceptual barrier to this enterprise which views ASD in terms that are contradicted by current science, and which may have its origins in the current definition of the condition and in its historical associations. To address this perceptual barrier, we propose a re-definition of ASD in early brain development terms, with a view to revisit the world of opportunities afforded by current science to optimize children's outcomes despite the risks that they are born with. This view is presented here to counter outdated notions that potentially devastating disability is determined the moment a child is born, and that these burdens are inevitable, with opportunities for improvement being constrained to only alleviation of symptoms or limited improvements in adaptive skills. The impetus for this piece is the concern that such views of complex neurodevelopmental conditions, such as ASD, can become self-fulfilling science and policy, in ways that are diametrically opposed to what we currently know, and are learning every day, of how genetic risk becomes, or not, instantiated as lifetime disabilities. En ligne : http://dx.doi.org/10.1017/s0954579420000802 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433 [article] Affording autism an early brain development re-definition [texte imprimé] / Ami KLIN, Auteur ; Megan MICHELETTI, Auteur ; Cheryl KLAIMAN, Auteur ; Sarah SHULTZ, Auteur ; John N. CONSTANTINO, Auteur ; Warren JONES, Auteur . - p.1175-1189. Langues : Anglais (eng) in Development and Psychopathology > 32-4 (October 2020) . - p.1175-1189 Mots-clés : autism spectrum disorder  brain development  definition  early diagnosis  early intervention Index. décimale : PER Périodiques Résumé : The national priority to advance early detection and intervention for children with autism spectrum disorder (ASD) has not reduced the late age of ASD diagnosis in the US over several consecutive Centers for Disease Control and Prevention (CDC) surveillance cohorts, with traditionally under-served populations accessing diagnosis later still. In this review, we explore a potential perceptual barrier to this enterprise which views ASD in terms that are contradicted by current science, and which may have its origins in the current definition of the condition and in its historical associations. To address this perceptual barrier, we propose a re-definition of ASD in early brain development terms, with a view to revisit the world of opportunities afforded by current science to optimize children's outcomes despite the risks that they are born with. This view is presented here to counter outdated notions that potentially devastating disability is determined the moment a child is born, and that these burdens are inevitable, with opportunities for improvement being constrained to only alleviation of symptoms or limited improvements in adaptive skills. The impetus for this piece is the concern that such views of complex neurodevelopmental conditions, such as ASD, can become self-fulfilling science and policy, in ways that are diametrically opposed to what we currently know, and are learning every day, of how genetic risk becomes, or not, instantiated as lifetime disabilities. En ligne : http://dx.doi.org/10.1017/s0954579420000802 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433

Autisme profond : Pourquoi en avons-nous besoin ? Qu'est ce c'est ? Quelle est la prochaine étape ? / Catherine LORD in Bulletin Scientifique de l'arapi (Le), 55 (2025/1)

Public ISBD [article]  inBulletin Scientifique de l'arapi (Le) > 55 (2025/1) . - p.5-13 Titre : Autisme profond : Pourquoi en avons-nous besoin ? Qu'est ce c'est ? Quelle est la prochaine étape ? Type de document : texte imprimé Auteurs : Catherine LORD, Auteur ; Megan MICHELETTI, Auteur ; Bernadette ROGE, Auteur Année de publication : 2025 Article en page(s) : p.5-13 Langues : Français (fre) Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571 [article] Autisme profond : Pourquoi en avons-nous besoin ? Qu'est ce c'est ? Quelle est la prochaine étape ? [texte imprimé] / Catherine LORD, Auteur ; Megan MICHELETTI, Auteur ; Bernadette ROGE, Auteur . - 2025 . - p.5-13. Langues : Français (fre) in Bulletin Scientifique de l'arapi (Le) > 55 (2025/1) . - p.5-13 Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571

Research Review: Outcomes of 24- to 36-month-old children with autism spectrum disorder vary by ascertainment strategy: a systematic review and meta-analysis / Megan MICHELETTI in Journal of Child Psychology and Psychiatry, 61-1 (January 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-1 (January 2020) . - p.4-17 Titre : Research Review: Outcomes of 24- to 36-month-old children with autism spectrum disorder vary by ascertainment strategy: a systematic review and meta-analysis Type de document : texte imprimé Auteurs : Megan MICHELETTI, Auteur ; Courtney E. MCCRACKEN, Auteur ; John N. CONSTANTINO, Auteur ; David S. MANDELL, Auteur ; Warren JONES, Auteur ; Ami KLIN, Auteur Article en page(s) : p.4-17 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  meta-analysis  outcomes  sampling bias  surveillance  systematic review  toddlers Index. décimale : PER Périodiques Résumé : BACKGROUND: Despite widespread recommendations for early surveillance of risk for autism spectrum disorder (ASD), no research to date has shown that early surveillance leads to better clinical outcomes. Preliminary research has suggested that children with ASD ascertained via prospective follow-up have better outcomes than those ascertained via community referral. Because prospective studies include early surveillance, by comparing outcomes of children with ASD across ascertainment strategies, we may gain insight into the effects of early surveillance relative to its absence. METHODS: A systematic review was conducted to identify studies reporting outcomes of 24- to 36-month-olds with ASD ascertained via prospective follow-up, community referral, or universal screening. A meta-analysis using a random effects model was used to calculate overall effect size estimates for developmental level and symptom severity across ascertainment cohorts. RESULTS: Eleven prospective, ten community referral, and eight universal screening studies were identified, reporting on 1,658 toddlers with ASD. We found no differences in outcomes between community referral and universal screening studies. Relative to both, prospective studies reported significantly higher developmental levels and lower symptom severities. CONCLUSIONS: Outcomes of young children with ASD ascertained via prospective follow-up are better than those of children with ASD recruited via community referral or universal screening. Although we discuss why sampling bias is not likely the driving force behind these findings, we cannot rule out the possibility that sampling bias contributes to the observed differences; future studies should probe the effects of sociodemographic variables on clinical outcomes as a function of ascertainment strategy. This limitation notwithstanding, our results raise the possibility that prospective follow-up may confer a 'surveillance effect' that contributes to improved developmental and diagnostic outcomes in children with ASD. Future research should test this hypothesis and determine the specific mechanism by which surveillance may improve outcomes. En ligne : http://dx.doi.org/10.1111/jcpp.13057 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=413 [article] Research Review: Outcomes of 24- to 36-month-old children with autism spectrum disorder vary by ascertainment strategy: a systematic review and meta-analysis [texte imprimé] / Megan MICHELETTI, Auteur ; Courtney E. MCCRACKEN, Auteur ; John N. CONSTANTINO, Auteur ; David S. MANDELL, Auteur ; Warren JONES, Auteur ; Ami KLIN, Auteur . - p.4-17. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-1 (January 2020) . - p.4-17 Mots-clés : Autism spectrum disorder  meta-analysis  outcomes  sampling bias  surveillance  systematic review  toddlers Index. décimale : PER Périodiques Résumé : BACKGROUND: Despite widespread recommendations for early surveillance of risk for autism spectrum disorder (ASD), no research to date has shown that early surveillance leads to better clinical outcomes. Preliminary research has suggested that children with ASD ascertained via prospective follow-up have better outcomes than those ascertained via community referral. Because prospective studies include early surveillance, by comparing outcomes of children with ASD across ascertainment strategies, we may gain insight into the effects of early surveillance relative to its absence. METHODS: A systematic review was conducted to identify studies reporting outcomes of 24- to 36-month-olds with ASD ascertained via prospective follow-up, community referral, or universal screening. A meta-analysis using a random effects model was used to calculate overall effect size estimates for developmental level and symptom severity across ascertainment cohorts. RESULTS: Eleven prospective, ten community referral, and eight universal screening studies were identified, reporting on 1,658 toddlers with ASD. We found no differences in outcomes between community referral and universal screening studies. Relative to both, prospective studies reported significantly higher developmental levels and lower symptom severities. CONCLUSIONS: Outcomes of young children with ASD ascertained via prospective follow-up are better than those of children with ASD recruited via community referral or universal screening. Although we discuss why sampling bias is not likely the driving force behind these findings, we cannot rule out the possibility that sampling bias contributes to the observed differences; future studies should probe the effects of sociodemographic variables on clinical outcomes as a function of ascertainment strategy. This limitation notwithstanding, our results raise the possibility that prospective follow-up may confer a 'surveillance effect' that contributes to improved developmental and diagnostic outcomes in children with ASD. Future research should test this hypothesis and determine the specific mechanism by which surveillance may improve outcomes. En ligne : http://dx.doi.org/10.1111/jcpp.13057 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=413

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