Early behavioral profiles elucidating vulnerability and resiliency to later ASD outcomes / Rebecca J. LANDA in Development and Psychopathology, 32-4 (October 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-4 (October 2020) . - p.1217-1229 Titre : Early behavioral profiles elucidating vulnerability and resiliency to later ASD outcomes Type de document : Texte imprimé et/ou numérique Auteurs : Rebecca J. LANDA, Auteur ; Rachel REETZKE, Auteur ; Madiha TAHSEEN, Auteur ; Christine Reiner HESS, Auteur Article en page(s) : p.1217-1229 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  high-risk siblings  resilience  symptomology  vulnerability Index. décimale : PER Périodiques Résumé : Infant siblings of children with autism spectrum disorder (ASD) exhibit greater heterogeneity in behavioral presentation and outcomes relative to infants at low familial risk (LR), yet there is limited understanding of the diverse developmental profiles that characterize these infants. We applied a hierarchical agglomerative cluster analysis approach to parse developmental heterogeneity in 420 toddlers with heightened (HR) and low (LR) familial risk for ASD using measures of four dimensions of development: language, social, play, and restricted and repetitive behaviors (RRB). Results revealed a two-cluster solution. Comparisons of clusters revealed significantly lower language, social, and play performance, and higher levels of restricted and repetitive behaviors in Cluster 1 relative to Cluster 2. In Cluster 1, 25% of children were later diagnosed with ASD compared to 8% in Cluster 2. Comparisons within Cluster 1 between subgroups of toddlers having ASD+ versus ASD- 36-month outcomes revealed significantly lower functioning in the ASD+ subgroup across cognitive, motor, social, language, symbolic, and speech dimensions. Findings suggest profiles of early development associated with resiliency and vulnerability to later ASD diagnosis, with multidimensional developmental lags signaling vulnerability to ASD diagnosis. En ligne : http://dx.doi.org/10.1017/s0954579420000814 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433 [article] Early behavioral profiles elucidating vulnerability and resiliency to later ASD outcomes [Texte imprimé et/ou numérique] / Rebecca J. LANDA, Auteur ; Rachel REETZKE, Auteur ; Madiha TAHSEEN, Auteur ; Christine Reiner HESS, Auteur . - p.1217-1229. Langues : Anglais (eng) in Development and Psychopathology > 32-4 (October 2020) . - p.1217-1229 Mots-clés : autism spectrum disorder  high-risk siblings  resilience  symptomology  vulnerability Index. décimale : PER Périodiques Résumé : Infant siblings of children with autism spectrum disorder (ASD) exhibit greater heterogeneity in behavioral presentation and outcomes relative to infants at low familial risk (LR), yet there is limited understanding of the diverse developmental profiles that characterize these infants. We applied a hierarchical agglomerative cluster analysis approach to parse developmental heterogeneity in 420 toddlers with heightened (HR) and low (LR) familial risk for ASD using measures of four dimensions of development: language, social, play, and restricted and repetitive behaviors (RRB). Results revealed a two-cluster solution. Comparisons of clusters revealed significantly lower language, social, and play performance, and higher levels of restricted and repetitive behaviors in Cluster 1 relative to Cluster 2. In Cluster 1, 25% of children were later diagnosed with ASD compared to 8% in Cluster 2. Comparisons within Cluster 1 between subgroups of toddlers having ASD+ versus ASD- 36-month outcomes revealed significantly lower functioning in the ASD+ subgroup across cognitive, motor, social, language, symbolic, and speech dimensions. Findings suggest profiles of early development associated with resiliency and vulnerability to later ASD diagnosis, with multidimensional developmental lags signaling vulnerability to ASD diagnosis. En ligne : http://dx.doi.org/10.1017/s0954579420000814 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433

Objective measurement of movement variability using wearable sensors predicts ASD outcomes in infants at high likelihood for ASD and ADHD / Sitaram VANGALA ; Rachel REETZKE ; Antonia PIERGIES ; Sally OZONOFF ; Meghan MILLER in Autism Research, 17-6 (June 2024)  

Public ISBD [article]  inAutism Research > 17-6 (June 2024) . - p.1094-1105 Titre : Objective measurement of movement variability using wearable sensors predicts ASD outcomes in infants at high likelihood for ASD and ADHD Type de document : Texte imprimé et/ou numérique Auteurs : Sitaram VANGALA, Auteur ; Rachel REETZKE, Auteur ; Antonia PIERGIES, Auteur ; Sally OZONOFF, Auteur ; Meghan MILLER, Auteur Article en page(s) : p.1094-1105 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Early motor delays and differences are common among children with autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). Yet, little work has shown whether there are early atypical motor signs that differentiate these groups. Quantitative measures of movement variability hold promise for improving the identification of subtle and specific differences in motor function among infants and toddlers at high likelihood for ASD and ADHD. To this end, we created a novel quantitative measure of movement variability (movement curvature) and conducted a preliminary investigation as to whether this measure improves outcome predictions. We used a wearable triaxial accelerometer to evaluate continuous motion-based activity in infants at high and low likelihood for ASD and ADHD at 12, 18, 24, and 36?months of age. At 36?months, participants were categorized into three outcome groups: ASD (n = 19), ADHD concerns (n = 17), and a comparison group (n = 82). We examined group differences in movement curvature and whether movement curvature is predictive of a later ASD or ADHD concerns classification. We found that movement curvature was significantly lower in infants with later ASD diagnosis at 18, 24, and 36?months of age compared to infants with either ADHD concerns or those in the comparison group. Movement curvature was also a significant predictor of ASD at 18, 24, and 36?months (AUC 0.66-0.71; p = 0.005-0.039) and when adjusting for high ASD likelihood at 18 and 24?months (AUC 0.90, p = 0.05-0.019). These results indicate that lower movement curvature may be a feature of early motor differences in infants with later ASD diagnosis as early as 18?months of age. En ligne : https://doi.org/10.1002/aur.3150 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=531 [article] Objective measurement of movement variability using wearable sensors predicts ASD outcomes in infants at high likelihood for ASD and ADHD [Texte imprimé et/ou numérique] / Sitaram VANGALA, Auteur ; Rachel REETZKE, Auteur ; Antonia PIERGIES, Auteur ; Sally OZONOFF, Auteur ; Meghan MILLER, Auteur . - p.1094-1105. Langues : Anglais (eng) in Autism Research > 17-6 (June 2024) . - p.1094-1105 Index. décimale : PER Périodiques Résumé : Abstract Early motor delays and differences are common among children with autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). Yet, little work has shown whether there are early atypical motor signs that differentiate these groups. Quantitative measures of movement variability hold promise for improving the identification of subtle and specific differences in motor function among infants and toddlers at high likelihood for ASD and ADHD. To this end, we created a novel quantitative measure of movement variability (movement curvature) and conducted a preliminary investigation as to whether this measure improves outcome predictions. We used a wearable triaxial accelerometer to evaluate continuous motion-based activity in infants at high and low likelihood for ASD and ADHD at 12, 18, 24, and 36?months of age. At 36?months, participants were categorized into three outcome groups: ASD (n = 19), ADHD concerns (n = 17), and a comparison group (n = 82). We examined group differences in movement curvature and whether movement curvature is predictive of a later ASD or ADHD concerns classification. We found that movement curvature was significantly lower in infants with later ASD diagnosis at 18, 24, and 36?months of age compared to infants with either ADHD concerns or those in the comparison group. Movement curvature was also a significant predictor of ASD at 18, 24, and 36?months (AUC 0.66-0.71; p = 0.005-0.039) and when adjusting for high ASD likelihood at 18 and 24?months (AUC 0.90, p = 0.05-0.019). These results indicate that lower movement curvature may be a feature of early motor differences in infants with later ASD diagnosis as early as 18?months of age. En ligne : https://doi.org/10.1002/aur.3150 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=531

Parental concerns of children with ASD by age: A qualitative analysis / Danika PFEIFFER in Research in Autism Spectrum Disorders, 86 (August 2021)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 86 (August 2021) . - 101817 Titre : Parental concerns of children with ASD by age: A qualitative analysis Type de document : Texte imprimé et/ou numérique Auteurs : Danika PFEIFFER, Auteur ; Calliope HOLINGUE, Auteur ; Emily DILLON, Auteur ; Luke G. KALB, Auteur ; Rachel REETZKE, Auteur ; Rebecca LANDA, Auteur Article en page(s) : 101817 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Parental concerns  Children  Age  Qualitative Index. décimale : PER Périodiques Résumé : Background Eliciting parents’ concerns about their children is an important initial step in the ASD diagnostic process. This information is often collected through forced-choice questionnaires utilizing professional terminology and may limit the potential concerns that can be reported. Parent concern studies to date have largely used deductive qualitative methods with only one age group of children. Inductive qualitative studies are needed to examine parental concerns of children with ASD across age groups with one coding scheme. Method We used an inductive qualitative analysis process to analyze concerns reported by parents of children ages 1–11 years on intake forms (n = 455) at an urban outpatient ASD specialty clinic. Analyses were based on three age groups (toddler, preschooler, middle childhood). Results Using conventional content analysis, 12 categories of concerns emerged from parents’ responses: communication, social, behavioral/emotional, cognition, life skills, atypical behaviors, sensory, academic, health, seeking diagnostic clarity or resources, developmental, and motor skills. We found that parents reported the same concerns about their children across age groups in six of the 12 categories. The biggest difference in reported concerns across age groups was that parents of children in the preschooler and middle childhood groups reported a greater number of concerns related to mental health than parents of toddlers. Conclusion Our analysis yields specific information about similarities and differences in parents’ concerns depending on their child’s age. Ensuring that ASD evaluations are tailored to children’s unique needs has implications for timely diagnosis and access to care. En ligne : https://doi.org/10.1016/j.rasd.2021.101817 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 [article] Parental concerns of children with ASD by age: A qualitative analysis [Texte imprimé et/ou numérique] / Danika PFEIFFER, Auteur ; Calliope HOLINGUE, Auteur ; Emily DILLON, Auteur ; Luke G. KALB, Auteur ; Rachel REETZKE, Auteur ; Rebecca LANDA, Auteur . - 101817. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 86 (August 2021) . - 101817 Mots-clés : Autism spectrum disorders  Parental concerns  Children  Age  Qualitative Index. décimale : PER Périodiques Résumé : Background Eliciting parents’ concerns about their children is an important initial step in the ASD diagnostic process. This information is often collected through forced-choice questionnaires utilizing professional terminology and may limit the potential concerns that can be reported. Parent concern studies to date have largely used deductive qualitative methods with only one age group of children. Inductive qualitative studies are needed to examine parental concerns of children with ASD across age groups with one coding scheme. Method We used an inductive qualitative analysis process to analyze concerns reported by parents of children ages 1–11 years on intake forms (n = 455) at an urban outpatient ASD specialty clinic. Analyses were based on three age groups (toddler, preschooler, middle childhood). Results Using conventional content analysis, 12 categories of concerns emerged from parents’ responses: communication, social, behavioral/emotional, cognition, life skills, atypical behaviors, sensory, academic, health, seeking diagnostic clarity or resources, developmental, and motor skills. We found that parents reported the same concerns about their children across age groups in six of the 12 categories. The biggest difference in reported concerns across age groups was that parents of children in the preschooler and middle childhood groups reported a greater number of concerns related to mental health than parents of toddlers. Conclusion Our analysis yields specific information about similarities and differences in parents’ concerns depending on their child’s age. Ensuring that ASD evaluations are tailored to children’s unique needs has implications for timely diagnosis and access to care. En ligne : https://doi.org/10.1016/j.rasd.2021.101817 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458

Patterns of objectively measured motor activity among infants developing ASD and concerns for ADHD / Rachel REETZKE in Journal of Child Psychology and Psychiatry, 63-6 (June 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-6 (June 2022) . - p.663-673 Titre : Patterns of objectively measured motor activity among infants developing ASD and concerns for ADHD Type de document : Texte imprimé et/ou numérique Auteurs : Rachel REETZKE, Auteur ; Ana-Maria IOSIF, Auteur ; Burt HATCH, Auteur ; Leiana DE LA PAZ, Auteur ; Annie CHUANG, Auteur ; Sally OZONOFF, Auteur ; Meghan MILLER, Auteur Article en page(s) : p.663-673 Langues : Anglais (eng) Mots-clés : Activity level  attention-deficit/hyperactivity disorder  autism spectrum disorder  infancy Index. décimale : PER Périodiques Résumé : BACKGROUND: Heightened motor activity is a hallmark of attention-deficit/hyperactivity disorder (ADHD), yet high activity levels are also often reported in young children with autism spectrum disorder (ASD). It is currently unclear whether increased motor activity represents a distinct versus shared early predictor of ASD and ADHD; no prior studies have directly examined this prospectively. We investigated differences in longitudinal patterns of objectively measured motor activity during early development. METHODS: Participants included 113 infants at high and low risk for ASD or ADHD. Continuous motion-based activity was recorded using tri-axial accelerometers at 12, 18, 24, and 36?months of age. At 36?months, participants were categorized into one of three outcome groups: ASD (n=19), ADHD Concerns (n=17), and Typically Developing (TD; n=77). Group differences in trajectories of motor activity were examined in structured and semistructured contexts. Associations with behaviors relevant to ASD, ADHD, and general development were also examined. RESULTS: In both structured and semistructured contexts, both the ASD and ADHD Concerns groups exhibited heightened activity relative to the TD group by 18?months; the ASD group exhibited higher activity than the ADHD Concerns group at 24-36?months in the structured context only. Attention/behavior regulation, nonverbal, and verbal development-but not social engagement-were differentially associated with objectively measured activity by outcome group across contexts. CONCLUSIONS: Overactivity may be a shared, rather than distinct, precursor of atypical development in infants/toddlers developing ASD and concerns for ADHD, emerging as early as 18?months. Group differences in overactivity may be context-specific and associated with different underlying mechanisms. En ligne : http://dx.doi.org/10.1111/jcpp.13504 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475 [article] Patterns of objectively measured motor activity among infants developing ASD and concerns for ADHD [Texte imprimé et/ou numérique] / Rachel REETZKE, Auteur ; Ana-Maria IOSIF, Auteur ; Burt HATCH, Auteur ; Leiana DE LA PAZ, Auteur ; Annie CHUANG, Auteur ; Sally OZONOFF, Auteur ; Meghan MILLER, Auteur . - p.663-673. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-6 (June 2022) . - p.663-673 Mots-clés : Activity level  attention-deficit/hyperactivity disorder  autism spectrum disorder  infancy Index. décimale : PER Périodiques Résumé : BACKGROUND: Heightened motor activity is a hallmark of attention-deficit/hyperactivity disorder (ADHD), yet high activity levels are also often reported in young children with autism spectrum disorder (ASD). It is currently unclear whether increased motor activity represents a distinct versus shared early predictor of ASD and ADHD; no prior studies have directly examined this prospectively. We investigated differences in longitudinal patterns of objectively measured motor activity during early development. METHODS: Participants included 113 infants at high and low risk for ASD or ADHD. Continuous motion-based activity was recorded using tri-axial accelerometers at 12, 18, 24, and 36?months of age. At 36?months, participants were categorized into one of three outcome groups: ASD (n=19), ADHD Concerns (n=17), and Typically Developing (TD; n=77). Group differences in trajectories of motor activity were examined in structured and semistructured contexts. Associations with behaviors relevant to ASD, ADHD, and general development were also examined. RESULTS: In both structured and semistructured contexts, both the ASD and ADHD Concerns groups exhibited heightened activity relative to the TD group by 18?months; the ASD group exhibited higher activity than the ADHD Concerns group at 24-36?months in the structured context only. Attention/behavior regulation, nonverbal, and verbal development-but not social engagement-were differentially associated with objectively measured activity by outcome group across contexts. CONCLUSIONS: Overactivity may be a shared, rather than distinct, precursor of atypical development in infants/toddlers developing ASD and concerns for ADHD, emerging as early as 18?months. Group differences in overactivity may be context-specific and associated with different underlying mechanisms. En ligne : http://dx.doi.org/10.1111/jcpp.13504 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475

Prevalence of gastrointestinal symptoms among autistic individuals, with and without co-occurring intellectual disability / Calliope HOLINGUE in Autism Research, 16-8 (August 2023)  

Public ISBD [article]  inAutism Research > 16-8 (August 2023) . - p.1609-1618 Titre : Prevalence of gastrointestinal symptoms among autistic individuals, with and without co-occurring intellectual disability Type de document : Texte imprimé et/ou numérique Auteurs : Calliope HOLINGUE, Auteur ; Danika PFEIFFER, Auteur ; Natasha N. LUDWIG, Auteur ; Rachel REETZKE, Auteur ; Ji Su HONG, Auteur ; Luther G. KALB, Auteur ; Rebecca LANDA, Auteur Article en page(s) : p.1609-1618 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Gastrointestinal symptoms (GI) are very common among individuals on the autism spectrum. Prior research reports mixed findings regarding whether individuals with autism and co-occurring intellectual disability (ID) have elevated risk of gastrointestinal symptoms relative to individuals with autism alone. GI symptoms can be challenging to assess in individuals with autism spectrum disorder (ASD) and/or ID given challenges with language, communication, and interoception. Prior research has tended to only include individuals with documented presence or absence of GI symptoms or conditions, that is, to exclude observations in which there is uncertainty regarding presence of GI symptoms. Therefore, none of the prior autism studies reported the association between ID and the certainty regarding presence or absence of GI symptoms. The objective of this study was to examine differences in parental certainty and odds of reporting gastrointestinal signs and symptoms among children on the autism spectrum, with and without intellectual disability. Participants were 308 children (36% ID) with a clinical diagnosis of autism spectrum disorder (6-17?years). Parents endorsed whether their child had experienced or displayed a range of signs or symptoms related to GI problems in the past 3 months. Parents of autistic children with ID were less certain about the presence of more subjective symptoms, including abdominal pain, nausea, and bloating. Conversely, certainty regarding more objective signs (e.g., constipation, diarrhea, spitting up, etc.) was not significantly different. More accurate measures for GI signs/symptoms are needed for this population. En ligne : https://doi.org/10.1002/aur.2972 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510 [article] Prevalence of gastrointestinal symptoms among autistic individuals, with and without co-occurring intellectual disability [Texte imprimé et/ou numérique] / Calliope HOLINGUE, Auteur ; Danika PFEIFFER, Auteur ; Natasha N. LUDWIG, Auteur ; Rachel REETZKE, Auteur ; Ji Su HONG, Auteur ; Luther G. KALB, Auteur ; Rebecca LANDA, Auteur . - p.1609-1618. Langues : Anglais (eng) in Autism Research > 16-8 (August 2023) . - p.1609-1618 Index. décimale : PER Périodiques Résumé : Abstract Gastrointestinal symptoms (GI) are very common among individuals on the autism spectrum. Prior research reports mixed findings regarding whether individuals with autism and co-occurring intellectual disability (ID) have elevated risk of gastrointestinal symptoms relative to individuals with autism alone. GI symptoms can be challenging to assess in individuals with autism spectrum disorder (ASD) and/or ID given challenges with language, communication, and interoception. Prior research has tended to only include individuals with documented presence or absence of GI symptoms or conditions, that is, to exclude observations in which there is uncertainty regarding presence of GI symptoms. Therefore, none of the prior autism studies reported the association between ID and the certainty regarding presence or absence of GI symptoms. The objective of this study was to examine differences in parental certainty and odds of reporting gastrointestinal signs and symptoms among children on the autism spectrum, with and without intellectual disability. Participants were 308 children (36% ID) with a clinical diagnosis of autism spectrum disorder (6-17?years). Parents endorsed whether their child had experienced or displayed a range of signs or symptoms related to GI problems in the past 3 months. Parents of autistic children with ID were less certain about the presence of more subjective symptoms, including abdominal pain, nausea, and bloating. Conversely, certainty regarding more objective signs (e.g., constipation, diarrhea, spitting up, etc.) was not significantly different. More accurate measures for GI signs/symptoms are needed for this population. En ligne : https://doi.org/10.1002/aur.2972 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510

Replication study for ADOS-2 cut-offs to assist evaluation of autism spectrum disorder / Ji Su HONG in Autism Research, 15-11 (November 2022)  

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