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Résultat de la recherche
47 recherche sur le mot-clé 'Age'




Age-related Behavioural Change in Cornelia de Lange and Cri du Chat Syndromes: A Seven Year Follow-up Study / L. COCHRAN in Journal of Autism and Developmental Disorders, 49-6 (June 2019)
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Titre : Age-related Behavioural Change in Cornelia de Lange and Cri du Chat Syndromes: A Seven Year Follow-up Study Type de document : Texte imprimé et/ou numérique Auteurs : L. COCHRAN, Auteur ; A. WELHAM, Auteur ; C. OLIVER, Auteur ; A. ARSHAD, Auteur ; J. F. MOSS, Auteur Article en page(s) : p.2476-2487 Langues : Anglais (eng) Mots-clés : Age Autism spectrum disorder Behaviour Cornelia de Lange syndrome Cri du Chat syndrome Index. décimale : PER Périodiques Résumé : Age-related behavioural change in Cornelia de Lange syndrome is poorly understood. We report a 7 year follow-up study of adaptive behaviour, autism spectrum disorder symptomatology, language skills and behavioural characteristics in 30 individuals with Cornelia de Lange syndrome, compared with 18 individuals with Cri du Chat syndrome. The proportion of individuals with Cornelia de Lange syndrome meeting criteria for autism spectrum disorder on the Autism Diagnostic Observation Schedule increased, although patterns of change were complex. For both syndrome groups, absolute levels of adaptive ability were stable and receptive language improved, suggesting that changes over time do not result from an overall decline in ability. Reliable change index scores indicate heterogeneity within both groups in the occurrence of improvement or decline. En ligne : https://dx.doi.org/10.1007/s10803-019-03966-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400
in Journal of Autism and Developmental Disorders > 49-6 (June 2019) . - p.2476-2487[article] Age-related Behavioural Change in Cornelia de Lange and Cri du Chat Syndromes: A Seven Year Follow-up Study [Texte imprimé et/ou numérique] / L. COCHRAN, Auteur ; A. WELHAM, Auteur ; C. OLIVER, Auteur ; A. ARSHAD, Auteur ; J. F. MOSS, Auteur . - p.2476-2487.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-6 (June 2019) . - p.2476-2487
Mots-clés : Age Autism spectrum disorder Behaviour Cornelia de Lange syndrome Cri du Chat syndrome Index. décimale : PER Périodiques Résumé : Age-related behavioural change in Cornelia de Lange syndrome is poorly understood. We report a 7 year follow-up study of adaptive behaviour, autism spectrum disorder symptomatology, language skills and behavioural characteristics in 30 individuals with Cornelia de Lange syndrome, compared with 18 individuals with Cri du Chat syndrome. The proportion of individuals with Cornelia de Lange syndrome meeting criteria for autism spectrum disorder on the Autism Diagnostic Observation Schedule increased, although patterns of change were complex. For both syndrome groups, absolute levels of adaptive ability were stable and receptive language improved, suggesting that changes over time do not result from an overall decline in ability. Reliable change index scores indicate heterogeneity within both groups in the occurrence of improvement or decline. En ligne : https://dx.doi.org/10.1007/s10803-019-03966-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400 Age-related changes in brain signal variability in autism spectrum disorder / Nicholas KATHREIN ; Elijah GRAGAS ; Lauren KUPIS ; Lucina Q UDDIN ; Jason S NOMI in Molecular Autism, 16 (2025)
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Titre : Age-related changes in brain signal variability in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Nicholas KATHREIN, Auteur ; Elijah GRAGAS, Auteur ; Lauren KUPIS, Auteur ; Lucina Q UDDIN, Auteur ; Jason S NOMI, Auteur Article en page(s) : 8 Langues : Anglais (eng) Mots-clés : Humans Autism Spectrum Disorder/physiopathology/diagnostic imaging Brain/diagnostic imaging/physiopathology Male Adult Female Adolescent Child Magnetic Resonance Imaging Middle Aged Young Adult Child, Preschool Cross-Sectional Studies Age Factors Aging Brain Mapping Asd Age Brain-behavior relationships Mean square successive difference Resting-state fMRI contributions were based on studies approved by the local Institutional Review Boards, and all have approved both the initial data collection and the sharing of fully anonymized data (removing face information from structural images and all 18 Health Insurance Portability and Accountability (HIPAA)-protected health information identifiers). The written informed consent was obtained from all subjects. Detailed information on ethical statements for ABIDE can be found at http://fcon_1000.projects.nitrc.org/indi/abide/. Consent for publication: Not applicable. Competing interests: The authors declare that they have no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Brain signal variability (BSV) is an important understudied aspect of brain function linked to cognitive flexibility and adaptive behavior. Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social communication difficulties and restricted and repetitive behaviors (RRBs). While atypical brain function has been identified in individuals with ASD using fMRI task-activation and functional connectivity approaches, little is known about age-related relationships with resting-state BSV and repetitive behaviors in ASD. METHODS: We conducted a cross-sectional examination of resting-state BSV and its relationship with age and RRBs in a cohort of individuals with Autism Brain Imaging Data Exchange (n = 351) and typically developing (TD) individuals (n = 402) aged 5-50 years obtained from the Autism Brain Imaging Data Exchange. RRBs were assessed using the Autism Diagnostic Interview-Revised (ADI-RRB) scale. BSV was quantified using the root-mean-square successive difference (rMSSD) of the resting-state fMRI time series. We examined categorical group differences in rMSSD between ASD and TD groups, controlling for both linear and quadratic age. To identify dimensional relationships between age, group, and rMSSD, we utilized interaction regressors for group x age and group x quadratic age. Within a subset of individuals with ASD (269 subjects), we explored the relationship between rMSSD and ADI-RRB scores, both with and without age considerations. The relationship between rMSSD and ADI-RRB scores was further analyzed while accounting for linear and quadratic age. Additionally, we investigated the relationship between BSV, age, and ADI-RRB scores using interaction regressors for age x RRB and quadratic age x RRB. RESULTS: When controlling for linear age effects, we observed significant group differences between individuals with ASD and TD individuals in the default-mode network (DMN) and visual network, with decreased BSV in ASD. Similarly, controlling for quadratic age effects revealed significant group differences in the DMN and visual network. In both cases, individuals with ASD showed decreased BSV compared with TD individuals in these brain regions. The group * age interaction demonstrated significant group differences in the DMN, and visual network brain areas, indicating that rMSSD was greater in older individuals compared with younger individuals in the ASD group, while rMSSD was greater in younger individuals compared with older individuals in the TD group. The group * quadratic age interaction showed significant differences in the brain regions included in DMN, with an inverted U-shaped rMSSD-age relationship in ASD (higher rMSSD in younger individuals that slightly increased into middle age before decreasing) and a U-shaped rMSSD-age relationship in TD (higher rMSSD in younger and older individuals compared with middle-aged individuals). When controlling for linear and quadratic age effects, we found a significant positive association between rMSSD and ADI-RRB scores in brain regions within the DMN, salience, and visual network. While no significant results were observed for the linear age * RRB interaction, a significant association between quadratic age and ADI-RRB scores emerged in the DMN, dorsal attention network, and sensorimotor network. Individuals with high ADI-RRB scores exhibited an inverted U-shaped relationship between rMSSD and age, with lower rMSSD levels observed in both younger and older individuals, and higher rMSSD in middle-aged individuals. Those with mid-range ADI-RRB scores displayed a weak inverted U-shaped rMSSD-age association. In contrast, individuals with low ADI-RRB scores showed a U-shaped rMSSD-age association, with higher rMSSD levels in younger and older individuals, but a lower rMSSD in middle-aged individuals. CONCLUSION: These findings highlight age-related atypical BSV patterns in ASD and their association with repetitive behaviors, contributing to the growing literature on understanding alterations in functional brain maturation in ASD. En ligne : https://dx.doi.org/10.1186/s13229-024-00631-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555
in Molecular Autism > 16 (2025) . - 8[article] Age-related changes in brain signal variability in autism spectrum disorder [Texte imprimé et/ou numérique] / Nicholas KATHREIN, Auteur ; Elijah GRAGAS, Auteur ; Lauren KUPIS, Auteur ; Lucina Q UDDIN, Auteur ; Jason S NOMI, Auteur . - 8.
Langues : Anglais (eng)
in Molecular Autism > 16 (2025) . - 8
Mots-clés : Humans Autism Spectrum Disorder/physiopathology/diagnostic imaging Brain/diagnostic imaging/physiopathology Male Adult Female Adolescent Child Magnetic Resonance Imaging Middle Aged Young Adult Child, Preschool Cross-Sectional Studies Age Factors Aging Brain Mapping Asd Age Brain-behavior relationships Mean square successive difference Resting-state fMRI contributions were based on studies approved by the local Institutional Review Boards, and all have approved both the initial data collection and the sharing of fully anonymized data (removing face information from structural images and all 18 Health Insurance Portability and Accountability (HIPAA)-protected health information identifiers). The written informed consent was obtained from all subjects. Detailed information on ethical statements for ABIDE can be found at http://fcon_1000.projects.nitrc.org/indi/abide/. Consent for publication: Not applicable. Competing interests: The authors declare that they have no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Brain signal variability (BSV) is an important understudied aspect of brain function linked to cognitive flexibility and adaptive behavior. Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social communication difficulties and restricted and repetitive behaviors (RRBs). While atypical brain function has been identified in individuals with ASD using fMRI task-activation and functional connectivity approaches, little is known about age-related relationships with resting-state BSV and repetitive behaviors in ASD. METHODS: We conducted a cross-sectional examination of resting-state BSV and its relationship with age and RRBs in a cohort of individuals with Autism Brain Imaging Data Exchange (n = 351) and typically developing (TD) individuals (n = 402) aged 5-50 years obtained from the Autism Brain Imaging Data Exchange. RRBs were assessed using the Autism Diagnostic Interview-Revised (ADI-RRB) scale. BSV was quantified using the root-mean-square successive difference (rMSSD) of the resting-state fMRI time series. We examined categorical group differences in rMSSD between ASD and TD groups, controlling for both linear and quadratic age. To identify dimensional relationships between age, group, and rMSSD, we utilized interaction regressors for group x age and group x quadratic age. Within a subset of individuals with ASD (269 subjects), we explored the relationship between rMSSD and ADI-RRB scores, both with and without age considerations. The relationship between rMSSD and ADI-RRB scores was further analyzed while accounting for linear and quadratic age. Additionally, we investigated the relationship between BSV, age, and ADI-RRB scores using interaction regressors for age x RRB and quadratic age x RRB. RESULTS: When controlling for linear age effects, we observed significant group differences between individuals with ASD and TD individuals in the default-mode network (DMN) and visual network, with decreased BSV in ASD. Similarly, controlling for quadratic age effects revealed significant group differences in the DMN and visual network. In both cases, individuals with ASD showed decreased BSV compared with TD individuals in these brain regions. The group * age interaction demonstrated significant group differences in the DMN, and visual network brain areas, indicating that rMSSD was greater in older individuals compared with younger individuals in the ASD group, while rMSSD was greater in younger individuals compared with older individuals in the TD group. The group * quadratic age interaction showed significant differences in the brain regions included in DMN, with an inverted U-shaped rMSSD-age relationship in ASD (higher rMSSD in younger individuals that slightly increased into middle age before decreasing) and a U-shaped rMSSD-age relationship in TD (higher rMSSD in younger and older individuals compared with middle-aged individuals). When controlling for linear and quadratic age effects, we found a significant positive association between rMSSD and ADI-RRB scores in brain regions within the DMN, salience, and visual network. While no significant results were observed for the linear age * RRB interaction, a significant association between quadratic age and ADI-RRB scores emerged in the DMN, dorsal attention network, and sensorimotor network. Individuals with high ADI-RRB scores exhibited an inverted U-shaped relationship between rMSSD and age, with lower rMSSD levels observed in both younger and older individuals, and higher rMSSD in middle-aged individuals. Those with mid-range ADI-RRB scores displayed a weak inverted U-shaped rMSSD-age association. In contrast, individuals with low ADI-RRB scores showed a U-shaped rMSSD-age association, with higher rMSSD levels in younger and older individuals, but a lower rMSSD in middle-aged individuals. CONCLUSION: These findings highlight age-related atypical BSV patterns in ASD and their association with repetitive behaviors, contributing to the growing literature on understanding alterations in functional brain maturation in ASD. En ligne : https://dx.doi.org/10.1186/s13229-024-00631-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555 Age and Adaptive Functioning in Children and Adolescents with ASD: The Effects of Intellectual Functioning and ASD Symptom Severity / TreneshaL HILL in Journal of Autism and Developmental Disorders, 45-12 (December 2015)
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Titre : Age and Adaptive Functioning in Children and Adolescents with ASD: The Effects of Intellectual Functioning and ASD Symptom Severity Type de document : Texte imprimé et/ou numérique Auteurs : TreneshaL HILL, Auteur ; Sarah A O. GRAY, Auteur ; Jodi L. KAMPS, Auteur ; R. ENRIQUE VARELA, Auteur Article en page(s) : p.4074-4083 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Adaptive functioning Age ASD symptom severity Intellectual functioning Index. décimale : PER Périodiques Résumé : The present study examined the moderating effects of intellectual functioning and ASD symptom severity on the relation between age and adaptive functioning in 220 youth with autism spectrum disorder (ASD). Regression analysis indicated that intellectual functioning and ASD symptom severity moderated the relation between age and adaptive functioning. For younger children with lower intellectual functioning, higher ASD symptom severity was associated with better adaptive functioning than that of those with lower ASD symptom severity. Similarly, for older children with higher intellectual functioning, higher ASD symptom severity was associated with better adaptive functioning than that of those with lower ASD symptom severity. Analyses by subscales suggest that this pattern is driven by the Conceptual subscale. Clinical and research implications are discussed. En ligne : http://dx.doi.org/10.1007/s10803-015-2522-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=274
in Journal of Autism and Developmental Disorders > 45-12 (December 2015) . - p.4074-4083[article] Age and Adaptive Functioning in Children and Adolescents with ASD: The Effects of Intellectual Functioning and ASD Symptom Severity [Texte imprimé et/ou numérique] / TreneshaL HILL, Auteur ; Sarah A O. GRAY, Auteur ; Jodi L. KAMPS, Auteur ; R. ENRIQUE VARELA, Auteur . - p.4074-4083.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-12 (December 2015) . - p.4074-4083
Mots-clés : Autism spectrum disorder Adaptive functioning Age ASD symptom severity Intellectual functioning Index. décimale : PER Périodiques Résumé : The present study examined the moderating effects of intellectual functioning and ASD symptom severity on the relation between age and adaptive functioning in 220 youth with autism spectrum disorder (ASD). Regression analysis indicated that intellectual functioning and ASD symptom severity moderated the relation between age and adaptive functioning. For younger children with lower intellectual functioning, higher ASD symptom severity was associated with better adaptive functioning than that of those with lower ASD symptom severity. Similarly, for older children with higher intellectual functioning, higher ASD symptom severity was associated with better adaptive functioning than that of those with lower ASD symptom severity. Analyses by subscales suggest that this pattern is driven by the Conceptual subscale. Clinical and research implications are discussed. En ligne : http://dx.doi.org/10.1007/s10803-015-2522-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=274 Age and sex differences in problem behaviours in youth with autism spectrum disorder / Gemma GRAZIOSI in Research in Autism Spectrum Disorders, 100 (February 2023)
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Titre : Age and sex differences in problem behaviours in youth with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Gemma GRAZIOSI, Auteur ; Adrienne PERRY, Auteur Article en page(s) : 102075 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Problem Behaviour Age Sex Developmental level Index. décimale : PER Périodiques Résumé : Background Many youth with autism spectrum disorder (ASD) display problem behaviours. Although previous studies have examined age and sex differences in problem behaviours in youth with ASD, most have done so with samples that exhibited a limited range of adaptive or intellectual functioning. This study sought to examine age and sex differences in problem behaviours in youth with ASD who were diverse in age and developmental level. Method Levels of problem behaviour, as measured by the Aberrant Behavior Checklist, were examined according to age, sex, and developmental level using data from 457 inpatients (4 “20 years old; 94 females) enrolled in the SFARI Autism Inpatient Collection. Multiple regression analyses were conducted to determine the extent to which participant characteristics predict problem behaviours. Results Age was somewhat negatively correlated with irritability and total problem behaviours and moderately negatively correlated with hyperactivity. Females exhibited significantly greater scores for irritability than males. Developmental level was negatively correlated with most problem behaviours. Age, sex, and developmental level in combination accounted for a small amount of variance in most problem behaviours. Conclusions Specific problem behaviours in youth with ASD showed some age- and sex-related differences. Higher levels of problem behaviours were also associated with lower developmental level. The generalizability of these findings may be limited due to the sample consisting exclusively of inpatients. Nonetheless, recognizing differences in levels and types of problem behaviour among youth with ASD can be useful for the development and implementation of effective intervention strategies, especially in those with lower adaptive or intellectual functioning. En ligne : https://doi.org/10.1016/j.rasd.2022.102075 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491
in Research in Autism Spectrum Disorders > 100 (February 2023) . - 102075[article] Age and sex differences in problem behaviours in youth with autism spectrum disorder [Texte imprimé et/ou numérique] / Gemma GRAZIOSI, Auteur ; Adrienne PERRY, Auteur . - 102075.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 100 (February 2023) . - 102075
Mots-clés : Autism spectrum disorder Problem Behaviour Age Sex Developmental level Index. décimale : PER Périodiques Résumé : Background Many youth with autism spectrum disorder (ASD) display problem behaviours. Although previous studies have examined age and sex differences in problem behaviours in youth with ASD, most have done so with samples that exhibited a limited range of adaptive or intellectual functioning. This study sought to examine age and sex differences in problem behaviours in youth with ASD who were diverse in age and developmental level. Method Levels of problem behaviour, as measured by the Aberrant Behavior Checklist, were examined according to age, sex, and developmental level using data from 457 inpatients (4 “20 years old; 94 females) enrolled in the SFARI Autism Inpatient Collection. Multiple regression analyses were conducted to determine the extent to which participant characteristics predict problem behaviours. Results Age was somewhat negatively correlated with irritability and total problem behaviours and moderately negatively correlated with hyperactivity. Females exhibited significantly greater scores for irritability than males. Developmental level was negatively correlated with most problem behaviours. Age, sex, and developmental level in combination accounted for a small amount of variance in most problem behaviours. Conclusions Specific problem behaviours in youth with ASD showed some age- and sex-related differences. Higher levels of problem behaviours were also associated with lower developmental level. The generalizability of these findings may be limited due to the sample consisting exclusively of inpatients. Nonetheless, recognizing differences in levels and types of problem behaviour among youth with ASD can be useful for the development and implementation of effective intervention strategies, especially in those with lower adaptive or intellectual functioning. En ligne : https://doi.org/10.1016/j.rasd.2022.102075 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 Age Differences in Emergency Department Visits and Inpatient Hospitalizations in Preadolescent and Adolescent Youth with Autism Spectrum Disorders / Alyssa M. SCHLENZ in Journal of Autism and Developmental Disorders, 45-8 (August 2015)
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Titre : Age Differences in Emergency Department Visits and Inpatient Hospitalizations in Preadolescent and Adolescent Youth with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Alyssa M. SCHLENZ, Auteur ; Laura A. CARPENTER, Auteur ; Catherine BRADLEY, Auteur ; Jane CHARLES, Auteur ; Andrea BOAN, Auteur Année de publication : 2015 Article en page(s) : p.2382-2391 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Youth Age Acute care utilization Index. décimale : PER Périodiques Résumé : This paper evaluated age differences in emergency department care and inpatient hospitalizations in 252 preadolescent and adolescent youth with autism spectrum disorders (ASDs; ages 9–18). Records from youth with ASDs were linked to acute care utilization records and were compared to a demographically similar comparison group of youth without ASDs (N = 1260). A particular focus was placed on utilization for psychiatric concerns and injuries or accidents. Results suggested that psychiatric care was more likely for youth with ASDs in both the preadolescent and adolescent cohorts versus comparison youth, with no significant differences between age cohorts. In contrast, results for the accident and injury categories suggested age-specific findings. Results suggest opportunities for prevention efforts for youth with ASDs. En ligne : http://dx.doi.org/10.1007/s10803-015-2405-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263
in Journal of Autism and Developmental Disorders > 45-8 (August 2015) . - p.2382-2391[article] Age Differences in Emergency Department Visits and Inpatient Hospitalizations in Preadolescent and Adolescent Youth with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Alyssa M. SCHLENZ, Auteur ; Laura A. CARPENTER, Auteur ; Catherine BRADLEY, Auteur ; Jane CHARLES, Auteur ; Andrea BOAN, Auteur . - 2015 . - p.2382-2391.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-8 (August 2015) . - p.2382-2391
Mots-clés : Autism spectrum disorders Youth Age Acute care utilization Index. décimale : PER Périodiques Résumé : This paper evaluated age differences in emergency department care and inpatient hospitalizations in 252 preadolescent and adolescent youth with autism spectrum disorders (ASDs; ages 9–18). Records from youth with ASDs were linked to acute care utilization records and were compared to a demographically similar comparison group of youth without ASDs (N = 1260). A particular focus was placed on utilization for psychiatric concerns and injuries or accidents. Results suggested that psychiatric care was more likely for youth with ASDs in both the preadolescent and adolescent cohorts versus comparison youth, with no significant differences between age cohorts. In contrast, results for the accident and injury categories suggested age-specific findings. Results suggest opportunities for prevention efforts for youth with ASDs. En ligne : http://dx.doi.org/10.1007/s10803-015-2405-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263 Characterizing Health Disparities in the Age of Autism Diagnosis in a Study of 8-Year-Old Children / C. PARIKH in Journal of Autism and Developmental Disorders, 48-7 (July 2018)
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PermalinkComparing the effects of age, pubertal development, and symptom profile on cortisol rhythm in children and adolescents with autism spectrum disorder / A. MUSCATELLO RACHAEL in Autism Research, 11-1 (January 2018)
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PermalinkCross-Sectional Evidence for a Decrease in Cognitive Function With Age in Children With Autism Spectrum Disorders? / Petra Suzanne BARNEVELD in Autism Research, 7-5 (October 2014)
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PermalinkDisparity in autism spectrum disorder prevalence among Taiwan National Health Insurance enrollees: Age, gender and urbanization effects / Shang-Wei HSU in Research in Autism Spectrum Disorders, 6-2 (April-June 2012)
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PermalinkDivergence of Age-Related Differences in Social-Communication: Improvements for Typically Developing Youth but Declines for Youth with Autism Spectrum Disorder / Gregory L. WALLACE in Journal of Autism and Developmental Disorders, 47-2 (February 2017)
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