Association of prenatal antidepressant use with internalizing behaviors from kindergarten to adolescence / Amanda S. NITSCHKE in Journal of Child Psychology and Psychiatry, 67-3 (March 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-3 (March 2026) . - p.355-365 Titre : Association of prenatal antidepressant use with internalizing behaviors from kindergarten to adolescence Type de document : texte imprimé Auteurs : Amanda S. NITSCHKE, Auteur ; Paramdeep KAUR, Auteur ; Naomi PHAGAU, Auteur ; Helena Abreu DO VALLE, Auteur ; Jeffrey N. BONE, Auteur ; Brenda POON, Auteur ; Martin GUHN, Auteur ; Simone N. VIGOD, Auteur ; Tim F. OBERLANDER, Auteur ; Gillian E. HANLEY, Auteur Article en page(s) : p.355-365 Langues : Anglais (eng) Mots-clés : Prenatal antidepressants  childhood and adolescents mental health  anxiety  depression Index. décimale : PER Périodiques Résumé : Background To examine, using repeated measures, whether prenatal serotonin/norepinephrine reuptake inhibitor (SRI) antidepressant exposure is associated with increased anxious behaviors at kindergarten age and anxiety and/or depression behaviors after kindergarten and into adolescence. Methods This population-based retrospective cohort study included all live singleton infants delivered in British Columbia, Canada between January 2001 and December 2012 with complete outcome data. Follow-up lasted until December 2022. Logistic regression models were used to estimate unadjusted and adjusted odds ratios (OR). To minimize confounding, high-dimensional propensity score adjustment and a matched discordant sibling-pair analysis were conducted. Results Prenatal SRI exposure was associated with increased anxious behaviors in kindergarten (OR 1.77 [95% CI 1.59?1.97]) and anxiety and/or depression diagnostic codes in later childhood or adolescence (OR 2.09 [95% CI 1.97?2.22]). These associations attenuated but remained positive after high-dimensional propensity score adjustment; however, the associations did not remain in the conditional logistic regression of discordant sibling pairs (aORs 0.92 [95% CI 0.61?1.37] and 1.02 [95% CI 0.79?1.33]). Regardless of SRI exposure, children with high levels of anxious behaviors at kindergarten were more likely to receive anxiety and/or depression diagnostic codes later on (SRI exposed: aOR 1.59 [95% CI 1.24?2.06]; SRI unexposed: aOR 1.64 [95% CI 1.51?1.77]). Conclusions The associations of prenatal SRI exposure with increased internalizing behaviors at kindergarten and into adolescence are likely due to shared genetics or environmental factors. Findings also suggested kindergarten as a time for targeted interventions to address developmental vulnerabilities and prevent later development of anxiety and/or depression. En ligne : https://doi.org/10.1111/jcpp.70056 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=580 [article] Association of prenatal antidepressant use with internalizing behaviors from kindergarten to adolescence [texte imprimé] / Amanda S. NITSCHKE, Auteur ; Paramdeep KAUR, Auteur ; Naomi PHAGAU, Auteur ; Helena Abreu DO VALLE, Auteur ; Jeffrey N. BONE, Auteur ; Brenda POON, Auteur ; Martin GUHN, Auteur ; Simone N. VIGOD, Auteur ; Tim F. OBERLANDER, Auteur ; Gillian E. HANLEY, Auteur . - p.355-365. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-3 (March 2026) . - p.355-365 Mots-clés : Prenatal antidepressants  childhood and adolescents mental health  anxiety  depression Index. décimale : PER Périodiques Résumé : Background To examine, using repeated measures, whether prenatal serotonin/norepinephrine reuptake inhibitor (SRI) antidepressant exposure is associated with increased anxious behaviors at kindergarten age and anxiety and/or depression behaviors after kindergarten and into adolescence. Methods This population-based retrospective cohort study included all live singleton infants delivered in British Columbia, Canada between January 2001 and December 2012 with complete outcome data. Follow-up lasted until December 2022. Logistic regression models were used to estimate unadjusted and adjusted odds ratios (OR). To minimize confounding, high-dimensional propensity score adjustment and a matched discordant sibling-pair analysis were conducted. Results Prenatal SRI exposure was associated with increased anxious behaviors in kindergarten (OR 1.77 [95% CI 1.59?1.97]) and anxiety and/or depression diagnostic codes in later childhood or adolescence (OR 2.09 [95% CI 1.97?2.22]). These associations attenuated but remained positive after high-dimensional propensity score adjustment; however, the associations did not remain in the conditional logistic regression of discordant sibling pairs (aORs 0.92 [95% CI 0.61?1.37] and 1.02 [95% CI 0.79?1.33]). Regardless of SRI exposure, children with high levels of anxious behaviors at kindergarten were more likely to receive anxiety and/or depression diagnostic codes later on (SRI exposed: aOR 1.59 [95% CI 1.24?2.06]; SRI unexposed: aOR 1.64 [95% CI 1.51?1.77]). Conclusions The associations of prenatal SRI exposure with increased internalizing behaviors at kindergarten and into adolescence are likely due to shared genetics or environmental factors. Findings also suggested kindergarten as a time for targeted interventions to address developmental vulnerabilities and prevent later development of anxiety and/or depression. En ligne : https://doi.org/10.1111/jcpp.70056 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=580

Developmental profiles of children at risk for autism spectrum disorder at school entry / Angie IP in Autism Research, 15-7 (July 2022)  

Public ISBD [article]  inAutism Research > 15-7 (July 2022) . - p.1301-1310 Titre : Developmental profiles of children at risk for autism spectrum disorder at school entry Type de document : texte imprimé Auteurs : Angie IP, Auteur ; Brenda T. POON, Auteur ; Gillian E. HANLEY, Auteur ; Martin GUHN, Auteur ; Tim F. OBERLANDER, Auteur Article en page(s) : p.1301-1310 Langues : Anglais (eng) Mots-clés : attention deficit disorder  autism spectrum disorder  child development  cohort studies  diagnosis  functional status  health equity Index. décimale : PER Périodiques Résumé : Functional abilities in children with autism spectrum disorder (ASD) are highly heterogenous, and impairments can overlap with non-ASD neurodevelopmental disorders. We compared the profiles of children assessed for ASD with and without an ASD diagnosis using a retrospective cohort study of 101,739 children born in British Columbia (2000-2008). The children were grouped into the following five comparison groups: (1) ASD- (n = 1131), (2) ASD+ (n = 1583), (3) Ministry of Education designated ASD+ (n = 654), (4) special need other than ASD (n = 11,663), and (5) typically developing (n = 86,708). Five developmental domains were assessed using the Early Development Instrument. ANCOVA was used to control for covariates, Tukey's HSD test for multiple comparisons, and Cohen's d for effect size. The ASD- group had slightly higher scores than the ASD+ group with small to medium effect sizes in all domains (d = 0.20-0.48). The ASD- group had slightly higher scores than the Ministry of Education ASD+ group in only three domains with small effect sizes (d = 0.21-0.25). The ASD- group had lower scores in all domains compared to the typically developing group with large effect sizes in all domains (d = 1.12-1.77). The ASD- group received less education funding at school entry than both ASD+ groups. Overall, only small to medium differences in development were detected between the ASD- and ASD+ groups. While these children differ diagnostically, they share similar functional profiles and have substantially more difficulties than typically developing children. Therefore, differences in levels of support at school entry raise critical questions of equity. LAY SUMMARY: Comparison of children in British Columbia who have been referred for an autism assessment, with or without a diagnosis, shows similarities in their functional and developmental profiles in kindergarten. Furthermore, both groups of children have more difficulties than typically developing children. However, children who have been referred for assessment without an autism diagnosis receive less financial support at school entry, raising important questions on equity. En ligne : http://dx.doi.org/10.1002/aur.2742 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] Developmental profiles of children at risk for autism spectrum disorder at school entry [texte imprimé] / Angie IP, Auteur ; Brenda T. POON, Auteur ; Gillian E. HANLEY, Auteur ; Martin GUHN, Auteur ; Tim F. OBERLANDER, Auteur . - p.1301-1310. Langues : Anglais (eng) in Autism Research > 15-7 (July 2022) . - p.1301-1310 Mots-clés : attention deficit disorder  autism spectrum disorder  child development  cohort studies  diagnosis  functional status  health equity Index. décimale : PER Périodiques Résumé : Functional abilities in children with autism spectrum disorder (ASD) are highly heterogenous, and impairments can overlap with non-ASD neurodevelopmental disorders. We compared the profiles of children assessed for ASD with and without an ASD diagnosis using a retrospective cohort study of 101,739 children born in British Columbia (2000-2008). The children were grouped into the following five comparison groups: (1) ASD- (n = 1131), (2) ASD+ (n = 1583), (3) Ministry of Education designated ASD+ (n = 654), (4) special need other than ASD (n = 11,663), and (5) typically developing (n = 86,708). Five developmental domains were assessed using the Early Development Instrument. ANCOVA was used to control for covariates, Tukey's HSD test for multiple comparisons, and Cohen's d for effect size. The ASD- group had slightly higher scores than the ASD+ group with small to medium effect sizes in all domains (d = 0.20-0.48). The ASD- group had slightly higher scores than the Ministry of Education ASD+ group in only three domains with small effect sizes (d = 0.21-0.25). The ASD- group had lower scores in all domains compared to the typically developing group with large effect sizes in all domains (d = 1.12-1.77). The ASD- group received less education funding at school entry than both ASD+ groups. Overall, only small to medium differences in development were detected between the ASD- and ASD+ groups. While these children differ diagnostically, they share similar functional profiles and have substantially more difficulties than typically developing children. Therefore, differences in levels of support at school entry raise critical questions of equity. LAY SUMMARY: Comparison of children in British Columbia who have been referred for an autism assessment, with or without a diagnosis, shows similarities in their functional and developmental profiles in kindergarten. Furthermore, both groups of children have more difficulties than typically developing children. However, children who have been referred for assessment without an autism diagnosis receive less financial support at school entry, raising important questions on equity. En ligne : http://dx.doi.org/10.1002/aur.2742 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

Teacher-Reported Prevalence of FASD in Kindergarten in Canada: Association with Child Development and Problems at Home / Jacqueline PEI in Journal of Autism and Developmental Disorders, 51-2 (February 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-2 (February 2021) . - p.433-443 Titre : Teacher-Reported Prevalence of FASD in Kindergarten in Canada: Association with Child Development and Problems at Home Type de document : texte imprimé Auteurs : Jacqueline PEI, Auteur ; Caroline REID-WESTOBY, Auteur ; Ayesha SIDDIQUA, Auteur ; Yomna ELSHAMY, Auteur ; Devyn ROREM, Auteur ; Teresa BENNETT, Auteur ; Catherine S. BIRKEN, Auteur ; Robert J. COPLAN, Auteur ; Eric DUKU, Auteur ; Mark A. FERRO, Auteur ; Barry FORER, Auteur ; Stelios GEORGIADES, Auteur ; Jan Willem GORTER, Auteur ; Martin GUHN, Auteur ; Jonathon L. MAGUIRE, Auteur ; Heather MANSON, Auteur ; Rob SANTOS, Auteur ; Marni BROWNELL, Auteur ; Magdalena JANUS, Auteur Article en page(s) : p.433-443 Langues : Anglais (eng) Mots-clés : Developmental health  Early Development Instrument  Fetal Alcohol Spectrum Disorder  Kindergarten  Prevalence  Problems at home Index. décimale : PER Périodiques Résumé : The prevalence of Fetal Alcohol Spectrum Disorder (FASD) may be underestimated as it can be difficult to diagnose in early childhood possibly reflecting unique developmental trajectories relative to other Neurodevelopmental Disabilities (NDDs). Using data collected via the Early Development Instrument (EDI) between 2010 and 2015, we examined the prevalence of kindergarten children with FASD and their concurrent developmental outcomes. We found that the prevalence of FASD ranged from 0.01 to 0.31%. A greater percentage of children with FASD had teacher-reported home problems that interfered with their classroom functioning. Overall children with FASD had higher mean scores on the developmental domains compared to children with NDDs. Results of the current study can inform strategies and policies for early identification and intervention. En ligne : http://dx.doi.org/10.1007/s10803-020-04545-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=440 [article] Teacher-Reported Prevalence of FASD in Kindergarten in Canada: Association with Child Development and Problems at Home [texte imprimé] / Jacqueline PEI, Auteur ; Caroline REID-WESTOBY, Auteur ; Ayesha SIDDIQUA, Auteur ; Yomna ELSHAMY, Auteur ; Devyn ROREM, Auteur ; Teresa BENNETT, Auteur ; Catherine S. BIRKEN, Auteur ; Robert J. COPLAN, Auteur ; Eric DUKU, Auteur ; Mark A. FERRO, Auteur ; Barry FORER, Auteur ; Stelios GEORGIADES, Auteur ; Jan Willem GORTER, Auteur ; Martin GUHN, Auteur ; Jonathon L. MAGUIRE, Auteur ; Heather MANSON, Auteur ; Rob SANTOS, Auteur ; Marni BROWNELL, Auteur ; Magdalena JANUS, Auteur . - p.433-443. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-2 (February 2021) . - p.433-443 Mots-clés : Developmental health  Early Development Instrument  Fetal Alcohol Spectrum Disorder  Kindergarten  Prevalence  Problems at home Index. décimale : PER Périodiques Résumé : The prevalence of Fetal Alcohol Spectrum Disorder (FASD) may be underestimated as it can be difficult to diagnose in early childhood possibly reflecting unique developmental trajectories relative to other Neurodevelopmental Disabilities (NDDs). Using data collected via the Early Development Instrument (EDI) between 2010 and 2015, we examined the prevalence of kindergarten children with FASD and their concurrent developmental outcomes. We found that the prevalence of FASD ranged from 0.01 to 0.31%. A greater percentage of children with FASD had teacher-reported home problems that interfered with their classroom functioning. Overall children with FASD had higher mean scores on the developmental domains compared to children with NDDs. Results of the current study can inform strategies and policies for early identification and intervention. En ligne : http://dx.doi.org/10.1007/s10803-020-04545-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=440

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