Autism Detection in Children by Combined Use of Gaze Preference and the M-CHAT-R in a Resource-Scarce Setting / Kelly JENSEN in Journal of Autism and Developmental Disorders, 51-3 (March 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-3 (March 2021) . - p.994-1006 Titre : Autism Detection in Children by Combined Use of Gaze Preference and the M-CHAT-R in a Resource-Scarce Setting Type de document : texte imprimé Auteurs : Kelly JENSEN, Auteur ; Sassan NOAZIN, Auteur ; Leandra BITTERFELD, Auteur ; Andrea CARCELEN, Auteur ; Natalia I. VARGAS-CUENTAS, Auteur ; Daniela HIDALGO, Auteur ; Alejandra VALENZUELA, Auteur ; Avid ROMAN-GONZALEZ, Auteur ; Casey KREBS, Auteur ; Vincent CLEMENT, Auteur ; Cody NOLAN, Auteur ; Franklin BARRIENTOS, Auteur ; Ardi KNOBEL MENDOZA, Auteur ; Paola NORIEGA-DONIS, Auteur ; Claudia PALACIOS, Auteur ; Andrea RAMIREZ, Auteur ; Macarena VITTET, Auteur ; Emil HAFEEZ, Auteur ; Mariana TORRES-VISO, Auteur ; Myriam VELARDE, Auteur ; Lawrence H. MOULTON, Auteur ; Michael D. POWERS, Auteur ; Robert H. GILMAN, Auteur ; Mirko ZIMIC, Auteur Article en page(s) : p.994-1006 Langues : Anglais (eng) Mots-clés : ASD diagnosis  Autism spectrum disorder  Developmental disorder  Eye tracking  Gaze preference Index. décimale : PER Périodiques Résumé : Most children with autism spectrum disorder (ASD), in resource-limited settings (RLS), are diagnosed after the age of four. Our work confirmed and extended results of Pierce that eye tracking could discriminate between typically developing (TD) children and those with ASD. We demonstrated the initial 15 s was at least as discriminating as the entire video. We evaluated the GP-MCHAT-R, which combines the first 15 s of manually-coded gaze preference (GP) video with M-CHAT-R results on 73 TD children and 28 children with ASD, 36-99 months of age. The GP-MCHAT-R (AUC = 0.89 (95%CI: 0.82-0.95)), performed significantly better than the MCHAT-R (AUC = 0.78 (95%CI: 0.71-0.85)) and gaze preference (AUC = 0.76 (95%CI: 0.64-0.88)) alone. This tool may enable early screening for ASD in RLS. En ligne : http://dx.doi.org/10.1007/s10803-021-04878-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443 [article] Autism Detection in Children by Combined Use of Gaze Preference and the M-CHAT-R in a Resource-Scarce Setting [texte imprimé] / Kelly JENSEN, Auteur ; Sassan NOAZIN, Auteur ; Leandra BITTERFELD, Auteur ; Andrea CARCELEN, Auteur ; Natalia I. VARGAS-CUENTAS, Auteur ; Daniela HIDALGO, Auteur ; Alejandra VALENZUELA, Auteur ; Avid ROMAN-GONZALEZ, Auteur ; Casey KREBS, Auteur ; Vincent CLEMENT, Auteur ; Cody NOLAN, Auteur ; Franklin BARRIENTOS, Auteur ; Ardi KNOBEL MENDOZA, Auteur ; Paola NORIEGA-DONIS, Auteur ; Claudia PALACIOS, Auteur ; Andrea RAMIREZ, Auteur ; Macarena VITTET, Auteur ; Emil HAFEEZ, Auteur ; Mariana TORRES-VISO, Auteur ; Myriam VELARDE, Auteur ; Lawrence H. MOULTON, Auteur ; Michael D. POWERS, Auteur ; Robert H. GILMAN, Auteur ; Mirko ZIMIC, Auteur . - p.994-1006. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-3 (March 2021) . - p.994-1006 Mots-clés : ASD diagnosis  Autism spectrum disorder  Developmental disorder  Eye tracking  Gaze preference Index. décimale : PER Périodiques Résumé : Most children with autism spectrum disorder (ASD), in resource-limited settings (RLS), are diagnosed after the age of four. Our work confirmed and extended results of Pierce that eye tracking could discriminate between typically developing (TD) children and those with ASD. We demonstrated the initial 15 s was at least as discriminating as the entire video. We evaluated the GP-MCHAT-R, which combines the first 15 s of manually-coded gaze preference (GP) video with M-CHAT-R results on 73 TD children and 28 children with ASD, 36-99 months of age. The GP-MCHAT-R (AUC = 0.89 (95%CI: 0.82-0.95)), performed significantly better than the MCHAT-R (AUC = 0.78 (95%CI: 0.71-0.85)) and gaze preference (AUC = 0.76 (95%CI: 0.64-0.88)) alone. This tool may enable early screening for ASD in RLS. En ligne : http://dx.doi.org/10.1007/s10803-021-04878-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443

Elevated symptoms of executive dysfunction predict lower adaptive functioning in 3-year-olds with autism spectrum disorder / Kelly POWELL in Autism Research, 15-7 (July 2022)  

Public ISBD [article]  inAutism Research > 15-7 (July 2022) . - p.1336-1347 Titre : Elevated symptoms of executive dysfunction predict lower adaptive functioning in 3-year-olds with autism spectrum disorder Type de document : texte imprimé Auteurs : Kelly POWELL, Auteur ; Suzanne L. MACARI, Auteur ; Emma BRENNAN-WYDRA, Auteur ; Hannah FEINER, Auteur ; Maureen BUTLER, Auteur ; Diogo GONCALVES FORTES, Auteur ; Alexandra BOXBERGER, Auteur ; Mariana TORRES-VISO, Auteur ; Chelsea D. MORGAN, Auteur ; Megan LYONS, Auteur ; Katarzyna CHAWARSKA, Auteur Article en page(s) : p.1336-1347 Langues : Anglais (eng) Mots-clés : autism  executive function  sibling  toddlers Index. décimale : PER Périodiques Résumé : Executive functioning (EF) deficits co-occur frequently with autism spectrum disorder (ASD) and have a long-term detrimental impact on quality of life of children and their families. Timely identification of risk for EF vulnerabilities may hasten access to early intervention and alleviate their long-term consequences. This study examines (1) if EF deficits are elevated in toddlers with ASD compared to nonautistic siblings of children with ASD, typically developing (TYP) toddlers, and toddlers with atypical developmental presentation; and (2) if EF deficits have a detrimental effect on adaptive functioning in ASD. Participants were recruited between September 2014 and October 2019 and included 73 toddlers with ASD, 33 nonautistic siblings of children with ASD, 35 toddlers with atypical development, and 28 TYP toddlers matched on chronological age (M = 39.01 months, SD = 3.11). EF deficits were measured using the BRIEF-P; adaptive skills were measured using the VABS-II. Whenever appropriate, analyses were controlled for MSEL verbal and nonverbal developmental quotient, ADOS-2 autism severity scores, and sex. Analyses revealed that toddlers with ASD exhibited elevated BRIEF-P scores across all domains compared to each of the three comparison groups. Higher BRIEF-P scores were associated with lower adaptive social, communication, and daily living skills while controlling for symptom severity, verbal and nonverbal functioning, and sex. In conclusion, marked vulnerabilities in EF are already present in 3-year-old toddlers with ASD and are predictive of the level of adaptive functioning in ASD. EF vulnerabilities in toddlers should be targeted for intervention to improve long-term outcomes in ASD. LAY SUMMARY: Many children with autism experience vulnerabilities in executive functioning (EF), which may include challenges with inhibition, working memory, cognitive flexibility, and planning. The study shows that these vulnerabilities can already be detected at age three and that their presence is linked with lower social, communication, and daily living skills. Screening children with ASD for EF challenges and helping those who have difficulties may improve their long-term outcomes. En ligne : http://dx.doi.org/10.1002/aur.2715 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] Elevated symptoms of executive dysfunction predict lower adaptive functioning in 3-year-olds with autism spectrum disorder [texte imprimé] / Kelly POWELL, Auteur ; Suzanne L. MACARI, Auteur ; Emma BRENNAN-WYDRA, Auteur ; Hannah FEINER, Auteur ; Maureen BUTLER, Auteur ; Diogo GONCALVES FORTES, Auteur ; Alexandra BOXBERGER, Auteur ; Mariana TORRES-VISO, Auteur ; Chelsea D. MORGAN, Auteur ; Megan LYONS, Auteur ; Katarzyna CHAWARSKA, Auteur . - p.1336-1347. Langues : Anglais (eng) in Autism Research > 15-7 (July 2022) . - p.1336-1347 Mots-clés : autism  executive function  sibling  toddlers Index. décimale : PER Périodiques Résumé : Executive functioning (EF) deficits co-occur frequently with autism spectrum disorder (ASD) and have a long-term detrimental impact on quality of life of children and their families. Timely identification of risk for EF vulnerabilities may hasten access to early intervention and alleviate their long-term consequences. This study examines (1) if EF deficits are elevated in toddlers with ASD compared to nonautistic siblings of children with ASD, typically developing (TYP) toddlers, and toddlers with atypical developmental presentation; and (2) if EF deficits have a detrimental effect on adaptive functioning in ASD. Participants were recruited between September 2014 and October 2019 and included 73 toddlers with ASD, 33 nonautistic siblings of children with ASD, 35 toddlers with atypical development, and 28 TYP toddlers matched on chronological age (M = 39.01 months, SD = 3.11). EF deficits were measured using the BRIEF-P; adaptive skills were measured using the VABS-II. Whenever appropriate, analyses were controlled for MSEL verbal and nonverbal developmental quotient, ADOS-2 autism severity scores, and sex. Analyses revealed that toddlers with ASD exhibited elevated BRIEF-P scores across all domains compared to each of the three comparison groups. Higher BRIEF-P scores were associated with lower adaptive social, communication, and daily living skills while controlling for symptom severity, verbal and nonverbal functioning, and sex. In conclusion, marked vulnerabilities in EF are already present in 3-year-old toddlers with ASD and are predictive of the level of adaptive functioning in ASD. EF vulnerabilities in toddlers should be targeted for intervention to improve long-term outcomes in ASD. LAY SUMMARY: Many children with autism experience vulnerabilities in executive functioning (EF), which may include challenges with inhibition, working memory, cognitive flexibility, and planning. The study shows that these vulnerabilities can already be detected at age three and that their presence is linked with lower social, communication, and daily living skills. Screening children with ASD for EF challenges and helping those who have difficulties may improve their long-term outcomes. En ligne : http://dx.doi.org/10.1002/aur.2715 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

Motor stereotypies in toddlers with and without autism: A transdiagnostic dimension / Katarzyna CHAWARSKA in Journal of Child Psychology and Psychiatry, 67-1 (January 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-1 (January 2026) . - p.104-114 Titre : Motor stereotypies in toddlers with and without autism: A transdiagnostic dimension Type de document : texte imprimé Auteurs : Katarzyna CHAWARSKA, Auteur ; Thomas V. FERNANDEZ, Auteur ; Anna MILGRAMM, Auteur ; Fred VOLKMAR, Auteur ; Mariana TORRES-VISO, Auteur ; Kelly POWELL, Auteur ; Angelina VERNETTI, Auteur ; Suzanne MACARI, Auteur ; Chelsea MORGAN, Auteur Article en page(s) : p.104-114 Langues : Anglais (eng) Mots-clés : Motor stereotypies  autism  neurodevelopmental conditions  toddlers  outcomes  transdiagnostic Index. décimale : PER Périodiques Résumé : Background Motor stereotypies (MS) represent one of the transdiagnostic symptom dimensions identified by the NIMH Research Domain Criteria work group as relevant to psychopathology. MS are common in neurodevelopmental conditions, but they remain poorly understood, particularly in early childhood. The present study examined MS in 648 toddlers with autism spectrum disorder (autism, n?=?455) and other neurodevelopmental conditions (non-autism, n?=?193) and their concurrent and prospective links with other phenotypic characteristics. Methods Toddlers were recruited between February 2000 and October 2018 and evaluated at 24 +/? 5?months (Time 1, N?=?648) and 41 +/? 6?months (Time 2, N?=?455). The presence of MS was determined based on the Autism Diagnostic Observation Schedule assessment. The phenotypic measures included adaptive socialization skills, severity of social symptoms of autism, and verbal, nonverbal, and motor skills. The analysis was conducted using the general linear models while controlling for age, sex, visit year, group, and other relevant covariates. Results MS were present in both groups, but were more common and intense in autism, and their prevalence did not vary by sex in either group. Regardless of group, MS was associated concurrently with higher social-affective symptoms [p? En ligne : https://doi.org/10.1111/jcpp.70023 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Motor stereotypies in toddlers with and without autism: A transdiagnostic dimension [texte imprimé] / Katarzyna CHAWARSKA, Auteur ; Thomas V. FERNANDEZ, Auteur ; Anna MILGRAMM, Auteur ; Fred VOLKMAR, Auteur ; Mariana TORRES-VISO, Auteur ; Kelly POWELL, Auteur ; Angelina VERNETTI, Auteur ; Suzanne MACARI, Auteur ; Chelsea MORGAN, Auteur . - p.104-114. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-1 (January 2026) . - p.104-114 Mots-clés : Motor stereotypies  autism  neurodevelopmental conditions  toddlers  outcomes  transdiagnostic Index. décimale : PER Périodiques Résumé : Background Motor stereotypies (MS) represent one of the transdiagnostic symptom dimensions identified by the NIMH Research Domain Criteria work group as relevant to psychopathology. MS are common in neurodevelopmental conditions, but they remain poorly understood, particularly in early childhood. The present study examined MS in 648 toddlers with autism spectrum disorder (autism, n?=?455) and other neurodevelopmental conditions (non-autism, n?=?193) and their concurrent and prospective links with other phenotypic characteristics. Methods Toddlers were recruited between February 2000 and October 2018 and evaluated at 24 +/? 5?months (Time 1, N?=?648) and 41 +/? 6?months (Time 2, N?=?455). The presence of MS was determined based on the Autism Diagnostic Observation Schedule assessment. The phenotypic measures included adaptive socialization skills, severity of social symptoms of autism, and verbal, nonverbal, and motor skills. The analysis was conducted using the general linear models while controlling for age, sex, visit year, group, and other relevant covariates. Results MS were present in both groups, but were more common and intense in autism, and their prevalence did not vary by sex in either group. Regardless of group, MS was associated concurrently with higher social-affective symptoms [p? En ligne : https://doi.org/10.1111/jcpp.70023 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

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