Dimensions of Autistic Traits Rated by Parents of Children and Adolescents with Suspected Autism Spectrum Disorders / Teresa DEL GIUDICE in Journal of Autism and Developmental Disorders, 51-11 (November 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-11 (November 2021) . - p.3989-4002 Titre : Dimensions of Autistic Traits Rated by Parents of Children and Adolescents with Suspected Autism Spectrum Disorders Type de document : texte imprimé Auteurs : Teresa DEL GIUDICE, Auteur ; Christina DOSE, Auteur ; Anja GÖRTZ-DORTEN, Auteur ; Jennifer STEINER, Auteur ; Nicole BRUNING, Auteur ; Hannah BELL, Auteur ; Pamela ROLAND, Auteur ; Daniel WALTER, Auteur ; Michaela JUNGHÄNEL, Auteur ; Manfred DOPFNER, Auteur Article en page(s) : p.3989-4002 Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder/diagnosis  Autistic Disorder  Child  Humans  Parents  Psychometrics  Reproducibility of Results  Autism spectrum disorders  Children and adolescents  Factor structure  Parent ratings  Reliability  Validity  published by Guilford, Hogrefe, Enke, Beltz, and Huber, including the Symptom  Checklist for Autism Spectrum Disorders which is evaluated in this paper. MD has  received consulting income and research support from Lilly, Medice, Shire, Janssen  Cilag, Novartis, and Vifor, and research support from the German Research  Foundation, the German Ministry of Education and Research, and the German Ministry  of Health. TDG, CD, JS, NB, HB, PR, DW & MJ declare that they have no potential  conflict of interest. Index. décimale : PER Périodiques Résumé : To examine the factor structure of autism spectrum disorder (ASD) and the psychometric properties of the German Symptom Checklist for Autism Spectrum Disorders (SCL-ASD). Data were collected from 312 clinical referrals with suspected ASD (2-18 years). Confirmatory factor analyses and analyses of reliability, convergent and divergent validity were performed. A bifactor model with one general ASD factor and two specific factors (interaction-communication; restricted, repetitive behaviors) provided an adequate data fit. Internal consistencies of the SCL-ASD subscales and the total scale were > .70. Correlations with measures of ASD traits were higher than correlations with measures of externalizing and internalizing symptoms. The results support a factor structure consistent with DSM-5/ICD-11 criteria. The SCL-ASD has sound psychometric properties. En ligne : http://dx.doi.org/10.1007/s10803-020-04850-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454 [article] Dimensions of Autistic Traits Rated by Parents of Children and Adolescents with Suspected Autism Spectrum Disorders [texte imprimé] / Teresa DEL GIUDICE, Auteur ; Christina DOSE, Auteur ; Anja GÖRTZ-DORTEN, Auteur ; Jennifer STEINER, Auteur ; Nicole BRUNING, Auteur ; Hannah BELL, Auteur ; Pamela ROLAND, Auteur ; Daniel WALTER, Auteur ; Michaela JUNGHÄNEL, Auteur ; Manfred DOPFNER, Auteur . - p.3989-4002. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-11 (November 2021) . - p.3989-4002 Mots-clés : Adolescent  Autism Spectrum Disorder/diagnosis  Autistic Disorder  Child  Humans  Parents  Psychometrics  Reproducibility of Results  Autism spectrum disorders  Children and adolescents  Factor structure  Parent ratings  Reliability  Validity  published by Guilford, Hogrefe, Enke, Beltz, and Huber, including the Symptom  Checklist for Autism Spectrum Disorders which is evaluated in this paper. MD has  received consulting income and research support from Lilly, Medice, Shire, Janssen  Cilag, Novartis, and Vifor, and research support from the German Research  Foundation, the German Ministry of Education and Research, and the German Ministry  of Health. TDG, CD, JS, NB, HB, PR, DW & MJ declare that they have no potential  conflict of interest. Index. décimale : PER Périodiques Résumé : To examine the factor structure of autism spectrum disorder (ASD) and the psychometric properties of the German Symptom Checklist for Autism Spectrum Disorders (SCL-ASD). Data were collected from 312 clinical referrals with suspected ASD (2-18 years). Confirmatory factor analyses and analyses of reliability, convergent and divergent validity were performed. A bifactor model with one general ASD factor and two specific factors (interaction-communication; restricted, repetitive behaviors) provided an adequate data fit. Internal consistencies of the SCL-ASD subscales and the total scale were > .70. Correlations with measures of ASD traits were higher than correlations with measures of externalizing and internalizing symptoms. The results support a factor structure consistent with DSM-5/ICD-11 criteria. The SCL-ASD has sound psychometric properties. En ligne : http://dx.doi.org/10.1007/s10803-020-04850-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454

Modeling rare gene variation to gain insight into the oldest biomarker in autism: construction of the serotonin transporter Gly56Ala knock-in mouse / Jeremy VEENSTRA-VANDERWEELE in Journal of Neurodevelopmental Disorders, 1-2 (June 2009)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 1-2 (June 2009) . - p.158-71 Titre : Modeling rare gene variation to gain insight into the oldest biomarker in autism: construction of the serotonin transporter Gly56Ala knock-in mouse Type de document : texte imprimé Auteurs : Jeremy VEENSTRA-VANDERWEELE, Auteur ; Tammy N. JESSEN, Auteur ; Brent J. THOMPSON, Auteur ; Mark CARTER, Auteur ; Harish C. PRASAD, Auteur ; Jennifer A. STEINER, Auteur ; James S. SUTCLIFFE, Auteur ; Randy D. BLAKELY, Auteur Article en page(s) : p.158-71 Langues : Anglais (eng) Mots-clés : Autism  Polymorphism  Protein kinase G  Serotonin  Transgenic mouse  Transporter  p38 mitogen activated protein kinase Index. décimale : PER Périodiques Résumé : Alterations in peripheral and central indices of serotonin (5-hydroxytryptamine, 5-HT) production, storage and signaling have long been associated with autism. The 5-HT transporter gene (HTT, SERT, SLC6A4) has received considerable attention as a potential risk locus for autism-spectrum disorders, as well as disorders with overlapping symptoms, including obsessive-compulsive disorder (OCD). Here, we review our efforts to characterize rare, nonsynonymous polymorphisms in SERT derived from multiplex pedigrees carrying diagnoses of autism and OCD and present the initial stages of our effort to model one of these variants, Gly56Ala, in vivo. We generated a targeting vector to produce the Gly56Ala substitution in the Slc6a4 locus by homologous recombination. Following removal of a neomycin resistance selection cassette, animals exhibiting germline transmission of the Ala56 variant were bred to establish a breeding colony on a 129S6 background, suitable for initial evaluation of biochemical, physiological and behavioral alterations relative to SERT Gly56 (wild-type) animals. SERT Ala56 mice were achieved and exhibit a normal pattern of transmission. The initial growth and gross morphology of these animals is comparable to wildtype littermate controls. The SERT Ala56 variant can be propagated in 129S6 mice without apparent disruption of fertility and growth. We discuss both the opportunities and challenges that await the physiological/behavioral analysis of Gly56Ala transgenic mice, with particular reference to modeling autism-associated traits. En ligne : http://dx.doi.org/10.1007/s11689-009-9020-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=341 [article] Modeling rare gene variation to gain insight into the oldest biomarker in autism: construction of the serotonin transporter Gly56Ala knock-in mouse [texte imprimé] / Jeremy VEENSTRA-VANDERWEELE, Auteur ; Tammy N. JESSEN, Auteur ; Brent J. THOMPSON, Auteur ; Mark CARTER, Auteur ; Harish C. PRASAD, Auteur ; Jennifer A. STEINER, Auteur ; James S. SUTCLIFFE, Auteur ; Randy D. BLAKELY, Auteur . - p.158-71. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 1-2 (June 2009) . - p.158-71 Mots-clés : Autism  Polymorphism  Protein kinase G  Serotonin  Transgenic mouse  Transporter  p38 mitogen activated protein kinase Index. décimale : PER Périodiques Résumé : Alterations in peripheral and central indices of serotonin (5-hydroxytryptamine, 5-HT) production, storage and signaling have long been associated with autism. The 5-HT transporter gene (HTT, SERT, SLC6A4) has received considerable attention as a potential risk locus for autism-spectrum disorders, as well as disorders with overlapping symptoms, including obsessive-compulsive disorder (OCD). Here, we review our efforts to characterize rare, nonsynonymous polymorphisms in SERT derived from multiplex pedigrees carrying diagnoses of autism and OCD and present the initial stages of our effort to model one of these variants, Gly56Ala, in vivo. We generated a targeting vector to produce the Gly56Ala substitution in the Slc6a4 locus by homologous recombination. Following removal of a neomycin resistance selection cassette, animals exhibiting germline transmission of the Ala56 variant were bred to establish a breeding colony on a 129S6 background, suitable for initial evaluation of biochemical, physiological and behavioral alterations relative to SERT Gly56 (wild-type) animals. SERT Ala56 mice were achieved and exhibit a normal pattern of transmission. The initial growth and gross morphology of these animals is comparable to wildtype littermate controls. The SERT Ala56 variant can be propagated in 129S6 mice without apparent disruption of fertility and growth. We discuss both the opportunities and challenges that await the physiological/behavioral analysis of Gly56Ala transgenic mice, with particular reference to modeling autism-associated traits. En ligne : http://dx.doi.org/10.1007/s11689-009-9020-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=341

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